Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians’ offspring

Use and Abuse of HOMA Modeling

Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114 · see citing works

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

Renehan, A. G., Zwahlen, M., Minder, C., O'Dwyer, S. T., Shalet, S. M., & Egger, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16044-3 · Cited by 1,697 · see citing works

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,035 · see citing works

Age-related changes in total and regional fat distribution

Kuk, J. L., Saunders, T. J., Davidson, L. E., & Ross, R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.001 · Cited by 778 · see citing works

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703 · see citing works

Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease: A Population-Based Case-Control Study

Juul, A., Scheike, T., Davidsen, M., Gyllenborg, J., & Jørgensen, T. (2002) · Circulation · doi:10.1161/01.cir.0000027563.44593.cc · Cited by 640 · see citing works

Evolutionary medicine: from dwarf model systems to healthy centenarians?

Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575 · see citing works

Centenarians as a model for healthy aging

Franceschi, C., & Bonafè, M. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310457 · Cited by 380 · see citing works

Reduced insulin/IGF‐1 signalling and human longevity

van Heemst, D., Beekman, M., Mooijaart, S. P., Heijmans, B. T., Brandt, B. W., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00148.x · Cited by 338 · see citing works

Polymorphic Variants of Insulin-Like Growth Factor I (IGF-I) Receptor and Phosphoinositide 3-Kinase Genes Affect IGF-I Plasma Levels and Human Longevity: Cues for an Evolutionarily Conserved Mechanism of Life Span Control

Bonafè, M., Barbieri, M., Marchegiani, F., Olivieri, F., Ragno, E., Giampieri, C., Mugianesi, E., Centurelli, M., Franceschi, C., & Paolisso, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021810 · Cited by 312 · see citing works

Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes

Clemmons, D. R. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.04.017 · Cited by 298 · see citing works

The role of insulin‐like growth factor‐I and its binding proteins in glucose homeostasis and type 2 diabetes

Rajpathak, S. N., Gunter, M. J., Wylie‐Rosett, J., Ho, G., Kaplan, R. C., Muzumdar, R. H., Rohan, T. E., & Strickler, H. D. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.919 · Cited by 263 · see citing works

Circulating insulin‐like growth factor peptides and prostate cancer risk: A systematic review and meta‐analysis

Rowlands, M., Gunnell, D., Harris, R., VATTEN, L. J., Holly, J. M. P., & Martin, R. M. (2008) · International Journal of Cancer · doi:10.1002/ijc.24202 · Cited by 249 · see citing works

Serum Total IGF-I, Free IGF-I, and IGFBP-1 Levels in an Elderly Population

Janssen, J. A. M. J. L., Stolk, R. P., Pols, H. A. P., Grobbee, D. E., & Lamberts, S. W. J. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.2.277 · Cited by 243 · see citing works

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians

Franceschi, C., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Capri, M., Salvioli, S., Valensin, S., Benedictis, G. D., Iorio, A. D., et al. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.028 · Cited by 211 · see citing works

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10766 · Cited by 211 · see citing works

Human models of aging and longevity

Cevenini, E., Invidia, L., Lescai, F., Salvioli, S., Tieri, P., Castellani, G., & Franceschi, C. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.9.1393 · Cited by 195 · see citing works

Health and function of participants in the Long Life Family Study: A comparison with other cohorts

Newman, A. B., Glynn, N. W., Taylor, C. A., Sebastiani, P., Perls, T. T., Mayeux, R. P., Christensen, K., Zmuda, J. M., Barral, S., Lee, J. H., et al. (2011) · Aging · doi:10.18632/aging.100242 · Cited by 192 · see citing works

Clinical Phenotype of Families with Longevity

Atzmon, G., Schechter, C. B., Greiner, W., Davidson, D. E., Rennert, G., & Barzilai, N. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52068.x · Cited by 190 · see citing works

Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function

Paolisso, G., Ammendola, S., Buono, A. D., Gambardella, A., Riondino, M., Tagliamonte, M. R., Rizzo, M. R., Carella, C., & Varricchio, M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4087 · Cited by 181 · see citing works

A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum

Chen, J.-W., Ledet, T., Ørskov, H., Jessen, N., Lund, S. A., Whittaker, J., MEYTS, P. D., Larsen, M. B., Christiansen, J. S., & Frystyk, J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00410.2002 · Cited by 178 · see citing works

Lower All‐Cause, Cardiovascular, and Cancer Mortality in Centenarians' Offspring

Terry, D. F., Wilcox, M., McCormick, M. A., Pennington, J. Y., Sharp, E. S., Andersen, S. L., & Perls, T. T. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52561.x · Cited by 170 · see citing works

Insulin-Like Growth Factor (IGF) I, -II, and IGF Binding Protein-3 and Risk of Ischemic Stroke

Johnsen, S. P., Hundborg, H. H., Sørensen, H. T., Ørskov, H., Tjønneland, A. M., Overvad, K., & Jørgensen, J. O. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2088 · Cited by 168 · see citing works

Glucose tolerance and insulin action in healthy centenarians

Paolisso, G., Gambardella, A., Ammendola, S., D’Amore, A., Balbi, V., Varricchio, M., & D'Onofrio, F. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e890 · Cited by 160 · see citing works

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.16.13120 · Cited by 152 · see citing works

Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians

Barbieri, M., Rizzo, M. R., Manzella, D., & Paolisso, G. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.178 · Cited by 111 · see citing works

Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects

Colao, A., Somma, C. D., Cascella, T., Pivonello, R., Vitale, G., Grasso, L. F. S., Lombardi, G., & Savastano, S. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0201 · Cited by 101 · see citing works

Centenarian Offspring: Start Healthier and Stay Healthier

Adams, E. R., Nolan, V. G., Andersen, S. L., Perls, T. T., & Terry, D. F. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01949.x · Cited by 92 · see citing works

Low Circulating Insulin-Like Growth Factor I Bioactivity in Elderly Men Is Associated with Increased Mortality

Brugts, M. P., van den Beld, A. W., Hofland, L. J., van der Wansem, K., van Koetsveld, P. M., Frystyk, J., Lamberts, S. W. J., & Janssen, J. A. M. J. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1633 · Cited by 90 · see citing works

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to

Blagosklonny, M. V. (2012) · Aging · doi:10.18632/aging.100461 · Cited by 89 · see citing works

The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity

Arafat, A. M., Weickert, M. O., Frystyk, J., Spranger, J., Schöfl, C., Möhlig, M., & Pfeiffer, A. F. H. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0875 · Cited by 77 · see citing works

Insulin-Like Growth Factor-I and Cancer Mortality in Older Men

Major, J. M., Laughlin, G. A., Kritz‐Silverstein, D. C., Wingard, D. L., & Barrett-Connor, E. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1378 · Cited by 76 · see citing works

Cardiovascular risk factors in centenarians

Galioto, A., Dominguez, L. J., Pineo, A., Ferlisi, A., Putignano, E., Belvedere, M., Costanza, G., & Barbagallo, M. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.009 · Cited by 74 · see citing works

Human insulin/IGF-1 and familial longevity at middle age

Rozing, M. P., Westendorp, R. G. J., Frölich, M., de Craen, A. J. M., Beekman, M., Heijmans, B. T., Mooijaart, S. P., Blauw, G. J., Slagboom, P. E., van Heemst, D., et al. (2009) · Aging · doi:10.18632/aging.100071 · Cited by 71 · see citing works

Normal Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays

Brugts, M. P., Ranke, M. B., Hofland, L. J., van der Wansem, K., Weber, K., Frystyk, J., Lamberts, S. W. J., & Janssen, J. A. M. J. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2454 · Cited by 65 · see citing works

IGF-I/IGF-Binding Protein-3 Combination Improves Insulin Resistance By GH-Dependent and Independent Mechanisms

