Wittinghofer, Alfred

GEFs and GAPs: Critical Elements in the Control of Small G Proteins

Bos, J. L., Rehmann, H., & Wittinghofer, A. (2007) · Cell

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 1,903

The Guanine Nucleotide-Binding Switch in Three Dimensions

Vetter, I. R., & Wittinghofer, A. (2001) · Science

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 1,875

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,543

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Zimmermann, G., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S. A., Triola, G., Wittinghofer, A., Bastiaens, P. I. H., et al. (2013) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 596

Structural insight into filament formation by mammalian septins

Sirajuddin, M., Farkasovsky, M., Hauer, F., Kühlmann, D., Macara, I. G., Weyand, M., Stark, H., & Wittinghofer, A. (2007) · Nature

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 481

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

John, J., Sohmen, R., Feuerstein, J., Linke, R., Wittinghofer, A., & Goody, R. S. (1990) · Biochemistry

Protein Kinase Regulation and GTPase SignalingBiochemical and Molecular Research

Cited by 429

GTPase-activating proteins: Helping hands to complement an active site

Scheffzek, K., Ahmadian, M. R., & Wittinghofer, A. (1998) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 410

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

Chandra, A., Grecco, H. E., Pisupati, V., Perera, D., Cassidy, L., Skoulidis, F., Ismail, S. A., Hedberg, C., Hanzal-Bayer, M., Venkitaraman, A. R., et al. (2012) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 325

Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy

Ottmann, C., Marco, S., Jaspert, N., Marcon, C., Schauer, N., Weyand, M., Vandermeeren, C., Duby, G., Boutry, M., Wittinghofer, A., et al. (2007) · Molecular Cell

14-3-3 protein interactionsATP Synthase and ATPases Research

Cited by 255

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Ismail, S. A., Chen, Y.-X., Rusinova, A., Chandra, A., Bierbaum, M., Gremer, L., Triola, G., Waldmann, H., Bastiaens, P. I. H., & Wittinghofer, A. (2011) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 252

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

Gremer, L., Merbitz-Zahradnik, T., Dvorsky, R., Cirstea, I. C., Kratz, C. P., Zenker, M., Wittinghofer, A., & Ahmadian, M. R. (2011) · Human Mutation

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 158

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

Daumke, O., Weyand, M., Chakrabarti, P. P., Vetter, I. R., & Wittinghofer, A. (2004) · Nature

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 144

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

Ahmadian, M. R., Hoffmann, U., Goody, R. S., & Wittinghofer, A. (1997) · Biochemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 141

The interaction of Ras with GTPase‐activating proteins

Wittinghofer, A., Scheffzek, K., & Ahmadian, M. R. (1997) · FEBS Letters

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 135

The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

Scrima, A., Thomas, C., Deaconescu, D., & Wittinghofer, A. (2008) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 127

A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A

Ottmann, C., Weyand, M., Sassa, T., Inoue, T., Kato, N., Wittinghofer, A., & Oecking, C. (2009) · Journal of Molecular Biology

14-3-3 protein interactionsProtein Interaction Studies and Fluorescence Analysis

Cited by 94

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

Spoerner, M., Wittinghofer, A., & Kalbitzer, H. R. (2004) · FEBS Letters

Protein Kinase Regulation and GTPase SignalingAdvanced NMR Techniques and Applications

Cited by 70

The actin filament architecture: tightly regulated by the cells, manipulated by pathogens: International Titisee Conference on the actin cytoskeleton: from signalling to bacterial pathogenesis

Ahmadian, M. R., Wittinghofer, A., & Schmidt, G. (2002) · The EMBO Reports

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 10