Clevers, Hans

Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Schneeberger, K., Sánchez‐Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., et al. (2020) · Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 141

WNT Signaling and Lymphocyte Development

van de Wetering, M., de Lau, W., & Clevers, H. (2002) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 139

Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures

Urciuolo, A., Giobbe, G. G., Dong, Y., Michielin, F., Brandolino, L., Magnussen, M., Gagliano, O., Selmin, G., Scattolini, V., Raffa, P., et al. (2023) · Nature Communications

3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications

Cited by 121

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Yonekura, S., Terrisse, S., Alves Costa Silva, C., Lafarge, A., Iebba, V., Ferrere, G., Goubet, A.-G., Fahrner, J.-E., Lahmar, I., Ueda, K., et al. (2022) · Cancer Discovery

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 112

In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed

Bonanini, F., Kurek, D., Previdi, S., Nicolas, A., Hendriks, D., de Ruiter, S., Meyer, M., Clapés Cabrer, M., Dinkelberg, R., García, S. B., et al. (2022) · Angiogenesis

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 112

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer

Rosendahl Huber, A., Pleguezuelos-Manzano, C., Puschhof, J., Ubels, J., Boot, C., Saftien, A., Verheul, M., Trabut, L. T., Groenen, N., van Roosmalen, M., et al. (2024) · Cancer Cell

Genetic factors in colorectal cancerCancer Genomics and Diagnostics

Cited by 106

CRISPR engineering in organoids for gene repair and disease modelling

Geurts, M. H., & Clevers, H. (2023) · Nature Reviews Bioengineering

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 103

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor-positive breast cancer

Whittle, J. R., Vaillant, F., Surgenor, E., Policheni, A. N., Giner, G., Capaldo, B. D., Chen, H.-R., Liu, H. K., Dekkers, J. F., Sachs, N., et al. (2020) · Clinical Cancer Research

Advanced Breast Cancer TherapiesBreast Cancer Treatment Studies

Cited by 102

Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

Schneeberger, K., Spee, B., Costa, P., Sachs, N., Clevers, H., & Malda, J. (2017) · Biofabrication

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 100

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

Boonekamp, K. E., Kretzschmar, K., Wiener, D. J., Asra, P., Derakhshan, S., Puschhof, J., López-Iglesias, C., Peters, P. J., Basak, O., & Clevers, H. (2019) · Proceedings of the National Academy of Sciences

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 96

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., et al. (2020) · Scientific Reports

Pediatric Hepatobiliary Diseases and TreatmentsLiver physiology and pathology

Cited by 86

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

Geurts, M. H., Gandhi, S., Boretto, M. G., Akkerman, N., Derks, L. L. M., van Son, G., Celotti, M., Harshuk-Shabso, S., Peci, F., Begthel, H., et al. (2023) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 66

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Jager, M., Blokzijl, F., Sasselli, V., Boymans, S., Janssen, R., Besselink, N., Clevers, H., van Boxtel, R., & Cuppen, E. (2018) · Nature Protocols

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 66

Loss of Rnf43 accelerates kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

Hosein, A. N., Dangol, G., Okumura, T., Roszik, J., Rajapakshe, K., Siemann, M., Zaid, M., Ghosh, B., Monberg, M., Guerrero, P. A., et al. (2022) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchCancer Immunotherapy and Biomarkers

Cited by 61

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

Lin, L., DeMartino, J., Wang, D., van Son, G. J. F., van der Linden, R., Begthel, H., Korving, J., Andersson-Rolf, A., van den Brink, S., Lopez-Iglesias, C., et al. (2023) · Science

Developmental Biology and Gene RegulationDigestive system and related health

Cited by 50

Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity

Lee, M., Yoon, J., Song, H., Lee, B., Lam, D. T., Yoon, J., Baek, K., Clevers, H., & Jeong, Y. (2017) · Developmental Biology

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 48

Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids

Boonekamp, K. E., Heo, I., Artegiani, B., Asra, P., van Son, G., de Ligt, J., & Clevers, H. (2021) · Developmental Biology

Wnt/β-catenin signaling in development and cancerHippo pathway signaling and YAP/TAZ

Cited by 38

Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

Boretto, M., Geurts, M. H., Gandhi, S., Ma, Z., Staliarova, N., Celotti, M., Lim, S., He, G.-W., Millen, R., Driehuis, E., et al. (2024) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysHER2/EGFR in Cancer Research

Cited by 30

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

Plattner, C., Lamberti, G., Blattmann, P., Kirchmair, A., Rieder, D., Loncova, Z., Sturm, G., Scheidl, S., Ijsselsteijn, M., Fotakis, G., et al. (2023) · iScience

Advanced Proteomics Techniques and ApplicationsColorectal Cancer Treatments and Studies

Cited by 27

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B.-K., Dollé, P., Bloch-Zupan, A., et al. (2020) · Scientific Reports

Bone and Dental Protein Studiesdental development and anomalies

Cited by 25

Nanoblades allow high-level genome editing in murine and human organoids

Tiroille, V., Krug, A., Bokobza, E., Kahi, M., Bulcaen, M., Ensinck, M. M., Geurts, M. H., Hendriks, D., Vermeulen, F., Larbret, F., et al. (2023) · Molecular Therapy - Nucleic Acids

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 25

Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools

Celotti, M., Derks, L. L. M., van Es, J., van Boxtel, R., Clevers, H., & Geurts, M. H. (2024) · STAR Protocols

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 17