Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging
Open accessAbstract
We tested the hypothesis that short-term nitrite therapy reverses vascular endothelial dysfunction and large elastic artery stiffening with aging, and reduces arterial oxidative stress and inflammation. Nitrite concentrations were lower (P < 0.05) in arteries, heart, and plasma of old (26-28 month) male C57BL6 control mice, and 3 weeks of sodium nitrite (50 mg L(-1) in drinking water) restored nitrite levels to or above young (4-6 month) controls. Isolated carotid arteries of old control mice had lower acetylcholine (ACh)-induced endothelium-dependent dilation (EDD) (71.7 ± 6.1% vs. 93.0 ± 2.0%) mediated by reduced nitric oxide (NO) bioavailability (P < 0.05 vs. young), and sodium nitrite restored EDD (95.5 ± 1.6%) by increasing NO bioavailability. 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL), a superoxide dismutase (SOD) mimetic, apocynin, a nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) inhibitor, and sepiapterin (exogenous tetrahydrobiopterin) each restored EDD to ACh in old control, but had no effect in old nitrite-supplemented mice. Old control mice had increased aortic pulse wave velocity (478 ± 16 vs. 332 ± 12 AU, P < 0.05 vs. young), which nitrite supplementation lowered (384 ± 27 AU). Nitrotyrosine, superoxide production, and expression of NADPH oxidase were ∼100-300% greater and SOD activity was ∼50% lower in old control mice (all P < 0.05 vs. young), but were ameliorated by sodium nitrite treatment. Inflammatory cytokines were markedly increased in old control mice (P < 0.05), but reduced to levels of young controls with nitrite supplementation. Short-term nitrite therapy reverses age-associated vascular endothelial dysfunction, large elastic artery stiffness, oxidative stress, and inflammation. Sodium nitrite may be a novel therapy for treating arterial aging in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pre-clinical studies with nitrate or nitrite show the potential to protect against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness.
“Pre-clinical studies with nitrate or nitrite also show the potential to protect against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [150]
The Introduction reports that sodium nitrite protects against ischaemia-reperfusion injury, and the Discussion reports reduced large-artery stiffness and inflammatory markers in old mice. Our copy does not report a reduction in intimal thickness; that part of the claim is unsupported. (LLM, conf=0.87)
Experimental — accuracy not yet measuredSindler et al. found that nitrite reduced the elevated pulse wave velocity and levels of inflammatory cytokines IL-1b, IL6, INFg and TNFa.
“Thus, Sindler et al. found that nitrite reduced the elevated pulse wave velocity and levels of inflammatory cytokines IL-1b, IL6, INFg and TNFa [150].”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [150]
Sindler et al. found decreased plasma nitrite concentrations in old male C57BL6 control mice, depleted in arteries and heart, which were restored to youthful levels by 3 weeks' supplementation with sodium nitrite (50 mg l-1 in the drinking water).
“Sindler et al. also detected depleted concentrations in the arteries and heart, which were restored to youthful levels (4-6 month controls) by 3 weeks' supplementation with sodium nitrite (50 mg l -1 in the drinking water) [150].”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [150]
While the efficacy of dietary nitrate to reduce systemic blood pressure in older age has been extensively studied, relatively few studies have assessed the effects of nitrate supplementation on exercise capacity in healthy older individuals.
“While the efficacy of dietary NO 3 -to reduce systemic blood pressure in older age has been extensively studied (reviewed in 140; see also 139, 142), relatively few studies have assessed the effects of NO 3 -supplementation on exercise capacity in healthy older individuals.”
From Dietary Nitrate and Physical Performance (2018) · cites this paper as [142]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredOral supplementation with either nitrite or nitrate increases circulating nitrite levels and prevents and reverses endothelial dysfunction in a dose-dependent manner in mice and in healthy, hypertensive, and obese individuals, or in those with hypercholesterolemia and peripheral arterial disease.
“Oral supplementation with either nitrite or nitrate increases circulating nitrite levels and prevents and reverses endothelial dysfunction in a dose-dependent manner both in mice[68,69] and in healthy[70,71,97,111,112], hypertensive[113], and obese individuals[114], or in those with hypercholesterolemia[115] and peripheral arterial disease[116].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [69]
In old mice, short-term oral sodium nitrite supplementation ameliorates endothelial dysfunction, as indicated by normalization of nitric oxide-mediated endothelium-dependent dilation.
“ameliorates endothelial dysfunction, as indicated by normalization of NO-mediated endothelium-dependent dilation.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
In old mice, short-term oral sodium nitrite supplementation reduces aortic pulse wave velocity.
“In old mice, short-term oral sodium nitrite supplementation reduces aortic pulse wave velocity, the gold-standard measure of large elastic artery stiffness”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Improvements in age-related vascular dysfunction with nitrite are mediated by reductions in oxidative stress and inflammation.
