Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association

Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Mitochondria: In Sickness and in Health

Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479 · see citing works

Nitric oxide, oxidants, and protein tyrosine nitration

Radí, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307446101 · Cited by 1,456 · see citing works

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Li, N., Ragheb, K., Lawler, G., Sturgis, J., Rajwa, B. P., Melendez, J. A., & Robinson, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210432200 · Cited by 1,434 · see citing works

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173 · see citing works

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,086 · see citing works

Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults

Yeboah, J., Crouse, J. R., Hsu, F., Burke, G. L., & Herrington, D. M. (2007) · Circulation · doi:10.1161/circulationaha.106.678276 · Cited by 890 · see citing works

Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.

Blouin, A., Bolender, R. P., & Weibel, E. R. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.72.2.441 · Cited by 866 · see citing works

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works

Enhanced Peroxynitrite Formation Is Associated with Vascular Aging

van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

Adlam, V. J., Harrison, J. C., Porteous, C. M., James, A. M., Smith, R. A. J., Murphy, M. P., & Sammut, I. A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3718com · Cited by 618 · see citing works

A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease

Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A. J., Murphy, M. P., Taylor, K. M., & On behalf of the Protect Study Group (2010) · Movement Disorders · doi:10.1002/mds.23148 · Cited by 606 · see citing works

Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus

Shenouda, S. M., Widlansky, M. E., Chen, K., Xu, G., Holbrook, M., Tabit, C. E., Hamburg, N. M., Frame, A. A., Caiano, T. L., Kluge, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.014506 · Cited by 570 · see citing works

Endothelial aging

BRANDES, R., FLEMING, I., & BUSSE, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.027 · Cited by 563 · see citing works

Animal and human studies with the mitochondria‐targeted antioxidant MitoQ

Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 553 · see citing works

Mitochondrial Control of Cellular Life, Stress, and Death

Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 545 · see citing works

Mitochondrial dysfunction and the inflammatory response

López-Armada, M. J., Riveiro-Naveira, R. R., Vaamonde‐García, C., & Valcarcel‐Ares, M. N. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.003 · Cited by 528 · see citing works

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

Radi, R. (2013) · Accounts of Chemical Research · doi:10.1021/ar300234c · Cited by 525 · see citing works

Mitochondria and Endothelial Function

Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508 · see citing works

Mitochondrial pharmacology

Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 501 · see citing works

Mitochondrial Integrity and Function in Atherogenesis

Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 478 · see citing works

Mitochondria and Cardiovascular Aging

Dai, D., Rabinovitch, P. S., & Ungvari, Z. I. (2012) · Circulation Research · doi:10.1161/circresaha.111.246140 · Cited by 435 · see citing works

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

Zhang, D. X., & Gutterman, D. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01283.2006 · Cited by 432 · see citing works

Antioxidant Vitamin Supplements and Cardiovascular Disease

Kris‐Etherton, P. M., Lichtenstein, A. H., Howard, B. V., Steinberg, D. H., & Witztum, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000137822.39831.f1 · Cited by 408 · see citing works

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02250.x · Cited by 379 · see citing works

Mitochondria-Targeted Antioxidant MitoQ ₁₀ Improves Endothelial Function and Attenuates Cardiac Hypertrophy

Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130351 · Cited by 367 · see citing works

Mitochondria as signaling organelles in the vascular endothelium

Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 360 · see citing works

Increased mitochondrial H 2 O 2 production promotes endothelial NF-κB activation in aged rat arteries

Ungvari, Z. I., Orosz, Z. Z., Labinskyy, N., Rivera, A., Xiangmin, Z., Smith, K. E., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01346.2006 · Cited by 347 · see citing works

The role of mitochondrial oxidative stress in aging

Sastre, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00184-9 · Cited by 342 · see citing works

Endothelial dysfunction and aging: An update

Herrera, M. D., Mingorance, C., Rodríguez‐Rodríguez, R., & de Sotomayor, M. Á. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.002 · Cited by 322 · see citing works

Translational evidence that impaired autophagy contributes to arterial ageing

LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works

Genetic deletion of p66 ^Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress

Camici, G. G., Schiavoni, M., Francia, P., Bachschmid, M., Martin-Padura, I., Hersberger, M., Tanner, F. C., Pelicci, P., Volpe, M., Anversa, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609656104 · Cited by 249 · see citing works

