Kobilka, Brian K.

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 3,009

The structure and function of G-protein-coupled receptors

Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 2,534

The Molecular Basis of G Protein–Coupled Receptor Activation

Weis, W. I., & Kobilka, B. K. (2018) · Annual Review of Biochemistry

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 1,227

Structure and dynamics of GPCR signaling complexes

Hilger, D., Masureel, M., & Kobilka, B. K. (2018) · Nature Structural & Molecular Biology

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 969

Muscarinic acetylcholine receptors: novel opportunities for drug development

Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 437

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Huang, W., Masureel, M., Qu, Q., Janetzko, J., Inoue, A., Kato, H. E., Robertson, M. J., Nguyen, K. C., Glenn, J. S., Skiniotis, G., et al. (2020) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 373

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., et al. (2016) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 330

Nanobody stabilization of G protein-coupled receptor conformational states

Steyaert, J., & Kobilka, B. K. (2011) · Current Opinion in Structural Biology

Receptor Mechanisms and SignalingEnzyme Structure and Function

Cited by 234

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

Kawai, T., Sun, B., Yoshino, H., Feng, D., Suzuki, Y., Fukazawa, M., Nagao, S., Wainscott, D. B., Showalter, A. D., Droz, B. A., et al. (2020) · Proceedings of the National Academy of Sciences

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 231

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Masureel, M., Zou, Y., Picard, L.-P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., et al. (2018) · Nature Chemical Biology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 194

Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

Franowicz, J. S., Kessler, L. E., Borja, C. M. D., Kobilka, B. K., Limbird, L. E., & Arnsten, A. F. T. (2002) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 185

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5

Komolov, K. E., Du, Y., Duc, N. M., Betz, R. M., Rodrigues, J. P. G. L. M., Leib, R. D., Patra, D., Skiniotis, G., Adams, C. M., Dror, R. O., et al. (2017) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 152

Skeletal muscle hypertrophy and anti‐atrophy effects of clenbuterol are mediated by the β2‐adrenergic receptor

Hinkle, R. T., Hodge, K. M. B., Cody, D. B., Sheldon, R. J., Kobilka, B. K., & Isfort, R. J. (2002) · Muscle & Nerve

Muscle Physiology and DisordersPharmacological Effects and Assays

Cited by 152

Goniometer-based femtosecond crystallography with X-ray free electron lasers

Cohen, A. E., Soltis, S. M., González, A., Aguila, L., Alonso-Mori, R., Barnes, C. O., Baxter, E. L., Brehmer, W., Brewster, A. S., Brunger, A. T., et al. (2014) · Proceedings of the National Academy of Sciences

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 144

Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor

Batebi, H., Pérez-Hernández, G., Rahman, S. N., Lan, B., Kamprad, A., Shi, M., Speck, D., Tiemann, J. K. S., Guixà-González, R., Reinhardt, F., et al. (2024) · Nature Structural & Molecular Biology

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 38