“These improvements in age-related vascular dysfunction with nitrite are mediated by reductions in oxidative stress and inflammation”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Vascular endothelial function as assessed by carotid artery endothelium-dependent dilation in response to acetylcholine was impaired in old compared with young control animals.
“vascular endothelial function as assessed by carotid artery EDD in response to acetylcholine, was impaired in old compared with young control animals (Fig. 4, top).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sodium nitrite treatment restored endothelium-dependent dilation in old mice by increasing nitric oxide-dependent dilation.
“Sodium nitrite treatment restored EDD in old mice by increasing NO-dependent dilation (Fig. 4, bottom).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Staining intensity for nitrotyrosine, a cellular marker of oxidant modification of proteins, was markedly greater in aorta of old compared with young control mice.
“the staining intensity for nitrotyrosine, a cellular marker of oxidant modification of proteins, was markedly greater in aorta of old compared with young control mice (53, 171) (Fig. 5A).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Nitrite concentrations in plasma and large elastic arteries were lower in older animals, but sodium nitrite supplementation increased nitrite concentrations in old mice up to or above those of young control animals.
“Nitrite concentrations in the plasma and large elastic arteries (aorta and carotid arteries) were lower in older animals, but sodium nitrite supplementation increased nitrite concentrations in the old mice up to or above those of young control animals (Fig. 2) (171).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sodium nitrite had no effect on arterial function in young mice in this study.
“sodium nitrite had no effect on arterial function in the young mice in this study (171)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Aortic pulse wave velocity was markedly higher in old compared with young control mice.
“aortic PWV was markedly higher (i.e., the aorta was stiffer) in old compared with young control mice (Fig. 3A).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sodium nitrite treatment normalized aortic nitrotyrosine staining in old mice, indicating amelioration of age-associated arterial oxidative stress.
“Sodium nitrite treatment normalized aortic nitrotyrosine staining in old mice, indicating amelioration of age-associated arterial oxidative stress.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sodium nitrite treatment reduced aortic pulse wave velocity in old mice to well below old controls and not significantly different from that in young animals.
“Sodium nitrite treatment reduced aortic PWV in old mice to well below old controls and not significantly different from that in young animals.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Superoxide production is much greater in aorta from old mice than from young control mice.
“Superoxide production was much greater in aorta from old compared with young control mice”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Inhibition of nitric oxide using l-NAME markedly reduced endothelium-dependent dilation in young animals while having less effect in old mice, indicating that impaired endothelium-dependent dilation in old animals was mediated by reduced nitric oxide bioavailability.
“Inhibition of NO using the NO synthase inhibitor l-NAME, markedly reduced EDD in young animals while having less effect in old mice, indicating that the impaired EDD in old animals was mediated by reduced NO bioavailability.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Nitrite did not affect endothelium-independent dilation to sodium nitroprusside, indicating that improvements in endothelium-dependent dilation were not induced by increased vascular smooth muscle sensitivity to nitric oxide.
“Nitrite did not affect endothelium-independent dilation to sodium nitroprusside (171), indicating that the improvements in EDD were not induced by increased vascular smooth muscle sensitivity to NO.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Expression of proinflammatory cytokines IL-1β, IL-6, interferon-γ, and TNF-α is greater in aorta of old mice than young control mice.
“expression of the proinflammatory cytokines interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α (TNF-α) were shown to be greater in aorta of old mice than young control mice (171)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sepiapterin has no effect on EDD in old mice treated with sodium nitrite.
“although it had no effect on EDD in old mice treated with sodium nitrite (171)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
SOD activity is approximately 50% lower in aorta of old compared with young control mice.
“The activity of the major antioxidant enzyme SOD was found to be ∼50% lower in aorta of old compared with young control mice”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Protein expression of NADPH oxidase is threefold greater in aorta of old mice compared with young control mice.
“Protein expression of NADPH oxidase was threefold greater in aorta of old mice compared with those of young control mice”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Inhibition of NADPH oxidase with apocynin has no effect on EDD in arteries of old animals treated with sodium nitrite.
“Inhibition of NADPH oxidase with apocynin had no effect on EDD in arteries of old animals treated with sodium nitrite”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Short-term treatment with sodium nitrite completely normalizes superoxide formation in old animals.
“short-term treatment with sodium nitrite completely normalized superoxide formation in old animals (53, 171)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Sepiapterin restores acetylcholine-induced EDD selectively in carotid arteries of old control mice.
“Sepiapterin restored acetylcholine-induced EDD selectively in carotid arteries of old control mice”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
TEMPOL has no effect on EDD in old mice treated with sodium nitrite.
“TEMPOL had no effect on EDD in old mice treated with sodium nitrite”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Inhibition of NADPH oxidase with apocynin restores EDD in old control mice.
