Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts
Open accessAbstract
Reactive oxygen species (ROS) such as superoxide radicals are responsible for the pathogenesis of various human diseases. ROS are generated during normal metabolic process in all of the oxygen-utilizing organisms. The copper-zinc-containing SOD (SOD1) acts as a major defense against ROS by detoxifying the superoxide anion. In model organisms, SOD1 has been shown to play a role in the aging process. However, the exact role of the SOD1 protein in the human aging process remains to be resolved. We show that SOD1 RNA interference (RNAi) induces senescence in normal human fibroblasts. This premature senescence depends on p53 induction. In contrast, in human fibroblastic cells with inactivated p53, the SOD1 RNAi is without effect. Surprisingly, in cancer cells (HeLa), the SOD1 RNAi induces cell death rather then senescence. Together, these findings support the notion that in normal human cells the SOD1 protein may play a role in the regulation of cellular lifespan by p53 and may also regulate the death signals in cancer cells.
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Suppressed activity of antioxidant enzymes and increased levels of hydrogen peroxide trigger premature senescence in human fibroblasts.
“The suppressed activity of antioxidant enzymes and increased levels of hydrogen peroxide have been found to trigger premature senescence in human fibroblasts (Blander et al. 2003).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Blander et al. 2003
Oxidative stress is an important factor responsible for cell senescence.
“In addition, oxidative stress is another important factor responsible for cell senescence.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Blander et al. 2003
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works
Mitochondrial Superoxide Dismutase
Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43735-6 · Cited by 960 · see citing works
Rosen, D. (1993) · Nature · doi:10.1038/364362c0 · Cited by 922 · see citing works
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
Parkes, T. L., Elia, A., Dickinson, D., Hilliker, A. J., Phillips, J. P., & Boulianne, G. L. (1998) · Nature Genetics · doi:10.1038/534 · Cited by 862 · see citing works
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856 · see citing works
Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804 · see citing works
Sturtz, L. A., Diekert, K., Jensen, L. T., Lill, R., & Culotta, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105296200 · Cited by 719 · see citing works
Replicative Senescence: the Human Fibroblast Comes of Age
Goldstein, S. (1990) · Science · doi:10.1126/science.2204114 · Cited by 651 · see citing works
Regulation of the p53 Tumor Suppressor Protein
Oren, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36031 · Cited by 561 · see citing works
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547 · see citing works
Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae
Longo, V. D., Gralla, E. B., & Valentine, J. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12275 · Cited by 531 · see citing works
Cancer and ageing: rival demons?
Campisi, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1073 · Cited by 512 · see citing works
Harvey, D. M., & Levine, A. J. (1991) · Genes & Development · doi:10.1101/gad.5.12b.2375 · Cited by 453 · see citing works
Replicative Senescence: An Old Lives' Tale?
Campisi, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81023-5 · Cited by 434 · see citing works
Atomic structure and chemistry of human serum albumin
He, X. M., & Carter, D. C. (1993) · Nature · doi:10.1038/364362b0 · Cited by 415 · see citing works
Low oxygen concentration extends the lifespan of cultured human diploid cells
Packer, L., & FUEHR, K. (1977) · Nature · doi:10.1038/267423a0 · Cited by 393 · see citing works
Genes involved in senescence and immortalization
Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00155-1 · Cited by 313 · see citing works
Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., & Oda, K. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91403-y · Cited by 260 · see citing works
Rogan, E. M., Bryan, T. M., Hukku, B., Maclean, K. N., Chang, A. C.-M., Moy, E. L., Englezou, A., Warneford, S., Dalla‐Pozza, L., & Reddel, R. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4745 · Cited by 250 · see citing works
Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
Metz, T. M., Harris, A. W., & Adams, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90049-7 · Cited by 122 · see citing works
Antioxidant inhibitors for cancer therapy
Kong, Q., & Lillehei, K. O. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90036-6 · Cited by 122 · see citing works
BOND, J. A., Blaydes, J. P., Rowson, J., Haughton, M. F., Smith, J. R., Wynford‐Thomas, D., & Wyllie, F. S. (1995) · PubMed · Cited by 75 · see citing works
[Superoxide dismutase and catalase levels in diseases of the aged].
Casado, Á., de la Torre, R., López-Fernández, E., Carrascosa, D., & Venarucci, D. (1998) · PubMed · Cited by 15 · see citing works
Plasma and erythrocyte total antioxidant status in patients with benign and malign breast disease.