O’Connell, T., & Clemmons, D. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020343 · Cited by 56 · see citing works

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

D'Costa, A. P., LENHAM, J. E., Ingram, R. L., & Sonntag, W. E. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90035-p · Cited by 54 · see citing works

Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population

Aimaretti, G., Boschetti, M., Corneli, G., Gasco, V., Valle, D. D. L. N. M., Borsotti, M., Rossi, A., Barreca, A., Fazzuoli, L., Ferone, D., et al. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346389 · Cited by 49 · see citing works

Insulin‐like growth factor‐1 deficiency determines increased intima–media thickness at common carotid arteries in adult patients with growth hormone deficiency

Colao, A., Somma, C. D., Filippella, M., Rota, F., Pivonello, R., Orio, F., Vitale, G., & Lombardi, G. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02105.x · Cited by 49 · see citing works

IGF-I Bioactivity in an Elderly Population

Brugts, M. P., van Duijn, C. M., Hofland, L. J., Witteman, J. C. M., Lamberts, S. W. J., & Janssen, J. A. M. J. L. (2010) · Diabetes · doi:10.2337/db09-0583 · Cited by 47 · see citing works

Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted Rats

Sharma, N., Castorena, C. M., & Cartee, G. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038835 · Cited by 45 · see citing works

Positive association between circulating free insulin-like growth factor–1 levels and coronary flow reserve in arterial systemic hypertension

Galderisi, M., Caso, P., Cicala, S., Desimone, L.-A., Barbieri, M., Vitale, G., Dedivitiis, O., & Paolisso, G. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02967-9 · Cited by 35 · see citing works

IGF-I and Longevity

Janssen, J. A. M. J. L., & Lamberts, S. W. J. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080508 · Cited by 32 · see citing works

Insulin exposure controls the rate of mammalian aging

Parr, T. B. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01723-x · Cited by 32 · see citing works

An Insulin-Like Growth Factor-I Receptor Defect Associated with Short Stature and Impaired Carbohydrate Homeostasis in an Italian Pedigree

Mohn, A., Marcovecchio, M. L., de Giorgis, T., Pfaeffle, R. W., Chiarelli, F., & Kiess, W. (2011) · Hormone Research in Paediatrics · doi:10.1159/000324957 · Cited by 30 · see citing works

Inverse Association Between Free Insulin-Like Growth Factor-1 and Isovolumic Relaxation in Arterial Systemic Hypertension

Galderisi, M., Vitale, G., Lupoli, G., Barbieri, M., Varricchio, G., Carella, C., DIVITIIS, O. D., & Paolisso, G. (2001) · Hypertension · doi:10.1161/hy1001.091776 · Cited by 25 · see citing works

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

Mooijaart, S. P., van Heemst, D., Noordam, R., Rozing, M. P., Wijsman, C. A., de Craen, A. J. M., Westendorp, R. G. J., Beekman, M., & Slagboom, P. E. (2010) · Aging · doi:10.18632/aging.100250 · Cited by 23 · see citing works

Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

Ugalde, A. P., Mariño, G., & López-Otı́n, C. (2010) · Aging · doi:10.18632/aging.100262 · Cited by 15 · see citing works

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Horvath, S., Pirazzini, C., Bacalini, M. G., Gentilini, D., Di Blasio, A. M., Delledonne, M., Mari, D., Arosio, B., Monti, D., Passarino, G., et al. (2015) · Aging · doi:10.18632/aging.100861 · Cited by 316 · see citing works

Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer

Janssen, J. A. M. J. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157797 · Cited by 296 · see citing works

Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016) · Biogerontology · doi:10.1007/s10522-015-9631-7 · Cited by 274 · see citing works

Oxidative stress and the ageing endocrine system

Vitale, G., Salvioli, S., & Franceschi, C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.29 · Cited by 269 · see citing works

Serum copper to zinc ratio: Relationship with aging and health status

Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.01.004 · Cited by 227 · see citing works

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly153 · Cited by 219 · see citing works

Growth Hormone Deficiency: Health and Longevity

Aguiar-Oliveira, M. H., & Bartke, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00216 · Cited by 197 · see citing works

Resistin: A reappraisal

Acquarone, E., Monacelli, F., Borghi, R., Nencioni, A., & Odetti, P. R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.004 · Cited by 196 · see citing works

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective

Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166 · see citing works

Anti-aging pharmacology: Promises and pitfalls

Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 144 · see citing works

Will calorie restriction work in humans?