“but restored EDD in old control mice (171)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Short-term treatment with sodium nitrite restores SOD activity in aorta of old mice to levels observed in young controls.
“short-term treatment with sodium nitrite restored SOD activity in aorta of old mice to levels observed in young controls”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
TEMPOL completely restores EDD in old control animals.
“but completely restored EDD in old control animals”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
NADPH oxidase protein expression is normalized after sodium nitrite treatment in old mice.
“but this was normalized after sodium nitrite treatment”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Nitrite supplementation completely reverses age-associated arterial inflammation in old mice.
“Most importantly, nitrite supplementation completely reversed this age-associated arterial inflammation (171).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [171]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness
Vlachopoulos, C., Aznaouridis, K., & Stefanadis, C. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.061 · Cited by 4,165 · see citing works
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study
Mitchell, G. F., Hwang, S.-J., Vasan, R. S., Larson, M. G., Pencina, M. J., Hamburg, N. M., Vita, J. A., Levy, D., & Benjamin, E. J. (2010) · Circulation · doi:10.1161/circulationaha.109.886655 · Cited by 2,225 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Nitric oxide, oxidants, and protein tyrosine nitration
Radí, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307446101 · Cited by 1,456 · see citing works
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Sutton-Tyrrell, K., Najjar, S. S., Boudreau, R. M., Venkitachalam, L., Kupelian, V. A., Simonsick, E. M., Havlik, R. J., Lakatta, E. G., Spurgeon, H. A., Kritchevsky, S. B., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.483628 · Cited by 1,250 · see citing works
Vita, J. A., & Keaney, J. F. (2002) · Circulation · doi:10.1161/01.cir.0000028581.07992.56 · Cited by 743 · see citing works
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Self-citationAging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension
Taddei, S., Virdis, A., Mattei, P., Ghiadoni, L., Gennari, A., Fasolo, C. B., Sudano, I., & Salvetti, A. (1995) · Circulation · doi:10.1161/01.cir.91.7.1981 · Cited by 710 · see citing works
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
BRANDES, R., FLEMING, I., & BUSSE, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.027 · Cited by 563 · see citing works
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
Donato, A. J., Eskurza, I., Silver, A., Levy, A., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558 · see citing works
Self-citationLüscher, T. F., & Barton, M. (1997) · Clinical Cardiology · doi:10.1002/j.1932-8737.1997.tb00006.x · Cited by 537 · see citing works
Mechanisms of Vascular Aging: New Perspectives
Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works
Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons
Lakatta, E. G. (2002) · Heart Failure Reviews · doi:10.1023/a:1013797722156 · Cited by 445 · see citing works
Inflammation and endothelial dysfunction during aging: role of NF-κB
Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90470.2008 · Cited by 441 · see citing works
Nilsson, P. M., Boutouyrie, P., & Laurent, S. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.129114 · Cited by 381 · see citing works
eNOS uncoupling and endothelial dysfunction in aged vessels
Yang, Y., Huang, A., Kaley, G., & Sun, D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00230.2009 · Cited by 370 · see citing works
Zalba, G., Beaumont, J., José, G. S., Fortuño, A., Fortuño, M. A., Etayo, J. C., & Dı́ez, J. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1055 · Cited by 368 · see citing works
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.
Cosentino, F., Patton, S. R., d’Uscio, L. V., Werner, E. R., Werner‐Felmayer, G., Moreau, P. R., Maliñski, T., & Lüscher, T. F. (1998) · Journal of Clinical Investigation · doi:10.1172/jci650 · Cited by 351 · see citing works
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347 · see citing works
Self-citationNitric Oxide and the Regulation of Large Artery Stiffness
Wilkinson, I. B., Franklin, S. S., & Cockcroft, J. R. (2004) · Hypertension · doi:10.1161/01.hyp.0000138068.03893.40 · Cited by 274 · see citing works
Durrant, J., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 244 · see citing works
Self-citationKim, J. H., Bugaj, L. J., Oh, Y. J., Bivalacqua, T. J., Ryoo, S., Soucy, K. G., Santhanam, L., Webb, A. K., Camara, A., Sikka, G., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91393.2008 · Cited by 244 · see citing works
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
Muller‐Delp, J. M., Spier, S. A., Ramsey, M. W., & Delp, M. D. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2002 · Cited by 238 · see citing works
Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works
Self-citationSpier, S. A., Delp, M. D., Meininger, C. J., Donato, A. J., Ramsey, M. W., & Muller‐Delp, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060301 · Cited by 209 · see citing works
Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works
