Diverse Effect of Inflammatory Markers on Insulin Resistance and Insulin‐Resistance Syndrome in the Elderly
Abstract
Objectives: To evaluate the potential association between different inflammatory markers and insulin resistance (IR), as well as insulin‐resistance syndrome (IRS) in a large, population‐based study of older, nondiabetic persons. Design: Cross‐sectional study. Setting: Outpatient clinic in Greve in Chianti and Bagno a Ripoli (Italy). Participants: One thousand one hundred forty‐six nondiabetic subjects ranging in age from 22 to 104. Measurements: Anthropometric measurements; plasma fasting levels of glucose, insulin, and cholesterol (total, high‐density lipoprotein, low‐density lipoprotein); homeostasis model assessment to estimate degree of insulin resistance; tumor necrosis factor α (TNF‐α), interleukin 6 (IL‐6), soluble IL‐6 receptor (sIL‐6R), interleukin receptor antagonist (IL‐1ra), and C‐reactive protein (CRP) plasma concentrations; diastolic, systolic, and mean arterial blood pressure; and echo‐color‐Doppler duplex scanning examination of carotid arteries. Results: Insulin resistance correlated with age ( r= 0.102; P <.001) and plasma levels of TNF‐α ( r= 0.082; P= .007), IL‐1ra ( r= 0.147; P <.001), IL‐6 ( r= 0.133; P <.001), sIL‐6R ( r= −0.156; P <.001), and CRP ( r= 0.83; P <.001). Subjects in the upper tertile of IR degree were older and had higher serum levels of TNF‐α, IL‐1ra, and IL‐6 and lower levels of sIL‐6R than subjects in the lowest tertile. Independent of age, sex, body mass index, waist‐to‐hip ratio, triglycerides, drug intake, diastolic blood pressure, smoking habit, and carotid atherosclerotic plaques, higher IL‐6 ( t =2.987; P= .003) serum concentrations were associated with higher IR, whereas sIL‐6R levels ( t =−5.651; P <.001) were associated with lower IR. Furthermore, IL‐1ra concentrations ( t =2.448; P= .015) were associated with IRS, and higher sIL‐6R plasma levels continued to correlate negatively with IRS. Conclusion: Different inflammatory markers are associated with a diverse effect on IR and IRS in elderly nondiabetic subjects.
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Evidence indicates that inflammation causes insulin resistance.
“Evidence indicates that inflammation causes insulin resistance”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [282]
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- Authors
- Abbatecola, A. M., Ferrucci, L., Grella, R., Bandinelli, S., Bonafè, M., Barbieri, M., Corsi, A. M., Lauretani, F., Franceschi, C., & Paolisso, G.
- Affiliations
- University of Naples Federico II (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Paolisso, Giuseppe
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2004-02-12
- Volume
- 52
- Issue
- 3
- Pages
- 399-404
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1505294361
- Cited by
- 116
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- insulin resistance, metabolic syndrome, inflammatory markers, older adults, TNF-α, interleukin-6, soluble IL-6 receptor, interleukin-1 receptor antagonist, C-reactive protein, carotid atherosclerosis, carotid intima-media thickness, carotid plaque, cardiovascular risk, HOMA
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Blood Glucose, Blood Pressure, C-Reactive Protein, Cholesterol, Cross-Sectional Studies, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Interleukin-6, Metabolic Syndrome
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