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Roles of NAD + in Health and AgingPreprint

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PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All

Lloret, A., & Beal, M. F. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02809-1 · Cited by 52 · see citing works

Clinical Trials Targeting Aging

Nielsen, J. L., Bakula, D., & Scheibye‐Knudsen, M. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.820215 · Cited by 51 · see citing works

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Dellinger, R. W., Holmes, H. E., Hu-Seliger, T. T., Butt, R. W., Harrison, S. A., Mozaffarian, D., Chen, O., & Guarente, L. (2022) · Hepatology · doi:10.1002/hep.32778 · Cited by 49 · see citing works

Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process

Khaidizar, F. D., Bessho, Y., & Nakahata, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073709 · Cited by 48 · see citing works

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

Pencina, K. M., Valderrábano, R. J., Wipper, B., Orkaby, A. R., Reid, K. F., Storer, T. W., Lin, A. P., Merugumala, S. K., Wilson, L. A., Latham, N. K., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad027 · Cited by 47 · see citing works

Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns

Bhasin, S., Seals, D. R., Migaud, M. E., Musi, N., & Baur, J. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad019 · Cited by 47 · see citing works

Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?

Zainabadi, K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.007 · Cited by 47 · see citing works

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice

Obrador, E., Palmer, R. S., Marchio, P., López‐Blanch, R., Jihad-Jebbar, A., Rivera, P., Vallés, S. L., Banacloche, S., Alcácer, J., Colomer, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02188-7 · Cited by 46 · see citing works

Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis

Zhong, O., Wang, J., Tan, Y., Lei, X., & Tang, Z. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00653-9 · Cited by 46 · see citing works

Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial

Norheim, K. L., Ezra, M. B., Heckenbach, I., Andreasson, L. M., Eriksen, L. L., Dyhre‐Petersen, N., Damgaard, M. V., Berglind, M., Pricolo, L., Sampson, D. L., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00758-1 · Cited by 45 · see citing works

Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration

Jadeja, R. N., Thounaojam, M. C., Bartoli, M., & Martin, P. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2692794 · Cited by 43 · see citing works

Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise

Stocks, B., Ashcroft, S. P., Joanisse, S., Dansereau, L. C., Koay, Y. C., Elhassan, Y., Lavery, G. G., Quek, L., O’Sullivan, J., Philp, A. M., et al. (2021) · The Journal of Physiology · doi:10.1113/jp280825 · Cited by 43 · see citing works

Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications

Jha, N. K., Jha, N. K., Nuli, M. V., Gupta, S. K., Kanna, S., Gahtani, R. M., Hani, U., Singh, A. K., Abomughaid, M. M., Abomughayedh, A. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102224 · Cited by 42 · see citing works

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Biţă, A., Scorei, I. R., Ciocîlteu, M. V., Nicolaescu, O. E., Pîrvu, A. S., Bejenaru, L. E., Rău, G., Bejenaru, C., Radu, A., Neamţu, J., et al. (2023) · Molecules · doi:10.3390/molecules28166078 · Cited by 41 · see citing works

Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

Šimić, P., Parada, X. F. V., Parikh, S. M., Dellinger, R. W., Guarente, L., & Rhee, E. P. (2020) · BMC Nephrology · doi:10.1186/s12882-020-02006-1 · Cited by 41 · see citing works

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

Dall, M., Trammell, S. A. J., Asping, M., Hassing, A. S., Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, S., & Treebak, J. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006756 · Cited by 40 · see citing works

A systems-approach to NAD+ restoration

Conlon, N. J., & Ford, D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114946 · Cited by 40 · see citing works

A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals

Jensen, J. B., Dollerup, O. L., Møller, A. B., Billeskov, T. B., Dalbram, E., Chubanava, S., Damgaard, M. V., Dellinger, R. W., Trošt, K., Moritz, T., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158314 · Cited by 39 · see citing works

Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies

Poljšak, B., Kovač, V., & Milisav, I. (2022) · Antioxidants · doi:10.3390/antiox11091637 · Cited by 39 · see citing works

Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline

Dutta, B. J., Rakshe, P. S., Maurya, N., Chib, S., & Singh, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102125 · Cited by 39 · see citing works

Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B

Zhang, Z., Hamada, H., & Gerk, P. M. (2019) · BioMed Research International · doi:10.1155/2019/8361858 · Cited by 39 · see citing works

The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

Fletcher, R. S., & Lavery, G. G. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0085 · Cited by 39 · see citing works

A Method to Monitor the NAD+ Metabolome—From Mechanistic to Clinical Applications

Giner, M. P., Christen, S., Bártová, S., Makarov, M. V., Migaud, M. E., Cantó, C., & Moco, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910598 · Cited by 37 · see citing works

A Novel, Extremely Bioavailable Cocrystal of Pterostilbene

Bofill, L., Barbas, R., de Sande, D., Font‐Bardía, M., Ràfols, C., Alberti, J. J., & Prohens, R. (2021) · Crystal Growth & Design · doi:10.1021/acs.cgd.0c01716 · Cited by 36 · see citing works

Benefits of Resveratrol and Pterostilbene to Crops and Their Potential Nutraceutical Value to Mammals

Duke, S. O. (2022) · Agriculture · doi:10.3390/agriculture12030368 · Cited by 34 · see citing works

NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

Xu, W., Li, L., & Zhang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00901 · Cited by 33 · see citing works

Ageing and longevity genes in cardiovascular diseases

Liberale, L., Kraler, S. C., Camici, G. G., & Lüscher, T. F. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13426 · Cited by 33 · see citing works

NAD+ precursor supplementation in human ageing: clinical evidence and challenges

Vinten, K. T., Trętowicz, M. M., Coskun, E., van Weeghel, M., Cantó, C., Perez, R. Z., Janssens, G. E., & Houtkooper, R. H. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01387-7 · Cited by 32 · see citing works