Gonzalez, F. M., Shiva, S., Vincent, P. S., Ringwood, L. A., Hsu, L.-Y., Hon, Y. Y., Aletras, A. H., Cannon, R. O., Gladwin, M. T., & Arai, A. E. (2008) · Circulation · doi:10.1161/circulationaha.107.748814 · Cited by 175 · see citing works
Lonn, E., Bosch, J., Teo, K. K., Pais, P., Xavier, D., & Yusuf, S. (2010) · Circulation · doi:10.1161/circulationaha.109.873232 · Cited by 174 · see citing works
Dezfulian, C., Shiva, S., Alekseyenko, A., Pendyal, A., Beiser, D. G., Munasinghe, J. P., Anderson, S. A., Chesley, C. F., Vanden Hoek, T. L., & Gladwin, M. T. (2009) · Circulation · doi:10.1161/circulationaha.109.853267 · Cited by 174 · see citing works
Eskurza, I., Myerburgh, L. A., Kahn, Z. D., & Seals, D. R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092734 · Cited by 172 · see citing works
Self-citationNitric oxide synthase inhibition increases aortic stiffness measured by pulse wave velocity in rats
Fitch, R. M. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00299-1 · Cited by 172 · see citing works
Stokes, K. Y., Dugas, T. R., Tang, Y., Garg, H., Guidry, E., & Bryan, N. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2008 · Cited by 171 · see citing works
NAD(P)H Oxidase Inhibition Improves Endothelial Function in Rat and Human Blood Vessels
Hamilton, C., Brosnan, M. J., Al‐Benna, S., Berg, G. A., & Dominiczak, A. F. (2002) · Hypertension · doi:10.1161/01.hyp.0000037063.90643.0b · Cited by 167 · see citing works
Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats
Sun, D., Huang, A., Yan, E. H., Wu, Z., Yan, C., Kaminski, P. M., Oury, T. D., Wolin, M. S., & Kaley, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2003 · Cited by 167 · see citing works
Bryan, N. S., Calvert, J. W., Gundewar, S., & Lefer, D. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.040 · Cited by 161 · cited 5× · see citing works
“Sodium nitrite administration protects against ischemia ⁄ reperfusion injury (Bryan et al., 2007, 2008; Gonzalez et al., 2008) and improves vascular endothelial dysfunction in hypercholesterolemic mice (Stokes et al., 2009).”
BackgroundMethodResultInfluentialSelf-citationDelp, M. D., Behnke, B. J., Spier, S. A., Wu, G., & Muller‐Delp, J. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147686 · Cited by 160 · see citing works
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works
Self-citationEffects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
Sindler, A. L., Delp, M. D., Reyes, R., Wu, G., & Muller‐Delp, J. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172221 · Cited by 156 · see citing works
Self-citationRegulation of Tetrahydrobiopterin Synthesis and Bioavailability in Endothelial Cells
Shi, W., Meininger, C. J., Haynes, T. E., Hatakeyama, K., & Wu, G. (2004) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:41:3:415 · Cited by 137 · see citing works
Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
Elrod, J. W., Calvert, J. W., Gundewar, S., Bryan, N. S., & Lefer, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800700105 · Cited by 137 · see citing works
Self-citationSoucy, K. G., Ryoo, S., Benjo, A., Lim, H. K., Gupta, G., Sohi, J. S., Elser, J., Aon, M. A., Nyhan, D., Shoukas, A. A., et al. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00138.2006 · Cited by 135 · see citing works
Blackwell, K. A., Sorenson, J. P., Richardson, D. M., Smith, L. A., Suda, O., Nath, K. A., & Katušić, Z. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00248.2004 · Cited by 106 · see citing works
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00879.2003 · Cited by 105 · see citing works
Self-citationLesniewski, L. A., Connell, M., Durrant, J., Folian, B. J., Anderson, M. C., Donato, A. J., & Seals, D. R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln049 · Cited by 91 · see citing works
Self-citationMeasurement of aortic input impedance in mice: effects of age on aortic stiffness
Reddy, A. K., Li, Y.-H., Pham, T. T. M., Ochoa, L. N., Treviño, M. T., Hartley, C. J., Michael, L. H., Entman, M. L., & Taffet, G. E. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2003 · Cited by 76 · see citing works
Clinical translation of nitrite therapy for cardiovascular diseases
Calvert, J. W., & Lefer, D. J. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.001 · Cited by 72 · see citing works
Self-citationCarr, A. C., & Frei, B. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009082200 · Cited by 46 · see citing works
Nitrite reduction to nitric oxide in the vasculature
Lundberg, J. O., & Weitzberg, E. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00611.2008 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.14 · Cited by 1,167 · see citing works
Estrogen Signaling and Cardiovascular Disease
Murphy, E. (2011) · Circulation Research · doi:10.1161/circresaha.110.236687 · Cited by 498 · see citing works
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works
Self-citationMaia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Lidder, S., & Webb, A. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04420.x · Cited by 360 · see citing works
Metabolic Effects of Dietary Nitrate in Health and Disease
Lundberg, J. O., Carlström, M., & Weitzberg, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.007 · Cited by 374 · see citing works
Novel Aspects of Dietary Nitrate and Human Health
Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324 · see citing works
Sex differences in mechanisms of arterial stiffness