Cava, E., & Fontana, L. (2013) · Aging · doi:10.18632/aging.100581 · Cited by 124 · see citing works

Metabolic effects of prolactin

Pirchio, R., Graziadio, C., Colao, A., Pivonello, R., & Auriemma, R. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1015520 · Cited by 114 · see citing works

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Yen, K., Mehta, H. H., Kim, S., Lue, Y., Hoang, J., Guerrero, N., Port, J. M., Bi, Q., Navarrete, G., Brandhorst, S., et al. (2020) · Aging · doi:10.18632/aging.103534 · Cited by 110 · see citing works

Effect of Cabergoline on Metabolism in Prolactinomas

Auriemma, R. S., Granieri, L., Galdiero, M., Simeoli, C., Perone, Y., Vitale, P., Pivonello, C., Negri, M., Mannarino, T., Giordano, C. S. D. S., et al. (2013) · Neuroendocrinology · doi:10.1159/000357810 · Cited by 102 · see citing works

Aging of the endocrine system and its potential impact on sarcopenia

Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 106 · see citing works

Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease

Johnson, S. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_3 · Cited by 102 · see citing works

Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects

Bucci, L., Yani, S. L., Fabbri, C., Bijlsma, A. Y., Maier, A. B., Meskers, C. G. M., Narici, M. V., Jones, D. A., McPhee, J. S., Seppet, E. K., et al. (2013) · Biogerontology · doi:10.1007/s10522-013-9428-5 · Cited by 93 · see citing works

Meta-analysis of genetic variants associated with human exceptional longevity

Paola Sebastiani, B., Bae, H. T., Sun, F. X., Andersen, S. L., Daw, E. W., Malovini, A. L., Kojima, T., Hirose, N., Schupf, N., Puca, A. A., et al. (2013) · Aging · doi:10.18632/aging.100594 · Cited by 91 · see citing works

The IGF Hormonal Network in Endometrial Cancer: Functions, Regulation, and Targeting Approaches

Bruchim, I., Sarfstein, R., & Werner, H. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00076 · Cited by 86 · see citing works

Targeting the IGF-1R: The Tale of the Tortoise and the Hare

Crudden, C., Girnita, A., & Girnita, L. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00064 · Cited by 82 · see citing works

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

Franceschi, C., Ostan, R., & Santoro, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051637 · Cited by 81 · see citing works

The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective

Franceschi, C., Ostan, R., Mariotti, S., Monti, D., & Vitale, G. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00170 · Cited by 72 · see citing works

Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species

Mathew, R., Bhadra, M. P., & Bhadra, U. (2017) · Biogerontology · doi:10.1007/s10522-016-9670-8 · Cited by 75 · see citing works

Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

Bucci, L., Ostan, R., Cevenini, E., Pini, E., Scurti, M., Vitale, G., Mari, D., Caruso, C., Sansoni, P., Fanelli, F., et al. (2016) · Aging · doi:10.18632/aging.100912 · Cited by 71 · see citing works

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67 · see citing works

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Garagnani, P., Giuliani, C., Pirazzini, C., Olivieri, F., Bacalini, M. G., Ostan, R., Mari, D., Passarino, G., Monti, D., Bonfigli, A. R., et al. (2013) · Aging · doi:10.18632/aging.100562 · Cited by 66 · see citing works

