Chen, Jiandong

The Cell–Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

Chen, J. (2016) · Cold Spring Harbor Perspectives in Medicine

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 1,222

MDM2 suppresses p73 function without promoting p73 degradation

Zeng, X., Chen, L., Jost, C. A., Maya, R., Keller, D., Wang, X., Kaelin, W. G., Oren, M., Chen, J., & Lu, H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 334

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S., & Chen, J. (2005) · The EMBO Journal

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 260

MDM2 promotes ubiquitination and degradation of MDMX

Pan, Y., & Chen, J. (2003) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 246

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin

Hu, B., Gilkes, D. M., Farooqi, B., Sebti, S. M., & Chen, J. (2006) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 236

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Phan, J., Li, Z., Kasprzak, A., Li, B., Sebti, S., Guida, W., Schönbrunn, E., & Chen, J. (2010) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysProtein Structure and Dynamics

Cited by 173

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

Cheng, Q., Chen, L., Li, Z., Lane, W. S., & Chen, J. (2009) · The EMBO Journal

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 165

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

Zhang, M., Xiang, S., Joo, H.-Y., Wang, L., Williams, K. A., Liu, W., Hu, C., Tong, D., Haakenson, J., Wang, C., et al. (2014) · Molecular Cell

DNA Repair MechanismsHistone Deacetylase Inhibitors Research

Cited by 151

MDMX regulation of p53 response to ribosomal stress

Gilkes, D. M., Chen, L., & Chen, J. (2006) · The EMBO Journal

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 142

MDM2-ARF complex regulates p53 sumoylation

Chen, L., & Chen, J. (2003) · Oncogene

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 134

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal

Cancer-related Molecular Pathways14-3-3 protein interactions

Cited by 122

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

Chen, L., Marechal, V., Moreau, J., Levine, A. J., & Chen, J. (1997) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 121

Regulation of p53-MDMX interaction by casein kinase 1 alpha

Chen, L., Li, C., Pan, Y., & Chen, J. (2005) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 88

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Muppidi, A., Wang, Z., Li, X., Chen, J., & Lin, Q. (2011) · Chemical Communications

Chemical Synthesis and AnalysisRNA Interference and Gene Delivery

Cited by 87

Regulation of MDMX Expression by Mitogenic Signaling

Gilkes, D. M., Pan, Y., Coppola, D., Yeatman, T., Reuther, G. W., & Chen, J. (2008) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 82

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

Wei, X., Wu, S., Song, T., Chen, L., Gao, M., Borcherds, W., Daughdrill, G. W., & Chen, J. (2016) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 50

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.

Tang, J., Agrawal, T., Cheng, Q., Qu, L., Brewer, M. D., Chen, J., & Yang, X. (2013) · PLoS ONE

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 28

The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

Cheng, Q., & Chen, J. (2011) · Cell Cycle

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 21

Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction

Muppidi, A., Li, X., Chen, J., & Lin, Q. (2011) · Bioorganic & Medicinal Chemistry Letters

Chemical Synthesis and AnalysisCancer-related Molecular Pathways

Cited by 16