RIM1α is required for presynaptic long-term potentiation
Abstract
Two main forms of long-term potentiation (LTP)-a prominent model for the cellular mechanism of learning and memory-have been distinguished in the mammalian brain. One requires activation of postsynaptic NMDA (N-methyl d-aspartate) receptors, whereas the other, called mossy fibre LTP, has a principal presynaptic component. Mossy fibre LTP is expressed in hippocampal mossy fibre synapses, cerebellar parallel fibre synapses and corticothalamic synapses, where it apparently operates by a mechanism that requires activation of protein kinase A. Thus, presynaptic substrates of protein kinase A are probably essential in mediating this form of long-term synaptic plasticity. Studies of knockout mice have shown that the synaptic vesicle protein Rab3A is required for mossy fibre LTP, but the protein kinase A substrates rabphilin, synapsin I and synapsin II are dispensable. Here we report that mossy fibre LTP in the hippocampus and the cerebellum is abolished in mice lacking RIM1alpha, an active zone protein that binds to Rab3A and that is also a protein kinase A substrate. Our results indicate that the long-term increase in neurotransmitter release during mossy fibre LTP may be mediated by a unitary mechanism that involves the GTP-dependent interaction of Rab3A with RIM1alpha at the interface of synaptic vesicles and the active zone.
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In vertebrates, RIM1α is required for all types of long-term presynaptic plasticity analyzed.
“In vertebrates, RIM1α is additionally required for all types of long-term presynaptic plasticity analyzed (Castillo et al., 2002; Huang et al., 2005; Chevaleyre et al., 2007; Fourcaudot et al., 2008; Pelkey et al., 2008; Lachamp et al., 2009).”
From The Presynaptic Active Zone (2012) · cites this paper as Castillo et al., 2002
All forms of presynaptic long-term plasticity investigated-both LTP and LTD-are blocked by the constitutive knockout of RIM1α.
“Strikingly, up to now all forms of presynaptic long-term plasticity investigated—both long-term potentiation (LTP) and long-term depression (LTD)—are blocked by the constitutive knockout of RIM1α (which only partly impairs basal release since all other RIM isoforms are still present), suggesting that the amount of RIM1α available at a synapse is crucial (Castillo et al., 2002; Chevaleyre et al., 2”
From The Presynaptic Active Zone (2012) · cites this paper as Castillo et al., 2002
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- Authors
- Castillo, P. E., Schoch, S., Schmitz, F., Südhof, T. C., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 2002-01
- Volume
- 415
- Issue
- 6869
- Pages
- 327-330
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2051524905
- Cited by
- 389
- References
- 29
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 18 · 2016: 5 · 2015: 14 · 2014: 13 · 2013: 24 · 2012: 16
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Rab3A, active zone, synaptic vesicles, hippocampus, cerebellum, neurotransmitter release, synaptic plasticity, synapsin
- MeSH terms
- Animals, Cerebellum, Guanosine Triphosphate, Hippocampus, Nerve Fibers, Nerve Tissue Proteins, Purkinje Cells, Synaptic Vesicles, Presynaptic Terminals, Long-Term Potentiation, Neurotransmitter Agents, GTP-Binding Proteins, Mossy Fibers, Hippocampal, Mice, In Vitro Techniques
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