The effects of hyperprolactinemia and its control on metabolic diseases

Auriemma, R. S., Alcubierre, D. D., Pirchio, R., Pivonello, R., & Colao, A. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1434412 · Cited by 51 · see citing works

Insulin Analogs and Cancer

Sciacca, L., Moli, R. L., & Vigneri, R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00021 · Cited by 52 · see citing works

Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity

Milman, S., Atzmon, G., Crandall, J. P., & Barzilai, N. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219101551 · Cited by 44 · see citing works

“Is there any association between insulin resistance and thyroid cancer? : a case control study”

Balkan, F., Önal, E. D., Usluogullari, A. C., Tüzün, D., Özdemir, D., İnançlı, S. S., Ersoy, R., & Çakır, B. (2013) · Endocrine · doi:10.1007/s12020-013-9942-x · Cited by 45 · see citing works

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Bareja, A., Lee, D. E., & White, J. P. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00183 · Cited by 41 · see citing works

Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging

Jung, M., Jin, S., Zhang, X., Xiong, W., Gogoshin, G., Rodin, A. S., & Pfeifer, G. P. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv473 · Cited by 39 · see citing works

Demographic, genetic and phenotypic characteristics of centenarians in Italy: Focus on gender differences

Montesanto, A., Rango, F. D., Pirazzini, C., Guidarelli, G., Domma, F., Franceschi, C., & Passarino, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.04.008 · Cited by 37 · see citing works

GH/IGF-I/insulin system in centenarians

Vitale, G., Barbieri, M., Kamenetskaya, M., & Paolisso, G. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.001 · Cited by 35 · see citing works

Age-Related Hormones Changes and Its Impact on Health Status and Lifespan

Biagetti, B., & Puig‐Domingo, M. (2023) · Aging and Disease · doi:10.14336/ad.2022.1109 · Cited by 39 · see citing works

Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines

Ostan, R., Bucci, L., Cevenini, E., Palmas, M. G., Pini, E., Scurti, M., Vescovini, R., Caruso, C., Mari, D., Vitale, G., et al. (2012) · AGE · doi:10.1007/s11357-012-9483-x · Cited by 33 · see citing works

The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

Pivonello, C., Martino, M. C. D., Negri, M., Cuomo, G., Cariati, F., Izzo, F., Colao, A., & Pivonello, R. (2014) · Infectious Agents and Cancer · doi:10.1186/1750-9378-9-27 · Cited by 33 · see citing works

Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function

Perice, L., Barzilai, N., Verghese, J., Weiss, E. F., Holtzer, R., Cohen, P., & Milman, S. (2016) · Aging · doi:10.18632/aging.101063 · Cited by 33 · see citing works

Mechanisms of ageing: growth hormone, dietary restriction, and metformin

Khan, J., Pernicova, I., Nisar, K., & Korbonits, M. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00001-3 · Cited by 32 · see citing works

Aging under endocrine hormone regulation

Xing, Y., Fan, X., Wang, K., & Zhang, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1223529 · Cited by 32 · see citing works

Dysregulation of the mTOR pathway in p53-deficient mice

Leontieva, O. V., Novototskaya, L. R., Paszkiewicz, G., Komarova, E. A., Gudkov, A. V., & Blagosklonny, M. V. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.26947 · Cited by 30 · see citing works

M(o)TOR of aging: MTOR as a universal molecular hypothalamus

Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100580 · Cited by 28 · see citing works

Centenarians as models of healthy aging: Example of REST

Marcos-Pérez, D., Saenz‐Antoñanzas, A., & Matheu, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101392 · Cited by 26 · see citing works

Growth Hormone, Not IGF-1 Is the Key Longevity Regulator in Mammals

Brown‐Borg, H. M. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac092 · Cited by 23 · see citing works

Vitamin D in physiological and pathological aging: Lesson from centenarians

Ferri, E., Casati, M., Cesari, M., Vitale, G., & Arosio, B. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09522-y · Cited by 23 · see citing works

