Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
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More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
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KRAS mutations may be acquired as later events during systemic treatment for metastatic disease and have been found as subclonal genetic alterations in a subset of CRC patients.
“however, may be acquired as later events during systemic treatment for metastatic disease and have been found as subclonal genetic alterations in a subset of CRC patients ([25-27])”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
The Abstract reports that KRAS mutations occur in only a fraction of cells in early pancreatic intraepithelial neoplasia, supporting the subclonal aspect. It does not establish that KRAS mutations arise during systemic treatment for metastatic disease or that this occurs in colorectal cancer patients. (LLM, conf=0.85)
Experimental — accuracy not yet measuredKRAS mutations are often a founder genetic event involved in the pathogenesis of PDAC and are consistently found in precancerous pancreatic intraepithelial neoplasms.
“First, KRAS mutations are often a founder genetic event involved in the pathogenesis of PDAC and are consistently found in precancerous pancreatic intraepithelial neoplasms”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
The paper reports KRAS mutations in 163 of 169 PanINs (96.4%), supporting their frequent presence in these precancerous lesions. It proposes that KRAS mutations can initiate PanIN development, but calls this a hypothesis rather than establishing that they are often a founder event in PDAC. (LLM, conf=0.85)
Experimental — accuracy not yet measuredKRAS mutations are observed in most low-grade PanINs and IPMNs, suggesting KRAS is the initiating genetic event in exocrine neoplasia.
“KRAS mutations are observed in most low-grade PanINs and IPMNs, suggesting KRAS is the initiating genetic event driving exocrine neoplasia46,47.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [46]
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Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Self-citationCirculating mutant DNA to assess tumor dynamics
Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746 · see citing works
Self-citationVincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,613 · see citing works
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Self-citationHruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126 · see citing works
Self-citationSenescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872 · see citing works
Self-citationRecurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786 · see citing works
Self-citationWhen cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404 · see citing works
Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia
van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363 · see citing works
Self-citationLöhr, M., Klöppel, G., Maisonneuve, P., Lowenfels, A. B., & Lüttges, J. (2005) · Neoplasia · doi:10.1593/neo.04445 · Cited by 343 · see citing works
Prasad, N. B., Biankin, A. V., Fukushima, N., Maitra, A., Dhara, S., ELKAHLOUN, A. G., Hruban, R. H., Goggins, M., & Leach, S. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1413 · Cited by 240 · see citing works
Self-citationIncreased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M. I., Ali, S. Z., Schulick, R. D., Palmisano, E., & Hruban, R. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0004 · Cited by 210 · see citing works
Self-citationWu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184 · see citing works
Vincent, A., Omura, N., Hong, S., Jaffe, A. E., Eshleman, J. R., & Goggins, M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3431 · Cited by 177 · see citing works
Self-citationHigh resolution melting analysis for gene scanning
Erali, M., & Wittwer, C. T. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.013 · Cited by 172 · see citing works
Strobel, O., Rosow, D. E., Rakhlin, E. Y., Lauwers, G. Y., Trainor, A. G., Alsina, J., del Castillo, C. F., Warshaw, A. L., & Thayer, S. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.12.005 · Cited by 162 · see citing works
Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
Lee, K. E., & Bar‐Sagi, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.020 · Cited by 133 · see citing works
