Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022 · see citing works

The Molecular Signatures Database Hallmark Gene Set Collection

Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807 · see citing works

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

A protein conjugation system essential for autophagy

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,701 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Autophagy maintains stemness by preventing senescence

García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355 · see citing works

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348 · see citing works

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Ulland, T. K., Song, W. M., Huang, S. C.-C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.023 · Cited by 1,263 · see citing works

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176 · see citing works

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove, H., Martens, L., Scheyltjens, I., De Vlaminck, K., Pombo Antunes, A. R., De Prijck, S., Vandamme, N., De Schepper, S., Van Isterdael, G., Scott, C. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0393-4 · Cited by 1,160 · see citing works

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S. A., Spencer, B. J., Rockenstein, E. M., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,072 · see citing works

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N., & Yue, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1854 · Cited by 1,005 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Spangenberg, E., Severson, P. L., Hohsfield, L. A., Crapser, J., Zhang, J., Burton, E. A., Zhang, Y., Spevak, W., Lin, J., Phan, N. Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11674-z · Cited by 939 · see citing works

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151948 · Cited by 840 · see citing works

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.003 · Cited by 817 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19737-2 · Cited by 722 · see citing works

VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots

Goedhart, J., & Luijsterburg, M. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-76603-3 · Cited by 719 · see citing works

Autophagy mediates degradation of nuclear lamina

Dou, Z., Xu, C., Donahue, G., Shimi, T., Pan, J.-A., Zhu, J., Ivanov, A., Capell, B. C., Drake, A. M., Shah, P. P., et al. (2015) · Nature · doi:10.1038/nature15548 · Cited by 655 · see citing works

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Lee, J.-H., Yang, D.-S., Goulbourne, C. N., Im, E., Stavrides, P., Pensalfini, A., Chan, H., Bouchet-Marquis, C., Bleiwas, C., Berg, M. J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01084-8 · Cited by 638 · see citing works

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Choi, I., Zhang, Y., Seegobin, S. P., Pruvost, M., Wang, Q., Purtell, K., Zhang, B., & Yue, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15119-w · Cited by 549 · see citing works

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works

A transcriptomic atlas of aged human microglia

Olah, M., Patrick, E., Villani, A.-C., Xu, J., White, C. C., Ryan, K. J., Piehowski, P., Kapasi, A., Nejad, P., Cimpean, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02926-5 · Cited by 482 · see citing works

SIRT1 is downregulated by autophagy in senescence and ageing

Xu, C., Wang, L., Fozouni, P., Evjen, G., Chandra, V., Jiang, J., Lu, C., Nicastri, M. C., Bretz, C. L., Winkler, J. D., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00579-5 · Cited by 471 · see citing works

Mapping microglia states in the human brain through the integration of high-dimensional techniques

Sankowski, R., Böttcher, C., Masuda, T., Geirsdottir, L., Sagar, Sindram, E., Seredenina, T., Muhs, A., Scheiwe, C., Shah, M. J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0532-y · Cited by 449 · see citing works

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Möller, T., Biber, K., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02263-w · Cited by 441 · see citing works

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Srinivasan, K., Friedman, B. A., Etxeberria, A., Huntley, M. A., van der Brug, M. P., Foreman, O., Paw, J. S., Modrusan, Z., Beach, T. G., Serrano, G. E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107843 · Cited by 427 · see citing works

Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging

Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A.-C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4631 · Cited by 401 · see citing works

A multidimensional systems biology analysis of cellular senescence in aging and disease

Avelar, R. A., Ortega, J. G., Tacutu, R., Tyler, E. J., Bennett, D., Binetti, P., Budovsky, A., Chatsirisupachai, K., Johnson, E., Murray, A., et al. (2020) · Genome Biology · doi:10.1186/s13059-020-01990-9 · Cited by 399 · see citing works

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

Cho, M.-H., Cho, K., Kang, H.-J., Jeon, E.-Y., Kim, H.-S., Kwon, H.-J., Kim, H.-M., Kim, D.-H., & Yoon, S.-Y. (2014) · Autophagy · doi:10.4161/auto.29647 · Cited by 395 · see citing works

