Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice
Abstract
The varepsilon4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease (AD). In order to gain a better understanding of the molecular mechanisms by which apoE and possibly other apolipoproteins produced in the central nervous system (CNS) influence AD pathogenesis, we have purified and characterized the two most abundant apolipoproteins produced in the CNS, apoE and apoJ. We purified apoE and apoJ from primary cultures of mouse astrocytes, which were derived from transgenic mice expressing human apoE isoforms in the absence of mouse apoE. Utilizing antibody affinity columns, we were able to purify both human apoE3 and apoE4, as well as mouse apoJ-containing lipoproteins. Astrocyte-secreted human apoE was present in high density-like lipoproteins of three predominant sizes ranging from 8 to 15 nm in diameter. Mouse apoJ was in particles between 10 and 17 nm in diameter with a peak size range of approximately 11 nm. ApoE and apoJ were in distinct lipoproteins. Utilization of quick-freeze, deep-etch electron microscopy revealed the apoE particles were discs while the apoJ particles were smaller and more irregular in appearance. The lipid composition of apoE particles was very different from those containing apoJ. ApoE-particles contained a similar mass of apoE and lipid, with cholesterol and phospholipid being about equal in mass per particle. ApoJ-particles were relatively lipid poor (three parts protein, one part lipid), with phospholipids being much more abundant than cholesterol. Detailed characterization of phospholipid composition by electrospray ionization mass spectrometry analysis revealed ethanolamine glycerophospholipids to be the most abundant phospholipid present in both apoE and apoJ particles. Analysis of cerebrospinal fluid from apoE3 and apoE4 transgenic mice revealed that human and mouse apoE were in particles the same size as those secreted by astrocytes. Further use of physiological preparations of CNS-derived lipoproteins may allow for a detailed understanding of the role of these molecules in the normal brain and in diseases such as AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Long-chain saturated FFAs and VLCPCs are normally of relatively low abundance in membranes and ApoE- and ApoJ-containing lipoparticles.
“lipids that are normally of relatively low abundance in membranes and ApoE- and ApoJ-containing lipoparticles14”
From Neurotoxic reactive astrocytes induce cell death via saturated lipids (2021) · cites this paper as [14]
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works
Self-citationMiyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 889 · see citing works
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
Selkoe, D. J. (1997) · Science · doi:10.1126/science.275.5300.630 · Cited by 871 · see citing works
Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871 · see citing works
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802 · see citing works
Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795 · see citing works
A protein cofactor of lecithin:Cholesterol acyltransferase
Fielding, C. J., Shore, V. G., & Fielding, P. E. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(72)90776-0 · Cited by 728 · see citing works
Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714 · see citing works
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693 · see citing works
Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575 · see citing works
Self-citationIsoform-specific binding of apolipoprotein E to beta-amyloid.
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works
Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15233 · Cited by 486 · see citing works
Apolipoprotein E and Alzheimer's disease
Strittmatter, W. J., & Roses, A. D. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.000413 · Cited by 477 · see citing works
Han, X., & Gross, R. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10635 · Cited by 436 · see citing works
Self-citationInnerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433 · see citing works
Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404 · see citing works
Clusterin is a secreted mammalian chaperone
Wilson, M. R., & Easterbrook‐Smith, S. B. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01534-0 · Cited by 380 · see citing works
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
Linton, M. F., Gish, R., Hubl, S. T., Bütler, E., Esquivel, C., Bry, W. I., Boyles, J. K., Wardell, M. R., & Young, S. G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115288 · Cited by 367 · see citing works
Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss‐Coray, T., Mucke, L., & Mahley, R. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04867.1999 · Cited by 355 · see citing works
Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y., & Paul, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6179 · Cited by 349 · see citing works
Self-citationEvans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.763 · Cited by 333 · see citing works
Poirier, J., Baccichet, A., Dea, D., & Gauthier, S. G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90456-p · Cited by 329 · see citing works
Ghiso, J., Matsubara, E., Koudinov, A., Choi-Miura, N. H., Tomita, M., Wisniewski, T., & Frangione, B. (1993) · Biochemical Journal · doi:10.1042/bj2930027 · Cited by 304 · see citing works
Golde, T. E., Eckman, C. B., & Younkin, S. G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00043-0 · Cited by 300 · see citing works
Nascent astrocyte particles differ from lipoproteins in CSF
LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052070.x · Cited by 285 · see citing works
Self-citationApolipoproteins in human cerebrospinal fluid.