Afrasyap, L., Güvenen, G., & Türkmen, S. (1998) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Nanotechnology for Multimodal Synergistic Cancer Therapy
Fan, W., Yung, B. C., Huang, P., & Chen, X. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,804 · see citing works
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
The signals and pathways activating cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046 · see citing works
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
Mitochondria are required for pro-ageing features of the senescent phenotype
Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796 · see citing works
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
Coryell, P. R., Diekman, B. O., & Loeser, R. F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00533-7 · Cited by 761 · see citing works
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A., & Grant, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019194 · Cited by 594 · see citing works
RetractedMethods to Detect Biomarkers of Cellular Senescence
Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 516 · see citing works
DNA damage, cellular senescence and organismal ageing: causal or correlative?
Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 481 · see citing works
Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
Wondrak, G. T. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2541 · Cited by 462 · see citing works
Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
Hong, E. J., Choi, D. G., & Shim, M. S. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.01.007 · Cited by 361 · see citing works
Lu, T., & Finkel, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.011 · Cited by 327 · see citing works
Molecular Pathogenesis of Osteosarcoma
Kansara, M., & Thomas, D. M. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0505 · Cited by 273 · see citing works
Juarez, J. C., Manuia, M., Burnett, M. E., Betancourt, O., Boivin, B., Shaw, D. E., Tonks, N. K., Mazar, A. P., & Doñate, F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709451105 · Cited by 255 · see citing works
Transcriptional responses to oxidative stress: Pathological and toxicological implications
Ma, Q. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.004 · Cited by 248 · see citing works
Roles of Antioxidative Enzymes in Wound Healing
Kurahashi, T., & Fujii, J. (2015) · Journal of Developmental Biology · doi:10.3390/jdb3020057 · Cited by 249 · see citing works
Kaempferol induces apoptosis in glioblastoma cells through oxidative stress
Sharma, V., Joseph, C., Ghosh, S. K., Agarwal, A., Mishra, M. K., & Sen, E. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0788 · Cited by 244 · see citing works
The in vivo gene expression signature of oxidative stress
Han, E., Müller, F. L., Pérez, V., Qi, W., Liang, H., Liang, X., Fu, C., Doyle, E., Hickey, M., Cornell, J. E., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00239.2007 · Cited by 236 · see citing works
Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging
Ferrari, C. K. B. (2004) · Biogerontology · doi:10.1007/s10522-004-2566-z · Cited by 227 · see citing works
Hu, T., Liú, D., Chen, Y., Wu, J., & Wang, S. (2009) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.12.004 · Cited by 205 · see citing works
Foust, K. D., Salazar, D. L., Likhite, S. B., Ferraiuolo, L., Ditsworth, D., Ilieva, H. S., Meyer, K., Schmelzer, L., Braun, L., Cleveland, D. W., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.211 · Cited by 205 · see citing works
Wei, D., Chen, T., Yan, M., Zhao, W., Li, F., Cheng, W., & Yuan, L. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.02.029 · Cited by 187 · see citing works
Rai, P., Önder, T. T., Young, J. J., McFaline‐Figueroa, J. L., Pang, B., Dedon, P. C., & Weinberg, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809834106 · Cited by 180 · see citing works
Sun, H.-H., Mao, W.-J., Chen, Y., Guo, S., Li, H., Qi, X., Chen, Y., & Xu, J. F. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.04.017 · Cited by 175 · see citing works
An Overview on Natural Polysaccharides with Antioxidant Properties
Wang, H., Liu, Y., Zhou, Q., Wang, S., Liu, S., Li, X., Wang, H., & Xia, X. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320230006 · Cited by 164 · see citing works
Juarez, J. C., Betancourt, O., Pirie-Shepherd, S. R., Guan, X., Price, M. L., Shaw, D. E., Mazar, A. P., & Doñate, F. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0171 · Cited by 160 · see citing works
Chu, F., Chou, P. M., Zheng, X. S., Mirkin, B. L., & Rebbaa, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2002 · Cited by 161 · see citing works
Neuronal differentiation and long-term culture of the human neuroblastoma line SH-SY5Y
Constantinescu, R., Constantinescu, A.-T., Reichmann, H., & Janetzky, B. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_3 · Cited by 156 · see citing works
Mitochondrial function as a determinant of life span