Microglial pathology

Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317 · see citing works

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

Khan, A., Ali, T., Rehman, S. U., Khan, M. S., Alam, S. I., Ikram, M. A., Muhammad, T., Saeed, K. M., Badshah, H., & Kim, M. O. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01383 · Cited by 262 · see citing works

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Sobue, A., Komine, O., Hara, Y., Endo, F., Mizoguchi, H., Watanabe, S., Murayama, S., Saito, T., Saido, T. C., Sahara, N., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01099-x · Cited by 253 · see citing works

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

Bai, B., Vanderwall, D., Li, Y., Wang, X., Poudel, S., Wang, H., Dey, K. K., Chen, P., Yang, K., & Peng, J. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00474-z · Cited by 252 · see citing works

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

Nguyen, A. T., Wang, K., Hu, G., Wang, X., Miao, Z., Azevedo, J. A., Suh, E., Van Deerlin, V. M., Choi, D., Roeder, K., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02200-3 · Cited by 241 · see citing works

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Van Acker, Z. P., Bretou, M., & Annaert, W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0323-7 · Cited by 222 · see citing works

Autophagy and Its Normal and Pathogenic States in the Brain

Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204 · see citing works

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203 · see citing works

Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Kenkhuis, B., Somarakis, A., de Haan, L., Dzyubachyk, O., IJsselsteijn, M. E., de Miranda, N. F. C. C., Lelieveldt, B. P. F., Dijkstra, J., van Roon-Mom, W. M. C., Höllt, T., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01126-5 · Cited by 184 · see citing works

Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain

Shahidehpour, R. K., Higdon, R. E., Crawford, N. G., Neltner, J. H., Ighodaro, E. T., Patel, E., Price, D., Nelson, P. T., & Bachstetter, A. D. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.12.003 · Cited by 173 · see citing works

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

Xu, Y., Propson, N. E., Du, S., Xiong, W., & Zheng, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023418118 · Cited by 171 · see citing works

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

Tammineni, P., Ye, X., Feng, T., Aikal, D., & Cai, Q. (2017) · eLife · doi:10.7554/elife.21776 · Cited by 169 · see citing works

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Ryu, K., Lee, H., Woo, H., Kang, R.-J., Han, K., Park, H., Lee, S. M., Lee, J., Jeong, Y. J., Nam, H.-W., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1561-x · Cited by 160 · see citing works

A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

Chatsirisupachai, K., Palmer, D. H., Ferreira, S., & de Magalhães, J. P. (2019) · Aging Cell · doi:10.1111/acel.13041 · Cited by 149 · see citing works

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

Berglund, R., Guerreiro-Cacais, A. O., Adzemovic, M. Z., Zeitelhofer, M., Lund, H., Ewing, E., Ruhrmann, S., Nutma, E., Parsa, R., Thessen-Hedreul, M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5077 · Cited by 149 · see citing works

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Xu, P., Wang, M., Song, W.-M., Wang, Q., Yuan, G.-C., Sudmant, P. H., Zare, H., Tu, Z., Orr, M. E., & Zhang, B. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00507-7 · Cited by 114 · see citing works

Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells

Bertolo, A., Baur, M., Guerrero, J., Pötzel, T., & Stoyanov, J. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-38546-2 · Cited by 112 · see citing works

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Lachance, V., Wang, Q., Sweet, E., Choi, I., Cai, C.-Z., Zhuang, X.-X., Zhang, Y., Jiang, J. L., Blitzer, R. D., Bozdagi-Gunal, O., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0342-4 · Cited by 96 · see citing works

Genetic variation within endolysosomal system is associated with late-onset Alzheimer’s disease

Gao, S., Casey, A., Sargeant, T. J., & Mäkinen, V. (2018) · Brain · doi:10.1093/brain/awy197 · Cited by 75 · see citing works