Mitochondria in Vascular Health and Disease

Dromparis, P., & Michelakis, E. D. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183804 · Cited by 236 · see citing works

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging

Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

Rodriguez-Cuenca, S., Cochemé, H. M., Logan, A., Abakumova, I., Prime, T. A., Rose, C., Vidal-Puig, A., Smith, A. C., Rubinsztein, D. C., Fearnley, I. M., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.039 · Cited by 218 · see citing works

The autophagy enhancer spermidine reverses arterial aging

LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

Wenzel, P., Schuhmacher, S., Kienhöfer, J., Müller, J., Hortmann, M., Oelze, M., Schulz, E., Treiber, N., Kawamoto, T., Scharffetter-Kochanek, K., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn182 · Cited by 207 · see citing works

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Ross, M. F., Prime, T. A., Abakumova, I., James, A. M., Porteous, C. M., Smith, R. A. J., & Murphy, M. P. (2008) · Biochemical Journal · doi:10.1042/bj20080063 · Cited by 206 · see citing works

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines

Dikalov, S., Kirilyuk, I. A., Voinov, M. A., & Григорьев, И. А. (2010) · Free Radical Research · doi:10.3109/10715762.2010.540242 · Cited by 177 · see citing works

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works

PGC-1α in aging and anti-aging interventions

Anderson, R., & Prolla, T. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.005 · Cited by 162 · see citing works

Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works

Vascular aging: Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease

Bachschmid, M. M., Schildknecht, S., Matsui, R., Zee, R. S., Haeussler, D. J., Cohen, R. A., Pimental, D. R., & van der Loo, B. (2012) · Annals of Medicine · doi:10.3109/07853890.2011.645498 · Cited by 154 · see citing works

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 145 · see citing works

Production of endothelium derived relaxant factor is dependent on oxidative phosphorylation and extracellular calcium

Griffith, T. M., Edwards, D. H., Newby, A. C., LEWIS, M. J., & Henderson, A. H. (1986) · Cardiovascular Research · doi:10.1093/cvr/20.1.7 · Cited by 143 · see citing works

Mitochondrial targeting of quinones: Therapeutic implications

Cochemé, H. M., Kelso, G. F., James, A. M., Ross, M. F., Trnka, J., Mahendiran, T., Asin-Cayuela, J., Blaikie, F. H., Manas, A. B., Porteous, C. M., et al. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.007 · Cited by 138 · see citing works

Impaired quality control of mitochondria: Aging from a new perspective

Weber, T. A., & Reichert, A. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.018 · Cited by 110 · see citing works

Effect of Aging, MnSOD Deficiency, and Genetic Background on Endothelial Function

Brown, K. A., Didion, S. P., Andresen, J. J., & Faraci, F. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.146852 · Cited by 90 · see citing works

Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products

Fleenor, B. S., Sindler, A. L., Eng, J. S., Nair, D. P., Dodson, R. B., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.004 · Cited by 85 · see citing works

The Lifespan-regulator p66Shc in mitochondria: redox enzyme or redox sensor?

Gertz, M., & Steegborn, C. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3147 · Cited by 75 · see citing works

Altered mitochondrial energy metabolism may play a role in vascular aging

Csiszár, A., Labinskyy, N., Orosz, Z. Z., & Ungvari, Z. I. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.03.037 · Cited by 39 · see citing works

Effects of metabolic inhibitors on endothelium‐dependent and endothelium‐independent vasodilatation of rat and rabbit aorta

Weir, C. J., Gibson, I. F., & Martin, W. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12147.x · Cited by 36 · see citing works

Current Inbred and Hybrid Rat and Mouse Models

Sprott, R. L., & Ramírez, I. (1997) · ILAR Journal · doi:10.1093/ilar.38.3.104 · Cited by 34 · see citing works

Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets

Lakshminarasimhan, M., & Steegborn, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.024 · Cited by 28 · see citing works

Difference in Effect of Inhibitors of Energy Metabolism on Endothelium-dependent Relaxation of Rat Pulmonary Artery and Aorta