Zou, H., Taylor, W. R., Harrington, J. J., Hussain, F. T. N., Cao, X., Loprinzi, C. L., Levine, T. R., Rex, D. K., Ahnen, D. J., Knigge, K. L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.023 · Cited by 97 · see citing works
Wan, H., Yuan, W., Ruan, M., Ye, Q., Wang, R., Li, Z., Zhou, G., Yao, Z., & Yang, Y. (2013) · Cited by 1 · see citing works
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- [2]Hruban RH Clin Cancer Res 2000 6 2969 2972 10955772
Cited by
Sorted by citations
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
Kamisawa, T., Wood, L. D., Itoi, T., & Takaori, K. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00141-0 · Cited by 2,212 · see citing works
Park, W., Chawla, A., & O'Reilly, E. M. (2021) · JAMA · doi:10.1001/jama.2021.13027 · Cited by 1,931 · see citing works
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
Self-citationKRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031435 · Cited by 875 · see citing works
Basturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000533 · Cited by 864 · see citing works
Self-citationKopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
KRAS: feeding pancreatic cancer proliferation
Bryant, K. L., Mancias, J. D., Kimmelman, A. C., & Der, C. J. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.004 · Cited by 675 · see citing works
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor
Hallin, J., Bowcut, V., Calinisan, A., Briere, D. M., Hargis, L., Engstrom, L. D., Laguer, J., Medwid, J., Vanderpool, D., Lifset, E., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02007-7 · Cited by 533 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
Oncogenic KRAS signalling in pancreatic cancer
EŞER, S., Schnieke, A., Schneider, G., & Saur, D. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.215 · Cited by 506 · see citing works
Stoop, T. F., Javed, A. A., Oba, A., Koerkamp, B. G., Seufferlein, T. T. W., Wilmink, J. W., & Besselink, M. G. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00261-2 · Cited by 552 · see citing works
Orth, M., Metzger, P., Gerum, S., Mayerle, J. V., Schneider, G., Belka, C., Schnurr, M., & Lauber, K. (2019) · Radiation Oncology · doi:10.1186/s13014-019-1345-6 · Cited by 488 · see citing works
Sullivan, R. J., Infante, J. R., Jankú, F., Wong, D. J. L., Sosman, J. A., Keedy, V. L., Patel, M. R., Shapiro, G. I., Mier, J. W., Tolcher, A. W., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1119 · Cited by 437 · see citing works
Pancreatic cancer biology and genetics from an evolutionary perspective
Makohon-Moore, A. P., & Iacobuzio–Donahue, C. A. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.66 · Cited by 430 · see citing works
Olivares, O., Mayers, J. R., Gouirand, V., Torrence, M. E., Gicquel, T., Borge, L., Lac, S., Roques, J., Lavaut, M.-N., Berthezène, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms16031 · Cited by 413 · see citing works
A model for RAS mutation patterns in cancers: finding the sweet spot
Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0076-6 · Cited by 384 · see citing works
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391 · see citing works
“318 Cancer Cell 22, 318–330, September 11, 2012 ª2012 Elsevier In including low-grade PanINs already carry mutations in K-RAS oncogenes, along with loss or inactivation of the P16INK4a tumor suppressor (Kanda et al., 2012).”
Roles for KRAS in Pancreatic Tumor Development and Progression
di Magliano, M. P., & Logsdon, C. D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.071 · Cited by 397 · see citing works
Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385 · see citing works
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
Connor, A. A., & Gallinger, S. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00418-1 · Cited by 369 · see citing works
Li, A., Yu, J., Kim, H., Wolfgang, C. L., Canto, M. I., Hruban, R. H., & Goggins, M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3092 · Cited by 295 · see citing works
Self-citationMolecular alterations and targeted therapy in pancreatic ductal adenocarcinoma
Qian, Y., Gong, Y., Fan, Z., Luo, G., Huang, Q., Deng, S., Cheng, H., Jin, K., Ni, Q., Yu, X., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00958-3 · Cited by 312 · see citing works
Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 263 · see citing works
