Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation
Open accessAbstract
Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein-1 (Abi-1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi-1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi-1, Eps8 and Sos-1. Abi-1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi-1 co-immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E-box-regulated gene transcription. Downregulation of Abi-1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi-1 has the opposite effect. Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation.
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Upon NMDA application, ABI1 translocates from PSDs to nuclei in primary cultured hippocampal neurons and in pyramidal neurons in acute rat brain slices.
“Upon NMDA application, ABI1 translocates from PSDs to nuclei in primary cultured hippocampal neurons and in pyramidal neurons in acute rat brain slices50.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [50]
ABI is enriched in dendritic spines and localizes to the postsynaptic density.
“ABI is enriched in dendritic spines and localizes to the postsynaptic density (PSD)50.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [50]
In the nucleus, ABI1 interacts with the transcription factor complex of Myc/Max proteins and enhances E-box-regulated gene transcription.
“In the nucleus, ABI1 interacts with the transcription factor complex of Myc/Max proteins and enhances E-box-regulated gene transcription50.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [50]
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An Architectural Framework That May Lie at the Core of the Postsynaptic Density
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Self-citationDendritic spine actin cytoskeleton in autism spectrum disorder
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The WAVE complex in developmental and adulthood brain disorders
Kim, H.-G., Berdasco, C., Nairn, A. C., & Kim, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01386-w · Cited by 8 · see citing works
- Authors
- Proepper, C., Johannsen, S., Liebau, S., Dahl, J., Vaida, B., Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., & Boeckers, T. M.
- Affiliations
- Universität Ulm (DE)
- Leibniz Institute for Neurobiology (DE)
- Corresponding author
- Boeckers, Tobias M
- Venue
- The EMBO Journal
- Published
- 2007-02-15
- Volume
- 26
- Issue
- 5
- Pages
- 1397-1409
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1817621
- OpenAlex
- W2106971401
- Cited by
- 124
- References
- 3
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 2 · 2016: 9 · 2015: 3 · 2014: 12 · 2013: 9 · 2012: 10
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 426)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Abi-1, dendrite morphogenesis, synaptogenesis, actin cytoskeleton, postsynaptic density, Eps8, NMDA receptor signaling, nuclear translocation, Abelson kinase, dendritic spines, neuronal development
- MeSH terms
- Actins, Amino Acid Sequence, Animals, Brain, Cells, Cultured, Cytoskeletal Proteins, Dendrites, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nuclear Proteins, Phosphorylation, Proline, Protein Binding, Recombinant Fusion Proteins, Synapses, Tyrosine, Blotting, Western, N-Methylaspartate, In Situ Hybridization, Two-Hybrid System Techniques, Adaptor Proteins, Signal Transducing, Green Fluorescent Proteins, Rats
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