Rodman, D. M., Mallet, J., & McMurtry, I. F. (1991) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/4.3.237 · Cited by 18 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works

Mechanisms of Vascular Aging

Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919 · see citing works

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Donato, A. J., Machin, D. R., & Lesniewski, L. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312563 · Cited by 699 · see citing works

Cellular and molecular biology of aging endothelial cells

Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works

Redox regulation of immunometabolism

Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 501 · see citing works

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

Ungvari, Z. I., Tarantini, S., Kiss, T., Wren, J. D., Giles, C. B., Griffin, C. T., Murfee, W. L., Pacher, P., & Csiszár, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0030-z · Cited by 478 · see citing works

Mitochondria‐targeted antioxidants

Oyewole, A. O., & Birch‐Machin, M. A. (2015) · The FASEB Journal · doi:10.1096/fj.15-275404 · Cited by 467 · see citing works

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Rossman, M. J., Santos-Parker, J. R., Steward, C. A. C., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., Woodward, K. A., Chonchol, M., Gioscia-Ryan, R. A., Murphy, M. P., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10787 · Cited by 456 · see citing works

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 435 · see citing works

Mitochondrial function in hypoxic ischemic injury and influence of aging

Ham, P. B., & Raju, R. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.006 · Cited by 367 · see citing works

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 312 · see citing works

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Apostolova, N., & Víctor, V. M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5952 · Cited by 303 · see citing works

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Tarantini, S., Valcarcel‐Ares, M. N., Tóth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M. T., Ballabh, P., Süle, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101192 · Cited by 285 · see citing works

AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 285 · see citing works

Hallmarks of cardiovascular ageing

Abdellatif, M., Rainer, P. P., Sedej, S., & Kroemer, G. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00881-3 · Cited by 285 · see citing works

Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

Umehara, T., Winstanley, Y. E., Andreas, E., Morimoto, A., Williams, E. J., Smith, K. M., Carroll, J., Febbraio, M. A., Shimada, M., Russell, D. L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn4564 · Cited by 248 · see citing works

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257 · see citing works

Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

Mason, S. A., Trewin, A. J., Parker, L., & Wadley, G. D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101471 · Cited by 226 · see citing works

Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?

McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00655 · Cited by 223 · see citing works

Mitochondria-Targeted Drugs

Zinovkin, R. A., & Zamyatnin, A. A. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666181127151059 · Cited by 209 · see citing works

Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives

Hu, D., Prabhakaran, H. S., Zhang, Y.-Y., Luo, G., He, W., & Liou, Y. (2024) · Critical Care · doi:10.1186/s13054-024-05069-w · Cited by 204 · see citing works

Treatment with the mitochondrial‐targeted antioxidant peptide SS ‐31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

Tarantini, S., Valcarcel‐Ares, M. N., Yabluchanskiy, A., Fülöp, G. Á., Hertelendy, P., Gautam, T., Farkas, E., Perz, A., Rabinovitch, P. S., Sonntag, W. E., et al. (2018) · Aging Cell · doi:10.1111/acel.12731 · Cited by 193 · see citing works

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

Gano, L. B., Donato, A. J., Pasha, H. M., Hearon, C. M., Sindler, A. L., & Seals, D. R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2014 · Cited by 188 · see citing works

Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy

Chang, X., Liu, R., Li, R., Peng, Y., Zhu, P., & Zhou, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76223 · Cited by 190 · see citing works

Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

Carvalho, C., & Moreira, P. I. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00806 · Cited by 175 · see citing works

Mitohormesis, an Antiaging Paradigm

Bárcena, C., Mayoral, P., & Quirós, P. M. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.002 · Cited by 167 · see citing works

Cellular Redox Homeostasis

Gal, K. L., Schmidt, E. E., & Sayin, V. I. (2021) · Antioxidants · doi:10.3390/antiox10091377 · Cited by 159 · see citing works

Autophagy in health and disease: focus on the cardiovascular system

Mialet‐Perez, J., & Vindis, C. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170022 · Cited by 149 · see citing works

The Role of Mitochondria in Cardiovascular Diseases

Poznyak, A. V., Ivanova, E. A., Sobenin, I. A., Yet, S., & Orekhov, A. N. (2020) · Biology · doi:10.3390/biology9060137 · Cited by 149 · see citing works

Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases

Liu, Y., Huang, Y., Xu, C. B., An, P., Luo, Y., Jiao, L., Luo, J., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416053 · Cited by 149 · see citing works

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works

Aerobic exercise and other healthy lifestyle factors that influence vascular aging

Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works

You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging

Seals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · see citing works

Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

Gioscia‐Ryan, R. A., Battson, M. L., Cuevas, L. M., Eng, J. S., Murphy, M. P., & Seals, D. R. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00670.2017 · Cited by 124 · see citing works

Electron Paramagnetic Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine Spin Probes

Dikalov, S., Polienko, Y. F., & Kirilyuk, I. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7396 · Cited by 122 · see citing works

Endoplasmic reticulum stress and the development of endothelial dysfunction.

Battson, M. L., Lee, D. M., & Gentile, C. (2017) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00437.2016 · Cited by 104 · see citing works

Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

Strong, R., Miller, R. A., Bogue, M. A., Fernández, E., Javors, M. A., Libert, S., Martinez, P. A., Murphy, M. P., Musi, N., Nelson, J. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13269 · Cited by 99 · see citing works

Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model

Nuzzo, A. M., Camm, E. J., Sferruzzi-Perri, A. N., Ashmore, T. J., Yung, H. W., Cindrová‐Davies, T., Spiroski, A., Sutherland, M. R., Logan, A., Austin‐Williams, S., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.07.027 · Cited by 94 · see citing works

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

Tamer, T. M., Collins, M. N., Valachová, K., Hassan, M. A., Omer, A. M., Eldin, M. S. M., Švík, K., Jurčí­k, R., Ondruška, Ľ., Biró, C., et al. (2018) · Materials · doi:10.3390/ma11040569 · Cited by 94 · see citing works

Role of endothelial NAD+deficiency in age-related vascular dysfunction

Csiszár, A., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Kiss, T., Farkas, E., Baur, J. A., & Ungvari, Z. I. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00039.2019 · Cited by 93 · see citing works

Acute mitochondrial antioxidant intake improves endothelial function, antioxidant enzyme activity, and exercise tolerance in patients with peripheral artery disease

Park, S., Pekas, E. J., Headid, R. J., Son, W., Wooden, T. K., Song, J., Layec, G., Yadav, S. K., Mishra, P. K., & Pipinos, I. I. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00235.2020 · Cited by 91 · see citing works

Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis

Shemiakova, T. S., Ivanova, E. A., Grechko, A. V., Владимировна, Г. Е., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8060166 · Cited by 89 · see citing works

Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway

Cui, L., Zhou, Q., Zheng, X., Sun, B., & Zhao, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.028 · Cited by 88 · see citing works

Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation

Mistriotis, P., & Andreadis, S. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.006 · Cited by 88 · see citing works

Cellular redox dysfunction in the development of cardiovascular diseases

Kanaan, G. N., & Harper, M. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.07.027 · Cited by 87 · see citing works

Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

Hu, X., & Zhang, L. (2021) · Antioxidants · doi:10.3390/antiox10030405 · Cited by 88 · see citing works

Nutrition and other lifestyle influences on arterial aging

LaRocca, T. J., Martens, C. R., & Seals, D. R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.002 · Cited by 83 · see citing works

Healthy lifestyle-based approaches for successful vascular aging

Rossman, M. J., LaRocca, T. J., Martens, C. R., & Seals, D. R. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2018 · Cited by 82 · see citing works

Age-related decline in peripheral vascular health predicts cognitive impairment

Csípő, T., Lipécz, Á., Fülöp, G., Hand, R. A., Ngo, B.-T. N., Dzialendzik, M., Tarantini, S., Balasubramanian, P., Kiss, T., Yabluchanska, V., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00063-5 · Cited by 83 · see citing works

Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

Clayton, Z. S., Brunt, V. E., Hutton, D. A., VanDongen, N. S., D’Alessandro, A., Reisz, J. A., Ziemba, B. P., & Seals, D. R. (2020) · JACC CardioOncology · doi:10.1016/j.jaccao.2020.06.010 · Cited by 83 · see citing works

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure

Hahad, O., Frenis, K., Kuntić, M., Daiber, A., & Münzel, T. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052419 · Cited by 83 · see citing works

Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults

Lipécz, Á., Csípő, T., Tarantini, S., Hand, R. A., Ngo, B.-T. N., Conley, S. M., Németh, G., Tsorbatzoglou, A., Courtney, D. L., Yabluchanska, V., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00078-y · Cited by 79 · see citing works

Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review

Manful, C. F., Fordjour, E., Ikumoinein, E., Abbey, L., & Thomas, R. (2025) · BioChem · doi:10.3390/biochem5040035 · Cited by 89 · see citing works

Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis

Bao, W., Xing, H., Cao, S., Long, X., Liu, H., Ma, J., Guo, F., Deng, Z., & Liu, X. (2022) · Nature Communications · doi:10.1038/s41467-022-32325-w · Cited by 76 · see citing works

Regulation of exercise blood flow: Role of free radicals

Trinity, J. D., Broxterman, R. M., & Richardson, R. S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.017 · Cited by 75 · see citing works

Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase

Favor, J. D. L., Dubis, G. S., Yan, H., White, J. D., Nelson, M. A. M., Anderson, E. J., & Hickner, R. C. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308339 · Cited by 74 · see citing works

Noncoding RNAs in age-related cardiovascular diseases

Jusic, A., Thomas, P. B., Wettinger, S. B., Dogan, S., Farrugia, R., Gaetano, C., Tuna, B. G., Pinet, F., Robinson, E. L., Tual-Chalot, S., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101610 · Cited by 70 · see citing works

Target acquired: Selective autophagy in cardiometabolic disease

Evans, T. D., Sergin, I., Zhang, X., & Razani, B. (2017) · Science Signaling · doi:10.1126/scisignal.aag2298 · Cited by 73 · see citing works

The impact of age and sex on body composition and glucose sensitivity in C57BL/6J mice

Reynolds, T., Dalton, A., Calzini, L. O., Tuluca, A., Hoyte, D., & Ives, S. J. (2019) · Physiological Reports · doi:10.14814/phy2.13995 · Cited by 72 · see citing works

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

Daiber, A., Andreadou, I., Oelze, M. W., Davidson, S. M., & Hausenloy, D. J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.026 · Cited by 73 · see citing works

Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging

Clayton, Z. S., Hutton, D. A., Brunt, V. E., VanDongen, N. S., Ziemba, B. P., Casso, A. G., Greenberg, N., Mercer, A. N., Rossman, M. J., Campisi, J., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00118.2021 · Cited by 73 · see citing works

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

Zhang, J., Culp, M. L., Craver, J., & Darley-Usmar, V. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14308 · Cited by 73 · see citing works

Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood

Kiss, T., Tarantini, S., Csípő, T., Balasubramanian, P., Nyúl‐Tóth, Á., Yabluchanskiy, A., Wren, J. D., Garman, L., Huffman, D. M., Csiszár, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00180-6 · Cited by 73 · see citing works

Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases

Ajith, T. A. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i10.1091 · Cited by 70 · see citing works

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice

Csiszár, A., Yabluchanskiy, A., Ungvari, A., Ungvari, Z. I., & Tarantini, S. (2019) · GeroScience · doi:10.1007/s11357-019-00111-0 · Cited by 69 · see citing works

Eating the dead to keep atherosclerosis at bay

Brophy, M. L., Dong, Y., Wu, H., Rahman, H. N. A., Song, K., & Chen, H. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00002 · Cited by 68 · see citing works

Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice

Gioscia‐Ryan, R. A., Clayton, Z. S., Zigler, M. C., Richey, J. J., Cuevas, L. M., Rossman, M. J., Battson, M. L., Ziemba, B. P., Hutton, D. A., VanDongen, N. S., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280607 · Cited by 68 · see citing works

Mitochondria‐specific antioxidant supplementation does not influence endurance exercise training‐induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake

Shill, D. D., Southern, W. M., Willingham, T. B., Lansford, K. A., McCully, K. K., & Jenkins, N. T. (2016) · The Journal of Physiology · doi:10.1113/jp272491 · Cited by 67 · see citing works