Quantitative Protein Analysis by Mass Spectrometry

Pagala, V., High, A. A., Wang, X., Tan, H., Kodali, K., Mishra, A., Kavdia, K., Xu, Y., Wu, Z., & Peng, J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2425-7_17 · Cited by 66 · see citing works

Molecular estimation of neurodegeneration pseudotime in older brains

Mukherjee, S., Heath, L. M., Preuß, C., Jayadev, S., Garden, G. A., Greenwood, A. K., Sieberts, S. K., Jager, P. L. D., Ertekin‐Taner, N., Carter, G. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19622-y · Cited by 60 · see citing works

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Veremeyko, T., Starossom, S. C., Weiner, H. L., & Ponomarev, E. D. (2012) · Journal of Visualized Experiments · doi:10.3791/4097 · Cited by 37 · see citing works

Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation

Hernández-Silva, D., Cantón-Sandoval, J., Martínez-Navarro, F. J., Pérez‐Sánchez, H., de Oliveira, S., Mulero, V., Alcaraz‐Pérez, F., & Cayuela, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810468 · Cited by 23 · see citing works

A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer’s Disease

Chen, H., Chen, F., Zhang, M., Chen, Y., Cui, L., & Liang, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210602 · Cited by 15 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Nixon, R. A., & Rubinsztein, D. C. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00757-5 · Cited by 435 · see citing works

Autophagy, aging, and age-related neurodegeneration

Palmer, J. E., Wilson, N., Son, S. M., Obrocki, P., Wróbel, L., Rob, M., Takla, M., Korolchuk, V. I., & Rubinsztein, D. C. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.015 · Cited by 255 · see citing works

Cellular senescence in brain aging and neurodegeneration

dos Santos, L. M., Trombetta-Lima, M., Eggen, B. J. L., & Demaria, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102141 · Cited by 158 · see citing works

Emerging role of senescent microglia in brain aging-related neurodegenerative diseases

Rim, C., You, M., Nahm, M., & Kwon, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00402-3 · Cited by 147 · see citing works

Human Ageing Genomic Resources: updates on key databases in ageing research

de Magalhães, J. P., Abidi, Z., dos Santos, G. A., Avelar, R. A., Barardo, D., Chatsirisupachai, K., Clark, P. A., De‐Souza, E. A., Johnson, E. J., Lopes, I., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad927 · Cited by 133 · see citing works

Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

Zhou, Z., Yao, J., Wu, D., Huang, X., Wang, Y., Li, X., Lu, Q., & Qiu, Y. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.001 · Cited by 120 · see citing works

Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics

Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 95 · see citing works

Multifunctional Hydrogel Microneedle Patches Modulating Oxi‐inflamm‐aging for Diabetic Wound Healing

Tian, S., Mei, J., Zhang, L., Wang, S., Yuan, Y., Li, J., Liu, H., Zhu, W., & Xu, D. (2024) · Small · doi:10.1002/smll.202407340 · Cited by 83 · see citing works

Immune Activation in Alzheimer Disease

Mary, A., Mancuso, R., & Heneka, M. T. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035222 · Cited by 79 · see citing works

Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets

Qian, S., Long, Y., Tan, G., Li, X., Xiang, B., Tao, Y., Xie, Z., & Zhang, X. (2024) · MedComm · doi:10.1002/mco2.70024 · Cited by 72 · see citing works

Therapeutic targeting of senescent cells in the CNS

Rießland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01033-z · Cited by 74 · see citing works

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

Wu, N., Zheng, W., Zhou, Y., Tian, Y., Tang, M., Feng, X., Ashrafizadeh, M., Wang, Y. Z., Niu, X., Tambuwala, M. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102428 · Cited by 56 · see citing works

Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics

Rießland, M., & Orr, M. E. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.104 · Cited by 55 · see citing works

H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alzheimer-like pathology through mTOR-regulated autophagy and activation of microglia

Wang, H., Xia, H., Bai, J., Wang, Z., Wang, Y., Lin, J., Cheng, C., Chen, W., Zhang, J., Zhang, Q., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137310 · Cited by 49 · see citing works

ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease

Tang, X., Walter, E., Wohleb, E., Fan, Y.-B., & Wang, C.-R. (2023) · Autophagy · doi:10.1080/15548627.2023.2277634 · Cited by 44 · see citing works

Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration

Richardson, M., & Richardson, D. R. (2023) · Molecular Pharmacology · doi:10.1124/molpharm.123.000803 · Cited by 48 · see citing works

Resolving the mysteries of brain clearance and immune surveillance

Kipnis, J., Benveniste, H., Eichmann, A., Thomas, J., Reich, D. S., Lewis, L. D., Tsai, L., Drieu, A., Bakker, E. N. T. P., Kelley, D. H., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.036 · Cited by 47 · see citing works

Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain

Tamatta, R., Pai, V., Jaiswal, C., Singh, I., & Singh, A. K. (2025) · Biogerontology · doi:10.1007/s10522-025-10199-x · Cited by 49 · see citing works

Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis

Lemche, E., Killick, R., Mitchell, J., Caton, P., Choudhary, P., & Howard, J. K. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106485 · Cited by 42 · see citing works

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration

Tang, Q., Tang, K., Markby, G. R., Parys, M., Phadwal, K., MacRae, V. E., & CORCORAN, B. M. (2025) · Autophagy · doi:10.1080/15548627.2025.2469315 · Cited by 39 · see citing works

Hypoxia-associated autophagy flux dysregulation in human cancers

Fu, J., Lin, J., Dai, Z., Lin, B., & Zhang, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216823 · Cited by 37 · see citing works

Prevention and Treatment Strategies for Alzheimer’s Disease: Focusing on Microglia and Astrocytes in Neuroinflammation

Zhang, S.-S., Gao, Z., Feng, L., & Li, M. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s483412 · Cited by 38 · see citing works

Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

Caldarelli, M., Rio, P., Marrone, A., Ocarino, F., Chiantore, M., Candelli, M., Gasbarrini, A., Gambassi, G., & Cianci, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105377 · Cited by 36 · see citing works

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E. V., Demmings, M. D., Fernandez, R. F., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 35 · see citing works

Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury

Luo, N., Zhu, W., Li, X., Fu, M., Zhang, Y., Yang, F., Zhang, Y., Chen, Z., Zhang, Q., Peng, B., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae153 · Cited by 38 · see citing works

Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer's disease based on Cu2+ chelation and photothermal therapy

Li, L., Xiong, Y., Zhang, Y., Yan, Y., Zhao, R., Yang, F., & Xie, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.09.009 · Cited by 33 · see citing works

Relationships between protein degradation, cellular senescence, and organismal aging

Hamazaki, J., & Murata, S. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae016 · Cited by 32 · see citing works

Unlocking the Therapeutic Potential of Natural Products for Alzheimer’s Disease

Li, Z., Zhang, Z., & Yu, B. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c03049 · Cited by 33 · see citing works

Neurodegenerative diseases and neuroinflammation-induced apoptosis

Huang, S., Lu, Y., Fang, W., Huang, Y., Li, Q., & Xu, Z. (2025) · Open Life Sciences · doi:10.1515/biol-2022-1051 · Cited by 31 · see citing works

Microglia programmed cell death in neurodegenerative diseases and CNS injury

Cai, L., Fan, Q., Pang, R., Chen, C., Zhang, Y., Xie, H., Huang, J., Wang, Y., Li, P., Huang, D., et al. (2024) · APOPTOSIS · doi:10.1007/s10495-024-02041-5 · Cited by 32 · see citing works

Preferential clustering of microglia and astrocytes around neuritic plaques during progression of Alzheimer's disease neuropathological changes

Tsering, W., de la Rosa, A., Ruan, I. Y., Philips, J. L., Bathe, T., Villareal, J. A. B., & Prokop, S. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16275 · Cited by 30 · see citing works

Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders

Risen, S. J., Boland, S. W., Sharma, S., Weisman, G. M., Shirley, P. M., Latham, A. S., Hay, A. J. D., Gilberto, V. S., Hines, A. D., Brindley, S. M., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00846 · Cited by 26 · see citing works

