Südhof, Thomas C.

A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

Butz, S., Okamoto, M., & Südhof, T. C. (1998) · Cell

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 548

Snares and Munc18 in synaptic vesicle fusion

Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 539

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 528

β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs

Rhee, J.-S., Betz, A., Pyott, S., Reim, K., Varoqueaux, F., Augustin, I., Hesse, D., Südhof, T. C., Takahashi, M., Rosenmund, C., et al. (2002) · Cell

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 500

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 480

Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

Rothwell, P. E., Fuccillo, M. V., Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., Fowler, S. C., Malenka, R. C., & Südhof, T. C. (2014) · Cell

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 477

A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins

Boucard, A. A., Chubykin, A. A., Comoletti, D., Taylor, P., & Südhof, T. C. (2005) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 470

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Südhof, T. C., & Powell, C. M. (2010) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 450

Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 447

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H.-B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E., et al. (2004) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 438

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

Gokce, O., Stanley, G. M., Treutlein, B., Neff, N. F., Camp, J. G., Malenka, R. C., Rothwell, P. E., Fuccillo, M. V., Südhof, T. C., & Quake, S. R. (2016) · Cell Reports

Single-cell and spatial transcriptomicsNeuroscience and Neuropharmacology Research

Cited by 430

Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release

Betz, A., Ashery, U., Rickmann, M., Augustin, I., Neher, E., Südhof, T. C., Rettig, J., & Brose, N. (1998) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 425

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

Brose, N., Hofmann, K., Hata, Y., & Südhof, T. C. (1995) · Journal of Biological Chemistry

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 412

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

Davis, C. G., Goldstein, J. L., Südhof, T. C., Anderson, R. G. W., Russell, D. W., & Brown, M. S. (1987) · Nature

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 411

Munc18-1 Promotes Large Dense-Core Vesicle Docking

Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron

Cellular transport and secretionExtracellular vesicles in disease

Cited by 396

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 389

RIM1α is required for presynaptic long-term potentiation

Castillo, P. E., Schoch, S., Schmitz, F., Südhof, T. C., & Malenka, R. C. (2002) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 389

The cell biology of synapse formation

Südhof, T. C. (2021) · Journal of Cell Biology

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 358

A dual-Ca2+-sensor model for neurotransmitter release in a central synapse

Sun, J., Pang, Z. P., Qin, D., Fahim, A. T., Adachi, R., & Südhof, T. C. (2007) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 357

RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone

Han, Y., Kaeser, P. S., Südhof, T. C., & Schneggenburger, R. (2011) · Neuron

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 354

Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing

Treutlein, B., Gokce, O., Quake, S. R., & Südhof, T. C. (2014) · Proceedings of the National Academy of Sciences

RNA Research and SplicingNeuroscience and Neuropharmacology Research

Cited by 348

Generation of pure GABAergic neurons by transcription factor programming

Yang, N., Chanda, S., Marro, S., Ng, Y.-H., Janas, J. A., Haag, D., Ang, C. E., Tang, Y., Flores, Q., Mall, M., et al. (2017) · Nature Methods

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 341

Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons

Xu, J., Mashimo, T., & Südhof, T. C. (2007) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 336

Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons

Yi, F., Danko, T., Botelho, S. C., Patzke, C., Pak, C., Wernig, M., & Südhof, T. C. (2016) · Science

Genetics and Neurodevelopmental DisordersIon channel regulation and function

Cited by 313