Self-citationZhang, Y., Yan, W., Collins, M. A., Bednar, F., Rakshit, S., Zetter, B. R., Stanger, B. Z., Chung, I., Rhim, A. D., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1558-t · Cited by 261 · see citing works
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
Poggetto, E. D., Ho, I., Balestrieri, C., Yen, E.-Y., Zhang, S.-J., Citron, F., Shah, R., Corti, D., Diaferia, G., Li, C.-Y., et al. (2021) · Science · doi:10.1126/science.abj0486 · Cited by 222 · see citing works
Self-citationMolecular Pathogenesis of Pancreatic Cancer
Grant, T. J., Hua, K., & Singh, A. (2016) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.09.008 · Cited by 237 · see citing works
Germann, U. A., Furey, B. F., Markland, W., Hoover, R. R., Aronov, A. M., Roix, J. J., Hale, M. R., Boucher, D. M., Sorrell, D. A., Martínez-Botella, G., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0456 · Cited by 234 · see citing works
Hif1α deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia
Lee, K., Spata, M., Bayne, L., Buza, E., Durham, A., Allman, D., Vonderheide, R., & Simon, M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0822 · Cited by 203 · see citing works
Gruber, R., Panayiotou, R., Nye, E. L., Spencer‐Dene, B., Stamp, G., & Behrens, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.006 · Cited by 214 · see citing works
METTL13 methylation of eEF1A increases translational output to promote tumorigenesis
Liu, S., Hausmann, S., Carlson, S. M., Fuentes, M. E., Francis, J., Pillai, R., Lofgren, S. M., Hulea, L., Tandoc, K. V., Lu, J.-W., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.038 · Cited by 175 · see citing works
Self-citationThe pancreatic cancer genome revisited
Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00463-z · Cited by 211 · see citing works
Franco, J., Witkiewicz, A. K., & Knudsen, E. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2270 · Cited by 207 · see citing works
Preoperative<i>GNAS</i>and<i>KRAS</i>Testing in the Diagnosis of Pancreatic Mucinous Cysts
Singhi, A. D., Nikiforova, M. N., Fasanella, K. E., McGrath, K. M., Pai, R. K., Ohori, N. P., Bartholow, T. L., Brand, R. E., Chennat, J. S., Lu, X., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0513 · Cited by 207 · see citing works
Organoid models of gastrointestinal cancers in basic and translational research
Lau, H. C.-H., Kranenburg, O., Xiao, H., & Yu, J. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0255-2 · Cited by 195 · see citing works
Self-citationClinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer
Takai, E., Totoki, Y., Nakamura, H., Morizane, C., Nara, S., Hama, N., Suzuki, M., Furukawa, E., Kato, M., Hayashi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep18425 · Cited by 173 · see citing works
Omori, Y., Ono, Y., Tanino, M. A., Karasaki, H., Yamaguchi, H., Furukawa, T., Enomoto, K., Ueda, J., Sumi, A., Katayama, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.029 · Cited by 189 · see citing works
Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C., Won, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.036 · Cited by 188 · see citing works
Metastatic pancreatic cancer is dependent on oncogenic Kras in mice
Collins, M. A., Brisset, J.-C., Zhang, Y., Bednar, F., Pierre, J., Heist, K. A., Galbán, C. J., Galbán, S., & di Magliano, M. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049707 · Cited by 178 · see citing works
Evolution and dynamics of pancreatic cancer progression
Yachida, S., & Iacobuzio–Donahue, C. A. (2013) · Oncogene · doi:10.1038/onc.2013.29 · Cited by 185 · see citing works
Kanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181 · see citing works
Self-citationKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment
Zeitouni, D., Pylayeva‐Gupta, Y., Der, C. J., & Bryant, K. L. (2016) · Cancers · doi:10.3390/cancers8040045 · Cited by 179 · see citing works
Kanda, M., Knight, S., Topazian, M. D., Syngal, S., Farrell, J. J., Lee, J. D., Kamel, I. R., Lennon, A. M., Borges, M. W., Young, A., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302823 · Cited by 170 · see citing works
Self-citationYu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-311166 · Cited by 164 · see citing works
Self-citationSchlitter, A. M., Born, D., Bettstetter, M., Specht, K., Kim‐Fuchs, C., Riener, M., Jeliazkova, P., Sipos, B., Siveke, J. T., Terris, B., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.112 · Cited by 162 · see citing works