Age‐related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature

Park, S. ‐., Kwon, O. S., Andtbacka, R. H. I., Hyngstrom, J. R., Reese, V. R., Murphy, M. P., & Richardson, R. S. (2017) · Acta Physiologica · doi:10.1111/apha.12893 · Cited by 67 · see citing works

Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease

Yoo, S., Park, J., Kim, S., & Jung, Y. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.274 · Cited by 65 · see citing works

Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: Potential implications in atherosclerosis

Karnewar, S., Vasamsetti, S. B., Gopoju, R., Kanugula, A. K., Ganji, S. K., Prabhakar, S., Rangaraj, N., Tupperwar, N., Kumar, J. M., & Kotamraju, S. (2016) · Scientific Reports · doi:10.1038/srep24108 · Cited by 62 · see citing works

Metabolic and Immune Crosstalk in Cardiovascular Disease

Mohanta, S. K., Heron, C., Klaus‐Bergmann, A., Horstmann, H., Bråkenhielm, E., Giannarelli, C., Habenicht, A. J. R., Gerhardt, H., & Weber, C. (2025) · Circulation Research · doi:10.1161/circresaha.125.325496 · Cited by 67 · see citing works

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

Kadlec, A. O., Beyer, A., Ait‐Aissa, K., & Gutterman, D. D. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0546-5 · Cited by 59 · see citing works

Role of mitochondria-derived reactive oxygen species in microvascular dysfunction in chronic kidney disease

Kirkman, D. L., Muth, B. J., Ramick, M. G., Townsend, R. R., & Edwards, D. G. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00321.2017 · Cited by 62 · see citing works

Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences

Pierce, G. L., Coutinho, T. A., DuBose, L. E., & Donato, A. J. (2021) · Physiology · doi:10.1152/physiol.00035.2021 · Cited by 64 · see citing works

Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice

Gioscia‐Ryan, R. A., Battson, M. L., Cuevas, L. M., Zigler, M. C., Sindler, A. L., & Seals, D. R. (2016) · Aging · doi:10.18632/aging.101099 · Cited by 61 · see citing works

Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice

Wiedenhoeft, T., Tarantini, S., Nyúl‐Tóth, Á., Yabluchanskiy, A., Csípő, T., Balasubramanian, P., Lipécz, Á., Kiss, T., Csiszár, A., Csiszár, Á., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00102-1 · Cited by 61 · see citing works

Cardiovascular disease and the biology of aging

Moturi, S., Ghosh-Choudhary, S. K., & Finkel, T. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.04.005 · Cited by 56 · see citing works

The Effect of MitoQ on Aging‐Related Biomarkers: A Systematic Review and Meta‐Analysis

Braakhuis, A. J., Nagulan, R., & Somerville, V. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8575263 · Cited by 56 · see citing works

Mitochondrial regulation of diabetic vascular disease: an emerging opportunity

Widlansky, M. E., & Hill, R. B. (2018) · Translational research · doi:10.1016/j.trsl.2018.07.015 · Cited by 57 · see citing works

Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation

Vincent, G., Novak, E. A., Siow, V. S., Cunningham, K. E., Griffith, B. D., Comerford, T. E., Mentrup, H. L., Stolz, D. B., Loughran, P., Ranganathan, S., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7702 · Cited by 57 · see citing works

Effects of regular exercise on vascular function with aging: Does sex matter?

Moreau, K. L., Clayton, Z. S., DuBose, L. E., Rosenberry, R., & Seals, D. R. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00392.2023 · Cited by 54 · see citing works

Keynote lecture: strategies for optimal cardiovascular aging

Seals, D. R., Brunt, V. E., & Rossman, M. J. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00734.2017 · Cited by 53 · see citing works

Cardiovascular aging: spotlight on mitochondria

Ali, M. A., Gioscia‐Ryan, R. A., Yang, D., Sutton, N. R., & Tyrrell, D. J. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00632.2023 · Cited by 53 · see citing works

Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

Demyanenko, I. A., Popova, E. N., Zakharova, V., Ilyinskaya, O. P., Vasilieva, T. V., Romashchenko, V. P., Fedorov, A. V., Манских, В. Н., Skulachev, M. V., Zinovkin, R. A., et al. (2015) · Aging · doi:10.18632/aging.100772 · Cited by 52 · see citing works