Metabolic syndrome-breast cancer link varies by intrinsic molecular subtype

Capasso, I., Esposito, E., Laurentiis, M. D., Maurea, N., Cavalcanti, E., Botti, G., Petrillo, A., Montella, M., D’Aiuto, M., Coppola, C., et al. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-105 · Cited by 22 · see citing works

Decreased muscle mass is not an independent risk factor for metabolic syndrome in Korean population aged 70 or older

Koo, H. S., Kim, M. J., Kim, K., & Kim, Y. (2014) · Clinical Endocrinology · doi:10.1111/cen.12509 · Cited by 22 · see citing works

Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: A five-year prospective study

Schutte, A. E., Conti, E., Mels, C. M. C., Smith, W. T., Kruger, R., Roux, S. B., Gnessi, L., Volpe, M., & Huisman, H. W. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316661436 · Cited by 21 · see citing works

Insulin Analogs and Cancer: A Note of Caution

Janssen, J. A. M. J. L., & Varewijck, A. J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00079 · Cited by 19 · see citing works

IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

Azpurua, J., Yang, J.-N., Meter, M. V., Liu, Z., Kim, J. J., Ladd, A. A. B. L., Ribeiro, A. A. C. M., Gorbunova, V. A., & Seluanov, A. (2013) · Aging · doi:10.18632/aging.100552 · Cited by 19 · see citing works

Rates of erythropoiesis in mammals and their relationship with lifespan and hematopoietic stem cells aging

Udroiu, I., & Sgura, A. (2019) · Biogerontology · doi:10.1007/s10522-019-09804-7 · Cited by 18 · see citing works

The Impact of Westernization on the Insulin/IGF-I Signaling Pathway and the Metabolic Syndrome: It Is Time for Change

Janssen, J. A. M. J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054551 · Cited by 16 · see citing works

A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

Pirazzini, C., Azevedo, T., Baldelli, L., Bartoletti‐Stella, A., Buonaura, G. C., Molin, A. D., Dimitri, G. M., Doykov, I., Gómez‐Garre, P., Hägg, S., et al. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111426 · Cited by 15 · see citing works

Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling.

Hamoudane, M., Maffioli, S., Cordera, R., Maggi, D. C., & Salani, B. (2013) · PubMed · doi:10.3275/8848 · Cited by 14 · see citing works

Sleep and Insulin-Like Growth Factors in the Cardiovascular Health Study

Shah, N. A., Rice, T., Tracy, D., Rohan, T. E., Bůžková, P., Newman, A. B., & Kaplan, R. C. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3260 · Cited by 13 · see citing works

Changes in Insulin‐Like Growth Factor‐I and Its Binding Proteins Are Associated with Diabetes Mellitus in Older Adults

Aneke-Nash, C. S., Parrinello, C. M., Rajpathak, S. N., Rohan, T. E., Strotmeyer, E. S., Kritchevsky, S. B., Psaty, B. M., Bůžková, P., Kizer, J. R., Newman, A. B., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13390 · Cited by 13 · see citing works

Non-Genomic Hallmarks of Aging—The Review

Holmannová, D., Borský, P., Kovaříková, H., Štveráková, T., Vošmik, M., Hruška, L., Fiala, Z., & Borská, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015468 · Cited by 12 · see citing works

Major depressive disorder and accelerated aging from a peripheral IGF-1 overexpression perspective

Levada, O. A., & Troyan, A. S. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109610 · Cited by 12 · see citing works

Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring

He, Y., Chen, X., Yan, D., Xiao, F., Lin, R., Liao, X.-P., Liu, Y.-W., Pu, S.-Y., Yu, Q., Sun, H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.026 · Cited by 12 · see citing works

Considering GH replacement for GH-deficient adults with a previous history of cancer: a conundrum for the clinician

Yuen, K. C. J., Heaney, A. P., & POPOVIC, V. M. (2016) · Endocrine · doi:10.1007/s12020-015-0840-2 · Cited by 11 · see citing works

