Murphy, Michael P.

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

Rodriguez-Cuenca, S., Cochemé, H. M., Logan, A., Abakumova, I., Prime, T. A., Rose, C., Vidal-Puig, A., Smith, A. C., Rubinsztein, D. C., Fearnley, I. M., et al. (2010) · Free Radical Biology and Medicine

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 218

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Ross, M. F., Prime, T. A., Abakumova, I., James, A. M., Porteous, C. M., Smith, R. A. J., & Murphy, M. P. (2008) · Biochemical Journal

Mitochondrial Function and PathologyBioactive Compounds and Antitumor Agents

Cited by 206

Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

Chacko, B. K., Reily, C., Srivastava, A., Johnson, M. S., Ye, Y., Ulasova, E., Agarwal, A., Zinn, K. R., Murphy, M. P., Kalyanaraman, B., et al. (2010) · Biochemical Journal

Chronic Kidney Disease and DiabetesMitochondrial Function and Pathology

Cited by 204

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

Saretzki, G., Murphy, M. P., & Von Zglinicki, T. (2003) · Aging Cell

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 203

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

Dare, A. J., Bolton, E. A., Pettigrew, G. J., Bradley, J. A., Saeb-Parsy, K., & Murphy, M. P. (2015) · Redox Biology

Acute Kidney Injury ResearchMitochondrial Function and Pathology

Cited by 202

Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer

Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., et al. (2019) · Cancer Discovery

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 198

Persistent S-Nitrosation of Complex I and Other Mitochondrial Membrane Proteins by S-Nitrosothiols but Not Nitric Oxide or Peroxynitrite

Dahm, C. C., Moore, K., & Murphy, M. P. (2006) · Journal of Biological Chemistry

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 194

Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant

Asin-Cayuela, J., Manas, A.-R. B., James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · FEBS Letters

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 184

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

Hurd, T. R., Requejo, R., Filipovska, A., Brown, S., Prime, T. A., Robinson, A. J., Fearnley, I. M., & Murphy, M. P. (2008) · Journal of Biological Chemistry

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 182

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

Minczuk, M., Papworth, M. A., Kolasinska, P., Murphy, M. P., & Klug, A. (2006) · Proceedings of the National Academy of Sciences

CRISPR and Genetic EngineeringMitochondrial Function and Pathology

Cited by 166

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

Lim, P. J., Duarte, T. L., Arezes, J., Garcia-Santos, D., Hamdi, A., Pasricha, S.-R., Armitage, A. E., Mehta, H., Wideman, S., Santos, A. G., et al. (2019) · Nature Metabolism

Iron Metabolism and DisordersGenomics, phytochemicals, and oxidative stress

Cited by 147

Mitochondrial uncouplers with an extraordinary dynamic range

Lou, P.-H., Hansen, B. S., Olsen, P. H., Tullin, S., Murphy, M. P., & Brand, M. D. (2007) · Biochemical Journal

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 141

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

Murphy, M. P., & O’Neill, L. A. J. (2024) · Nature

Mitochondrial Function and PathologyInflammasome and immune disorders

Cited by 138

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

Chouchani, E. T., Hurd, T. R., Nadtochiy, S. M., Brookes, P. S., Fearnley, I. M., Lilley, K. S., Smith, R. A. J., & Murphy, M. P. (2010) · Biochemical Journal

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 137

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis

Chacko, B. K., Srivastava, A., Johnson, M. S., Benavides, G. A., Chang, M. J., Ye, Y., Jhala, N., Murphy, M. P., Kalyanaraman, B., & Darley-Usmar, V. M. (2011) · Hepatology

Alcohol Consumption and Health EffectsCoenzyme Q10 studies and effects

Cited by 122

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

Porteous, C. M., Logan, A., Evans, C., Ledgerwood, E. C., Menon, D. K., Aigbirhio, F., Smith, R. A. J., & Murphy, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects

Mitochondrial Function and PathologyNeuroprotection in Cerebral Ischemia

Cited by 121

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

Dare, A. J., Logan, A., Prime, T. A., Rogatti, S., Goddard, M., Bolton, E. M., Bradley, J. A., Pettigrew, G. J., Murphy, M. P., & Saeb-Parsy, K. (2015) · The Journal of Heart and Lung Transplantation

Transplantation: Methods and OutcomesCardiac Ischemia and Reperfusion

Cited by 119

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

Packer, M. A., Porteous, C. M., & Murphy, M. P. (1996) · IUBMB Life

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 118

Non-enzymatic N-acetylation of lysine residues by acetylCoA often occurs via a proximal S-acetylated thiol intermediate sensitive to glyoxalase II

James, A. M., Hoogewijs, K., Logan, A., Hall, A. R., Ding, S., Fearnley, I. M., & Murphy, M. P. (2017) · Cell Reports

Sirtuins and Resveratrol in MedicineRedox biology and oxidative stress

Cited by 112

Characterization of the mitochondrial respiratory pathways in Candida albicans

Helmerhorst, E. J., Murphy, M. P., Troxler, R. F., & Oppenheim, F. G. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyAntifungal resistance and susceptibility

Cited by 95

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

Kohlhauer, M., Dawkins, S., Costa, A. S. H., Lee, R., Young, T., Pell, V. R., Choudhury, R. P., Banning, A. P., Kharbanda, R. K., Study, O. A. M. I. (., et al. (2018) · Journal of the American Heart Association

Cardiac Ischemia and ReperfusionAcute Myocardial Infarction Research

Cited by 91

Targeting coenzyme Q derivatives to mitochondria

Smith, R. A. J., Kelso, G. F., James, A. M., & Murphy, M. P. (2004) · Methods in Enzymology

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 87

Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption

Venkatraman, A., Landar, A., Davis, A. J., Ulasova, E., Page, G., Murphy, M. P., Darley-Usmar, V., & Bailey, S. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Redox biology and oxidative stressAlcohol Consumption and Health Effects

Cited by 85

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys

Mitchell, T., Rotaru, D., Saba, H., Smith, R. A. J., Murphy, M. P., & MacMillan-Crow, L. A. (2011) · The Journal of Pharmacology and Experimental Therapeutics

Organ Transplantation Techniques and OutcomesMitochondrial Function and Pathology

Cited by 84