Roheim, P. S., Carey, M., Forte, T., & Vega, G. L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4646 · Cited by 282 · see citing works
TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works
Fibrillogenesis in Alzheimer's disease of amyloid <i>β</i> peptides and apolipoprotein E
Castano, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, R. A., Soto, C., & Frangione, B. (1995) · Biochemical Journal · doi:10.1042/bj3060599 · Cited by 267 · see citing works
Silva, H. V. D., Stuart, W. D., Duvic, C. R., Wetterau, J. R., Ray, M. J., Ferguson, D. G., Albers, H. W., Smith, W. R., & Harmony, J. A. K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38290-0 · Cited by 265 · see citing works
Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro
Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., Hajian, H., & Finch, C. E. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6360 · Cited by 237 · see citing works
Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., & Finch, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03180.1998 · Cited by 237 · see citing works
Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30001 · Cited by 222 · see citing works
Self-citationProcedure for freeze-drying molecules adsorbed to mica flakes
Heuser, J. E. (1983) · Journal of Molecular Biology · doi:10.1016/s0022-2836(83)80179-x · Cited by 218 · see citing works
Self-citationMotor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury
Chen, Y., Lomnitski, L., Michaelson, D. M., & Shohami, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00007-9 · Cited by 214 · see citing works
Sun, Y., Wu, S., Bu, G., Onifade, M. K., Patel, S. N., LaDu, M. J., Fagan, A. M., & Holtzman, D. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03261.1998 · Cited by 213 · see citing works
Self-citationClusterin contributes to caspase-3–independent brain injury following neonatal hypoxia-ischemia
Han, B. H., Demattos, R. B., Dugan, L. L., Kim‐Han, J. S., Brendza, R. P., Fryer, J. D., Kierson, M., Cirrito, J. R., Quick, K. L., Harmony, J. A. K., et al. (2001) · Nature Medicine · doi:10.1038/85487 · Cited by 206 · see citing works
Self-citationCharacterization of Apolipoprotein J-Alzheimer's Aβ Interaction
Matsubara, E., Frangione, B., & Ghiso, J. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7563 · Cited by 195 · see citing works
Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid
LaDu, M. J., Pederson, T. M., Frail, D. E., Reardon, C. A., Getz, G. S., & Falduto, M. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9039 · Cited by 189 · see citing works
Näslund, J., Thyberg, J., Tjernberg, L. O., Wernstedt, C., Karlström, A. R., Bogdanović, N., Gandy, S., Lannfelt, L., Terenius, L. Y., & Nordstedt, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90079-9 · Cited by 189 · see citing works
Apolipoprotein J and Alzheimer's amyloid β solubility
Matsubara, E., Soto, C. A., Governale, S., Frangione, B., & Ghiso, J. A. (1996) · Biochemical Journal · doi:10.1042/bj3160671 · Cited by 187 · see citing works
Lipoprotein-receptor interactions
Innerarity, T. L., Pitas, R. E., & Mahley, R. W. (1986) · Methods in Enzymology · doi:10.1016/0076-6879(86)29091-6 · Cited by 186 · see citing works
Biology of Aβ Amyloid in Alzheimer's Disease
Wısnıewskı, T., Ghiso, J. A., & Frangione, B. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0147 · Cited by 185 · see citing works
Apolipoprotein E suppresses glial cell secretion of TNFα
Laskowitz, D. T., Goel, S., Bennett, E. R., & Matthew, W. D. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00021-0 · Cited by 175 · see citing works
Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration
May, P. C., & Finch, C. E. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90190-j · Cited by 170 · see citing works
SP-40,40 is a constituent of Alzheimer's amyloid
Choi-Miura, N. H., Ihara, Y., Fukuchi, K., Takeda, M., Nakano, Y., Tobe, T., & Tomita, M. (1992) · Acta Neuropathologica · doi:10.1007/bf00296787 · Cited by 158 · see citing works
Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid
Borghini, I., Barja, F., Pometta, D., & James, R. W. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00232-n · Cited by 154 · see citing works
Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07100.1999 · Cited by 148 · see citing works
Masliah, E., Samuel, W., Veinbergs, I., Mallory, M., Mante, M., & Saitoh, T. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01420-5 · Cited by 146 · see citing works
Bales, K. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00143-3 · Cited by 143 · see citing works
