Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

Gouspillou, Gilles; Hepple, Russell T.

doi:10.1016/j.exger.2013.03.004

Cited by 42Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologySirtuins and Resveratrol in Medicine

Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

Gouspillou, Gilles, Hepple, Russell T.·2013·Experimental Gerontology

DOI 10.1016/j.exger.2013.03.004

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Abstract

Caloric restriction (CR) has pronounced benefits in promoting healthy aging. Amongst the most frequently implicated physiological mechanisms implicated in this benefit is altered mitochondrial function. Whereas a reduction in mitochondrial reactive oxygen species (ROS) production is a widely consistent effect of CR, an increase in mitochondrial biogenesis, which is accepted by many as fact, is contradicted on several levels, most critically by a lack of increase in mitochondrial protein synthesis rate in vivo. Furthermore, an increase in PGC-1α protein and markers of mitochondrial content with CR is a highly variable observation between studies. On the other hand, deacetylation of several mitochondrial proteins by the sirtuin, Sirt3, is an increasingly reported observation and at least so far, this observation is consistent between studies. Notwithstanding this point, the controversies evident in the published literature underscore the significant questions that remain in our understanding of how CR impacts the mitochondrion and suggest we have yet to fully understand the complexities herein.

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Calorie restriction and endurance training improve mitochondrial function.
“In addition, the two most efficient non‐pharmacological strategies to attenuate the effects of ageing on skeletal muscle, calorie‐restriction (Mayhew et al. 1998; Baker et al. 2006; Hepple et al. 2006) and endurance training (Coggan et al. 1992; Song et al. 2006), are known to improve mitochondrial function (Gouspillou & Hepple, 2013).”
From Parkin overexpression protects from ageing‐related loss of muscle mass and strength (2019) · cites this paper as Gouspillou & Hepple, 2013
Exercise training and calorie restriction improve mitochondrial health.
“both well-known to improve mitochondrial health [28].”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [28]
Calorie restriction improves mitochondrial health.
“and to improve mitochondrial health [28]”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [28]

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Authors: Gouspillou, G., & Hepple, R. T.
Affiliations: McGill University Health Centre (CA)
Corresponding author: Hepple, Russell T.
ORCID: Gouspillou, Gilles
Hepple, Russell T.
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2013-10
Volume: 48
Issue: 10
Pages: 1075-1084
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2013.03.004
OpenAlex: W2078444226
Cited by: 42
References: 118
Citations by year: 2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 2
FWCI: 0.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (MOP57808, MOP119583)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: caloric restriction, mitochondrial function, healthy aging, mitochondrial biogenesis, mitochondrial reactive oxygen species, PGC-1α, SIRT3, mitochondrial translation, mitochondrial content
MeSH terms: Aging, Animals, Cardiolipins, DNA, Mitochondrial, Humans, Mitochondria, Reactive Oxygen Species, Caloric Restriction, Sirtuins, Rats, Mitochondrial Turnover

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Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

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