Murphy, Michael P.

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 432

Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins

Beer, S. M., Taylor, E. R., Brown, S. E., Dahm, C. C., Costa, N. J., Runswick, M. J., & Murphy, M. P. (2004) · Journal of Biological Chemistry

Redox biology and oxidative stressSulfur Compounds in Biology

Cited by 404

Mitochondria-Targeted Small Molecule Therapeutics and Probes

Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling

Mitochondrial Function and PathologyNanoparticle-Based Drug Delivery

Cited by 399

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 398

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., et al. (2021) · Science

Liver physiology and pathologyOrgan Transplantation Techniques and Outcomes

Cited by 394

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., & Brand, M. D. (2002) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 388

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International

Hepatitis C virus researchDrug-Induced Hepatotoxicity and Protection

Cited by 379

Mitochondrial ROS produced via reverse electron transport extend animal lifespan

Scialò, F., Sriram, A., Fernández-Ayala, D., Gubina, N., Lõhmus, M., Nelson, G., Logan, A., Cooper, H. M., Navas, P., Enríquez, J. A., et al. (2016) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 371

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 367

Selective targeting of bioactive compounds to mitochondria

Murphy, M. P. (1997) · Trends in Biotechnology

Mitochondrial Function and PathologyNanoparticle-Based Drug Delivery

Cited by 366

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

James, A. M., Cochemé, H. M., Smith, R. A. J., & Murphy, M. P. (2005) · Journal of Biological Chemistry

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 353

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

Kelly, B., Tannahill, G. M., Murphy, M. P., & O'Neill, L. A. J. (2015) · Journal of Biological Chemistry

Inflammasome and immune disordersMetabolism, Diabetes, and Cancer

Cited by 334

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressGenetics, Aging, and Longevity in Model Organisms

Cited by 313

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Hinchy, E. C., Gruszczyk, A. V., Willows, R., Navaratnam, N., Hall, A. R., Bates, G., Bright, T. P., Krieg, T., Carling, D., & Murphy, M. P. (2018) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerRedox biology and oxidative stress

Cited by 302

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics

Coenzyme Q10 studies and effectsAntioxidant Activity and Oxidative Stress

Cited by 292

Macrophage-derived extracellular succinate licenses neural stem cells to suppress chronic neuroinflammation

Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S. H., Kwok, C. K., Leonardi, T., Booty, L. M., Bicci, I., Balzarotti, B., Volpe, G., et al. (2018) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 285

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Liou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 270

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

Gioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 263

Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

James, A. M., Sharpley, M. S., Manas, A.-R. B., Frerman, F. E., Hirst, J., Smith, R. A. J., & Murphy, M. P. (2007) · Journal of Biological Chemistry

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 262

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

Lowes, D. A., Thottakam, B. M. V., Webster, N. R., Murphy, M. P., & Galley, H. F. (2008) · Free Radical Biology and Medicine

Sepsis Diagnosis and TreatmentMitochondrial Function and Pathology

Cited by 261

Mitochondrial complex I activity in microglia sustains neuroinflammation

Peruzzotti-Jametti, L., Willis, C. M., Krzak, G., Hamel, R., Pirvan, L., Ionescu, R.-B., Reisz, J. A., Prag, H. A., Garcia-Segura, M. E., Wu, V., et al. (2024) · Nature

Neuroinflammation and Neurodegeneration MechanismsMitochondrial Function and Pathology

Cited by 239

Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

Requejo, R., Hurd, T. R., Costa, N. J., & Murphy, M. P. (2010) · The FEBS Journal

Redox biology and oxidative stressSulfur Compounds in Biology

Cited by 231

Mitochondrially targeted compounds and their impact on cellular bioenergetics

Reily, C., Mitchell, T., Chacko, B. K., Benavides, G. A., Murphy, M. P., & Darley-Usmar, V. M. (2013) · Redox Biology

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 227

A mitochondria-targeted S -nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Prime, T. A., Blaikie, F. H., Evans, C., Nadtochiy, S. M., James, A. M., Dahm, C. C., Vitturi, D. A., Patel, R. P., Hiley, C. R., Abakumova, I., et al. (2009) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 222