Clevers, Hans

The inner nuclear membrane protein Emerin regulates β‐catenin activity by restricting its accumulation in the nucleus

Markiewicz, E., Tilgner, K., Barker, N., van de Wetering, M., Clevers, H., Dorobek, M., Hausmanowa‐Petrusewicz, I., Ramaekers, F. C., Broers, J. L., Blankesteijn, W. M., et al. (2006) · The EMBO Journal

Nuclear Structure and FunctionWnt/β-catenin signaling in development and cancer

Cited by 246

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., & Näthke, I. S. (2010) · Cell Stem Cell

Microtubule and mitosis dynamicsDevelopmental Biology and Gene Regulation

Cited by 242

Critical Involvement of Tcf-1 in Expansion of Thymocytes

Schilham, M. W., Wilson, A., Moerer, P., Benaissa-Trouw, B. J., Cumano, A., & Clevers, H. C. (1998) · The Journal of Immunology

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 237

Patient-derived micro-organospheres enable clinical precision oncology

Ding, S., Hsu, C., Wang, Z., Natesh, N. R., Millen, R., Negrete, M., Giroux, N., Rivera, G. O., Dohlman, A., Bose, S., et al. (2022) · Cell Stem Cell

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 228

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

Lamers, M. M., van der Vaart, J., Knoops, K., Riesebosch, S., Breugem, T. I., Mykytyn, A. Z., Beumer, J., Schipper, D., Bezstarosti, K., Koopman, C. D., et al. (2021) · The EMBO Journal

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 227

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts, M. H., de Poel, E., Amatngalim, G. D., Oka, R., Meijers, F. M., Kruisselbrink, E., van Mourik, P., Berkers, G., de Winter-de Groot, K. M., Michel, S., et al. (2020) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 222

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., et al. (2019) · Cell Stem Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesChromatin Remodeling and Cancer

Cited by 218

Distinct β-catenins mediate adhesion and signalling functions in C. elegans

Korswagen, H. C., Herman, M. A., & Clevers, H. C. (2000) · Nature

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 218

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

Schepers, A. G., Vries, R., van den Born, M., van de Wetering, M., & Clevers, H. (2011) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 217

Wnt signaling mediates regional specification in the vertebrate face

Brugmann, S. A., Goodnough, L. H., Gregorieff, A., Leucht, P., ten Berge, D., Fuerer, C., Clevers, H., Nusse, R., & Helms, J. A. (2007) · Development

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 213

Promises and challenges of organoid-guided precision medicine

Bose, S., Clevers, H., & Shen, X. (2021) · Med

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 213

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer

Lõhmussaar, K., Oka, R., Espejo Valle-Inclan, J., Smits, M. H. H., Wardak, H., Korving, J., Begthel, H., Proost, N., van de Ven, M., Kranenburg, O. W., et al. (2021) · Cell Stem Cell

Cervical Cancer and HPV ResearchCancer Cells and Metastasis

Cited by 211

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., et al. (2020) · Cell Stem Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 202

Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF

Schuijers, J., Mokry, M., Hatzis, P., Cuppen, E., & Clevers, H. (2014) · The EMBO Journal

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 191

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 186

Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

He, G.-W., Lin, L., DeMartino, J., Zheng, X., Staliarova, N., Dayton, T., Begthel, H., van de Wetering, W. J., Bodewes, E., van Zon, J., et al. (2022) · Cell Stem Cell

IL-33, ST2, and ILC PathwaysInflammatory Bowel Disease

Cited by 178

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers, B., Eppink, B., James, M. I., Cortina, C., Cañellas-Socias, A., Boj, S. F., Hernando-Momblona, X., Glodzik, D., Roovers, R. C., van de Wetering, M., et al. (2022) · Nature Cancer

Monoclonal and Polyclonal Antibodies ResearchCancer Cells and Metastasis

Cited by 178

The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 171

SnapShot: Growing Organoids from Stem Cells

Sato, T., & Clevers, H. (2015) · Cell

Pluripotent Stem Cells ResearchCancer Cells and Metastasis

Cited by 168

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., et al. (2016) · EMBO Molecular Medicine

TGF-β signaling in diseasesColorectal Cancer Treatments and Studies

Cited by 159

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., et al. (2016) · Nature Communications

Neurogenesis and neuroplasticity mechanismsWnt/β-catenin signaling in development and cancer

Cited by 154

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., et al. (2020) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 151

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

Geurts, M. H., de Poel, E., Pleguezuelos-Manzano, C., Oka, R., Carrillo, L., Andersson-Rolf, A., Boretto, M., Brunsveld, J. E., van Boxtel, R., Beekman, J. M., et al. (2021) · Life Science Alliance

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 151

Tissue-specific designs of stem cell hierarchies

Visvader, J. E., & Clevers, H. (2016) · Nature Cell Biology

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 150