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Cited by 162Genetics, Aging, and Longevity in Model OrganismsCytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

Open access
Gerli, Roberto, Monti, Daniela, Bistoni, Onelia, M. Mazzone, Anna, Peri, Giuseppe, Cossarizza, Andrea, Di Gioacchino, Mario, E. F. Cesarotti, Monica, Doni, Andrea, Mantovani, Alberto, Franceschi, Claudio, Paganelli, Roberto·2001·Mechanisms of Ageing and Development
DOI 10.1016/s0047-6374(00)00195-0
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Abstract

Several lines of evidence point to a profound remodelling of the cytokine network in healthy elderly subjects, with decreased type-1 cytokine production (IL 2) and a shift to type 0 and 2. We have also observed an increase of proinflammatory cytokines (IL-1, IL-6, TNF-alpha) in vitro, and an increase of circulating stem cell factor in vivo. In this setting, we studied changes of chemokines (MCP-1 and RANTES) with aging, as well as other molecules, namely, sTNF-RI and sTNF-RII, and the soluble form of the CD30 molecule (sCD30), involved in the pro- and antiinflammatory cytokine balance. The subjects enrolled in the study belonged to three different selected healthy groups of young, aged and centenarians. The presence of rheumatoid factor (RF) and antinuclear antibodies (ANA) was simultaneously assessed. The results show that MCP-1 serum levels were higher in the healthy aged and lowest in the young, while RANTES increased exclusively in centenarians. Only centenarians had autoantibodies (ANA and RF). sTNF-RI and sTNF-RII were significantly elevated in healthy old subjects compared to the young, and even higher in selected centenarians compared to the other age groups. sCD30 serum levels were significantly raised in centenarians compared to the young, despite absence of circulating CD30+ cells in the peripheral blood of the whole study population. No relationship among serum values of these different members of the TNF-R family was found, despite a strong correlation for sTNF-RI and sTNF-RII in all groups. We hypothesize that the increased chemokine levels in aged people, and raised sCD30 levels in centenarians, may reflect a general shift towards type 0/2 cytokines in normal aging, which may be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age.

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Crossref · 10.1016/s0047-6374(00)00195-0

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Research works printed but not linked: 1

  1. Gerli, 1999, Solubile CD30 in primary Sjogren's sindrome, Clin. Exp. Rheumatol., 17, 389

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Metadata

Authors
Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., Franceschi, C., & Paganelli, R.
Affiliations
  • University of Perugia (IT)
  • University of Florence (IT)
  • Mario Negri Institute for Pharmacological Research (IT)
  • University of Modena and Reggio Emilia (IT)
  • Istituto Nazionale di Riposo e Cura per Anziani (IT)
  • University of Chieti-Pescara (IT)
Corresponding author
Paganelli, Roberto
ORCID
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2001-01
Volume
121
Issue
1-3
Pages
37-46
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/s0047-6374(00)00195-0
OpenAlex
W2030493262
Cited by
162
References
27
Citations by year
2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 7
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
chemokines, soluble TNF receptors, soluble CD30, centenarians, healthy aging, MCP-1, RANTES, autoantibodies, rheumatoid factor, antinuclear antibodies, inflammatory cytokines
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Antibodies, Antinuclear, Humans, Reference Values, Rheumatoid Factor, Solubility, Ki-1 Antigen, Receptors, Tumor Necrosis Factor, Chemokines, Chemokine CCL2, Chemokine CCL5

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