Pathology and Molecular Genetics of Pancreatic Neoplasms
Wood, L. D., & Hruban, R. H. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e31827459b6 · Cited by 161 · see citing works
Self-citationHosoda, W., Chianchiano, P. E., Griffin, J. F., Pittman, M. E., Brosens, L. A. A., Noë, M., Yu, J., Shindo, K., Suenaga, M., Rezaee, N., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4884 · Cited by 158 · see citing works
Self-citationWei, D., Wang, L., Yan, Y., Jia, Z., Gagea, M., Li, Z., Zuo, X., Kong, X., Huang, S., & Xie, K. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.005 · Cited by 156 · see citing works
Dawson, D. W., Hertzer, K. M., Moro, A., Donald, G. W., Chang, H.-H., Go, V. L. W., Pandol, S. J., Lugea, A., Gukovskaya, A. S., Li, G., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0065 · Cited by 155 · see citing works
Iacobuzio–Donahue, C. A., Velculescu, V. E., Wolfgang, C. L., & Hruban, R. H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0315 · Cited by 149 · see citing works
Self-citationCarpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0013 · Cited by 152 · see citing works
3D genomic mapping reveals multifocality of human pancreatic precancers
Braxton, A. M., Kiemen, A. L., Grahn, M. P., Forjaz, A., Parksong, J., Babu, J. M., Lai, J., Zheng, L., Niknafs, N., Jiang, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07359-3 · Cited by 158 · see citing works
Self-citationPerspectives in the treatment of pancreatic adenocarcinoma
Arregui, A. C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i31.9297 · Cited by 142 · see citing works
Intracellular and extracellular TGF-β signaling in cancer: some recent topics
Miyazono, K., Katsuno, Y., Koinuma, D., Ehata, S., & Morikawa, M. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0646-8 · Cited by 141 · see citing works
Mahalingam, D., Goel, S., Aparo, S., Arora, S. P., Noronha, N., Tran, H., Chakrabarty, R., Selvaggi, G., Gutierrez, A., Coffey, M., et al. (2018) · Cancers · doi:10.3390/cancers10060160 · Cited by 139 · see citing works
Organoid based personalized medicine: from bench to bedside
Li, Y., Tang, P., Cai, S., Peng, J., & Hua, G. (2020) · Cell Regeneration · doi:10.1186/s13619-020-00059-z · Cited by 138 · see citing works
Collins, M. A., Yan, W., Sebolt–Leopold, J. S., & Pasca di Magliano, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.052 · Cited by 133 · see citing works
Pancreatic cancer: A comprehensive review and update
Muniraj, T., Jamidar, P. A., & Aslanian, H. R. (2013) · Disease-a-Month · doi:10.1016/j.disamonth.2013.08.001 · Cited by 129 · see citing works
Ferreira, R. M. M., Sancho, R., Messal, H. A., Nye, E. L., Spencer‐Dene, B., Stone, R. K., Stamp, G., Rosewell, I. R., Quaglia, A., & Behrens, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.093 · Cited by 130 · see citing works
Precancerous neoplastic cells can move through the pancreatic ductal system
Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0481-8 · Cited by 120 · see citing works
Self-citationEarly detection of pancreatic cancer using DNA-based molecular approaches
Singhi, A. D., & Wood, L. D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00470-0 · Cited by 127 · see citing works
Novel Diagnostic and Predictive Biomarkers in Pancreatic Adenocarcinoma
Chang, J. C. S., & Kundranda, M. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030667 · Cited by 127 · see citing works
ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation
Dumartin, L., Alrawashdeh, W., Trabulo, S. M. D., Radon, T. P., Steiger, K., Feakins, R. M., di Magliano, M. P., Heeschen, C., Esposito, I., Lemoine, N. R., et al. (2016) · Oncogene · doi:10.1038/onc.2016.459 · Cited by 126 · see citing works
Hsu, M., Sasaki, M., Igarashi, S., Sato, Y., & Nakanuma, Y. (2013) · Cancer · doi:10.1002/cncr.27955 · Cited by 126 · see citing works
Patra, K. C., Bardeesy, N. M., & Mizukami, Y. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.3 · Cited by 126 · see citing works
Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Pelosi, E., Castelli, G., & Testa, U. (2017) · Biomedicines · doi:10.3390/biomedicines5040065 · Cited by 124 · see citing works
Tjensvoll, K., Nordgård, O., & Smaaland, R. (2013) · International Journal of Cancer · doi:10.1002/ijc.28134 · Cited by 123 · see citing works
KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered?
