Williams, Graham R.

An atlas of genetic influences on osteoporosis in humans and mice

23andMe Research Team, Morris, J. A., Kemp, J. P., Youlten, S. E., Laurent, L., Logan, J. G., Chai, R. C., Vulpescu, N. A., Forgetta, V., Kleinman, A., et al. (2019) · Nature Genetics

Bone health and osteoporosis researchGenetic Associations and Epidemiology

Cited by 773

Role of Thyroid Hormones in Skeletal Development and Bone Maintenance

Bassett, J. H. D., & Williams, G. R. (2016) · Endocrine Reviews

Thyroid Disorders and TreatmentsBone Metabolism and Diseases

Cited by 540

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

McDonald, M. M., Khoo, W. H., Ng, P. Y., Xiao, Y., Zamerli, J., Thatcher, P., Kyaw, W., Pathmanandavel, K., Grootveld, A. K., Moran, I., et al. (2021) · Cell

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 433

Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis

Blum, M. R., Bauer, D. C., Collet, T.-H., Fink, H. A., Cappola, A. R., da Costa, B. R., Wirth, C. D., Peeters, R. P., Åsvold, B. O., den Elzen, W. P. J., et al. (2015) · JAMA

Thyroid Disorders and TreatmentsBone health and osteoporosis research

Cited by 343

Thyroid diseases and bone health

Williams, G. R., & Bassett, J. H. D. (2018) · Journal of Endocrinological Investigation

Thyroid Disorders and TreatmentsBone health and osteoporosis research

Cited by 276

The molecular actions of thyroid hormone in bone

Duncan Bassett, J. H., & Williams, G. R. (2003) · Trends in Endocrinology & Metabolism

Bone Metabolism and DiseasesThyroid Disorders and Treatments

Cited by 261

Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee

Okosieme, O., Gilbert, J., Abraham, P., Boelaert, K., Dayan, C., Gurnell, M., Leese, G., McCabe, C., Perros, P., Smith, V., et al. (2016) · Clinical Endocrinology

Thyroid Disorders and TreatmentsThyroid and Parathyroid Surgery

Cited by 208

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models: Report of the American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action

Bianco, A. C., Anderson, G., Forrest, D., Galton, V. A., Gereben, B., Kim, B. W., Kopp, P. A., Liao, X. H., Obregon, M. J., Peeters, R. P., et al. (2014) · Thyroid

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 205

Thyroid Hormone Acts Directly on Growth Plate Chondrocytes to Promote Hypertrophic Differentiation and Inhibit Clonal Expansion and Cell Proliferation1

Robson, H., Siebler, T., Stevens, D. A., Shalet, S. M., & Williams, G. R. (2000) · Endocrinology

Osteoarthritis Treatment and MechanismsGrowth Hormone and Insulin-like Growth Factors

Cited by 188

Thyroid Function within the Upper Normal Range Is Associated with Reduced Bone Mineral Density and an Increased Risk of Nonvertebral Fractures in Healthy Euthyroid Postmenopausal Women

Murphy, E., Glüer, C. C., Reid, D. M., Felsenberg, D., Roux, C., Eastell, R., & Williams, G. R. (2010) · The Journal of Clinical Endocrinology & Metabolism

Bone health and osteoporosis researchThyroid Disorders and Treatments

Cited by 180

Thyroid Hormone Excess Rather Than Thyrotropin Deficiency Induces Osteoporosis in Hyperthyroidism

Bassett, J. H. D., O’Shea, P. J., Sriskantharajah, S., Rabier, B., Boyde, A., Howell, P. G. T., Weiss, R. E., Roux, J.-P., Malaval, L., Clement-Lacroix, P., et al. (2007) · Molecular Endocrinology

Thyroid Disorders and TreatmentsBone Metabolism and Diseases

Cited by 167

The skeletal consequences of thyrotoxicosis

Nicholls, J. J., Brassill, M. J., Williams, G. R., & Bassett, J. H. D. (2012) · Journal of Endocrinology

