Clevers, Hans

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Giobbe, G. G., Crowley, C., Luni, C., Campinoti, S., Khedr, M., Kretzschmar, K., De Santis, M. M., Zambaiti, E., Michielin, F., Meran, L., et al. (2019) · Nature Communications

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cited by 500

Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues

Simons, B. D., & Clevers, H. (2011) · Cell

Developmental Biology and Gene RegulationHematopoietic Stem Cell Transplantation

Cited by 489

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G. M., van der Velden, D. L., Peeper, D. S., Cuppen, E. P. J. G., et al. (2015) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 482

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 461

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

Hombrink, P., Helbig, C., Backer, R. A., Piet, B., Oja, A. E., Stark, R., Brasser, G., Jongejan, A., Jonkers, R. E., Nota, B., et al. (2016) · Nature Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 455

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

Driehuis, E., Kolders, S., Spelier, S., Lõhmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., et al. (2019) · Cancer Discovery

Cancer Cells and MetastasisHead and Neck Cancer Studies

Cited by 408

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., et al. (2017) · Nature

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 403

Xenograft and organoid model systems in cancer research

Bleijs, M., van de Wetering, M., Clevers, H., & Drost, J. (2019) · The EMBO Journal

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 400

Organoids in immunological research

Bar-Ephraim, Y. E., Kretzschmar, K., & Clevers, H. (2020) · Nature Reviews Immunology

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 361

Microbiota controls the homeostasis of glial cells in the gut lamina propria

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron

Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomalies

Cited by 358

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A., & Clevers, H. (2019) · Cell

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 346

Human tissues in a dish: The research and ethical implications of organoid technology

Bredenoord, A. L., Clevers, H., & Knoblich, J. A. (2017) · Science

Biomedical Ethics and RegulationPluripotent Stem Cells Research

Cited by 334

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 320

Reg4 + deep crypt secretory cells function as epithelial niche for Lgr5 + stem cells in colon

Sasaki, N., Sachs, N., Wiebrands, K., Ellenbroek, S. I. J., Fumagalli, A., Lyubimova, A., Begthel, H., van den Born, M., van Es, J. H., Karthaus, W. R., et al. (2016) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 314

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., et al. (2017) · Scientific Data

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 310

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., et al. (2019) · Cell Reports

Cystic Fibrosis Research AdvancesTissue Engineering and Regenerative Medicine

Cited by 310

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Crosby, P., Hamnett, R., Putker, M., Hoyle, N. P., Reed, M., Karam, C. J., Maywood, E. S., Stangherlin, A., Chesham, J. E., Hayter, E. A., et al. (2019) · Cell

Circadian rhythm and melatoninSleep and Work-Related Fatigue

Cited by 309

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte, C. J., Espejo Valle-Inclan, J., Hami, N., Lõhmussaar, K., Kopper, O., Vreuls, C. P. H., Jonges, G. N., van Diest, P., Nguyen, L., Clevers, H., et al. (2020) · Cell Reports

Ovarian cancer diagnosis and treatmentBRCA gene mutations in cancer

Cited by 303

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

Heijmans, J., van Lidth de Jeude, J. F., Koo, B.-K., Rosekrans, S. L., Wielenga, M. C. B., van de Wetering, M., Ferrante, M., Lee, A. S., Onderwater, J. J. M., Paton, J. C., et al. (2013) · Cell Reports

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 293

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

Schuijers, J., Junker, J. P., Mokry, M., Hatzis, P., Koo, B.-K., Sasselli, V., van der Flier, L. G., Cuppen, E., van Oudenaarden, A., & Clevers, H. (2015) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 273

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., Wetering, M. V. D., Egan, D. A., et al. (2016) · eLife

Colorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase Signaling

Cited by 263

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

Artegiani, B., Lyubimova, A., Muraro, M., van Es, J. H., van Oudenaarden, A., & Clevers, H. (2017) · Cell Reports

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 259

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 255

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra, K. K., Monkhorst, K., Schipper, L. J., Hartemink, K. J., Smit, E. F., Kaing, S., de Groot, R., Wolkers, M. C., Clevers, H., Cuppen, E., et al. (2020) · Cell Reports

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 254