Metabolic regulation of NLRP 3

The Inflammasome

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Non-canonical inflammasome activation targets caspase-11

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

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Cellular mechanisms and physiological consequences of redox-dependent signalling

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

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Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Human Monocytes Engage an Alternative Inflammasome Pathway

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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

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Inflammasome is a central player in the induction of obesity and insulin resistance

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

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The inflammation highway: metabolism accelerates inflammatory traffic in obesity

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Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

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PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against <i>Salmonella</i>

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

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K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

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Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

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β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

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CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

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Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

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The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

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The interplay between inflammation and metabolism in rheumatoid arthritis

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Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

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Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

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Reversible Cysteine Oxidation in Hydrogen Peroxide Sensing and Signal Transduction

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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

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The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

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Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

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Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

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Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

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High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

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Inhibition of caspase-3 activity and activation by protein glutathionylation

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The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases

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Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis

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Innate Immune System Cells in Atherosclerosis

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Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome

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The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice

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Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

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The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production

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TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells

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AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome

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Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation

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Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication

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Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors

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The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome

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A mechanistic insight into curcumin modulation of the IL-1β secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells

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Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

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JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

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The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis

Wang, X., Li, X.-L., & Qin, L.-J. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00607-4 · Cited by 51 · see citing works

Crosstalk Between Staphylococcus aureus and Innate Immunity: Focus on Immunometabolism

Horn, C. M., & Kielian, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.621750 · Cited by 51 · see citing works

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome

Zhang, T., Ding, S., & Wang, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910866 · Cited by 51 · see citing works

Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview

Gupta, A., Marzook, H., & Ahmad, F. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00821-4 · Cited by 49 · see citing works

Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer’s disease

Zhang, Z., Li, M., Li, X., Feng, Z., Luo, G., Wang, Y., & Gao, X. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03254-w · Cited by 53 · see citing works

Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway

Zhang, Z., Xie, S., Qian, J., Gao, F.-Q., Jin, W.-J., Wang, L.-Q., Yan, L., Chen, H., Yao, W., Li, M.-Q., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04313-1 · Cited by 44 · see citing works

Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats

Chen, X., Li, Y., Li, J., Liu, T., Jiang, Q., Hong, Y., Wang, Q., Li, C., Guo, D., & Wang, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114841 · Cited by 46 · see citing works

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

Liu, J., Wang, C., Li, J., Yu, Y., Liu, Y., Liu, H., Peng, Q., & Guan, X. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00811-2 · Cited by 46 · see citing works

Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis

Li, H., Liu, X., Lee, M., & Li, H. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15803 · Cited by 44 · see citing works

NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats

Danielski, L. G., Giustina, A. D., Bonfante, S., Goldim, M. P. D. S., Joaquim, L. D. S., Metzker, K. L. L., Biehl, E., Vieira, T. C., de Medeiros, F. D., da Rosa, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02089-9 · Cited by 43 · see citing works

Activation of autophagy inhibits nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome activation and attenuates myocardial ischemia‐reperfusion injury in diabetic rats

Zhang, D., He, Y., Ye, X., Cai, Y., Xu, J., Zhang, L., Li, M., Liu, H., Wang, S., & Xia, Z. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13235 · Cited by 41 · see citing works

NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

Xue, Y., Li, R., Fang, P., Ye, Z.-Q., Zhao, Y. L., Zhou, Y., Zhang, K., & Li, L. (2021) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0305 · Cited by 41 · see citing works

Role of Stat3 in NLRP3/caspase‐1‐mediated hippocampal neuronal pyroptosis in epileptic mice

Jiang, Q., Tang, G. Q., Zhong, X., Ding, D., Wang, H., & Li, J. (2021) · Synapse · doi:10.1002/syn.22221 · Cited by 41 · see citing works

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Magnotti, F., Chirita, D., Dalmon, S., Martin, A., Bronnec, P., Sousa, J., Helynck, O., Lee, W., Kastner, D. L., Chae, J. J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111472 · Cited by 40 · see citing works

NLRP3 Attenuates Intraocular Inflammation by Inhibiting AIM2‐Mediated Pyroptosis Through the Phosphorylated Salt‐Inducible Kinase 1/Sterol Regulatory Element Binding Transcription Factor 1 Pathway

Meng, J., Li, N., Liu, X., Qiao, S., Zhou, Q., Tan, J., Zhang, T., Dong, Z., Qi, X., Kijlstra, A., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42420 · Cited by 40 · see citing works

Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction

Rosa, C. P., Belo, T. C. A., Santos, N. C. D. M., Silva, E. N., Gasparotto, J., Corsetti, P. P., & de Almeida, L. A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122076 · Cited by 40 · see citing works

Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells

Yang, H., Lin, P.-Y., Vadivalagan, C., Lin, Y., Lin, K., & Hseu, Y. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03456-w · Cited by 39 · see citing works

Regulation of NLRPs by reactive oxygen species: A story of crosstalk

Ziehr, B. K., & MacDonald, J. A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119823 · Cited by 39 · see citing works

Metabolic Regulation of the NLRP3 Inflammasome

Ye, Q., Chen, S., & Wang, D. (2021) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000057 · Cited by 9 · see citing works

The NLRP3 inflammasome: regulation by metabolic signals

Olona, A., Leishman, S., & Anand, P. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.10.003 · Cited by 117 · see citing works

Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities

Ortega, M. A., León-Oliva, D. D., Montero, C. G., Fraile‐Μartinez, O., Boaru, D. L., de Castro, A. V., Sáez, M. A., López-González, L., Buján, J., Álvarez-Mon, M. Á., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1232629 · Cited by 50 · see citing works

Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

Yu, Q., Guo, M., Zeng, W., Zeng, M., Zhang, X., Zhang, Y., Zhang, W., Jiang, X., & Yu, B. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.581 · Cited by 52 · see citing works

The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways

Jiang, D., Chen, S., Sun, R., Zhang, X., & Wang, D. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.034 · Cited by 94 · see citing works