Resistance and aerobic training in older men: effects onV˙ o 2 peak and the capillary supply to skeletal muscle

Hepple, R. T.; Mackinnon, S. L. M.; Goodman, J. M.; Thomas, S. G.; Plyley, M. J.

doi:10.1152/jappl.1997.82.4.1305

Cited by 203Cardiovascular and exercise physiologySports Performance and TrainingMuscle metabolism and nutrition

Resistance and aerobic training in older men: effects onV˙ o 2 peak and the capillary supply to skeletal muscle

Hepple, R. T., Mackinnon, S. L. M., Goodman, J. M., Thomas, S. G., Plyley, M. J.·1997·Journal of Applied Physiology

DOI 10.1152/jappl.1997.82.4.1305

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Abstract

Hepple, R. T., S. L. M. Mackinnon, J. M. Goodman, S. G. Thomas, and M. J. Plyley. Resistance and aerobic training in older men: effects onV˙o 2 peak and the capillary supply to skeletal muscle. J. Appl. Physiol. 82(4): 1305–1310, 1997.—Both aerobic training (AT) and resistance training (RT) may increase aerobic power (V˙o 2 peak ) in the older population; however, the role of changes in the capillary supply in this response has not been evaluated. Twenty healthy men (age 65–74 yr) engaged in either 9 wk of lower body RT followed by 9 wk of AT on a cycle ergometer (RT→AT group) or 18 wk of AT on a cycle ergometer (AT→AT group). RT was performed three times per week and consisted of three sets of four exercises at 6–12 repetitions maximum. AT was performed three times per week for 30 min at 60–70% heart rate reserve.V˙o 2 peak was increased after both RT and AT ( P < 0.05). Biopsies (vastus lateralis) revealed that the number of capillaries per fiber perimeter length was increased after both AT and RT ( P < 0.05), paralleling the changes in V˙o 2 peak , whereas capillary density was increased only after AT ( P < 0.01). These results, and the finding of a significant correlation between the change in capillary supply and V˙o 2 peak ( r = 0.52), suggest the possibility that similar mechanisms may be involved in the increase ofV˙o 2 peak after high-intensity RT and AT in the older population.

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PRT is more effective than aerobic training for increasing muscle size and muscle fiber cross-sectional area in older adults.
“studies in older adults have shown that PRT is more effective for increasing muscle size and muscle fiber cross-sectional area [[364], [365], [366]].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [365]

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Quantitating the capillary supply and the response to resistance training in older men
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Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men
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Authors: Hepple, R. T., Mackinnon, S. L. M., Goodman, J. M., Thomas, S. G., & Plyley, M. J.
Affiliations: University of Toronto (CA)
ORCID: Hepple, R. T.
Goodman, J. M.
Thomas, S. G.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1997-04-01
Volume: 82
Issue: 4
Pages: 1305-1310
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1997.82.4.1305
OpenAlex: W2097443151
Cited by: 203
References: 32
Citations by year: 2026: 3 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 7
FWCI: 4.44
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: resistance training, aerobic exercise, older men, peak oxygen uptake, capillary supply, capillary density, vastus lateralis, skeletal muscle capillarization, exercise training response, aging
MeSH terms: Aged, Capillaries, Exercise Test, Humans, Male, Oxygen Consumption, Physical Fitness, Regional Blood Flow, Weight Lifting, Anaerobic Threshold, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal

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Resistance and aerobic training in older men: effects onV˙ o 2 peak and the capillary supply to skeletal muscle

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