Han, X., Gubitosi‐Klug, R., Collins, B. J., & Gross, R. W. (1996) · Biochemistry · doi:10.1021/bi952927v · Cited by 135 · see citing works
Self-citationDeMattos, R. B., Curtiss, L. K., & Williams, D. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4206 · Cited by 123 · see citing works
Self-citationExpression of apolipoprotein E mRNA in rat microglia
Nakai, M., Kawamata, T., Taniguchi, T., Maeda, K., & Tanaka, C. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12716-6 · Cited by 118 · see citing works
Seeding of Aβ Fibril Formation Is Inhibited by All Three Isotypes of Apolipoprotein E
Wood, S. J., Chan, W., & Wetzel, R. B. (1996) · Biochemistry · doi:10.1021/bi961074j · Cited by 115 · see citing works
Clusterin (Apo J) Protects Against In Vitro Amyloid‐β(1–40) Neurotoxicity
Boggs, L. N., Fuson, K. S., Baez, M., Churgay, L. M., McClure, D. B., Becker, G., & May, P. C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031324.x · Cited by 108 · see citing works
Protocol for 3‐D visualization of molecules on mica via the quick‐freeze, deep‐etch technique
Heuser, J. (1989) · Journal of Electron Microscopy Technique · doi:10.1002/jemt.1060130310 · Cited by 96 · see citing works
Self-citationOpposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.
Russo, C., Angelini, G., Dapino, D., Piccini, A., Piombo, G., Schettini, G., Chen, S. G., Teller, J., Zaccheo, D., Gambetti, P., et al. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.26.15598 · Cited by 94 · see citing works
Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures
Teter, B., Harris‐White, M. E., Frautschy, S. A., & Cole, G. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00630-7 · Cited by 70 · see citing works
Isolation and Characterization of Apolipoproteins from Murine Microglia
Xu, Q., Li, Y., Cyras, C., Sanan, D. A., & Cordell, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002796200 · Cited by 69 · see citing works
Apolipoprotein E Attenuates β‐Amyloid‐Induced Astrocyte Activation
Hu, J., LaDu, M. J., & Eldik, L. J. V. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041626.x · Cited by 62 · see citing works
Permanne, B., Pérez, C. A., Soto, C., Frangione, B., & Wisniewski, T. (1997) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1997.7727 · Cited by 62 · see citing works
McCall, M. R., Forte, T. M., & Shore, V. G. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38448-0 · Cited by 56 · see citing works
Pasinetti, G. M., & Finch, C. E. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90213-d · Cited by 55 · see citing works
Krul, E. S., Tikkanen, M. J., & Schonfeld, G. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38434-0 · Cited by 50 · see citing works
Immunoaffinity isolation of apolipoprotein E-containing lipoproteins
Gibson, J. C., Rubinstein, A., Ngai, N., Ginsberg, H. N., Le, N., Gordon, R. E., Goldberg, I. J., & Brown, W. V. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90037-2 · Cited by 23 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Self-citationCole (2000) · doi:10.1002/1097-0029(20000815)50:4
Flagged first, then by citations
Cited by
Sorted by citations
Yeh, F. L., Wang, Y., Tom, I., Gonzalez, L. C., & Sheng, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.015 · Cited by 943 · see citing works
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works
Self-citationNeurotoxic reactive astrocytes induce cell death via saturated lipids
Guttenplan, K. A., Weigel, M. K., Prakash, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U., Münch, A. E., Blum, J. A., Fine, J., Neal, M. C., et al. (2021) · Nature · doi:10.1038/s41586-021-03960-y · Cited by 578 · see citing works
Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works
Self-citationCholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
Self-citationCholesterol homeostasis and function in neurons of the central nervous system
Pfrieger, F. W. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3018-7 · Cited by 453 · see citing works
Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?
Pfrieger, F. W. (2003) · BioEssays · doi:10.1002/bies.10195 · Cited by 308 · see citing works
DeMattos, R. B., O'dell, M. A., Parsadanian, M., Taylor, J. W., Harmony, J. A. K., Bales, K. R., Paul, S. M., Aronow, B. J., & Holtzman, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162228299 · Cited by 359 · see citing works
Self-citationHuman<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works
Self-citationAchariyar, T. M., Li, B., Peng, W., Verghese, P. B., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takano, T., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0138-8 · Cited by 250 · see citing works
Self-citationWhat are lipoproteins doing in the brain?
