The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

Surmeier, D.J.; Guzman, J.N.; Sanchez-Padilla, J.; Schumacker, P.T.

doi:10.1016/j.neuroscience.2011.08.045

Cited by 236Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingMitochondrial Function and Pathology

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

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Surmeier, D.J., Guzman, J.N., Sanchez-Padilla, J., Schumacker, P.T.·2011·Neuroscience

DOI 10.1016/j.neuroscience.2011.08.045PMC PMC3244353

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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease in developed countries. The core motor symptoms are attributable to the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Why these neurons succumb in PD is not clear. One potential clue has come from the observation that the engagement of L-type Ca²⁺ channels during autonomous pacemaking elevates the sensitivity of SNc DA neurons to mitochondrial toxins used to create animal models of PD, suggesting that Ca²⁺ entry is a factor in their selective vulnerability. Recent work has shown that this Ca²⁺ entry also elevates mitochondrial oxidant stress and that this stress is exacerbated by deletion of DJ-1, a gene associated with an early onset, recessive form of PD. Epidemiological data also support a linkage between L-type Ca²⁺ channels and the risk of developing PD. This review examines the hypothesis that the primary factor driving neurodegenerative changes in PD is the metabolic stress created by Ca²⁺ entry, particularly in the face of genetic or environmental factors that compromise oxidative defenses or proteostatic competence.

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Intracellular regulation of Ca2+ is maintained by ATP-dependent pumps, which trigger mitochondrial activity and accompanying enhanced ROS formation.
“Intracellular regulation of Ca2+ is maintained by the action of ATP-dependent pumps, which trigger mitochondrial activity and accompanying enhanced ROS formation (Surmeier et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Surmeier et al. 2011

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Authors: Surmeier, D. J., Guzman, J. N., Sanchez-Padilla, J., & Schumacker, P. T.
Affiliations: Northwestern University (US)
ORCID: Surmeier, D.J.
Schumacker, P.T.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2011-12
Volume: 198
Pages: 221-231
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2011.08.045
PMC: PMC3244353
OpenAlex: W2034939939
Cited by: 236
References: 122
Citations by year: 2026: 13 · 2025: 13 · 2024: 8 · 2023: 21 · 2022: 12 · 2021: 6 · 2020: 17 · 2019: 11 · 2018: 13 · 2017: 18 · 2016: 19 · 2015: 22 · 2014: 16 · 2013: 27 · 2012: 16
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL035440, HL35440)
National Institute of Neurological Disorders and Stroke (NS047085, P30NS054850, P50NS047085)
National Center for Research Resources (R21RR025355, RR025355)
Medical Research and Materiel Command
Topics: Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: Parkinson's disease, substantia nigra pars compacta, dopaminergic neurons, neuronal loss, L-type calcium channels, calcium influx, DJ-1, mitochondrial toxins, oxidative stress, proteostasis, neurodegeneration
MeSH terms: Animals, Calcium, Humans, Levodopa, Mitochondria, Parkinson Disease, Substantia Nigra, Dopamine Agents, Oxidative Stress, Calcium Channels, L-Type, Dopaminergic Neurons

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The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

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