Lanza, I. R., & Nair, K. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0724-5 · Cited by 148 · see citing works
Kim, K. S., Kang, K. W., Seu, Y. B., Baek, S., & Kim, J.-R. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.11.004 · Cited by 146 · see citing works
A new generation of proto-oncogenes: Cold-inducible RNA binding proteins
LLeonart, M. E. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.001 · Cited by 145 · see citing works
Kondoh, H., LLeonart, M. E., Bernard, D., & Gil, J. (2007) · PubMed · doi:10.14670/hh-22.85 · Cited by 142 · see citing works
Colorimetric Detection of Senescence-Associated β Galactosidase
Itahana, K., Itahana, Y., & Dimri, G. P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_8 · Cited by 135 · see citing works
Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications
Sodhi, R. K., Singh, N., & Jaggi, A. S. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.06.003 · Cited by 131 · see citing works
The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence
Mallette, F. A., & Ferbeyre, G. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4516 · Cited by 125 · see citing works
The role of cold‐inducible RNA binding protein in cell stress response
Liao, Y., Tong, L., Tang, L., & Wu, S. (2017) · International Journal of Cancer · doi:10.1002/ijc.30833 · Cited by 116 · see citing works
Genes encoding longevity: from model organisms to humans
Kuningas, M., Mooijaart, S. P., van Heemst, D., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00366.x · Cited by 115 · see citing works
Görg, B., Karababa, A., Shafigullina, A. K., Bidmon, H. J., & Häussinger, D. (2014) · Glia · doi:10.1002/glia.22731 · Cited by 115 · see citing works
Dou, J., Meng, Y., Liu, L., Li, J., Ren, D., & Guo, Y. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.053 · Cited by 106 · see citing works
Theurey, P., & Pizzo, P. (2018) · Genes · doi:10.3390/genes9010022 · Cited by 103 · see citing works
Free-radical scavenging and antioxidative activities of some polysaccharides in emulsions
Kishk, Y. F. M., & Al‐Sayed, H. M. A. (2005) · LWT · doi:10.1016/j.lwt.2005.11.004 · Cited by 101 · see citing works
A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
Morris, B. J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173509.45363.dd · Cited by 98 · see citing works
Mitochondrial longevity pathways
Vendelbo, M. H., & Nair, K. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.029 · Cited by 90 · see citing works
Li, K.-D., Liu, T., Chen, J., Ni, H.-Y., & Li, W.-H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013805 · Cited by 76 · see citing works
Mao, G., Wang, Y., Qiu, Q., Deng, H., Yuan, L.-G., Li, R., Song, D., Li, Y. Y., Li, D.-D., & Wang, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.10.003 · Cited by 90 · see citing works
Cell division drives DNA methylation loss in late-replicating domains in primary human cells
Endicott, J. L., Nolte, P. A., Shen, H., & Laird, P. W. (2022) · Nature Communications · doi:10.1038/s41467-022-34268-8 · Cited by 91 · see citing works
Ding, W., Vaught, J. L., Yamauchi, H., & Lind, S. E. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1109.3.9 · Cited by 84 · see citing works
Yanase, S., Onodera, A., Tedesco, P., Johnson, T. E., & Ishii, N. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp020 · Cited by 82 · see citing works
Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role
Javadov, S. A., Jang, S., Chapa‐Dubocq, X. R., Khuchua, Z. A., & Camara, A. K. S. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02004-8 · Cited by 73 · see citing works
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Altmeyer, M., & Hottiger, M. O. (2009) · Aging · doi:10.18632/aging.100052 · Cited by 76 · see citing works
Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence
Han, Y., Kim, H.-S., Kim, J., Kim, S., Yu, D., & Moon, E. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.049 · Cited by 73 · see citing works
Hour, T., Lai, Y., Kuan, C.-I., Chou, C., Wang, J., Tu, H.-Y., Hu, H., Lin, C., Wu, W., Pu, Y., et al. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.007 · Cited by 70 · see citing works
Formulation and characterization of α-tocopherol loaded poly ɛ-caprolactone (PCL) nanoparticles
Byun, Y., Hwang, J. B., Bang, S. H., Darby, D. O., Cooksey, K., Dawson, P., Park, H. J., & Whiteside, S. (2010) · LWT · doi:10.1016/j.lwt.2010.06.032 · Cited by 68 · see citing works
Hsu, C., Chiu, Y.-C., Hsu, W.-L., & Chan, Y.-P. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.12.1267 · Cited by 68 · see citing works
Barabutis, N., & Schally, A. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811209106 · Cited by 65 · see citing works
Rai, P. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.07.010 · Cited by 65 · see citing works
Aquilano, K., Vigilanza, P., Rotilio, G., & Ciriolo, M. R. (2006) · The FASEB Journal · doi:10.1096/fj.05-5225fje · Cited by 63 · see citing works