Wang, H., & Eckel, R. H. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.003 · Cited by 234 · see citing works
Clusterin: A forgotten player in Alzheimer's disease
Nuutinen, T., Suuronen, T., Kauppinen, A., & Salminen, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.007 · Cited by 267 · see citing works
Apolipoproteins in the brain: implications for neurological and psychiatric disorders
Elliott, D. A., Weickert, C. S., & Garner, B. (2010) · Clinical Lipidology · doi:10.2217/clp.10.37 · Cited by 196 · see citing works
Simpson, J. E., Ince, P. G., Shaw, P. J., Heath, P. R., Raman, R., Garwood, C. J., Gelsthorpe, C., Baxter, L., Forster, G., Matthews, F. E., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.04.013 · Cited by 188 · see citing works
ApoE Lipidation as a therapeutic target in Alzheimer’s disease
Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189 · see citing works
Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works
Apolipoprotein E and cholesterol in aging and disease in the brain
de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works
Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J. A., Li, Y., Schmidt, S. D., Mathews, P. M., Fryer, J. D., Holtzman, D. M., Sigurdsson, E. M., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63355-x · Cited by 154 · see citing works
Self-citationMammalian P4-ATPases and ABC transporters and their role in phospholipid transport
Coleman, J. A., Quazi, F., & Molday, R. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.10.006 · Cited by 154 · see citing works
Huang, Y.-W. A., Zhou, B., Nabet, A. M., Wernig, M., & Südhof, T. C. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2994-18.2019 · Cited by 152 · see citing works
Mielke, M. M., & Lyketsos, C. G. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8121-y · Cited by 141 · see citing works
Huynh, T.-P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0337-1 · Cited by 139 · see citing works
Self-citationFryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139 · see citing works
Self-citationIn Vivo Effects of ApoE and Clusterin on Amyloid-β Metabolism and Neuropathology
Holtzman, D. M. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:247 · Cited by 138 · see citing works
Self-citationMorikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E., Schindler, S. E., Demattos, R. B., Odell, M., Fagan, A. M., Lashuel, H. A., Walz, T., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.11.005 · Cited by 136 · see citing works
Self-citationExpression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia
Karten, B., Campenot, R. B., Vance, D. E., & Vance, J. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508915200 · Cited by 136 · see citing works
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., Landreth, G. E., Castellano, J. M., Jiang, H., Cirrito, J. R., et al. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-13 · Cited by 128 · see citing works
Self-citationFitz, N. F., Nam, K. N., Wolfe, C. M., Letronne, F., Playso, B. E., Iordanova, B. E., Kozai, T. D. Y., Biedrzycki, R. J., Kagan, V. E., Tyurina, Y. Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23762-0 · Cited by 129 · see citing works
Self-citationNovel Role for Apolipoprotein E in the Central Nervous System
Han, X., Cheng, H., Fryer, J. D., Fagan, A. M., & Holtzman, D. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212340200 · Cited by 126 · see citing works
Self-citationABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
Boehm-Cagan, A., Bar, R., Liraz, O., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160467 · Cited by 116 · see citing works
Dhiman, K., Blennow, K., Zetterberg, H., Martins, R. N., & Gupta, V. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03040-5 · Cited by 114 · see citing works
Cheng, H., Jiang, X., & Han, X. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04342.x · Cited by 113 · see citing works
Self-citationNutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet
Seneff, S., Wainwright, G., & Mascitelli, L. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.12.017 · Cited by 108 · see citing works
Zhao, L., Gottesdiener, A. J., Parmar, M., Li, M., Kaminsky, S. M., Chiuchiolo, M. J., Sondhi, D., Sullivan, P. M., Holtzman, D. M., Crystal, R. G., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.020 · Cited by 107 · see citing works
Self-citationEffect of Different Anti-Aβ Antibodies on Aβ Fibrillogenesis as Assessed by Atomic Force Microscopy
Legleiter, J. A., Czilli, D. L., Gitter, B. D., Demattos, R. B., Holtzman, D. M., & Kowalewski, T. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.11.019 · Cited by 104 · see citing works
