Kinzler, Kenneth W.

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 1,240

RAF/RAS oncogenes and mismatch-repair status

Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature

Genetic factors in colorectal cancerDNA Repair Mechanisms

Cited by 1,224

Detection and quantification of mutations in the plasma of patients with colorectal tumors

Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

Cited by 1,188

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Tie, J., Cohen, J. D., Lahouel, K., Lo, S. N., Wang, Y., Kosmider, S., Wong, R., Shapiro, J., Lee, M., Harris, S., et al. (2022) · New England Journal of Medicine

Colorectal Cancer Treatments and StudiesColorectal Cancer Surgical Treatments

Cited by 1,091

Altered Telomeres in Tumors with ATRX and DAXX Mutations

Heaphy, C. M., de Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., et al. (2011) · Science

Telomeres, Telomerase, and SenescenceChromatin Remodeling and Cancer

Cited by 1,083

Disruption of p53 in human cancer cells alters the responses to therapeutic agents.

Bunz, F., Hwang, P. M., Torrance, C., Waldman, T., Zhang, Y., Dillehay, L., Williams, J., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Journal of Clinical Investigation

Cancer-related Molecular PathwaysGenetic factors in colorectal cancer

Cited by 1,044

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Samuels, Y., Diaz, L. A., Schmidt-Kittler, O., Cummins, J. M., DeLong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., et al. (2005) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 915

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Yun, J., Rago, C., Cheong, I., Pagliarini, R., Angenendt, P., Rajagopalan, H., Schmidt, K., Willson, J. K. V., Markowitz, S., Zhou, S., et al. (2009) · Science

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 914

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Nature

14-3-3 protein interactionsDNA Repair Mechanisms

Cited by 895

Role of BAX in the Apoptotic Response to Anticancer Agents

Zhang, L., Yu, J., Park, B. H., Kinzler, K. W., & Vogelstein, B. (2000) · Science

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 863

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science

BRCA gene mutations in cancerPancreatic and Hepatic Oncology Research

Cited by 826

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., et al. (2012) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 741

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

Waldman, T., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1996) · Nature

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 728

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences

Gut microbiota and healthBacterial biofilms and quorum sensing

Cited by 700

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

Kim, K., Skora, A. D., Li, Z., Liu, Q., Tam, A. J., Blosser, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2014) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersImmune cells in cancer

Cited by 676

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Tie, J., Cohen, J. D., Wang, Y., Christie, M., Simons, K., Lee, M., Wong, R., Kosmider, S., Ananda, S., McKendrick, J., et al. (2019) · JAMA Oncology

Cancer Genomics and DiagnosticsColorectal Cancer Treatments and Studies

Cited by 668

Using the transcriptome to annotate the genome

Saha, S., Sparks, A. B., Rago, C., Akmaev, V., Wang, C. J., Vogelstein, B., Kinzler, K. W., & Velculescu, V. E. (2002) · Nature Biotechnology

Genomics and Phylogenetic StudiesGene expression and cancer classification

Cited by 630

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

Lovejoy, C. A., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J. H. J., Sung, P. A., Jasin, M., et al. (2012) · PLoS Genetics

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 629

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., et al. (2017) · New England Journal of Medicine

Endometriosis Research and TreatmentCancer Genomics and Diagnostics

Cited by 628

The Antisense Transcriptomes of Human Cells

He, Y., Vogelstein, B., Velculescu, V. E., Papadopoulos, N., & Kinzler, K. W. (2008) · Science

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 531

ATM Mutations in Patients with Hereditary Pancreatic Cancer

Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., et al. (2012) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancer

Cited by 491

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., et al. (2015) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 477

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

Reitman, Z. J., Jin, G., Karoly, E. D., Spasojevic, I., Yang, J., Kinzler, K. W., He, Y., Bigner, D. D., Vogelstein, B., & Yan, H. (2011) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 449

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., et al. (2017) · Nature Genetics

Cancer Genomics and DiagnosticsPancreatic and Hepatic Oncology Research

Cited by 403