DuPont, J. J., Kenney, R. M., Patel, A. R., & Jaffe, I. Z. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14624 · Cited by 305 · see citing works
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292 · see citing works
Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 285 · see citing works
Self-citationGioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.268680 · Cited by 263 · see citing works
Self-citationTranslational evidence that impaired autophagy contributes to arterial ageing
LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works
Self-citationKapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Arginine de novo and nitric oxide production in disease states
Luiking, Y. C., Have, G. A. M. T., Wolfe, R. R., & Deutz, N. E. P. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2012 · Cited by 243 · see citing works
Kelly, J., Fulford, J., Vanhatalo, A., Blackwell, J. R., French, O., Bailey, S. J., Gilchrist, M., Winyard, P. G., & Jones, A. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00406.2012 · Cited by 232 · see citing works
Age-related changes in endothelial function and blood flow regulation
Toda, N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.004 · Cited by 212 · see citing works
The autophagy enhancer spermidine reverses arterial aging
LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works
Self-citationDietary Nitrate and Physical Performance
Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051622 · Cited by 206 · see citing works
Brunt, V. E., LaRocca, T. J., Bazzoni, A. E., Sapinsley, Z. J., Miyamoto-Ditmon, J., Gioscia-Ryan, R. A., Neilson, A. P., Link, C. D., & Seals, D. R. (2021) · GeroScience · doi:10.1007/s11357-020-00257-2 · Cited by 197 · see citing works
Self-citationA Procedure for Creating a Frailty Index Based on Deficit Accumulation in Aging Mice
Parks, R. J., Fares, E., MacDonald, J. K., Ernst, M. C., Sinal, C. J., Rockwood, K. J., & Howlett, S. E. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr193 · Cited by 194 · see citing works
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models
Roh, J. D., Hill, J. A., Singh, A. S. C., Valero‐Muñoz, M., & Sam, F. (2022) · Circulation Research · doi:10.1161/circresaha.122.320257 · Cited by 193 · see citing works
Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction
Durik, M., Kavousi, M., van der Pluijm, I., Isaacs, A. J., Cheng, C., Verdonk, K., Loot, A. E., Oeseburg, H., Bhaggoe, U. M., Leijten, F. P. J., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.104380 · Cited by 191 · see citing works
Gano, L. B., Donato, A. J., Pasha, H. M., Hearon, C. M., Sindler, A. L., & Seals, D. R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2014 · Cited by 188 · see citing works
Self-citationKoch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182 · see citing works
Self-citationTherapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175 · see citing works
Lyle, A. N., & Raaz, U. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308563 · Cited by 166 · see citing works
Jones, A. M., Vanhatalo, A., Seals, D. R., Rossman, M. J., Piknova, B., & Jonvik, K. L. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002470 · Cited by 156 · see citing works
Self-citationCurcumin ameliorates arterial dysfunction and oxidative stress with aging
Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 145 · see citing works
Self-citationKirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works
Self-citationAerobic exercise and other healthy lifestyle factors that influence vascular aging
Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works
Self-citationSeals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · see citing works
Self-citationSuperoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice
Fleenor, B. S., Seals, D. R., Zigler, M. L., & Sindler, A. L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00783.x · Cited by 133 · see citing works
Self-citationInorganic nitrite and nitrate: evidence to support consideration as dietary nutrients
Bryan, N. S., & Ivy, J. L. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.06.001 · Cited by 131 · see citing works
Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction
Bhayadia, R., Schmidt, B. M. W., Melk, A., & Hömme, M. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv008 · Cited by 126 · see citing works
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 126 · see citing works
Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice
Gioscia‐Ryan, R. A., Battson, M. L., Cuevas, L. M., Eng, J. S., Murphy, M. P., & Seals, D. R. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00670.2017 · Cited by 124 · see citing works
Self-citationPenna, C. R. R., & Pagliaro, P. (2025) · Antioxidants · doi:10.3390/antiox14030256 · Cited by 134 · see citing works
Nitrite Reduction and Cardiovascular Protection
Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121 · see citing works
Dikalov, S., Polienko, Y. F., & Kirilyuk, I. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7396 · Cited by 122 · see citing works
Mitochondrial Oxidative Stress in Aortic Stiffening With Age
Zhou, R.-H., Vendrov, A. E., Tchivilev, I., Niu, X.-L., Molnar, K., Rojas, M., Carter, J. D., Tong, H., Stouffer, G. A., Madamanchi, N. R., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.243121 · Cited by 125 · see citing works
New insights into arterial stiffening: does sex matter?