Montllor-Albalate, C., Colin, A. E., Chandrasekharan, B. P., Bolaji, N., Andersen, J. L., Outten, F. W., & Reddi, A. R. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.022 · Cited by 63 · see citing works
Spontaneous skin damage and delayed wound healing in SOD1-deficient mice
Iuchi, Y., Roy, D., Okada, F., Kibe, N., Tsunoda, S., Suzuki, S., Takahashi, M., Yokoyama, H., Yoshitake, J., Kondo, S., et al. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0449-y · Cited by 61 · see citing works
Cellular senescence and protein degradation
Deschênes‐Simard, X., Lessard, F., Gaumont‐Leclerc, M., Bardeesy, N. M., & Ferbeyre, G. (2014) · Cell Cycle · doi:10.4161/cc.29335 · Cited by 61 · see citing works
Targeting superoxide dismutase 1 to overcome cisplatin resistance in human ovarian cancer
Brown, D. P. G., Chin-Sinex, H., Nie, B., Mendonca, M. S., & Wang, M. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0791-x · Cited by 57 · see citing works
藤原敏宏, Dohi, T., Maan, Z. N., Rustad, K. C., Kwon, S. H., Padmanabhan, J., Whittam, A. J., D, H. S. M., Duscher, D., Rodrigues, M., et al. (2017) · Experimental Dermatology · doi:10.1111/exd.13404 · Cited by 56 · see citing works
Li, B., Xu, H., Wang, X., Wan, Y., Jiang, N., Qi, H., & Liu, X. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.061 · Cited by 56 · see citing works
Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress‐induced premature senescence
Volonté, D., & Galbiati, F. (2009) · EMBO Reports · doi:10.1038/embor.2009.215 · Cited by 54 · see citing works
Vijayaraghavan, P., Vankayala, R., Chiang, C., Sung, H., & Hwang, K. C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.039 · Cited by 53 · see citing works
Wang, C. R., Ng, T. B., Li, L., Fang, J. C., Jiang, Y., Wen, T., Qiao, W. T., Li, N., & Liu, F. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01274.x · Cited by 53 · see citing works
Yan, M., Mao, W.-J., Liu, X., Wang, S., Zheng, X., Cao, S., Li, J., Qin, L., & Xian, H.-L. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.03.090 · Cited by 51 · see citing works
Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during Senescence
Wu, J., Xue, L., Weng, M., Sun, Y., Zhang, Z., Wang, W., & Tong, T. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000164 · Cited by 50 · see citing works
Kim, H. J., Kim, K. S., Kim, S. H., Baek, S.-H., Kim, H. Y., Lee, C., & Kim, J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln055 · Cited by 50 · see citing works
Energy, quiescence and the cellular basis of animal life spans
Stuart, J. A., & Brown, M. F. (2005) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2005.11.002 · Cited by 48 · see citing works
Ki, M., Lee, H.-R., Goo, M., Hong, I., Hee, S., Jeong, D., Yang, H., Yuan, D., Park, J., & Jeong, K. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00281.2007 · Cited by 48 · see citing works
Kimura, N., Tsunoda, S., Iuchi, Y., Abé, H., Totsukawa, K., & Fujii, J. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq007 · Cited by 47 · see citing works
Asker, M. S., Ahmed, Y. M., & Ramadan, M. F. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.01.037 · Cited by 46 · see citing works
Yang, J., Dong, S., Jiang, Q., Si, Q., Liu, X., & Yang, J. (2013) · Gene · doi:10.1016/j.gene.2012.12.101 · Cited by 46 · see citing works
Regulation of replicative senescence by NADP+-dependent isocitrate dehydrogenase
Kil, I. S., Huh, T. L., Lee, Y. S., Lee, Y. M., & Park, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.021 · Cited by 44 · see citing works
ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging
Guo, Y., Guan, T., Yu, Q., Sanghai, N., Shafiq, K., Li, M., Jiao, X., Na, D., Zhang, G., & Kong, J. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102972 · Cited by 46 · see citing works
Yan, J., Wang, W., Ma, H., & Wu, J. (2012) · Molecules · doi:10.3390/molecules18010167 · Cited by 42 · see citing works
Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease
Hruby, A. J., & Higuchi‐Sanabria, R. (2025) · npj Aging · doi:10.1038/s41514-025-00291-4 · Cited by 44 · see citing works
miR-290 acts as a physiological effector of senescence in mouse embryo fibroblasts
Pitto, L., Rizzo, M., Simili, M., Colligiani, D., Evangelista, M., Mercatanti, A., Mariani, L., Cremisi, F., & Rainaldi, G. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00085.2009 · Cited by 38 · see citing works
Informatics-assisted Protein Profiling in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Lukas, T. J., Luo, W., Mao, H., Cole, N., & Siddique, T. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500431-mcp200 · Cited by 38 · see citing works
Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration
Gomez-Jenkins, M., & Germain, D. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.04.003 · Cited by 37 · see citing works
Vandenberk, B., Brouwers, B. A. H., Hatse, S., & Wildiers, H. P. M. W. (2011) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2011.08.004 · Cited by 37 · see citing works
Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?
