Kroemer, Guido

Mitochondrial apoptosis without VDAC

Galluzzi, L., & Kroemer, G. (2007) · Nature Cell Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

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Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer

Aranda, F., Bloy, N., Pesquet, J., Petit, B., Chaba, K., Sauvat, A., Kepp, O., Khadra, N., Enot, D., Pfirschke, C., et al. (2015) · Oncogene

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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Melanoma and microbiota: Current understanding and future directions

Routy, B., Jackson, T., Mählmann, L., Baumgartner, C. K., Blaser, M., Byrd, A., Corvaia, N., Couts, K., Davar, D., Derosa, L., et al. (2024) · Cancer Cell

Gut microbiota and healthCancer Immunotherapy and Biomarkers

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Endonuclease G mediates α‐synuclein cytotoxicity during Parkinson's disease

Büttner, S., Habernig, L., Broeskamp, F., Ruli, D., Vögtle, F. N., Vlachos, M., Macchi, F., Küttner, V., Carmona‐Gutierrez, D., Eisenberg, T., et al. (2013) · The EMBO Journal

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 87

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

Lévesque, S., Le Naour, J., Pietrocola, F., Paillet, J., Kremer, M., Castoldi, F., Baracco, E. E., Wang, Y., Vacchelli, E., Stoll, G., et al. (2019) · OncoImmunology

Cancer Immunotherapy and BiomarkersDietary Effects on Health

Cited by 86

Escherichia coli –Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Goubet, A.-G., Lordello, L., Alves Costa Silva, C., Peguillet, I., Gazzano, M., Mbogning-Fonkou, M. D., Thelemaque, C., Lebacle, C., Thibault, C., Audenet, F., et al. (2022) · Cancer Discovery

Cancer Immunotherapy and BiomarkersBladder and Urothelial Cancer Treatments

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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms

Wu, Q., Tian, A.-L., Li, B., Leduc, M., Forveille, S., Hamley, P., Galloway, W., Xie, W., Liu, P., Zhao, L., et al. (2021) · Journal for ImmunoTherapy of Cancer

Autophagy in Disease and TherapyCancer Immunotherapy and Biomarkers

Cited by 83

Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges

Tang, D., Kroemer, G., & Kang, R. (2021) · Molecular Cancer

Protein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

Cited by 80

Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer

Terrisse, S., Goubet, A.-G., Ueda, K., Thomas, A. M., Quiniou, V., Thelemaque, C., Dunsmore, G., Clave, E., Gamat-Huber, M., Yonekura, S., et al. (2022) · Journal for ImmunoTherapy of Cancer

Prostate Cancer Treatment and ResearchGut microbiota and health

Cited by 80

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

Kasikova, L., Hensler, M., Truxova, I., Skapa, P., Laco, J., Belicova, L., Praznovec, I., Vosahlikova, S., Halaska, M. J., Brtnicky, T., et al. (2019) · Journal for ImmunoTherapy of Cancer

Ovarian cancer diagnosis and treatmentImmunotherapy and Immune Responses

Cited by 79

Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Vitale, I., Galluzzi, L., Vivet, S., Nanty, L., Dessen, P., Senovilla, L., Olaussen, K. A., Lazar, V., Prudhomme, M., Golsteyn, R. M., et al. (2007) · PLoS ONE

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 77

The intestinal microbiota determines the clinical efficacy of immune checkpoint blockers targeting PD-1/PD-L1

Derosa, L., Routy, B., Kroemer, G., & Zitvogel, L. (2018) · OncoImmunology

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 74

Obesity accelerates cardiovascular ageing

Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal

Cardiovascular Function and Risk FactorsGenetics, Aging, and Longevity in Model Organisms

Cited by 73

Trial watch: immune checkpoint blockers for cancer therapy

Vanpouille-Box, C., Lhuillier, C., Bezu, L., Aranda, F., Yamazaki, T., Kepp, O., Fucikova, J., Spisek, R., Demaria, S., Formenti, S. C., et al. (2017) · OncoImmunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 73

The propeptide of yeast cathepsin D inhibits programmed necrosis

Carmona-Gutiérrez, D., Bauer, M. A., Ring, J., Knauer, H., Eisenberg, T., Büttner, S., Ruckenstuhl, C., Reisenbichler, A., Magnes, C., Rechberger, G. N., et al. (2011) · Cell Death & Disease

Cell death mechanisms and regulationGenetics, Aging, and Longevity in Model Organisms

Cited by 69

Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

Chen, J., Levy, A., Tian, A.-L., Huang, X., Cai, G., Fidelle, M., Rauber, C., Ly, P., Pizzato, E., Sitterle, L., et al. (2025) · Cancer Cell

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., et al. (2016) · Cell Reports

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 64

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology

Cardiovascular Health and Disease PreventionTelomeres, Telomerase, and Senescence

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Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva, M., Melendez, E., Chondronasiou, D., Pietrocola, F., Bernad, R., Caballe, A., Junza, A., Capellades, J., Holguín-Horcajo, A., Prats, N., et al. (2023) · Nature Metabolism

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

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Multifaceted modes of action of the anticancer probiotic Enterococcus hirae

Goubet, A.-G., Wheeler, R., Fluckiger, A., Qu, B., Lemaître, F., Iribarren, K., Mondragón, L., Tidjani Alou, M., Pizzato, E., Durand, S., et al. (2021) · Cell Death & Differentiation

Bacterial Cancer TherapyProbiotics and Fermented Foods

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Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease

Yakhine-Diop, S. M. S., Morales-García, J. A., Niso-Santano, M., González-Polo, R. A., Uribe-Carretero, E., Martinez-Chacon, G., Durand, S., Maiuri, M. C., Aiastui, A., Zulaica, M., et al. (2020) · Aging

Parkinson's Disease Mechanisms and TreatmentsMetabolomics and Mass Spectrometry Studies

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PCSK9 in metabolism and diseases

Ajoolabady, A., Pratico, D., Mazidi, M., Davies, I. G., Lip, G. Y. H., Seidah, N., Libby, P., Kroemer, G., & Ren, J. (2025) · Metabolism

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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TG2 regulates the heat‐shock response by the post‐translational modification of HSF1

Rossin, F., Villella, V. R., D'Eletto, M., Farrace, M. G., Esposito, S., Ferrari, E., Monzani, R., Occhigrossi, L., Pagliarini, V., Sette, C., et al. (2018) · The EMBO Reports

Heat shock proteins researchEndoplasmic Reticulum Stress and Disease

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Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI)

Joseph, A., Moriceau, S., Sica, V., Anagnostopoulos, G., Pol, J., Martins, I., Lafarge, A., Maiuri, M. C., Leboyer, M., Loftus, J., et al. (2020) · Cell Death & Disease

Regulation of Appetite and ObesityEating Disorders and Behaviors

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