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Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

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The postsynaptic density proteins Homer and Shank form a polymeric network structure

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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

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An Architectural Framework That May Lie at the Core of the Postsynaptic Density

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The postsynaptic density

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Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

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Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

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Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

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Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

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Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology

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Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4‐9 Deletion Mouse Model of Autism

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Cerebellar associative sensory learning defects in five mouse autism models

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Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

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Phelan–McDermid Syndrome and SHANK3: Implications for Treatment

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Scaffolding proteins at the postsynaptic density: shank as the architectural framework

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A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders

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A role for zinc in postsynaptic density asSAMbly and plasticity?

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Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA

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Identification and functional characterization of rare SHANK2 variants in schizophrenia

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Scaffold Proteins at the Postsynaptic Density

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Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

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Copy-number variations are enriched for neurodevelopmental genes in children with developmental coordination disorder

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Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID

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Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons

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The spectrum of epilepsy and electroencephalographic abnormalities due to SHANK 3 loss‐of‐function mutations

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Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice

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Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

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The role of glutamate receptors in traumatic brain injury: Implications for postsynaptic density in pathophysiology

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Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength

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The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

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Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region

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Activity induced changes in the distribution of Shanks at hippocampal synapses

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Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants

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Shank–cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses

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ProSAP-interacting Protein 1 (ProSAPiP1), a Novel Protein of the Postsynaptic Density That Links the Spine-associated Rap-Gap (SPAR) to the Scaffolding Protein ProSAP2/Shank3

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Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction

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SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region

Mameza, M. G., Dvoretskova, E., Bamann, M., Hönck, H., Güler, T., Boeckers, T. M., Schoen, M., Verpelli, C., Sala, C., Barsukov, I., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.424747 · Cited by 50 · see citing works

An SK3 Channel/nWASP/Abi-1 Complex Is Involved in Early Neurogenesis

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Shank Proteins Differentially Regulate Synaptic Transmission

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Differential Distribution of Shank and GKAP at the Postsynaptic Density

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Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome

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Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

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Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus

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A 29 Mainland Chinese cohort of patients with Phelan–McDermid syndrome: genotype–phenotype correlations and the role of SHANK3 haploinsufficiency in the important phenotypes

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Shankopathies in the Developing Brain in Autism Spectrum Disorders

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SHANK genes in autism: Defining therapeutic targets

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The Role of Zinc and NMDA Receptors in Autism Spectrum Disorders

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Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders

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SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Lutz, A.-K., Arévalo, A. P., Ioannidis, V., Stirmlinger, N., Demestre, M., Delorme, R., Bourgeron, T., & Boeckers, T. M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.773571 · Cited by 37 · see citing works

Heterogeneous Nuclear Ribonucleoprotein K Interacts with Abi-1 at Postsynaptic Sites and Modulates Dendritic Spine Morphology

Proepper, C., Steinestel, K., Schmeißer, M. J., Heinrich, J., Steinestel, J., Bockmann, J., Liebau, S., & Boeckers, T. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027045 · Cited by 37 · see citing works

SPAR2, a novel SPAR‐related protein with GAP activity for Rap1 and Rap2

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Maturation of Synaptic Contacts in Differentiating Neural Stem Cells

Liebau, S., Vaida, B., Storch, A., & Boeckers, T. M. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0823 · Cited by 34 · see citing works

Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy

Javed, S., Selliah, T., Lee, Y., & Huang, W. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.009 · Cited by 31 · see citing works

Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

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Association study of SHANK3 gene polymorphisms with autism in Chinese Han population

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Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders

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Molecular architecture of postsynaptic Interactomes

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Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report

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A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

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Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3

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Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism

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Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)—scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system

Raab, M., Boeckers, T. M., & Neuhuber, W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.041 · Cited by 27 · see citing works

A Presynaptic Function of Shank Protein inDrosophila

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Activity and circadian rhythm influence synaptic Shank3 protein levels in mice

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Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear β‐catenin signaling

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Structural basis for PDZ domain interactions in the post‐synaptic density scaffolding protein Shank3

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Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/− mouse model of autism spectrum disorders

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Identification of two novel Shank3 transcripts in the developing mouse neocortex

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Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity

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Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model

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Sam Domains in Multiple Diseases

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POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function

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Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7 –/– Mice

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ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3

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Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol

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SHANK family on stem cell fate and development

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SHANK1 and autism spectrum disorders

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Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries

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Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans

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SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry

Lutz, A.-K., Bauer, H. F., Ioannidis, V., Schön, M., & Boeckers, T. M. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.890231 · Cited by 16 · see citing works

Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: anin vitrostudy

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The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform

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The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein

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A blueprint for research on Shankopathies: A view from research on autism spectrum disorder

Carbonetto, S. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22150 · Cited by 12 · see citing works

Sticky, Adaptable, and Many‐sided: SAM protein versatility in normal and pathological hematopoietic states

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Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system

Grabrucker, A. M., Vaida, B., Bockmann, J., & Boeckers, T. M. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.05.008 · Cited by 11 · see citing works

nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders

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Two de novo novel mutations in one SHANK3 allele in a patient with autism and moderate intellectual disability

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SHANK Mutations in Intellectual Disability and Autism Spectrum Disorder

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GluA1-Shank3 interaction decreases in response to chronic neuronal depolarization

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Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases

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The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling

Woike, D., Tibbe, D., Nia, F. H., Martens, V., Wang, E. Q., Barsukov, I., & Kreienkamp, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03611-5 · Cited by 8 · see citing works

Investigation of Genetic Polymorphism in Autism Spectrum Disorder: a Pathogenesis of the Neurodevelopmental Disorder

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POSH undergoes phase separation and co-condensation with SHANK2/3 to regulate spine development

Yao, M., Yuan, L., Zheng, Y., & Xu, Z. (2025) · Protein & Cell · doi:10.1093/procel/pwaf066 · Cited by 2 · see citing works

Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system

Grabrucker, A. M., Vaida, B., Bockmann, J., & Boeckers, T. M. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.05.008 · Cited by 11 · see citing works

The Shank/ProSAP N-terminal (SPN) domain of Shank3 regulates targeting to postsynaptic sites and postsynaptic signallingPreprint

Woike, D., Tibbe, D., Nia, F. H., Martens, V., Wang, E., Barsukov, I., & Kreienkamp, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.28.538665 · Cited by 1 · see citing works

ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease

Boeckers, T. M., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00931.x · Cited by 349 · see citing works

The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling

Woike, D., Tibbe, D., Nia, F. H., Martens, V., Wang, E. Q., Barsukov, I., & Kreienkamp, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03611-5 · Cited by 8 · see citing works

Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)—scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system

Raab, M., Boeckers, T. M., & Neuhuber, W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.041 · Cited by 27 · see citing works