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

Tran, K. M., Kwang, N. E., Butler, C. A., Gomez-Arboledas, A., Kawauchi, S., Mar, C., Chao, D., Barahona, R. A., Da Cunha, C., Tsourmas, K. I., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00793-x · Cited by 28 · see citing works

High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury

Li, L. M., Kodosaki, E., Heslegrave, A., Zetterberg, H., Graham, N., Zimmerman, K. A., Soreq, E., Parker, T. D., Garbero, E., Moro, F., et al. (2024) · Brain · doi:10.1093/brain/awae305 · Cited by 30 · see citing works

Remodeling of senescent macrophages in synovium alleviates trauma- and aging-induced osteoarthritis

Liu, Y., Duan, J., Dang, Y., Hao, R., Wang, H., Tan, E., Wang, R., Li, Y., Zhang, S., Wang, Y., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.016 · Cited by 26 · see citing works

Macrophages and autophagy: partners in crime

Vitaliti, A., Reggio, A., & Palma, A. (2024) · The FEBS Journal · doi:10.1111/febs.17305 · Cited by 23 · see citing works

Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities

Hudson, H. R., Sun, X., & Orr, M. E. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00519 · Cited by 26 · see citing works

Making tracks: microglia and the extracellular matrix

Wareham, L. K., & Calkins, D. J. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00898-x · Cited by 31 · see citing works

Autophagy prevents microglial senescence

Amin, S., Liu, B., & Gan, L. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01168-y · Cited by 25 · see citing works

Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats

Liu, Y.-C., Chen, S.-Y., Chen, Y.-Y., Chang, H., Chiang, I., & Yen, G. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133898 · Cited by 24 · see citing works

α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription

Pei, C., Hou, X., Ma, Z., Tu, H., Qian, H.-C., Li, Y., Li, K., Liu, C., Ouyang, L., Liu, J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03268-4 · Cited by 26 · see citing works

APOE4 impairs autophagy and Aβ clearance by microglial cells

Bassal, R., Rivkin-Natan, M., Rabinovich, A., Michaelson, D. M., Frenkel, D., & Pinkas-Kramarski, R. (2025) · Inflammation Research · doi:10.1007/s00011-025-02016-5 · Cited by 23 · see citing works

TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice

Lin, J. E., Yuan, Y., Huang, C., Zi, J., Li, L., Liu, J., Wu, X., Li, W., Zhao, Q. H., Li, Y., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107929 · Cited by 22 · see citing works

The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer’s Disease

Tangavelou, K., & Bhaskar, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212335 · Cited by 24 · see citing works

Microglial lipid droplets as therapeutic targets in age-related neurodegenerative diseases

Sung, S., Kim, H.-J., Cha, S. J., Nahm, M., Kim, S. H., & Kwon, M. (2025) · npj Aging · doi:10.1038/s41514-025-00295-0 · Cited by 22 · see citing works

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Cai, Z., Wang, S., Cao, S. “., Chen, Y., Penati, S., Peng, V., Yuede, C. M., Beatty, W. L., Lin, K., Zhu, Y., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20230173 · Cited by 23 · see citing works

Brain macrophage senescence in glioma

Li, L., Zhang, T. C., Xiao, M., Lu, Y., & Gao, L. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.07.005 · Cited by 21 · see citing works

Delphinidin attenuates cognitive deficits and pathology of Alzheimer’s disease by preventing microglial senescence via AMPK/SIRT1 pathway

Liu, Y., Hong, T., Lv, M., Guo, X., Zhang, P. Y., Yan, A., & Wei, W. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01783-x · Cited by 20 · see citing works

Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications

Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 21 · see citing works

Cellular senescence: A novel therapeutic target for central nervous system diseases

Lei, S.-Y., Qu, Y., Yang, Y.-Q., Liu, J., Zhang, Y.-F., Zhou, S., He, Q., Jin, H., Yang, Y., & Guo, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117311 · Cited by 19 · see citing works

