Guarente, Leonard

Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase

Liszt, G., Ford, E., Kurtev, M., & Guarente, L. (2005) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineNuclear Structure and Function

Cited by 548

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Guarente, L. (2008) · Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 513

Sirtuins, Aging, and Medicine

Guarente, L. (2011) · New England Journal of Medicine

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 510

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell

Nitric Oxide and Endothelin EffectsSirtuins and Resveratrol in Medicine

Cited by 496

Sirtuins as potential targets for metabolic syndrome

Guarente, L. (2006) · Nature

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 468

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes & Development

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 464

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 462

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 440

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell

Genomics and Chromatin DynamicsFungal and yeast genetics research

Cited by 435

Genetics and the Specificity of the Aging Process

Hekimi, S., & Guarente, L. (2003) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 434

Increase in Activity During Calorie Restriction Requires Sirt1

Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 419

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

Sinclair, D. A., Mills, K., & Guarente, L. (1997) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 401

It takes two to tango: NAD(+) and sirtuins in aging/longevity control

Imai, S.-I., & Guarente, L. (2016) · npj Aging and Mechanisms of Disease

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 394

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae

Kennedy, B. K., Gotta, M., Sinclair, D. A., Mills, K., McNabb, D. S., Murthy, M., Pak, S. M., Laroche, T., Gasser, S. M., & Guarente, L. (1997) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 375

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Fendt, S.-M., Bell, E. L., Keibler, M. A., Olenchock, B. A., Mayers, J. R., Wasylenko, T. M., Vokes, N. I., Guarente, L., Heiden, M. G. V., & Stephanopoulos, G. (2013) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 364

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation

Sirtuins and Resveratrol in MedicineChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 358

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

Mills, K. D., Sinclair, D. A., & Guarente, L. (1999) · Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 334

Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae

Smeal, T., Claus, J., Kennedy, B., Cole, F., & Guarente, L. (1996) · Cell

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 308

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

Marcus, G. A., Silverman, N., Berger, S. L., Horiuchi, J., & Guarente, L. (1994) · The EMBO Journal

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 276

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C., & Guarente, L. (2001) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 269

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

Wellman, A. S., Metukuri, M. R., Kazgan, N., Xu, X., Xu, Q., Ren, N. S. X., Czopik, A., Shanahan, M. T., Kang, A., Chen, W., et al. (2017) · Gastroenterology

Gut microbiota and healthSirtuins and Resveratrol in Medicine

Cited by 191

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., et al. (2000) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 187

Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts

Blander, G., de Oliveira, R. M., Conboy, C. M., Haigis, M., & Guarente, L. (2003) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 183

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2017) · npj Aging and Mechanisms of Disease

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 181