Williams, David S.

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,214

The cell biology of the retinal pigment epithelium

Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 422

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

Allocca, M., Doria, M., Petrillo, M., Colella, P., Garcia-Hoyos, M., Gibbs, D., Kim, S. R., Maguire, A., Rex, T. S., Di Vicino, U., et al. (2008) · Journal of Clinical Investigation

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 292

Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein.

Gibbs, D., Kitamoto, J., & Williams, D. S. (2003) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersCellular transport and secretion

Cited by 250

A comparison of some organizational characteristics of the mouse central retina and the human macula

Volland, S., Esteve-Rudd, J., Hoo, J., Yee, C., & Williams, D. S. (2015) · PLoS ONE

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 229

Usher syndrome: Animal models, retinal function of Usher proteins, and prospects for gene therapy

Williams, D. S. (2008) · Vision Research

Retinal Development and DisordersGenetic and Kidney Cyst Diseases

Cited by 188

Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: A model for macular degeneration

Karan, G., Lillo, C., Yang, Z., Cameron, D. J., Locke, K. G., Zhao, Y., Thirumalaichary, S., Li, C., Birch, D. G., Vollmer-Snarr, H. R., et al. (2005) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 182

Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice

Liu, X., Ondek, B., & Williams, D. S. (1998) · Nature Genetics

Retinal Development and Disordersmelanin and skin pigmentation

Cited by 168

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes

Gibbs, D., Azarian, S. M., Lillo, C., Kitamoto, J., Klomp, A. E., Steel, K. P., Libby, R. T., & Williams, D. S. (2004) · Journal of Cell Science

Retinal Development and Disordersmelanin and skin pigmentation

Cited by 152

Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide

Hazim, R. A., Volland, S., Yen, A., Burgess, B. L., & Williams, D. S. (2019) · Experimental Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 126

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

Galloway, C. A., Dalvi, S., Hung, S. S. C., MacDonald, L. A., Latchney, L. R., Wong, R. C. B., Guymer, R. H., Mackey, D. A., Williams, D. S., Chung, M. M., et al. (2017) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 123

Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus

Lopes, V. S., Boye, S. E., Louie, C. M., Boye, S., Dyka, F., Chiodo, V, Fofo, H., Hauswirth, W. W., & Williams, D. S. (2013) · Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 112

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis

Jiang, M., Esteve-Rudd, J., Lopes, V. S., Diemer, T., Lillo, C., Rump, A., & Williams, D. S. (2015) · Journal of Cell Biology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 85

Retinal Pigment Epithelium Defects in Humans and Mice with Mutations in MYO7A : Imaging Melanosome-Specific Autofluorescence

Gibbs, D., Cideciyan, A. V., Jacobson, S. G., & Williams, D. S. (2009) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 82

Actin-based motor properties of native myosin VIIa

Udovichenko, I. P., Gibbs, D., & Williams, D. S. (2002) · Journal of Cell Science

Cardiomyopathy and Myosin StudiesMicrotubule and mitosis dynamics

Cited by 82

Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides

Stokin, G. B., Almenar-Queralt, A., Gunawardena, S., Rodrigues, E. M., Falzone, T., Kim, J., Lillo, C., Mount, S. L., Roberts, E. A., McGowan, E., et al. (2008) · Human Molecular Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 72

Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization

Hazim, R. A., Karumbayaram, S., Jiang, M., Dimashkie, A., Lopes, V. S., Li, D., Burgess, B. L., Vijayaraj, P., Alva-Ornelas, J. A., Zack, J. A., et al. (2017) · Stem Cell Research & Therapy

Retinal Development and DisordersPluripotent Stem Cells Research

Cited by 66

The contribution of melanoregulin to microtubule-associated protein 1 light chain 3 (LC3) associated phagocytosis in retinal pigment epithelium

Frost, L. S., Lopes, V. S., Bragin, A., Reyes-Reveles, J., Brancato, J., Cohen, A., Mitchell, C. H., Williams, D. S., & Boesze-Battaglia, K. (2015) · Molecular Neurobiology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 63

Changes of photoreceptor performance associated with the daily turnover of photoreceptor membrane in locusts

Williams, D. S. (1983) · Journal of Comparative Physiology A

Retinal Development and DisordersNeurobiology and Insect Physiology Research

Cited by 52

Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells

Damek-Poprawa, M., Diemer, T., Lopes, V. S., Lillo, C., Harper, D. C., Marks, M. S., Wu, Y., Sparrow, J. R., Rachel, R. A., Williams, D. S., et al. (2009) · Journal of Biological Chemistry

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 50

Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration

Esteve-Rudd, J., Hazim, R. A., Diemer, T., Paniagua, A. E., Volland, S., Umapathy, A., & Williams, D. S. (2018) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 42

Proteomic analysis of mature melanosomes from the retinal pigmented epithelium

Azarian, S. M., McLeod, I., Lillo, C., Gibbs, D., Yates, J. R., & Williams, D. S. (2006) · Journal of Proteome Research

Retinal Diseases and Treatmentsmelanin and skin pigmentation

Cited by 35

In vivo and in vitro monitoring of phagosome maturation in retinal pigment epithelium cells

Esteve-Rudd, J., Lopes, V. S., Jiang, M., & Williams, D. S. (2014) · Advances in experimental medicine and biology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 22

Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B)

Daniele, L. L., Caughey, J., Volland, S., Sharp, R. C., Dhingra, A., Williams, D. S., Philp, N. J., & Boesze-Battaglia, K. (2019) · American Journal of Physiology-Cell Physiology

Autophagy in Disease and TherapyRetinal Diseases and Treatments

Cited by 16