Ogola, B. O., Zimmerman, M. A., Clark, G. L., Abshire, C., Gentry, K. M., Miller, K. S., & Lindsey, S. H. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00132.2018 · Cited by 115 · see citing works
A comparison of organic and inorganic nitrates/nitrites
Omar, S. A., Artime, E., & Webb, A. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.008 · Cited by 106 · see citing works
Sodium Nitrate Supplementation Does Not Enhance Performance of Endurance Athletes
BESCÓS, R., FERRER-ROCA, V., GALILEA, P. A., ROIG, A., DROBNIC, F., SUREDA, A., MARTORELL, M., CORDOVA, A., TUR, J. A., & PONS, A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182687e5c · Cited by 107 · see citing works
Wang, M., Zhang, J., Telljohann, R. S., Jiang, L., Wu, J. T., Monticone, R. E., Kapoor, K., Talan, M. I., & Lakatta, E. G. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.191270 · Cited by 106 · see citing works
Carlström, M., & Montenegro, M. F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12818 · Cited by 97 · see citing works
Jädert, C., Petersson, J., Massena, S., Ahl, D., Grapensparr, L., Holm, L., Lundberg, J. O., & Phillipson, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.018 · Cited by 97 · see citing works
Dietary nitrate reduces resting metabolic rate: A randomized, crossover study in humans
Larsen, F. J., Schiffer, T. A., Ekblom, B., Mattsson, M. P., Checa, A., Wheelock, C. E., Nyström, T., Lundberg, J. O., & Weitzberg, E. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.079491 · Cited by 92 · see citing works
Arterial stiffness and cognitive impairment
Li, X., Lyu, P., Ren, Y., An, J., & Dong, Y. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.06.018 · Cited by 92 · see citing works
Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging
Gorini, S., Kim, S. K., Infante, M., Mammi, C., Vignera, S. L., Fabbri, A., Jaffe, I. Z., & Caprio, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00584 · Cited by 89 · see citing works
Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases
Maia, L. B., & Moura, J. J. G. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1234-2 · Cited by 86 · see citing works
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 86 · see citing works
Nutrition and other lifestyle influences on arterial aging
LaRocca, T. J., Martens, C. R., & Seals, D. R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.002 · Cited by 83 · see citing works
Self-citationFleenor, B. S., Sindler, A. L., Eng, J. S., Nair, D. P., Dodson, R. B., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.004 · Cited by 85 · see citing works
Self-citationKaplon, R. E., Hill, S. D., Bispham, N. Z., Santos‐Parker, J. R., Nowlan, M. J., Snyder, L. L., Chonchol, M., LaRocca, T. J., McQueen, M. B., & Seals, D. R. (2016) · Aging · doi:10.18632/aging.100962 · Cited by 84 · see citing works
Self-citationSuperoxide signaling in perivascular adipose tissue promotes age‐related artery stiffness
Fleenor, B. S., Eng, J. S., Sindler, A. L., Pham, B. T., Kloor, J., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12196 · Cited by 83 · see citing works
Self-citationHealthy lifestyle-based approaches for successful vascular aging
Rossman, M. J., LaRocca, T. J., Martens, C. R., & Seals, D. R. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2018 · Cited by 82 · see citing works
Self-citationDeVan, A. E., Johnson, L. C., Brooks, F. A., Evans, T. D., Justice, J. N., Cruickshank-Quinn, C. I., Reisdorph, N. A., Bryan, N. S., McQueen, M. B., Santos‐Parker, J. R., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00879.2015 · Cited by 82 · see citing works
Self-citationCastiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
Leloup, A. J. A., Hove, C. E. V., Heykers, A., Schrijvers, D. M., Meyer, G. R. Y. D., & Fransen, P. F. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00375 · Cited by 77 · see citing works
Hezel, M. P., Peleli, M., Liu, M. R., Zollbrecht, C., Jensen, B. L., Checa, A., Giulietti, A., Wheelock, C. E., Lundberg, J. O., Weitzberg, E., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.025 · Cited by 73 · see citing works
Clayton, Z. S., Hutton, D. A., Brunt, V. E., VanDongen, N. S., Ziemba, B. P., Casso, A. G., Greenberg, N., Mercer, A. N., Rossman, M. J., Campisi, J., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00118.2021 · Cited by 73 · see citing works
Self-citationCasey, D. P., Treichler, D. P., Ganger, C. T., Schneider, A. C., & Ueda, K. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00662.2014 · Cited by 70 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Self-citationGioscia‐Ryan, R. A., Clayton, Z. S., Zigler, M. C., Richey, J. J., Cuevas, L. M., Rossman, M. J., Battson, M. L., Ziemba, B. P., Hutton, D. A., VanDongen, N. S., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280607 · Cited by 68 · see citing works
Self-citationVanhatalo, A., L’Heureux, J. E., KELLY, J. A., Blackwell, J. R., Wylie, L. J., Fulford, J., Winyard, P. G., Williams, D. W., van der Giezen, M., & JONES, A. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101933 · Cited by 68 · see citing works
Gu, Q., Wang, B., Zhang, X.-F., Ma, Y.-P., Liu, J., & Wang, X. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.014 · Cited by 70 · see citing works
del Campo, L., Sánchez‐López, A., Salaíces, M., von Kleeck, R. A., Expósito, E., González‐Gómez, C., Cussó, L., Guzmán, G., Ruı́z-Cabello, J., Desco, M., et al. (2019) · Aging Cell · doi:10.1111/acel.12936 · Cited by 66 · see citing works
Omar, S. A., Fok, H., Tilgner, K., Nair, A., Hunt, J., Jiang, B., Taylor, P. D., Chowienczyk, P., & Webb, A. J. (2014) · Circulation · doi:10.1161/circulationaha.114.009554 · Cited by 63 · see citing works
Large elastic artery stiffness with aging: novel translational mechanisms and interventions.
