Ralser, Markus

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews

Biochemical and Molecular ResearchRedox biology and oxidative stress

Cited by 1,576

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., et al. (2020) · Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,461

Swarm Learning for decentralized and confidential clinical machine learning

Warnat-Herresthal, S., Schultze, H., Shastry, K. L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N. A., et al. (2021) · Nature

Privacy-Preserving Technologies in DataBlockchain Technology Applications and Security

Cited by 884

Remaining mysteries of molecular biology: the role of polyamines in the cell

Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology

Polyamine Metabolism and ApplicationsAmino Acid Enzymes and Metabolism

Cited by 658

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Messner, C. B., Demichev, V., Wendisch, D., Michalick, L., White, M., Freiwald, A., Textoris-Taube, K., Vernardis, S. I., Egger, A.-S., Kreidl, M., et al. (2020) · Cell Systems

Advanced Proteomics Techniques and ApplicationsCOVID-19 Clinical Research Studies

Cited by 561

Virus-induced senescence is a driver and therapeutic target in COVID-19

Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., et al. (2021) · Nature

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 350

Non-Enzymatic Glycolysis and Pentose Phosphate Pathway-Like Reactions in a Plausible Archean Ocean

Keller, M. A., Turchyn, A. V., & Ralser, M. (2014) · Molecular Systems Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 242

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L. J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., et al. (2022) · Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 218

A time-resolved proteomic and prognostic map of COVID-19

Demichev, V., Tober-Lau, P., Lemke, O., Nazarenko, T., Thibeault, C., Whitwell, H., Röhl, A., Freiwald, A., Szyrwiel, L., Ludwig, D., et al. (2021) · Cell Systems

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 200

Functional Metabolomics Describes the Yeast Biosynthetic Regulome

Mülleder, M., Calvani, E., Alam, M. T., Wang, R. K., Eckerstorfer, F., Zelezniak, A., & Ralser, M. (2016) · Cell

Fungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction

Cited by 178

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

Olin-Sandoval, V., Yu, J. S. L., Miller-Fleming, L., Alam, M. T., Kamrad, S., Correia-Melo, C., Haas, R., Segal, J., Peña Navarro, D. A., Herrera-Dominguez, L., et al. (2019) · Nature

Polyamine Metabolism and ApplicationsFungal and yeast genetics research

Cited by 163

Designing and interpreting ‘multi-omic’ experiments that may change our understanding of biology

Haas, R., Zelezniak, A., Iacovacci, J., Kamrad, S., Townsend, S., & Ralser, M. (2017) · Current Opinion in Systems Biology

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 131

An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life

Ralser, M. (2018) · Biochemical Journal

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 117

Conditional Iron and pH-Dependent Activity of a Non-Enzymatic Glycolysis and Pentose Phosphate Pathway

Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V., Griffin, J. L., & Ralser, M. (2016) · Science Advances

Origins and Evolution of LifeMicrobial Metabolic Engineering and Bioproduction

Cited by 106

Precise label-free quantitative proteomes in high-throughput by microLC and data-independent SWATH acquisition

Vowinckel, J., Zelezniak, A., Kibler, A., Bruderer, R., Muelleder, M., Reiter, L., & Ralser, M. (2016) · Scientific Reports

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 81

Natural proteome diversity links aneuploidy tolerance to protein turnover

Muenzner, J., Trébulle, P., Agostini, F., Zauber, H., Messner, C. B., Steger, M., Kilian, C., Lau, K., Barthel, N., Lehmann, A., et al. (2024) · Nature

Fungal and yeast genetics researchMicrotubule and mitosis dynamics

Cited by 81

Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast

Malecki, M., Kamrad, S., Ralser, M., & Bähler, J. (2020) · The EMBO Reports

Fungal and yeast genetics researchCancer, Hypoxia, and Metabolism

Cited by 50

The metabolic growth limitations of petite cells lacking the mitochondrial genome

Vowinckel, J., Hartl, J., Marx, H., Kerick, M., Runggatscher, K., Keller, M. A., Mülleder, M., Day, J., Weber, M., Rinnerthaler, M., et al. (2021) · Nature Metabolism

Mitochondrial Function and PathologyFungal and yeast genetics research

Cited by 48

Species-wide quantitative transcriptomes and proteomes reveal distinct genetic control of gene expression variation in yeast

Teyssonnière, E. M., Trébulle, P., Muenzner, J., Loegler, V., Ludwig, D., Amari, F., Mülleder, M., Friedrich, A., Hou, J., Ralser, M., et al. (2024) · Proceedings of the National Academy of Sciences

Fungal and yeast genetics researchGenetic Associations and Epidemiology

Cited by 40

Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance

Kamrad, S., Grossbach, J., Rodríguez‐López, M., Mülleder, M., Townsend, S., Cappelletti, V., Stojanovski, G., Correia‐Melo, C., Picotti, P., Beyer, A., et al. (2020) · Molecular Systems Biology

Fungal and yeast genetics researchCancer, Hypoxia, and Metabolism

Cited by 40

Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy

Kleeman, S. O., Thakir, T. M., Demestichas, B., Mourikis, N., Loiero, D., Ferrer, M., Bankier, S., Riazat-Kesh, Y. J. R. A., Lee, H., Chantzichristos, D., et al. (2023) · Cell Genomics

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 37

The Role of Metabolism in Shaping Enzyme Structures Over 400 Million Years of Evolution

Lemke, O., Heineike, B. M., Viknander, S., Cohen, N., Steenwyk, J. L., Spranger, L., Li, F., Agostini, F., Lee, C. T., Aulakh, S. K., et al. (2024) · Nature

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 28

The molecular landscape of cellular metal ion biology

Aulakh, S. K., Lemke, O., Szyrwiel, L., Kamrad, S., Chen, Y., Hartl, J., Mülleder, M., Nielsen, J., & Ralser, M. (2025) · Cell Systems

Fungal and yeast genetics researchTrace Elements in Health

Cited by 19

The amino acid sequence determines protein abundance through its conformational stability and reduced synthesis cost

Buric, F., Viknander, S., Fu, X., Lemke, O., Zrimec, J., Szyrwiel, L., Mueleder, M., Ralser, M., & Zelezniak, A. (2023) · Protein Science

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 12