Bannoura, S. F., Khan, H. Y., & Azmi, A. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1013902 · Cited by 118 · see citing works
Mills, L. D., Zhang, Y., Marler, R. J., Herreros‐Villanueva, M., Zhang, L., Almada, L. L., Couch, F. J., Wetmore, C., di Magliano, M. P., & Fernández-Zapico, M. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438846 · Cited by 119 · see citing works
High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells
Lin, E., Rivera-Báez, L., Fouladdel, S., Yoon, H. J., Guthrie, S. M., Wieger, J., Deol, Y. S., Keller, E. T., Sahai, V., Simeone, D. M., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2017.08.012 · Cited by 121 · see citing works
Huang, L., Desai, R., Conrad, D. N., Leite, N. C., Akshinthala, D., Lim, C. M., González, R. S., Muthuswamy, L. B., Gartner, Z. J., & Muthuswamy, S. K. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.022 · Cited by 119 · see citing works
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions
Brunner, M., Wu, Z., Krautz, C., Pilarsky, C. P., Grützmann, R., & Weber, G. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184543 · Cited by 115 · see citing works
Kras as a key oncogene and therapeutic target in pancreatic cancer
Collins, M., & di Magliano, M. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00407 · Cited by 127 · see citing works
CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice
Zhang, Y., Yan, W., Mathew, E., Bednar, F., Wan, S., Collins, M. A., Evans, R. A., Welling, T. H., Vonderheide, R. H., & di Magliano, M. P. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0016-t · Cited by 102 · see citing works
Biomarkers for pancreatic cancer: promising new markers and options beyond CA 19-9
Ballehaninna, U. K., & Chamberlain, R. S. (2013) · Tumor Biology · doi:10.1007/s13277-013-1033-3 · Cited by 108 · see citing works
Recent advances in the molecular diagnostics of gastric cancer
Kanda, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i34.9838 · Cited by 108 · see citing works
Self-citationRiquelme, E. M., Behrens, C., Lin, H. Y., Simon, G. R., Papadimitrakopoulou, V. A., Izzo, J. G., Moran, C. A., Kalhor, N., Lee, J. J., Minna, J. D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1141 · Cited by 113 · see citing works
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.018 · Cited by 110 · see citing works
State of the art and future directions of pancreatic ductal adenocarcinoma therapy
Neuzillet, C., Tijeras‐Raballand, A., Bourget, P., Cros, J. F., Couvelard, A., Sauvanet, A., Vullierme, M., Tournigand, C., & Hammel, P. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.08.006 · Cited by 107 · see citing works
Preclinical models of pancreatic ductal adenocarcinoma
Hwang, C., Boj, S. F., Clevers, H. C., & Tuveson, D. A. (2015) · The Journal of Pathology · doi:10.1002/path.4651 · Cited by 104 · see citing works
Targeting KRAS in pancreatic cancer: new drugs on the horizon
Bannoura, S. F., Uddin, M. H., Nagasaka, M., Fazili, F., Hallak, M. N. A., Philip, P. A., El‐Rayes, B. F., & Azmi, A. S. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09990-2 · Cited by 105 · see citing works
Yamamoto, K., Tateishi, K., Kudo, Y., Sato, T., Yamamoto, S., Miyabayashi, K., Matsusaka, K., Asaoka, Y., Ijichi, H., Hirata, Y., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu136 · Cited by 104 · see citing works
Inherited pancreatic cancer syndromes
Solomon, S., Das, S., Brand, R., & Whitcomb, D. C. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318278c4a6 · Cited by 120 · see citing works
DeTiN: overcoming tumor-in-normal contamination
Taylor-Weiner, A. N., Stewart, C., Giordano, T. J., Miller, M. L., Rosenberg, M. W., Macbeth, A., Lennon, N. J., Rheinbay, E., Landau, D. A., Wu, C. J., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0036-9 · Cited by 93 · see citing works
Sox9: a master regulator of the pancreatic program.