Mitochondria Inspire a Lifestyle

Krämer, P., & Bressan, P. (2019) · Advances in anatomy, embryology and cell biology · doi:10.1007/102_2018_5 · Cited by 10 · see citing works

The insulin-like growth factor-I receptor stimulating activity (IRSA) in health and disease

Janssen, J. A. M. J. L., Varewijck, A. J., & Brugts, M. P. (2019) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2019.08.001 · Cited by 10 · see citing works

Endocrinological aspects of sarcopenic obesity

Minnetti, M., Poggiogalle, E., Frigerio, F., Piciocchi, C., Pierantozzi, G., Vincenzo, O. D., Pinto, A., Gianfrilli, D., Isidori, A. M., Migliaccio, S., et al. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2626085 · Cited by 11 · see citing works

Tracking of Nascent Matrix Deposition during Muscle Stem Cell Activation across Lifespan Using Engineered Hydrogels

Duran, P., Yang, B. A., Plaster, E. M., Eiken, M. K., Loebel, C., & Aguilar, C. A. (2024) · Advanced Biology · doi:10.1002/adbi.202400091 · Cited by 8 · see citing works

Nutrient-Response Pathways in Healthspan and Lifespan Regulation

Dabrowska, A. F., Kumar, J., & Rallis, C. (2022) · Cells · doi:10.3390/cells11091568 · Cited by 8 · see citing works

Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis

Rajakumar, G., Cagigas, M. L., Wang, T., Pan, A. Y., Pelaia, T., Fuller, S. J., & Fontana, L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102531 · Cited by 7 · see citing works

Histopathological aspects of liver under variable food restriction: Has the intense one-week food restriction a protective effect on non-alcoholic-fatty-liver-disease (NAFLD) development?

Makovicky, P., Tumova, E., Volek, Z., Makovický, P., Vodičková, Ľ., Slyšková, J., Svoboda, M., Rejhova, A., Vodička, P., Samaşcă, G., et al. (2014) · Pathology - Research and Practice · doi:10.1016/j.prp.2014.08.007 · Cited by 6 · see citing works

Metabolic and hormonal contributors to survival in the participants of the M ataró A geing S tudy at 8 years follow‐up

Mora, M., Serra‐Prat, M., Palomera, E., & Puig‐Domingo, M. (2014) · Clinical Endocrinology · doi:10.1111/cen.12467 · Cited by 6 · see citing works

Cell-based assays for IGF-I bioactivity measurement: overview, limitations and current trends

Ramadhin, C., Pillay, B., & Olaniran, A. O. (2014) · Growth Factors · doi:10.3109/08977194.2014.939806 · Cited by 5 · see citing works

Centenarian Offspring as a Model of Successful Ageing

Aiello, A., Ligotti, M. E., & Cossarizza, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_3 · Cited by 7 · see citing works

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

Hjortebjerg, R., Pedersen, D. A., Mengel‐From, J., Jørgensen, L. H., Christensen, K., & Frystyk, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1193742 · Cited by 3 · see citing works

The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevityPreprint

Wang, X., Jung, H. J., Milholland, B., Cui, J., Tazearslan, C., Atzmon, G., Wang, X., Yang, J., Guo, Q., Barzilai, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.541542 · Cited by 4 · see citing works

Associations of IGF-1 and IGFBP-3 with Aging and the Development of Age-Associated Diseases

Константиновна, И. А., Matchekhina, L. V., Melnitskaia, A. A., & Strazhesko, I. D. (2024) · Advances in Gerontology · doi:10.1134/s2079057025600041 · Cited by 2 · see citing works

Hormonal Regulation and Systemic Signals of Skin Aging

Charville, G. W., & Chang, A. L. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-18380-0_4 · Cited by 1 · see citing works

Anti-Aging Drugs

Vaiserman, A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12295-4 · Cited by 1 · see citing works