NAD + Precursors in Human Health and Disease: Current Status and Future Prospects

Yaku, K., & Nakagawa, T. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0354 · Cited by 31 · see citing works

Host NAD+ metabolism and infections: therapeutic implications

Singhal, A., & Cheng, C. Y. (2018) · International Immunology · doi:10.1093/intimm/dxy068 · Cited by 30 · see citing works

Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+

Ratia, K. M., Shen, Z., Gordon-Blake, J. M., Lee, H., Laham, M. S., Krider, I. S., Christie, N., Ackerman-Berrier, M. S., Penton, C., Knowles, N. G., et al. (2023) · Biochemistry · doi:10.1021/acs.biochem.2c00655 · Cited by 30 · see citing works

Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death

Reddy, V. G., Krider, I. S., Alves, E. T. M., Courey, J. M., Laham, M. S., & Thatcher, G. R. J. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02112 · Cited by 27 · see citing works

Vitamin B3 forms as precursors to NAD+: Are they safe?

Poljšak, B., & Milisav, I. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.07.020 · Cited by 27 · see citing works

Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease

Maria Jose Perez, J., Baden, P., & Deleidi, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111499 · Cited by 25 · see citing works

NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

Chanvillard, L., Tammaro, A., & Sorrentino, V. (2022) · Cells · doi:10.3390/cells12010021 · Cited by 25 · see citing works

The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

Zhang, X., Zhang, Y., Sun, A., & Ge, J. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.04.001 · Cited by 23 · see citing works

Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging

Osipova, E. D., Komleva, Y. K., Morgun, A. V., Lopatina, O. L., Panina, Y. A., Olovyannikova, R. Y., Vais, E. F., Salmin, V. V., & Salmina, A. B. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00234 · Cited by 23 · see citing works

NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis

Obrador, E., Palmer, R. S., López‐Blanch, R., Dellinger, R. W., & Estrela, J. M. (2021) · Biomedicines · doi:10.3390/biomedicines9081000 · Cited by 22 · see citing works

A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Takanashi, Y., Tamannaa, Z., Kitamoto, T., Odagiri, K., & Setou, M. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.09.001 · Cited by 21 · see citing works

Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs)

Shen, Z., Ratia, K. M., Krider, I. S., Ackerman-Berrier, M. S., Penton, C., Musku, S. R., Gordon-Blake, J. M., Laham, M. S., Christie, N., Ma, N., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01406 · Cited by 21 · see citing works

A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease

Kim, S., Miller, B., Hartel, N. G., Ramírez, R., Braniff, R. G., Leelaprachakul, N., Huang, A., Wang, Y., Arpawong, T. E., Crimmins, E. M., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02344-0 · Cited by 21 · see citing works

Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases

Ungvari, A., Gulej, R., Patai, R., Papp, Z., Tóth, A., Szabó, A. Á., Podesser, B. K., Sótonyi, P., Benyó, Z., Yabluchanskiy, A., et al. (2025) · GeroScience · doi:10.1007/s11357-024-01489-2 · Cited by 21 · see citing works

Effects of NAD+ supplementation with oral nicotinamide riboside on vascular health and cognitive function in older adults with peripheral artery disease: Results from a pilot 4-week open-label clinical trial

Szarvas, Z., Reyff, Z., Péterfi, A., Pinto, C. B., Owens, C. D., Kaposzta, Z., Mukli, P., Pinaffi‐Langley, A. C. D. C., Adams, C., Muranyi, M., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103607 · Cited by 19 · see citing works

Quantitation of NAD+: Why do we need to measure it?

Liu, Y., Clement, J., Grant, R., Sachdev, P. S., & Braidy, N. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.07.023 · Cited by 19 · see citing works

Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Lenherr‐Taube, N., Christodoulou, J., Duley, J. A., Dobritzsch, D., Fairbanks, L. D., Datta, A., Filges, I., Gürtler, N., Roelofsen, J., Kuilenburg, A. B. P., et al. (2021) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2021.100709 · Cited by 19 · see citing works

Potential Efficacy of Nutrient Supplements for Treatment or Prevention of COVID-19

Bogan-Brown, K. L., Nkrumah-Elie, Y. M., Ishtiaq, Y., Redpath, P., & Shao, A. E. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2021.1881686 · Cited by 19 · see citing works

Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}

Song, M., Armenian, S. H., Bhandari, R., Lee, K., Ness, K. K., Putt, M., Lindenfeld, L., Manoukian, S. B., Wade, K., Dedio, A., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09845-1 · Cited by 18 · see citing works

NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence

Gallagher, C., & Emmanuel, O. O. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103057 · Cited by 17 · see citing works

Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis

Rodríguez‐Iturbe, B., Johnson, R. J., Lanaspa, M. A., Nakagawa, T., García‐Arroyo, F. E., & Sánchez‐Lozada, L. G. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00238.2021 · Cited by 17 · see citing works

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Conze, D., Brenner, C., & Kruger, C. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46120-z · Cited by 210 · see citing works

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697 · see citing works

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Hakamata, A., Onoda, Y., Sato, S., Yamazaki, F., Horikawa, M., Takahashi, Y., Kitamoto, T., Suzuki, M., et al. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.04.002 · Cited by 16 · see citing works

Part 1 of a 2-part, open-label clinical trial evaluating repeated nicotinamide riboside parenteral administration: 3 consecutive days of intramuscular and subcutaneous injectionsPreprint

Nkrumah-Elie, Y. M., Kwon, J., Russ, A., Simpson, S., Hailu, F., Allen, T., Chen, H., & Shao, A. E. (2026) · medRxiv · doi:10.64898/2026.10.12.26365345