Schwabe, Robert F.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 250

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., et al. (2022) · Nature

Pancreatic and Hepatic Oncology ResearchProtease and Inhibitor Mechanisms

Cited by 221

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

Kluwe, J., Pradere, J., Gwak, G., Mencin, A., De Minicis, S., Österreicher, C. H., Colmenero, J., Bataller, R., & Schwabe, R. F. (2010) · Gastroenterology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 217

Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis

Song, G., Pacher, M., Balakrishnan, A., Yuan, Q., Tsay, H.-C., Yang, D., Reetz, J., Brandes, S., Dai, Z., Pützer, B. M., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 208

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 204

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., et al. (2019) · Science Translational Medicine

Liver physiology and pathologyProteoglycans and glycosaminoglycans research

Cited by 166

Toll-like Receptor 4 and Hepatic Fibrogenesis

Pradere, J.-P., Troeger, J., Dapito, D., Mencin, A., & Schwabe, R. (2010) · Seminars in Liver Disease

Liver physiology and pathologyImmune Response and Inflammation

Cited by 158

CD40 Activates NF-κB and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells

Schwabe, R. F., Schnabl, B., Kweon, Y. O., & Brenner, D. A. (2001) · The Journal of Immunology

Liver physiology and pathologyNF-κB Signaling Pathways

Cited by 155

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Rezvani, M., Español-Suñer, R., Malato, Y., Dumont, L., Grimm, A. A., Kienle, E., Bindman, J. G., Wiedtke, E., Hsu, B. Y., Naqvi, S. J., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyVirus-based gene therapy research

Cited by 150

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Inzaugarat, M. E., Johnson, C. D., Holtmann, T. M., McGeough, M. D., Trautwein, C., Papouchado, B. G., Schwabe, R., Hoffman, H. M., Wree, A., & Feldstein, A. E. (2019) · Hepatology

Liver physiology and pathologyInflammasome and immune disorders

Cited by 148

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 133

Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

Savage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., et al. (2024) · Immunity

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 120

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 116

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 112

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 112

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis

Hernandez, C., Huebener, P., Pradere, J.-P., Antoine, D. J., Friedman, R. A., & Schwabe, R. F. (2018) · Journal of Clinical Investigation

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 110

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., et al. (2022) · Science Translational Medicine

Adenosine and Purinergic SignalingLiver physiology and pathology

Cited by 103

High-Mobility Group Box 1 Is Dispensable for Autophagy, Mitochondrial Quality Control, and Organ Function in Vivo

Huebener, P., Gwak, G.-Y., Pradere, J.-P., Quinzii, C. M., Friedman, R., Lin, C.-S., Trent, C. M., Mederacke, I., Zhao, E., Dapito, D. H., et al. (2014) · Cell Metabolism

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 86

Origin and function of myofibroblasts in the liver

Schwabe, R., & Wells, R. (2015) · Seminars in Liver Disease

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 86

Fibroblasts in liver cancer: functions and therapeutic translation

Affo, S., Filliol, A., Gores, G. J., & Schwabe, R. F. (2023) · The Lancet Gastroenterology & Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 49

Mouse model of NASH that replicates key features of the human disease and progresses to fibrosis stage 3

St. Rose, K., Yan, J., Xu, F., Williams, J., Dweck, V., Saxena, D., Schwabe, R. F., & Caviglia, J. M. (2022) · Hepatology Communications

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 14