Self-citationThe cell biology of APOE in the brain
Windham, I. A., & Cohen, S. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.09.004 · Cited by 103 · see citing works
Brodbeck, J., McGuire, J., Liu, Z., Meyer-Franke, A., Balestra, M. E., Jeong, D.-E., Pleiss, M., McComas, C., Hess, F., Witter, D., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217380 · Cited by 113 · see citing works
Impact of Apolipoprotein E on Alzheimer’s Disease
Hauser, P. S., & Ryan, R. O. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990156 · Cited by 101 · see citing works
Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases
Petrov, A. M., & Pikuleva, I. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00731-6 · Cited by 101 · see citing works
Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans
Farooqui, A. A., Ong, W., Horrocks, L. A., Chen, P., & Farooqui, T. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.004 · Cited by 100 · see citing works
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease
Dorey, E., Chang, N., Liu, Q. Y., Yang, Z., & Zhang, W. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1422-z · Cited by 99 · see citing works
The Blood–Brain Barrier in Alzheimer's Disease
Sharma, H. S., Castellani, R. J., Smith, M. A., & Sharma, A. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00003-x · Cited by 102 · see citing works
Chen, F., Swartzlander, D. B., Ghosh, A., Fryer, J. D., Wang, B., & Zheng, H. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00426-7 · Cited by 99 · see citing works
Self-citationHigh-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease
Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works
Apolipoprotein E4 Allele Presence and Functional Outcome after Severe Traumatic Brain Injury
Alexander, S. A., Kerr, M. E., Kim, Y., Kamboh, M. I., Beers, S. R., & Conley, Y. P. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0133 · Cited by 96 · see citing works
The CLU-files: disentanglement of a mystery
Rohne, P., Prochnow, H., & Koch-Brandt, C. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0026 · Cited by 94 · see citing works
Jacobsen, J. S., Reinhart, P. H., & Pangalos, M. N. (2005) · NeuroRx · doi:10.1602/neurorx.2.4.612 · Cited by 92 · see citing works
Han, X. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04708.x · Cited by 101 · see citing works
Self-citationLipoproteins in the Central Nervous System: From Biology to Pathobiology
Raulin, A.-C., Martens, Y. A., & Bu, G. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104801 · Cited by 89 · see citing works
George, A. J., Holsinger, R. M. D., McLean, C., Laughton, K. M., Beyreuther, K. T., Evin, G. M., Masters, C. L., & Li, Q. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.009 · Cited by 83 · see citing works
Molecular biology of apolipoprotein E
Strittmatter, W. J., & Hill, C. B. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00002 · Cited by 80 · see citing works
Lipid Metabolism and Glial Lipoproteins in the Central Nervous System
Hayashi, H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.453 · Cited by 80 · see citing works
Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid
Heinsinger, N. M., Gachechiladze, M. A., & Rebeck, G. W. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw067 · Cited by 74 · see citing works
Aβ42 neurotoxicity in primary co-cultures: effect of apoE isoform and Aβ conformation
Manelli, A. M., Bulfinch, L. C., Sullivan, P. M., & LaDu, M. J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.024 · Cited by 72 · see citing works
Self-citationLCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
Hirsch‐Reinshagen, V., Donkin, J. J., Stukas, S. K., Chan, J., Wilkinson, A., Fan, J., Parks, J. S., Kuivenhoven, J. A., ̈tjohann, D. L., Pritchard, H., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800584-jlr200 · Cited by 72 · see citing works
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
Fitz, N. F., Wolfe, C. M., Playso, B. E., Biedrzycki, R. J., Lu, Y., Nam, K. N., Lefterov, I., & Koldamova, R. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00394-4 · Cited by 68 · see citing works
Kang, M. K., Lee, J., Nguyen, A. H., & Sim, S. J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.05.017 · Cited by 69 · see citing works
The role of apolipoprotein E in lipid metabolism in the central nervous system
Han, X. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4009-z · Cited by 69 · see citing works
Self-citationKatsouri, L., Vizcaychipi, M. P., McArthur, S., Harrison, I. F., Suárez‐Calvet, M., Lleó, A., Lloyd, D. G., Ma, D., & Sastre, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.010 · Cited by 66 · see citing works