Fleenor, B. S. (2013) · Europe PMC (PubMed Central) · Cited by 63 · see citing works
Self-citationRaubenheimer, K., Bondonno, C. P., Blekkenhorst, L. C., Wagner, K., Peake, J. M., & Neubauer, O. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz025 · Cited by 63 · see citing works
Animal models of frailty: current applications in clinical research
Kane, A. E., Hilmer, S. N., Mach, J., Mitchell, S. J., de Cabo, R., & Howlett, S. E. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s105714 · Cited by 62 · see citing works
Babcock, M. C., DuBose, L. E., Witten, T. L., Stauffer, B. L., Hildreth, K. L., Schwartz, R. S., Kohrt, W. M., & Moreau, K. L. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab715 · Cited by 63 · see citing works
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation
Bailey, J., Feelisch, M., Horowitz, J. D., Frenneaux, M. P., & Madhani, M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.009 · Cited by 60 · see citing works
Mechanisms impairing blood pressure responses to nitrite and nitrate
Oliveira‐Paula, G. H., Pinheiro, L. C., & Tanus-Santos, J. E. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.01.015 · Cited by 60 · see citing works
Translational physiology: from molecules to public health
Seals, D. R. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.253195 · Cited by 59 · see citing works
Self-citationSindler, A. L., Reyes, R., Chen, B., Ghosh, P., Gurovich, A. N., Kang, L. S., Cardounel, A. J., Delp, M. D., & Muller‐Delp, J. M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00341.2012 · Cited by 58 · see citing works
Self-citationFrom nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease
Liu, H., Huang, Y., Huang, M., Wang, M., Ming, Y., Chen, W., Chen, Y., Tang, Z., & Jia, B. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01413-y · Cited by 58 · see citing works
Nitrate: The Dr. Jekyll and Mr. Hyde of human health?
Bondonno, C. P., Zhong, L., Bondonno, N. P., Sim, M., Blekkenhorst, L. C., Liu, A. H., Rajendra, A., Pokharel, P., Erichsen, D. W., Neubauer, O., et al. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.03.014 · Cited by 56 · see citing works
Maia, L. B., & Moura, J. J. G. (2018) · Redox Biology · doi:10.1016/j.redox.2018.08.020 · Cited by 56 · see citing works
Rocha, B. S., Nunes, C., Pereira, C., Barbosa, R. M., & Laranjinha, J. A. N. (2014) · Food & Function · doi:10.1039/c4fo00124a · Cited by 53 · see citing works
Justice, J. N., Johnson, L. C., DeVan, A. E., Cruickshank-Quinn, C. I., Reisdorph, N. A., Bassett, C. J., Evans, T. D., Brooks, F. A., Bryan, N. S., Chonchol, M. B., et al. (2015) · Aging · doi:10.18632/aging.100842 · Cited by 53 · see citing works
Self-citationOxidative Status and Lipofuscin Accumulation in Urothelial Cells of Bladder in Aging Mice
Perše, M., Injac, R., & Erman, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059638 · Cited by 51 · see citing works
Keszler, Á., Lindemer, B. J., Weihrauch, D., Jones, D. W., Hogg, N., & Lohr, N. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.012 · Cited by 51 · see citing works
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Rossman, M. J., Gioscia‐Ryan, R. A., Clayton, Z. S., Murphy, M. P., & Seals, D. R. (2020) · Clinical Science · doi:10.1042/cs20190559 · Cited by 50 · see citing works
Self-citationKypreos, K. E., Zafirovic, S. S., Πετροπούλου, Π.-Ι., Bjelogrlic, P., Resanović, I., TRAISH, A. M., & Isenović, E. R. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413513499 · Cited by 49 · see citing works
Microbiota and the nitrogen cycle: Implications in the development and progression of CVD and CKD
Briskey, D., Tucker, P. S., Johnson, D. W., & Coombes, J. S. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.05.002 · Cited by 47 · see citing works
SIRT1‐mediated ERβ suppression in the endothelium contributes to vascular aging
Kong, D., Zhan, Y., Liu, Z., Ding, T., Li, M., Yu, H., Zhang, L., Li, H., Luo, A., Zhang, D., et al. (2016) · Aging Cell · doi:10.1111/acel.12515 · Cited by 48 · see citing works
Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research