Robbins, D. F., & Zhao, Y. (2011) · Journal of Signal Transduction · doi:10.1155/2012/101465 · Cited by 34 · see citing works
Kim, H. J., Ham, S. A., Paek, K. S., Hwang, J. S., Jung, S. Y., Kim, M. Y., Jin, H., Kang, E. S., Woo, I. S., Kim, H. J., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.091 · Cited by 33 · see citing works
MtDNA mutations, functional decline and turnover of mitochondria in aging
Pang, C. (2008) · Frontiers in bioscience · doi:10.2741/2957 · Cited by 32 · see citing works
Azimi, A., Alexander, K. L., Ali, M., Arthur, J. W., Kossard, S., & Fernández‐Peñas, P. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.04.006 · Cited by 31 · see citing works
Topical application of synthetic melanin promotes tissue repair
Biyashev, D., Siwicka, Z. E., Onay, V., Demczuk, M. M., Xu, D., Ernst, M. K., Evans, S. T., Nguyen, C. V., Son, F. A., Paul, N. K., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00331-1 · Cited by 30 · see citing works
Han, Y., Kwon, J.-H., Yu, D., & Moon, E. (2006) · Free Radical Research · doi:10.1080/10715760600868552 · Cited by 30 · see citing works
Hammad, G., Legrain, Y., Touat-Hamici, Z., Duhieu, S., Cornu, D., Bulteau, A., & Chavatte, L. (2018) · Antioxidants · doi:10.3390/antiox7010019 · Cited by 29 · see citing works
Wang, S. K., Weaver, J. D., Zhang, S., & Lei, X. G. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.018 · Cited by 28 · see citing works
The Intricate Interplay between Mechanisms Underlying Aging and Cancer
Piano, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0209 · Cited by 28 · see citing works
Soo, K. Y., Atkin, J. D., Horne, M. K., & Nagley, P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05799.x · Cited by 28 · see citing works
Therapeutic gene silencing in neurological disorders, using interfering RNA
Ralph, G. S., Mazarakis, N., & Azzouz, M. (2005) · Journal of molecular medicine · doi:10.1007/s00109-005-0649-1 · Cited by 25 · see citing works
Medical application of exopolymers produced by marine bacteria
Abdelhamid, S. A., Mohamed, S. S., & Selim, M. S. (2020) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-020-00323-x · Cited by 28 · see citing works
Redox regulation, gene expression and longevity
Honda, Y., Tanaka, M., & Honda, S. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00591.x · Cited by 27 · see citing works
Vrailas‐Mortimer, A. D., Gomez, R., Dowse, H. B., & Sanyal, S. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.06.016 · Cited by 27 · see citing works
Britt‐Compton, B., Wyllie, F. S., Rowson, J., Capper, R., Jones, R. E., & Baird, D. M. (2009) · Biogerontology · doi:10.1007/s10522-009-9216-4 · Cited by 27 · see citing works
Banks, C. J., Rodriguez, N. W., Gashler, K. R., Pandya, R. R., Mortenson, J. B., Whited, M. D., Soderblom, E. J., Thompson, J. W., Moseley, M. A., Reddi, A. R., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00354-17 · Cited by 26 · see citing works
- Authors
- Blander, G., de Oliveira, R. M., Conboy, C. M., Haigis, M., & Guarente, L.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Guarente, Leonard
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 278
- Issue
- 40
- Pages
- 38966-38969
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2129326379
- Cited by
- 183
- References
- 28
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- superoxide dismutase 1, cellular senescence, premature senescence, p53 activation, human fibroblasts, reactive oxygen species, superoxide, aging, cellular lifespan, cancer cell death, HeLa cells, RNA interference
- MeSH terms
- Aging, Anions, beta-Galactosidase, Cell Line, Fibroblasts, Genetic Vectors, HeLa Cells, Humans, Microscopy, Fluorescence, Oxygen, Plasmids, Superoxide Dismutase, Transfection, Tumor Cells, Cultured, Blotting, Western, Tumor Suppressor Protein p53, Cellular Senescence, Cell Death, Reactive Oxygen Species, Transgenes, RNA Interference
About these checks
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