Thyroid Disorders and TreatmentsBone health and osteoporosis research

Cited by 138

Local control of thyroid hormone action: role of type 2 deiodinase

Williams, G. R., & Bassett, J. H. D. (2011) · Journal of Endocrinology

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 134

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Youlten, S. E., Kemp, J. P., Logan, J. G., Ghirardello, E. J., Sergio, C. M., Dack, M. R. G., Guilfoyle, S. E., Leitch, V. D., Butterfield, N. C., Komla-Ebri, D., et al. (2021) · Nature Communications

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 133

A Thyrotoxic Skeletal Phenotype of Advanced Bone Formation in Mice with Resistance to Thyroid Hormone

O’Shea, P. J., Harvey, C. B., Suzuki, H., Kaneshige, M., Kaneshige, K., Cheng, S.-Y., & Williams, G. R. (2003) · Molecular Endocrinology

Thyroid Disorders and TreatmentsBone Metabolism and Diseases

Cited by 131

Contrasting Skeletal Phenotypes in Mice with an Identical Mutation Targeted to Thyroid Hormone Receptor α1 or β

O’Shea, P. J., Bassett, J. H. D., Sriskantharajah, S., Ying, H., Cheng, S.-Y., & Williams, G. R. (2005) · Molecular Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 126

Thyroid Status during Skeletal Development Determines Adult Bone Structure and Mineralization

Bassett, J. H. D., Nordström, K., Boyde, A., Howell, P. G. T., Kelly, S., Vennström, B., & Williams, G. R. (2007) · Molecular Endocrinology

Thyroid Disorders and TreatmentsBone Metabolism and Diseases

Cited by 125

Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Jo, S., Fonseca, T. L., Bocco, B. M. L. C., Fernandes, G. W., McAninch, E. A., Bolin, A. P., Da Conceição, R. R., Werneck-de-Castro, J. P., Ignacio, D. L., Egri, P., et al. (2018) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsEndoplasmic Reticulum Stress and Disease

Cited by 107

Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone

Stevens, D. A., Harvey, C. B., Scott, A. J., O’Shea, P. J., Barnard, J. C., Williams, A. J., Brady, G., Samarut, J., Chassande, O., & Williams, G. R. (2003) · Molecular Endocrinology

Bone Metabolism and DiseasesFibroblast Growth Factor Research

Cited by 105

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling

Rauner, M., Baschant, U., Roetto, A., Pellegrino, R. M., Rother, S., Salbach-Hirsch, J., Weidner, H., Hintze, V., Campbell, G., Petzold, A., et al. (2019) · Nature Metabolism

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 87

Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts

Segna, D., Bauer, D. C., Feller, M., Schneider, C., Fink, H. A., Aubert, C. E., Collet, T. ‐., da Costa, B. R., Fischer, K., Peeters, R. P., et al. (2018) · Journal of Internal Medicine

Thyroid Disorders and TreatmentsBone health and osteoporosis research

Cited by 87

Classification and Proposed Nomenclature for Inherited Defects of Thyroid Hormone Action, Cell Transport, and Metabolism*

Refetoff, S., Bassett, J. H. D., Beck-Peccoz, P., Bernal, J., Brent, G., Chatterjee, K., De Groot, L. J., Dumitrescu, A. M., Jameson, J. L., Kopp, P. A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 79

Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression

O'Shea, P. J., Bassett, J. H. D., Cheng, S.-Y., & Williams, G. R. (2006) · Nuclear Receptor Signaling

Thyroid Disorders and TreatmentsBone Metabolism and Diseases

Cited by 53

Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women

van Rijn, L. E., Pop, V. J., & Williams, G. R. (2014) · European Journal of Endocrinology

Bone health and osteoporosis researchThyroid Disorders and Treatments

Cited by 50