Colonna, Marco

Circadian clock protein Rev-erbα regulates neuroinflammation

Griffin, P., Dimitry, J. M., Sheehan, P. W., Lananna, B. V., Guo, C., Robinette, M. L., Hayes, M. E., Cedeño, M. R., Nadarajah, C. J., Ezerskiy, L. A., et al. (2019) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsCircadian rhythm and melatonin

Cited by 263

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

Gratuze, M., Leyns, C. E. G., Sauerbeck, A. D., St-Pierre, M.-K., Xiong, M., Kim, N., Serrano, J. R., Tremblay, M.-È., Kummer, T. T., Colonna, M., et al. (2020) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 252

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer

Park, M. D., Reyes-Torres, I., LeBerichel, J., Hamon, P., LaMarche, N. M., Hegde, S., Belabed, M., Troncoso, L., Grout, J. A., Magen, A., et al. (2023) · Nature Immunology

Immune cells in cancerImmune Cell Function and Interaction

Cited by 251

TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis

Hou, J., Zhang, J., Cui, P., Zhou, Y., Liu, C., Wu, X., Ji, Y., Wang, S., Cheng, B., Ye, H., et al. (2021) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentSepsis Diagnosis and Treatment

Cited by 239

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Kober, D. L., Alexander-Brett, J. M., Karch, C. M., Cruchaga, C., Colonna, M., Holtzman, M. J., & Brett, T. J. (2016) · eLife

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 238

TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 219

Activated microglia mitigate Aβ-associated tau seeding and spreading

Gratuze, M., Chen, Y., Parhizkar, S., Jain, N., Strickland, M. R., Serrano, J. R., Colonna, M., Ulrich, J. D., & Holtzman, D. M. (2021) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 215

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

Wu, K., Byers, D. E., Jin, X., Agapov, E., Alexander-Brett, J., Patel, A. C., Cella, M., Gilfilan, S., Colonna, M., Kober, D. L., et al. (2015) · Journal of Experimental Medicine

Inflammation biomarkers and pathwaysImmune Response and Inflammation

Cited by 207

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Hou, J., Chen, Y., Grajales-Reyes, G., & Colonna, M. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 191

Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes

Panda, S. K., Peng, V., Sudan, R., Ulezko Antonova, A., Di Luccia, B., Ohara, T. E., Fachi, J. L., Grajales-Reyes, G. E., Jaeger, N., Trsan, T., et al. (2023) · Immunity

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 174

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xiang, X., Piers, T. M., Wefers, B., Zhu, K., Mallach, A., Brunner, B., Kleinberger, G., Song, W., Colonna, M., Herms, J., et al. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 170

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceAlzheimer's disease research and treatments

Cited by 169

Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P., & Meldolesi, J. (2004) · European Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathways

Cited by 165

TREM2 macrophages induced by human lipids drive inflammation in acne lesions

Do, T. H., Ma, F., Andrade, P. R., Teles, R., de Andrade Silva, B. J., Hu, C., Espinoza, A., Hsu, J.-E., Cho, C.-S., Kim, M., et al. (2022) · Science Immunology

Acne and Rosacea Treatments and EffectsDermatology and Skin Diseases

Cited by 139

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 126

Phospholipase C-γ2 Is a Critical Signaling Mediator for Murine NK Cell Activating Receptors

Tassi, I., Presti, R., Kim, S., Yokoyama, W. M., Gilfillan, S., & Colonna, M. (2005) · The Journal of Immunology

Immune Cell Function and Interactioninterferon and immune responses

Cited by 121

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread

Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., et al. (2024) · Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 120

Aryl hydrocarbon receptor: Linking environment to immunity

Cella, M., & Colonna, M. (2015) · Seminars in Immunology

Toxic Organic Pollutants ImpactImmunotoxicology and immune responses

Cited by 119

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

Shirotani, K., Hori, Y., Yoshizaki, R., Higuchi, E., Colonna, M., Saito, T., Hashimoto, S., Saito, T., Saido, T. C., & Iwata, N. (2019) · Scientific Reports

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 116

Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory t cells

Yun, T. J., Lee, J. S., Machmach, K., Shim, D., Choi, J., Wi, Y. J., Jang, H. S., Jung, I.-H., Kim, K., Yoon, W. K., et al. (2016) · Cell Metabolism

Atherosclerosis and Cardiovascular DiseasesT-cell and B-cell Immunology

Cited by 116

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.

Gratuze, M., Schlachetzki, J. C. M., D’Oliveira Albanus, R., Jain, N., Novotny, B., Brase, L., Rodriguez, L., Mansel, C., Kipnis, M., O’Brien, S., et al. (2023) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 115

TREM2 triggers microglial density and age-related neuronal loss

Linnartz‐Gerlach, B., Bodea, L., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., & Neumann, H. (2019) · Glia

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 104

Interkeukin‐34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells

Wang, Y., & Colonna, M. (2014) · European Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsCytokine Signaling Pathways and Interactions

Cited by 97

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

Iizasa, E., Chuma, Y., Uematsu, T., Kubota, M., Kawaguchi, H., Umemura, M., Toyonaga, K., Kiyohara, H., Yano, I., Colonna, M., et al. (2021) · Nature Communications

Tuberculosis Research and EpidemiologyImmune Response and Inflammation

Cited by 92