S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation

Xiong, Y., Liang, W., Wang, X., Zhu, H., Yi, P., Wei, G., Liu, H., Lin, Y., Zhang, L., Ying, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113375 · Cited by 18 · see citing works

Exposure to Manganese Induces Autophagy–Lysosomal Pathway Dysfunction-Mediated Tauopathy by Activating the cGAS–STING Pathway in the Brain

Zhang, X., Liu, J., Zhong, S., Zhang, Z., Zhou, Q., Yang, J., Chang, X., & Wang, H. (2024) · Environment & Health · doi:10.1021/envhealth.4c00176 · Cited by 19 · see citing works

Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models

Hu, W., Chen, M., Lin, Y., Zhang, H., Sun, L., Shao, W., Ye, Y., Cheng, Y., Zhou, S., Hu, P., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01378-x · Cited by 17 · see citing works

Autophagy in alzheimer disease pathogenesis and its therapeutic values

Angst, G., Jia, N., Esqueda, L. T., Fan, Y., Cai, Q., & Wang, C. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2471677 · Cited by 19 · see citing works

Acyl-CoA-binding protein as a driver of pathological aging

Montégut, L., Lambertucci, F., Moledo-Nodar, L., Fiuza‐Luces, C., Rodríguez-López, C., Rexach, J. A. S., Lachkar, S., Motiño, O., Abdellatif, M., Durand, S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2501584122 · Cited by 16 · see citing works

Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance

Yang, Y., Shi, G., Ge, Y., Huang, S.-S., Cui, N.-N., Tan, L., Liu, R., & Yang, X.-F. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03314-1 · Cited by 14 · see citing works

A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap

Lau, V. Z., Awogbindin, I. O., Frenkel, D., Whitehead, S. N., & Tremblay, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70363 · Cited by 15 · see citing works

The KEAP1/PGAM5/AIFM1-Mediated oxeiptosis pathway in Alzheimer’s disease

Zhong, F., Xiong, L., Wu, J., Chen, Y., Song, J., Yu, W., & Yang, L. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149173 · Cited by 15 · see citing works

Immunity in Alzheimer’s disease: From mechanisms to therapies

Chen, X., Holtzman, D. M., & Colonna, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.004 · Cited by 17 · see citing works

Biosynthesis of Nanoparticles with Green Tea for Inhibition of β-Amyloid Fibrillation Coupled with Ligands Analysis

Zhang, M., Li, Y., Han, C., Chu, S., Yu, P., & Cheng, W. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s451070 · Cited by 14 · see citing works

Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Wang, C., Wang, X., Sun, S., Chang, Y., Lian, P., Guo, H., Zheng, S., Ma, R., & Li, G. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00437-0 · Cited by 17 · see citing works

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

Njoku, G. C., & Kanmogne, G. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189069 · Cited by 15 · see citing works

Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis

Zhou, X., Cao, H., Liao, T., Hua, W., Zhao, R., Wang, D., Deng, H., Yang, Y., Liu, S., & Ni, G. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.07.005 · Cited by 13 · see citing works

Artemisiae Iwayomogii Herba mitigates excessive neuroinflammation and Aβ accumulation by regulating the pro-inflammatory response and autophagy-lysosomal pathway in microglia in 5xFAD mouse model of Alzheimer’s disease

Ju, I. G., Lee, S., Im, H., Kim, J.-H., Eo, H., & Oh, M. S. (2024) · GeroScience · doi:10.1007/s11357-024-01388-6 · Cited by 13 · see citing works

Sodium butyrate alleviates potential Alzheimer’s disease in vitro by suppressing Aβ and tau activation and ameliorates Aβ-induced toxicity

Bayazid, A. B., Jeong, Y. H., Jeong, S. A., & Lim, B. O. (2023) · Food and Agricultural Immunology · doi:10.1080/09540105.2023.2234100 · Cited by 13 · see citing works

Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer’s disease mouse modelsPreprint