Mitochondria Inspire a LifestylePreprint

Krämer, P., & Bressan, P. (2018) · doi:10.31234/osf.io/t49eg · Cited by 2 · see citing works

Inflammatory Markers in Frail Elderly Egyptian Adults and the Difference between the Sexes

Amer, M. S., Farid, T. M., Wahba, H. M. F., Saber, H. G., & Abdelwahab, R. R. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12896

Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review

Romain, G. (2014) · World Journal of Neurology · doi:10.5316/wjn.v4.i3.12

Estudio de envejecimiento de Mataró: Factores hormonales y genéticos que influyen en el envejecimiento

Mora, M. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

Growth Hormones and Aging

Lee, C. D., & Longo, V. D. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_27-1

Centenarians (Blue Zones?)

Bolzetta, F., & Cester, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62177-3

Growth Hormone and Mammalian Aging

van Heemst, D., van der Spoel, E., & Bartke, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11451-5

Growth Hormones and Aging

Lee, C. D., & Longo, V. D. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_27

The heterogeneous approach to reach longevity: the experience of Italian centenarians

Arosio, B., Ferri, E., Mari, D., & Vitale, G. (2024) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-n604

Lessons from Exceptionally Long-Lived Individuals and Long-Living Families

Smulders, L., & Deelen, J. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009007245.017

Associations of IGF-1 and IGFBP-3 with aging and the development of age-associated diseases

Константиновна, И. А., Matchekhina, L. V., Melnitskaia, A. A., & Strazhesko, I. D. (2024) · Problems of Geroscience · doi:10.37586/2949-4745-3-2024-131-140

Fasting-dietary therapy and intermittent fasting as a unifi ed treatment and preventive strategy for age-associated human diseases

Есипов, А. В., Gulyaev, N. I., Петрович, П. А., Александрович, П. А., Мироненко, Д. А., Khudziev, B. G., Kutenkova, I. V., & Krivolap, L. E. (2025) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2025-103-3-169-180

Short‐Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing

Andrews, C. J., Ribeiro, R. V., Gosby, A. K., Couteur, D. G. L., Raubenheimer, D., Tan, J., Simpson, S. J., & Senior, A. M. (2026) · Aging Cell · doi:10.1111/acel.70507

Endocrinological Aspects of Sarcopenia

Minnetti, M., Poggiogalle, E., Vincenzo, O. D., Migliaccio, S., & Donini, L. M. (2026) · Endocrinology · doi:10.1007/978-3-030-71067-5_22-1

Scoping review unravelling longevity secrets beyond the century mark

Ibrahim, S., Kheir‐Mataria, W. A. E., Abdelrahim, O., & Chun, S. (2026) · Discover Public Health · doi:10.1186/s12982-026-02363-6

Human insulin/IGF-1 and familial longevity at middle age

Rozing, M. P., Westendorp, R. G. J., Frölich, M., de Craen, A. J. M., Beekman, M., Heijmans, B. T., Mooijaart, S. P., Blauw, G. J., Slagboom, P. E., van Heemst, D., et al. (2009) · Aging · doi:10.18632/aging.100071 · Cited by 71 · see citing works

Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians' offspring

Vitale, G., Brugts, M. P., Ogliari, G., Castaldi, D., Fatti, L. M., Hofland, L. J., Monti, D., Cavagnini, F., Franceschi, C., Mari, D., et al. (2010)

GH/IGF-I/insulin system in centenarians

Vitale, G., Barbieri, M., Kamenetskaya, M., & Paolisso, G. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.001 · Cited by 35 · see citing works

The metabolic syndrome, IGF-1, and insulin action

Arai, Y., Kojima, T., Takayama, M., & Hirose, N. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.002 · Cited by 34 · see citing works

Serum insulin-like growth factor I (IGF-I) : functional ability and cognitive status in centenarians and centenarians offspring

Vitale, G., Ogliari, G., Castaldi, D., Fatti, L. M., Micale, G., Cavagnini, F., Franceschi, C., & Mari, D. (2008)