Hubin, E., Verghese, P. B., van Nuland, N., & Broersen, K. (2019) · FEBS Letters · doi:10.1002/1873-3468.13428 · Cited by 73 · see citing works
Apolipoprotein E protects cultured pericytes and astrocytes from D-Aβ1–40-mediated cell death
Bruinsma, I. B., Wilhelmus, M. M. M., Kox, M., Veerhuis, R., de Waal, R. M. W., & Verbeek, M. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.12.039 · Cited by 58 · see citing works
ApoE-Dependent Plasticity in Alzheimer's Disease
Teter, B. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:167 · Cited by 56 · see citing works
DeMattos, R. B. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:255 · Cited by 55 · see citing works
Self-citationSpagnuolo, M. S., Donizetti, A., Iannotta, L., Aliperti, V., Cupidi, C., Bruni, A. C., & Cigliano, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26480 · Cited by 52 · see citing works
de Retana, S. F., Marazuela, P., Solé, M., Colell, G., Bonaterra‐Pastra, A., Sánchez‐Quesada, J. L., Montaner, J., Maspoch, D., Cano‐Sarabia, M., & Hernández‐Guillamón, M. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0498-8 · Cited by 53 · see citing works
HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective
Chu, Q., Diedrich, J. K., Vaughan, J. M., Donaldson, C. J., Nunn, M. F., Lee, K.-F., & Saghatelian, A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b03463 · Cited by 46 · see citing works
Han, X. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8092-x · Cited by 47 · see citing works
Self-citationLambert, J., Luedecking‐Zimmer, E., Merrot, S., Hayes, A., Thaker, U., Desai, P., Houzet, A., Hermant, X., Cottel, D., Pritchard, A. L., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.6.424 · Cited by 46 · see citing works
A multi‐hit hypothesis for an <i>APOE4</i> ‐dependent pathophysiological state
Steele, O. G., Stuart, A. C., Minkley, L., Shaw, K., Bonnar, O., Anderle, S., Penn, A. C., Rusted, J., Serpell, L., Hall, C., et al. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15685 · Cited by 44 · see citing works
ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke
Cui, X., Chopp, M., Zhang, Z., Li, R., Zacharek, A., Landschoot‐Ward, J., Venkat, P., & Chen, J. (2016) · Stroke · doi:10.1161/strokeaha.116.015592 · Cited by 45 · see citing works
Bentley, N. M., LaDu, M. J., Rajan, C., Getz, G. S., & Reardon, C. A. (2002) · Biochemical Journal · doi:10.1042/bj20020207 · Cited by 43 · see citing works
Function and Comorbidities of Apolipoprotein E in Alzheimer′s Disease
Leduc, V., Domenger, D., Beaumont, L. D., Lalonde, D., Jasmin, S. B., & Poirier, J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/974361 · Cited by 45 · see citing works
Qi, X.-M., Wang, C., Chu, X., Li, G., & Ma, J. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0402-7 · Cited by 43 · see citing works
Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders
Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54 · see citing works
Raman, S., Brookhouser, N., & Brafman, D. A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104788 · Cited by 40 · see citing works
Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function
Minagawa, H., Watanabe, A., Akatsu, H., Adachi, K., Ohtsuka, C., Terayama, Y., Hosono, T., Takahashi, S., Wakita, H., Jung, C.-G., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146258 · Cited by 40 · see citing works
In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins
Legleiter, J. A., Demattos, R. B., Holtzman, D. M., & Kowalewski, T. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2004.05.009 · Cited by 38 · see citing works
Self-citationSharman, M. J., Shui, G., Fernandis, A. Z., Lim, W. L. F., Berger, T., Hone, E., Taddei, K., Martins, I. J., Ghiso, J., Buxbaum, J. D., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1348 · Cited by 35 · see citing works
Gupta, V. B., Hone, E., Pedrini, S., Doecke, J. D., O’Bryant, S. E., JAMES, I. R., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D. J., et al. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.04.003 · Cited by 35 · see citing works
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease
Yang, Y., Keene, C. D., Peskind, E. R., Galasko, D. R., Hu, S., Cudaback, E., Wilson, A. M., Li, G., Yu, C., Montine, K. S., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000207 · Cited by 34 · see citing works
Cholesterol Balance in Prion Diseases and Alzheimer’s Disease
Hannaoui, S., Shim, S. Y., Cheng, Y. C., Corda, E., & Gilch, S. (2014) · Viruses · doi:10.3390/v6114505 · Cited by 34 · see citing works
Relation between plasma and brain lipids
Wellington, C. L., & Frikke-Schmidt, R. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000291 · Cited by 33 · see citing works
Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins
Strickland, M. R., Rau, M. J., Summers, B., Basore, K., Wulf, J., Jiang, H., Chen, Y., Ulrich, J. D., Randolph, G. J., Zhang, R., et al. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.018 · Cited by 28 · see citing works
Self-citationKloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba‐Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13877 · Cited by 33 · see citing works
Self-citationSpagnuolo, M. S., Maresca, B., Mollica, M. P., Cavaliere, G., Cefaliello, C., Trinchese, G., Esposito, M. G., Scudiero, R., Crispino, M., Abrescia, P., et al. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00212 · Cited by 33 · see citing works
Ito, J., Nagayasu, Y., Lu, R., Kheirollah, A., Hayashi, M., & Yokoyama, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400313-jlr200 · Cited by 33 · see citing works
LaDu, M. J., Munson, G. W., Jungbauer, L. M., Getz, G. S., Reardon, C. A., Tai, L. M., & Yu, C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.11.005 · Cited by 32 · see citing works
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
Levi, O., Lütjohann, D., Devir, A., von Bergmann, K., Hartmann, T., & Michaelson, D. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03441.x · Cited by 33 · see citing works
Matsuo, M., Campenot, R. B., Vance, D. E., Ueda, K., & Vance, J. E. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.10.004 · Cited by 30 · see citing works
Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins
Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166195 · Cited by 29 · see citing works
Legleiter, J. A., Fryer, J. D., Holtzman, D. M., & Kowalewski, T. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn2000475 · Cited by 28 · see citing works
Self-citationDafnis, I., Raftopoulou, C., Mountaki, C., Megalou, E. V., Zannis, V. I., & Chroni, A. (2018) · Biochemical Journal · doi:10.1042/bcj20180068 · Cited by 29 · see citing works
TDP-43: A new player on the AD field?
Youmans, K. L., & Wolozin, B. L. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.018 · Cited by 28 · see citing works
Hajny, S., & Christoffersen, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081636 · Cited by 28 · see citing works
A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers
Wellnitz, S., Friedlein, A., Bonanni, C., Anquez, V., Goepfert, F., Loetscher, H., Adessi, C., & Czech, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03295.x · Cited by 26 · see citing works
Axl receptor tyrosine kinase is a regulator of apolipoprotein E
Zhao, W., Fan, J., Kulic, I., Koh, C., Clark, A., Meuller, J., Engkvist, O., Barichievy, S., Raynoschek, C., Hicks, R., et al. (2020) · Molecular Brain · doi:10.1186/s13041-020-00609-1 · Cited by 25 · see citing works
Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes
Fan, J., Zareyan, S., Zhao, W., Shimizu, Y., Pfeifer, T. A., Tak, J., Isman, M. B., den Hoven, B. G. V., Duggan, M. E., Wood, M. W., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162384 · Cited by 24 · see citing works
Clusterin/apolipoprotein J, its isoforms and Alzheimer's disease
Milinkeviciute, G., & Green, K. N. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1167886 · Cited by 24 · see citing works
Kara, E., Marks, J. D., Fan, Z., Klickstein, J. A., Roe, A. D., Krogh, K. A., Wegmann, S., Maesako, M., Luo, C. C., Mylvaganam, R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784264 · Cited by 23 · see citing works
- Authors
- DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Duke University (US)
- Corresponding author
- Holtzman, David M
- ORCID
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 39
- Issue
- 5-6
- Pages
- 415-425
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2017404389
- Cited by
- 180
- References
- 74
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 13 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 8
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- National Institute on Aging (AG00861, AG 05681, P50AG005681, AG13956)
- National Institute of General Medical Sciences (GM29647, R01GM029647)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E, clusterin, astrocytes, lipoprotein secretion, APOE ε4, APOE3, Alzheimer's disease, high-density lipoprotein, lipoprotein particle size, phospholipid composition, ethanolamine glycerophospholipids, cerebrospinal fluid
- MeSH terms
- Animals, Apolipoproteins E, Astrocytes, Cells, Cultured, Glycoproteins, Humans, Lipids, Lipoproteins, Lipoproteins, HDL, Mice, Transgenic, Particle Size, Phospholipids, Reference Values, Molecular Chaperones, Clusterin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review