Sokolova, D., Ghansah, S. A., Puletti, F., Georgiades, T., Schepper, S. D., Zheng, Y., Crowley, G., Wu, L., Rueda‐Carrasco, J., Koutsiouroumpa, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.31.606944 · Cited by 14 · see citing works

Berbamine targets the FKBP12-rapamycin-binding (FRB) domain of the mTOR complex to promote microglial autophagy and ameliorate neuroinflammation in Alzheimer’s disease

Ge, P., Guo, S., Wang, P., Zhou, P., Tang, Z., Yang, N., Guo, R., Xiao, Q., Chai, X., Zhang, Q., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156771 · Cited by 12 · see citing works

Connections Between Cellular Senescence and Alzheimer’s Disease—A Narrative Review

Kuźniar, J., Kozubek, P., Czaja, M., Sitka, H., Kochman, U., & Leszek, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178638 · Cited by 13 · see citing works

The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice

Le, L., Eliseeva, S. I., Plunk, E. C., Kara-Pabani, K., Li, H., Yarovinsky, F., & Majewska, A. K. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115176 · Cited by 12 · see citing works

Tauopathy after long‐term cervical lymphadenectomy

Wu, C., Yuan, J., Tian, Y., Wang, Y., He, X., Zhao, K., Huang, J., & Jiang, R. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70136 · Cited by 12 · see citing works

Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD

Hu, H., Cao, B., Huang, D. A., Lin, Y., Zhou, B., Ying, B., Huang, L., & Zhang, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-75284-6 · Cited by 11 · see citing works

Novel application of cycloastragenol target microglia for the treatment of Alzheimer's disease: Evidence from single-cell analysis, network pharmacology and experimental assessment

Weng, W., Lin, B., Zheng, J., Sun, Y., Li, Z., Chen, X., Wang, Y., & Pan, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156502 · Cited by 11 · see citing works

Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease

Ye, K., Han, X., Tian, M., Liu, L., Gao, X., Xia, Q. H., & Wang, D. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06324-6 · Cited by 11 · see citing works

Novel A- seco -nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy

Luo, R., Luo, Y., Fang, D.-S., Yao, Y., Qiu, M., & Peng, X. (2024) · Organic Chemistry Frontiers · doi:10.1039/d3qo02000b · Cited by 10 · see citing works

Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease

Liu, H., Li, J., Wang, X., Luo, S., Luo, D., Ge, W., & Ma, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03083-x · Cited by 9 · see citing works

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases

Walsh, A. E., & Lukens, J. R. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102552 · Cited by 13 · see citing works

Visualizing bulk autophagy in vivo by tagging endogenous LC3B

Gao, X., Xiong, Y., Ma, H., Zhou, H., Liu, W., & Sun, Q. (2025) · Autophagy · doi:10.1080/15548627.2025.2457910 · Cited by 9 · see citing works

Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy

Mi, C., Zhou, S., & Xue, J. (2025) · Aging and Disease · doi:10.14336/ad.2025.0061 · Cited by 9 · see citing works

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Du, H., Mizokami, A., Ni, J., Zhang, S.-M., Yamawaki, Y., Sano, T., Jimi, E., Tanida, I., & Kanematsu, T. (2025) · Advanced Science · doi:10.1002/advs.202413375 · Cited by 9 · see citing works

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 9 · see citing works

Glial cells as a promising therapeutic target of glaucoma: beyond the IOP

Shinozaki, Y., Namekata, K., Guo, X., & Harada, T. (2024) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1310226 · Cited by 9 · see citing works

Senescence- and Immunity-Related Changes in the Central Nervous System: A Comprehensive Review

Feng, H., Li, J., Wang, H., Wei, Z., & Feng, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0755 · Cited by 10 · see citing works

The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease

Shen, H., Xie, Y., Wang, Y., Xie, Y., Wang, Y., Su, Z., Zhao, L., Yao, S., Cao, X., Liang, J., et al. (2025) · Autophagy · doi:10.1080/15548627.2024.2447206 · Cited by 8 · see citing works