Siervo, M., Scialò, F., Shannon, O. M., Stephan, B. C. M., & Ashor, A. W. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000058 · Cited by 48 · see citing works
Ballak, D. B., Brunt, V. E., Sapinsley, Z. J., Ziemba, B. P., Richey, J. J., Zigler, M. C., Johnson, L. C., Gioscia‐Ryan, R. A., Culp‐Hill, R., Eisenmesser, E. Z., et al. (2019) · Aging Cell · doi:10.1111/acel.13074 · Cited by 47 · see citing works
Self-citationSchiffer, T. A., Lundberg, J. O., Weitzberg, E., & Carlström, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165811 · Cited by 48 · see citing works
Prasad, A. M., Morgan, D. A., Nuno, D. W., Ketsawatsomkron, P., Bair, T., Venema, A. N., Dibbern, M. E., Kutschke, W. J., Weiss, R. M., Lamping, K. G., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001949 · Cited by 45 · see citing works
Ferguson, S. K., Holdsworth, C. T., Colburn, T. D., Wright, J. L., Craig, J. C., Fees, A. J., JONES, A. M., Allen, J. D., Musch, T. I., & Poole, D. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00014.2016 · Cited by 45 · see citing works
Inorganic Nitrite Supplementation Improves Endothelial Function With Aging
Rossman, M. J., Gioscia‐Ryan, R. A., Santos‐Parker, J. R., Ziemba, B. P., Lubieniecki, K. L., Johnson, L. C., Poliektov, N. E., Bispham, N. Z., Woodward, K. A., Nagy, E., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16175 · Cited by 46 · see citing works
Self-citationA “green” diet-based approach to cardiovascular health? Is inorganic nitrate the answer?
Rathod, K. S., Velmurugan, S., & Ahluwalia, A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500313 · Cited by 42 · see citing works
Hughes, W. E., Ueda, K., Treichler, D. P., & Casey, D. P. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.06.007 · Cited by 39 · see citing works
Clayton, Z. S., Brunt, V. E., Hutton, D. A., Casso, A. G., Ziemba, B. P., Melov, S., Campisi, J., & Seals, D. R. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16759 · Cited by 40 · see citing works
Self-citationThe relationship between plasma and salivary NOx
Clodfelter, W. H., Basu, S., Bolden, C., Dos Santos, P. C., King, S. B., & Kim-Shapiro, D. B. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.04.003 · Cited by 39 · see citing works
Ling, W. C., Mustafa, M. R., Vanhoutte, P. M., & Murugan, D. D. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.003 · Cited by 40 · see citing works
Sex differences in vascular aging and impact of GPER deletion
Ogola, B. O., Abshire, C., Visniauskas, B., Kiley, J. X., Horton, A. C., Clark, G. L., Kilanowski‐Doroh, I., Diaz, Z. T., Bicego, A. N., McNally, A. B., et al. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2022 · Cited by 39 · see citing works
- Authors
- Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R.
- Affiliations
- University of Colorado Boulder (US)
- Emory University (US)
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2011-03-31
- Volume
- 10
- Issue
- 3
- Pages
- 429-437
- ISSN
- 1474-9718 (ISSN-L)
- PMC
- PMC3094511
- OpenAlex
- W1559904992
- Cited by
- 218
- References
- 56
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 17 · 2016: 19 · 2015: 23 · 2014: 22 · 2013: 11 · 2012: 17
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-000279, R37AG013038, R01AG013038, AG-013038, T32AG000279)
- National Heart, Lung, and Blood Institute (R01HL098481, HL007822, R01HL093579, T32HL007822, HL092141, R01HL092141, HL093579)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- nitrite supplementation, sodium nitrite, endothelial dysfunction, arterial stiffness, aging, nitric oxide bioavailability, oxidative stress, inflammation, NADPH oxidase, superoxide, tempol, apocynin, sepiapterin, pulse wave velocity, carotid artery, nitrotyrosine, inflammatory cytokines, arterial aging
- MeSH terms
- Acetophenones, Acetylcholine, Administration, Oral, Aging, Animals, Biopterins, Carotid Arteries, Cyclic N-Oxides, Elasticity, Endothelium, Vascular, Humans, Male, Myography, Nitric Oxide, Sodium Nitrite, Spin Labels, Superoxide Dismutase, Vasodilation, Vasodilator Agents, Cytokines, Oxidative Stress, NADPH Oxidases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
