Linsley, Peter S.

Gene expression profiling predicts clinical outcome of breast cancer

van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature

Breast Cancer Treatment StudiesGene expression and cancer classification

Cited by 9,536

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 4,755

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 3,159

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature

MicroRNA in disease regulationCancer-related Molecular Pathways

Cited by 2,692

Expression profiling reveals off-target gene regulation by RNAi

Jackson, A. L., Bartz, S. R., Schelter, J., Kobayashi, S. V., Burchard, J., Mao, M., Li, B., Cavet, G., & Linsley, P. S. (2003) · Nature Biotechnology

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 2,370

CTLA-4 can function as a negative regulator of T cell activation

Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B., & Bluestone, J. A. (1994) · Immunity

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 2,222

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S., Thompson, C. B., & Riley, J. L. (2005) · Molecular and Cellular Biology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 1,931

CTLA-4 is a second receptor for the B cell activation antigen B7.

Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 1,685

An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes

Herold, K. C., Bundy, B. N., Long, S. A., Bluestone, J. A., DiMeglio, L. A., Dufort, M. J., Gitelman, S. E., Gottlieb, P. A., Krischer, J. P., Linsley, P. S., et al. (2019) · New England Journal of Medicine

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 1,189

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Chen, L., Ashe, S., Brady, W. A., Hellström, I., Hellström, K. E., Ledbetter, J. A., McGowan, P., & Linsley, P. S. (1992) · Cell

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 1,050

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

Gabriely, G., Wurdinger, T., Kesari, S., Esau, C. C., Burchard, J., Linsley, P. S., & Krichevsky, A. M. (2008) · Molecular and Cellular Biology

MicroRNA in disease regulationProtease and Inhibitor Mechanisms

Cited by 888

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

Boldin, M. P., Taganov, K. D., Rao, D. S., Yang, L., Zhao, J. L., Kalwani, M., Garcia-Flores, Y., Luong, M., Devrekanli, A., Xu, J., et al. (2011) · Journal of Experimental Medicine

MicroRNA in disease regulationImmune Response and Inflammation

Cited by 861

Gene expression changes associated with progression and response in chronic myeloid leukemia

Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., et al. (2006) · Proceedings of the National Academy of Sciences

Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research

Cited by 583

MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

Ivanovska, I., Ball, A. S., Diaz, R. L., Magnus, J. F., Kibukawa, M., Schelter, J. M., Kobayashi, S. V., Lim, L., Burchard, J., Jackson, A. L., et al. (2008) · Molecular and Cellular Biology

MicroRNA in disease regulationCancer-related Molecular Pathways

Cited by 561

Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression

Linsley, P. S., Schelter, J., Burchard, J., Kibukawa, M., Martin, M. M., Bartz, S. R., Johnson, J. M., Cummins, J. M., Raymond, C. K., Dai, H., et al. (2007) · Molecular and Cellular Biology

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 552

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P., & Davis, S. J. (1997) · The Journal of Experimental Medicine

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 551

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

Lanier, L. L., O'Fallon, S., Somoza, C., Phillips, J. H., Linsley, P. S., Okumura, K., Ito, D., & Azuma, M. (1995) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 480

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

Long, S. A., Thorpe, J., DeBerg, H. A., Gersuk, V., Eddy, J. A., Harris, K. M., Ehlers, M., Herold, K. C., Nepom, G. T., & Linsley, P. S. (2016) · Science Immunology

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 250

Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

Leung, H. T., Bradshaw, J., Cleaveland, J. S., & Linsley, P. S. (1995) · Journal of Biological Chemistry

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 191

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

Wiedeman, A. E., Muir, V. S., Rosasco, M. G., DeBerg, H. A., Presnell, S., Haas, B., Dufort, M. J., Speake, C., Greenbaum, C. J., Serti, E., et al. (2019) · Journal of Clinical Investigation

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 168

Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial

Russell, W. E., Bundy, B. N., Anderson, M. S., Cooney, L. A., Gitelman, S. E., Goland, R. S., Gottlieb, P. A., Greenbaum, C. J., Haller, M. J., Krischer, J. P., et al. (2023) · Diabetes Care

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 108

Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes

Lledó-Delgado, A., Preston-Hurlburt, P., Currie, S., Clark, P., Linsley, P. S., Long, S. A., Liu, C., Koroleva, G., Martins, A. J., Tsang, J. S., et al. (2024) · Journal of Clinical Investigation

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 58

Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol

Ioannou, G. N., Lee, S. P., Linsley, P. S., Gersuk, V., Yeh, M. M., Chen, Y., Peng, Y., Dutta, M., Mascarinas, G., Molla, B., et al. (2022) · Hepatology Communications

Liver Disease Diagnosis and TreatmentCholesterol and Lipid Metabolism

Cited by 52