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

Liu, Z., Zhang, J., Jiang, F., Liu, C., Shao, Y., & Le, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70392 · Cited by 8 · see citing works

Fucosterol ameliorates depressive-like behaviours by suppressing microglial activation and neuroinflammation via inhibition the MAPK/ERK1/2 signaling pathway

Huang, L., Wang, S., Zhang, Q., Zhang, J., & Sun, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114821 · Cited by 8 · see citing works

PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice

Wei, M., Li, W., Bao, G., Yang, Z., Li, S., & Le, W. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118918 · Cited by 8 · see citing works

Stem-cell-derived extracellular vesicles in neurodegeneration and neuroaging: therapeutic potential and challenges

Kumar, M., Ray, S., & Sil, S. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.65 · Cited by 8 · see citing works

Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems

Qin, L., Wang, X., Liang, T., Bi, Y., Guo, Z., Li, W., & Liang, W. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102849 · Cited by 8 · see citing works

Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS

Shen, F.-S., Liu, C., Sun, H.-Z., Chen, X., Xue, Y., & Chen, L. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae098 · Cited by 8 · see citing works

Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus

Khan, T., Hussain, A. I., Casilli, T. P., Frayser, L. A., Cho, M., Williams, G., McFall, D. J., & Forcelli, P. A. (2024) · Aging Cell · doi:10.1111/acel.14239 · Cited by 9 · see citing works

JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia

Young, A. P., & Denovan‐Wright, E. M. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10115-z · Cited by 8 · see citing works

Application of mitochondrial miRNA-204 nanoprobes in Alzheimer's disease treatment by clearing reactive oxygen species-mediated autophagy

Li, W., Dong, M., Dai, H., Lu, S., Luo, R., Cao, J., Zhang, F., Mei, L., & Yu, J. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110614 · Cited by 7 · see citing works

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis

Lemche, E., Hortobágyi, T., Kiecker, C. M., & Turkheimer, F. (2025) · Physiological Reviews · doi:10.1152/physrev.00040.2024 · Cited by 8 · see citing works

The dual role of microglia in neurodegenerative diseases: A review

Zhang, N., Xiong, N., He, Y., & Zhou, L. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111887 · Cited by 8 · see citing works

Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity

Su, G., Chen, B., Song, Y., Yin, Q., Wang, W., Zhao, X., Fan, S., Lian, J., Li, D., Bi, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60389-x · Cited by 7 · see citing works

Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer’s disease by promoting microglia efferocytosis and neuroinflammation mitigation

Mu, Z., Chen, Y., Hu, Y., Wang, H., & Li, J. H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03750-y · Cited by 7 · see citing works

Advancement of disease-modifying therapy of Alzheimer’s disease: from the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease

Wu, J., Geng, C.-F., Liu, L., & Tang, Y. (2025) · Medicine Plus · doi:10.1016/j.medp.2025.100112 · Cited by 6 · see citing works

A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain

Orr, M. E. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231462 · Cited by 6 · see citing works

Interconnections between the Gut Microbiome and Alzheimer’s Disease: Mechanisms and Therapeutic Potential

Sait, A. M., & Day, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168619 · Cited by 6 · see citing works

Autophagy prevents microglial senescence

Amin, S., Liu, B., & Gan, L. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01168-y · Cited by 25 · see citing works

Microglial autophagy-mediated clearance of amyloid-beta plaques is dysfunctional in Alzheimer’s Disease mice

Daily, K. P., & Amer, A. O. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.206.supp.12.01

Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease

Ou-Yang, P., Cai, Z., & Zhang, Z.-H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0106 · Cited by 21 · see citing works

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

Pomilio, C., Gorojod, R. M., Riudavets, M., Vinuesa, A., Presa, J., Gregosa, A., Bentivegna, M., Alaimo, A., Alcon, S. P., Sevlever, G., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00161-9 · Cited by 109 · see citing works

Microglial senescence is a potential therapeutic target for Alzheimer disease

Wood, H. B. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00979-3 · Cited by 7 · see citing works