Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors

Raez, L. E., Papadopoulos, K., Ricart, A. D., Chiorean, E. G., DiPaola, R. S., Stein, M. N., Rocha Lima, C. M., Schlesselman, J. J., Tolba, K., Langmuir, V. K., et al. (2013) · Cancer Chemotherapy and Pharmacology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 543

Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription

Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., Ryan, S., Spiller, D. G., Unitt, J. F., Broomhead, D. S., et al. (2009) · Science

NF-κB Signaling PathwaysGene Regulatory Network Analysis

Cited by 543

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

Anders, L., Ke, N., Hydbring, P., Choi, Y. J., Widlund, H. R., Chick, J. M., Zhai, H., Vidal, M., Gygi, S. P., Braun, P., et al. (2011) · Cancer Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 543

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Xue, J. Y., Zhao, Y., Aronowitz, J., Mai, T. T., Vides, A., Qeriqi, B., Kim, D., Li, C., de Stanchina, E., Mazutis, L., et al. (2020) · Nature

Protein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

Cited by 543

Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006) · Developmental Cell

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 543

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age

Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., & Gilliland, D. (1996) · Blood

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesEpigenetics and DNA Methylation

Cited by 543

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

Yap, T. A., Garrett, M. D., Walton, M. I., Raynaud, F., de Bono, J. S., & Workman, P. (2008) · Current Opinion in Pharmacology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 543

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 543

Atg8: an autophagy-related ubiquitin-like protein family.

Shpilka, T., Weidberg, H., Pietrokovski, S., & Elazar, Z. (2011) · Genome biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 543

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., et al. (2018) · Journal of Controlled Release

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

Cited by 543

Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes

Kalodimos, C. G., Biris, N., Bonvin, A. M. J. J., Levandoski, M. M., Guennuegues, M., Boelens, R., & Kaptein, R. (2004) · Science

Diffusion and Search DynamicsProtein Structure and Dynamics

Cited by 543

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., et al. (2018) · Cancer Cell

Cancer, Stress, Anesthesia, and Immune ResponsePancreatic and Hepatic Oncology Research

Cited by 543

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 543

Microbial Dysbiosis Is Associated with Human Breast Cancer

Xuan, C., Shamonki, J. M., Chung, A., DiNome, M. L., Chung, M., Sieling, P. A., & Lee, D. J. (2014) · PLoS ONE

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 543

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

Yao, Z., Torres, N. M., Tao, A., Gao, Y., Luo, L., Li, Q., de Stanchina, E., Abdel-Wahab, O., Solit, D. B., Poulikakos, P. I., et al. (2015) · Cancer Cell

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 543

Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome

Xie, W., Barr, C. L., Kim, A., Yue, F., Lee, A. Y., Eubanks, J., Dempster, E. L., & Ren, B. (2012) · Cell

Genetic Syndromes and ImprintingEpigenetics and DNA Methylation

Cited by 543

Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis

Kang, C.-S., Ban, M., Choi, E.-J., Moon, H.-G., Jeon, J.-S., Kim, D.-K., Park, S.-K., Jeon, S. G., Roh, T.-Y., Myung, S.-J., et al. (2013) · PLoS ONE

Gut microbiota and healthInflammatory Bowel Disease

Cited by 543

Targeting the PI3K signaling pathway in cancer

Wong, K.-K., Engelman, J. A., & Cantley, L. C. (2010) · Current Opinion in Genetics & Development

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 543

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

Halestrap, A. P. (1975) · Biochemical Journal

Mitochondrial Function and PathologyBiochemical Acid Research Studies

Cited by 543

Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

Reddy, T. E., Pauli, F., Sprouse, R. O., Neff, N. F., Newberry, K. M., Garabedian, M. J., & Myers, R. M. (2009) · Genome Research

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 543

The antioxidant role of coenzyme Q

Bentinger, M., Brismar, K., & Dallner, G. (2007) · Mitochondrion

Coenzyme Q10 studies and effectsAntioxidant Activity and Oxidative Stress

Cited by 543

Disorders of carnitine transport and the carnitine cycle

Longo, N., Amat di San Filippo, C., & Pasquali, M. (2006) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics

Metabolism and Genetic DisordersMitochondrial Function and Pathology

Cited by 543

AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species

Rabinovitch, R. C., Samborska, B., Faubert, B., Ma, E. H., Gravel, S.-P., Andrzejewski, S., Raissi, T. C., Pause, A., St.-Pierre, J., & Jones, R. G. (2017) · Cell Reports

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 543

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., et al. (2010) · Nature

Genomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology

Cited by 543