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Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

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The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment

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Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

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Autism and the synapse

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Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder

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Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function

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Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development

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Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission

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Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.

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Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders

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Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities

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Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

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Modulation of actin dynamics by Rac1 to target cognitive function

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Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links

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Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice

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Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2−/− Mice

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Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism

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Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers

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Dendritic spine actin cytoskeleton in autism spectrum disorder

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Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

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Reversal of social deficits by subchronic oxytocin in two autism mouse models

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Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review

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The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

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Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum

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Shank–cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses

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Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

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Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals

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Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction

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Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice

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Aβ Selectively Impairs mGluR7 Modulation of NMDA Signaling in Basal Forebrain Cholinergic Neurons: Implication in Alzheimer's Disease

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Specific Roles of NMDA Receptor Subunits in Mental Disorders

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1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling

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Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model

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Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathies

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Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders

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NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

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Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice

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Neuronal Cytoskeleton in Intellectual Disability: From Systems Biology and Modeling to Therapeutic Opportunities

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Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity

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Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

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Synergistic Interactions between Drosophila Orthologues of Genes Spanned by De Novo Human CNVs Support Multiple-Hit Models of Autism

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Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons

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Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing

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Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer’s Disease

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Copy number variation analysis in adults with catatonia confirms haploinsufficiency of SHANK3 as a predisposing factor

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Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time

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Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats

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Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

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Glutamatergic candidate genes in autism spectrum disorder: an overview

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DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

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A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability

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Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders

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Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2

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Synergistic inhibition of histone modifiers produces therapeutic effects in adult Shank3-deficient mice

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Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report

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From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

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The role of F-actin in modulating Clathrin-mediated endocytosis: Lessons from neurons in health and neuropsychiatric disorder

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Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation

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Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/− mouse model of autism spectrum disorders

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Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control

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Cellular and molecular mechanisms underlying autism spectrum disorders and associated comorbidities: A pathophysiological review

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Shank3B mutant mice display pitch discrimination enhancements and learning deficits

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Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders

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The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior

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Impaired Object Recognition but Normal Social Behavior and Ultrasonic Communication in Cofilin1 Mutant Mice

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Novel functions for ADF/cofilin in excitatory synapses - lessons from gene-targeted mice

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Disruption of the Autism-Associated Pcdh9 Gene Leads to Transcriptional Alterations, Synapse Overgrowth, and Defective Network Activity in the CA1

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Targeting Shank3 deficiency and paresthesia in autism spectrum disorder: A brief review

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The gut-brain vagal axis scales hippocampal memory processes and plasticity

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LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice

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Synaptic compartmentalization by micropatterned masking of a surface adhesive cue in cultured neurons

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Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model

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Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size

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Clinical profiling of MRD48 and functional characterization of two novel pathogenic RAC1 variants

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Noninvasive Brain Stimulation Enhances Memory Acquisition and Is Associated with Synaptoneurosome Modification in the Rat Hippocampus

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Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice

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Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion

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SK Channel Modulates Synaptic Plasticity by Tuning CaMKIIα/β Dynamics

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Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood

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Evaluating the association between the SHANK3 gene and bipolar disorder

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