Age‐associated vascular inflammation promotes monocytosis during atherogenesis

Du, W., Wong, C. K., Song, Y., Shen, H., Mori, D. N., Rotllán, N., Price, N. L., Dobrian, A. D., Meng, H., Kleinstein, S. H., et al. (2016) · Aging Cell · doi:10.1111/acel.12488 · Cited by 52 · see citing works

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Murray, K. O., Mahoney, S. A., Venkatasubramanian, R., Seals, D., & Clayton, Z. S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112105 · Cited by 48 · see citing works

Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress

Murray, K. O., Ludwig, K. R., Darvish, S., Coppock, M. E., Seals, D. R., & Rossman, M. J. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00270.2023 · Cited by 51 · see citing works

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

Sulaimon, L. A., Afolabi, L. O., Adisa, R. A., Ayankojo, A. G., Afolabi, M. O., Adewolu, A. M., & Wan, X. (2022) · Advances in Redox Research · doi:10.1016/j.arres.2022.100037 · Cited by 49 · see citing works

Mitochondrial disorder and treatment of ischemic cardiomyopathy: Potential and advantages of Chinese herbal medicine

Chang, X., Liu, J., Wang, Y., Guan, X., & Liu, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114171 · Cited by 50 · see citing works

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors

Gulej, R., Nyúl‐Tóth, Á., Csík, B., Petersen, B., Faakye, J., Negri, S., Chandragiri, S. S., Mukli, P., Yabluchanskiy, A., Conley, S. M., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01039-2 · Cited by 51 · see citing works

Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

Wang, W.-L., Shih, Y.-T., Wei, S.-Y., & Chiu, J.-J. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01177-z · Cited by 50 · see citing works

Targeting mitochondrial fitness as a strategy for healthy vascular aging

Rossman, M. J., Gioscia‐Ryan, R. A., Clayton, Z. S., Murphy, M. P., & Seals, D. R. (2020) · Clinical Science · doi:10.1042/cs20190559 · Cited by 50 · see citing works

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling

Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48 · see citing works

Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe−/− mice

Karnewar, S., Pulipaka, S., Katta, S., Panuganti, D., Neeli, P. K., Thennati, R., Jerald, M. K., & Kotamraju, S. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.07.012 · Cited by 49 · see citing works

Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans: A study protocol

Murray, K. O., Berryman-Maciel, M., Darvish, S., Coppock, M. E., You, Z., Chonchol, M., Seals, D. R., & Rossman, M. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.980783 · Cited by 48 · see citing works

Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension

Ye, J., Wang, S., Ge, M., & Wang, D. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00356.2015 · Cited by 47 · see citing works

PGC-1α (Peroxisome Proliferator–Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure

Kadlec, A. O., Chabowski, D. S., Ait‐Aissa, K., Hockenberry, J. C., Otterson, M. F., Durand, M. J., Freed, J. K., Beyer, A., & Gutterman, D. D. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09289 · Cited by 49 · see citing works

Mitochondria‐targeted antioxidant therapy with MitoQ ameliorates age‐related vascular endothelial dysfunction

Gioscia‐Ryan, R. A., LaRocca, T. J., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.1125.10 · Cited by 1 · see citing works

The Effect Of Mitochondria-targeted Antioxidant On The Vasodilatory Function In Human Skeletal Muscle Feed Arteries.

Kwon, O. S., Park, S., Andtbacka, R. H. I., Hyngstrom, J. R., Reese, V. R., & Richardson, R. S. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000485595.91832.2c

Mitochondrial oxidative stress and antioxidant therapy in arterial aging

Gioscia‐Ryan, R. A. (2016) · CU Scholar (University of Colorado Boulder)

Age‐related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature

Park, S. ‐., Kwon, O. S., Andtbacka, R. H. I., Hyngstrom, J. R., Reese, V. R., Murphy, M. P., & Richardson, R. S. (2017) · Acta Physiologica · doi:10.1111/apha.12893 · Cited by 67 · see citing works

Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans: A study protocol

Murray, K. O., Berryman-Maciel, M., Darvish, S., Coppock, M. E., You, Z., Chonchol, M., Seals, D. R., & Rossman, M. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.980783 · Cited by 48 · see citing works