Seymour, P. A. (2014) · The review of diabetic studies : RDS · doi:10.1900/rds.2014.11.51 · Cited by 100 · see citing works
Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment
Polireddy, K., & Chen, Q. (2016) · Journal of Cancer · doi:10.7150/jca.14922 · Cited by 98 · see citing works
Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming
Velez-Delgado, A., Donahue, K. L., Brown, K. L., Du, W., Irizarry-Negron, V., Menjivar, R. E., Lasse Opsahl, E. L., Steele, N. G., The, S., Lazarus, J., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.016 · Cited by 91 · see citing works
Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine
Conway, J. R. W., Herrmann, D., Evans, T. J., Morton, J. P., & Timpson, P. (2018) · Gut · doi:10.1136/gutjnl-2018-316822 · Cited by 93 · see citing works
Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations
Kulemann, B., Rösch, S., Seifert, S., Timme, S., Bronsert, P., Seifert, G. J., Martini, V., Kuvendjiska, J., Glatz, T., Hussung, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04601-z · Cited by 94 · see citing works
Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?
Minciacchi, V. R., Zijlstra, A., Rubin, M. A., & Vizio, D. D. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.7 · Cited by 93 · see citing works
Miglietta, G., Cogoi, S., Marinello, J., Capranico, G., Tikhomirov, A. S., Shchekotikhin, A. E., & Xodo, L. E. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00622 · Cited by 92 · see citing works
Clinical applications of circulating tumor DNA and circulating tumor cells in pancreatic cancer
Riva, F., Dronov, O. I., Khomenko, D. I., Huguet, F., Louvet, C., Mariani, P., Stern, M., Lantz, O. J., Proudhon, C., Pierga, J., et al. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.01.006 · Cited by 93 · see citing works
Fischer, C. G., & Wood, L. D. (2018) · The Journal of Pathology · doi:10.1002/path.5154 · Cited by 91 · see citing works
Genetics of familial and sporadic pancreatic cancer
Wood, L. D., Yurgelun, M. B., & Goggins, M. G. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.039 · Cited by 91 · see citing works
Self-citationNagaraju, G. P., Zhu, S., Wen, J., Farris, A. B., Adsay, V. N., Diaz, R., Snyder, J. P., Shoji, M., & El‐Rayes, B. F. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.002 · Cited by 91 · see citing works
Matsuda, Y., Furukawa, T., Yachida, S., Nishimura, M., Seki, A., Nonaka, K., Aida, J., Takubo, K., Ishiwata, T., Kimura, W., et al. (2017) · Pancreas · doi:10.1097/mpa.0000000000000786 · Cited by 89 · see citing works
HLA ligandome tumor antigen discovery for personalized vaccine approach
Rammensee, H., & Singh‐Jasuja, H. (2013) · Expert Review of Vaccines · doi:10.1586/14760584.2013.836911 · Cited by 88 · see citing works
Yang, K., Li, Y., Lian, G., Lin, H., Shang, C., Zeng, L., Chen, S., Li, J., Huang, C., Huang, K., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31248 · Cited by 88 · see citing works
Wang, W., Friedland, S. C., Guo, B., O'Dell, M. R., Alexander, W. B., Whitney-Miller, C. L., Agostini-Vulaj, D., Huber, A. R., Myers, J. R., Ashton, J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315541 · Cited by 70 · see citing works
- Authors
- Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Goggins, Michael
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 730-733.e9
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321090
- OpenAlex
- W2081681778
- Cited by
- 741
- References
- 22
- Citations by year
- 2026: 45 · 2025: 51 · 2024: 47 · 2023: 57 · 2022: 47 · 2021: 76 · 2020: 49 · 2019: 41 · 2018: 61 · 2017: 68 · 2016: 50 · 2015: 44 · 2014: 39 · 2013: 40 · 2012: 25
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Krebshilfe
- Lustgarten Foundation
- National Institutes of Health (CA62924, R01CA120432, P01CA134292, R01CA97075, RC2CA148376)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic intraepithelial neoplasia, somatic mutations, KRAS, CDKN2A, p16, GNAS, BRAF, pancreatic ductal adenocarcinoma, precancerous lesions, tumor progression, genetic susceptibility
- MeSH terms
- Carcinoma in Situ, Chromogranins, DNA Mutational Analysis, Humans, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins, Baltimore, Proto-Oncogene Proteins p21(ras), ras Proteins, GTP-Binding Protein alpha Subunits, Gs, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Proto-Oncogene Proteins B-raf
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