Clevers, Hans

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Hu, H., Gehart, H., Artegiani, B., LÖpez-Iglesias, C., Dekkers, F., Basak, O., van Es, J., Chuva de Sousa Lopes, S. M., Begthel, H., Korving, J., et al. (2018) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 837

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

Broutier, L., Andersson-Rolf, A., Hindley, C. J., Boj, S. F., Clevers, H., Koo, B.-K., & Huch, M. (2016) · Nature Protocols

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 834

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., et al. (2019) · Nature Medicine

Ovarian cancer diagnosis and treatmentCancer Cells and Metastasis

Cited by 834

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., Vries, R., Peters, P. J., & Clevers, H. (2015) · Gastroenterology

Helicobacter pylori-related gastroenterology studiesCancer Cells and Metastasis

Cited by 820

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Ooft, S. N., Weeber, F., Dijkstra, K. K., McLean, C. M., Kaing, S., van Werkhoven, E., Schipper, L., Hoes, L., Vis, D. J., van de Haar, J., et al. (2019) · Science Translational Medicine

Colorectal Cancer Treatments and StudiesCancer Cells and Metastasis

Cited by 813

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 805

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 767

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Nikolaev, M., Mitrofanova, O., Broguiere, N., Geraldo, S., Dutta, D., Tabata, Y., Elci, B., Brandenberg, N., Kolotuev, I., Gjorevski, N., et al. (2020) · Nature

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 755

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Yao, Y., Xu, X., Yang, L., Zhu, J., Wan, J., Shen, L., Xia, F., Fu, G., Deng, Y., Pan, M., et al. (2020) · Cell Stem Cell

Cancer Cells and MetastasisColorectal Cancer Surgical Treatments

Cited by 755

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 751

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 730

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Yan, H. H. N., Siu, H. C., Law, S., Ho, S. L., Yue, S. S. K., Tsui, W. Y., Chan, D., Chan, A. S., Ma, S., Lam, K. O., et al. (2018) · Cell Stem Cell

Cancer Cells and MetastasisGastric Cancer Management and Outcomes

Cited by 724

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., et al. (2011) · Nature Medicine

Cancer Cells and MetastasisHematopoietic Stem Cell Transplantation

Cited by 709

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

Radtke, F., & Clevers, H. (2005) · Science

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 690

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes & Development

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 656

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

Farin, H. F., Van Es, J. H., & Clevers, H. (2012) · Gastroenterology

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 655

The intestinal stem cell

Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes & Development

Digestive system and related healthWnt/β-catenin signaling in development and cancer

Cited by 629

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 621

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

Grün, D., Muraro, M. J., Boisset, J.-C., Wiebrands, K., Lyubimova, A., Dharmadhikari, G., van den Born, M., van Es, J., Jansen, E., Clevers, H., et al. (2016) · Cell Stem Cell

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 586

Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters

Tetteh, P. W., Basak, O., Farin, H. F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J. H., et al. (2016) · Cell stem cell

Digestive system and related healthWnt/β-catenin signaling in development and cancer

Cited by 575

A rectal cancer organoid platform to study individual responses to chemoradiation

Ganesh, K., Wu, C., O’Rourke, K. P., Szeglin, B. C., Zheng, Y., Sauvé, C.-E. G., Adileh, M., Wasserman, I., Marco, M. R., Kim, A. S., et al. (2019) · Nature Medicine

Cancer Cells and MetastasisColorectal Cancer Surgical Treatments

Cited by 569

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Ye, F., Chen, Y., Hoang, T., Montgomery, R. L., Zhao, X.-H., Bu, H., Hu, T., Taketo, M. M., van Es, J. H., Clevers, H., et al. (2009) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsWnt/β-catenin signaling in development and cancer

Cited by 559

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

Dekkers, J. F., Berkers, G., Kruisselbrink, E., Vonk, A., de Jonge, H. R., Janssens, H. M., Bronsveld, I., van de Graaf, E. A., Nieuwenhuis, E. E. S., Houwen, R. H. J., et al. (2016) · Science Translational Medicine

Cystic Fibrosis Research AdvancesGenetic and Kidney Cyst Diseases

Cited by 548

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M., et al. (2016) · Nature

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 525