Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Regulated portals of entry into the cell

Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,816 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666 · see citing works

Molecular Pathways of Neurodegeneration in Parkinson's Disease

Dawson, T. M., & Dawson, V. L. (2003) · Science · doi:10.1126/science.1087753 · Cited by 1,659 · see citing works

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Le‐Deygen, I. M., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky‐Papkov, M., Okolie, O., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,498 · see citing works

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works

Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway

Qian, Z., Li, H., Sun, H., & Ho, K. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.561 · Cited by 1,021 · see citing works

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886 · see citing works

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748 · see citing works

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

Nakagawa, S., Deli, M. A., Kawaguchi, H., Shimizudani, T., Shimono, T., Kittel, Á., Tanaka, K., & Niwa, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.002 · Cited by 728 · see citing works

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

Fishman, J. B., Rubin, J. B., Handrahan, J. V., Connor, J. R., & Fine, R. E. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180206 · Cited by 545 · see citing works

Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease

Asanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 518 · see citing works

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 482 · see citing works

Exosomes: Looking back three decades and into the future

Harding, C. V., Heuser, J. E., & Stahl, P. D. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212113 · Cited by 464 · see citing works

The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

Huot, P., Johnston, T. H., Koprich, J. B., Fox, S. H., & Brotchie, J. M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005678 · Cited by 324 · see citing works

Exosomes purified from a single cell type have diverse morphology

Zabeo, D., Cvjetkovic, A., Lässer, C., Schorb, M., Lötvall, J. O., & Höög, J. L. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1329476 · Cited by 297 · see citing works

Dopamine and adult neurogenesis

Borta, A., & Höglinger, G. U. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04241.x · Cited by 192 · see citing works

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

Ingato, D., Lee, J. U., Sim, S. J., & Kwon, Y. J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.016 · Cited by 175 · see citing works

Asymmetric distribution of phospholipids in the membrane of vesicles released during in vitro maturation of guinea pig reticulocytes: Evidence precluding a role for “aminophospholipid translocase”

Vidal, M., Sainte‐Marie, J., Philippot, J. R., & Bienvenüe, A. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041400308 · Cited by 172 · see citing works

Exosomes: A new delivery system for tumor antigens in cancer immunotherapy

Cho, J., Yeo, D.-J., Son, H., Kim, H., Jung, D., Ko, J., Koh, J. S., Kim, Y.-N., & Kim, C. (2004) · International Journal of Cancer · doi:10.1002/ijc.20757 · Cited by 160 · see citing works

How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH

Eckenroth, B. E., Steere, A. N., Chasteen, N. D., Everse, S. J., & Mason, A. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105786108 · Cited by 154 · see citing works

Characterisation of behavioural and neurodegenerative changes induced by intranigral 6‐hydroxydopamine lesions in a mouse model of Parkinson’s disease

Grealish, S., Mattsson, B., Draxler, P., & Björklund, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07265.x · Cited by 147 · see citing works

Exosome release by reticulocytes—An integral part of the red blood cell differentiation system

Blanc, L., Gassart, A. D., Géminard, C., Bette‐Bobillo, P., & Vidal, M. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.008 · Cited by 111 · see citing works

Creatine kinase in regulation of heart function and metabolism. I. Further evidence for compartmentation of adenine nucleotides in cardiac myofibrillar and sarcolemmal coupled ATPase-creatine kinase systems

Saks, V. A., Ventura‐Clapier, R., Huchua, Z. A., Preobrazhenskiĭ, A. N., & Emelin, I. V. (1984) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(84)90115-0 · Cited by 85 · see citing works

Rhein protects against acetaminophen-induced hepatic and renal toxicity

Zhao, Y., Zhou, G., Yang, H., Wang, J., Shan, L., Li, R., & Xiao, X. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.04.011 · Cited by 82 · see citing works

Drug Delivery Systems for Imaging and Therapy of Parkinson';s Disease

Silindir‐Gunay, M., Özer, A. Y., & Chalon, S. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151230124904 · Cited by 81 · see citing works

Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays

Gao, H., Yang, Z. H., Zhang, S., Pang, Z., Liu, Q., & Jiang, X. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.11.003 · Cited by 79 · see citing works

Stability of Hematologic Parameters in Healthy Subjects: Intraindividual versus Interindividual Variation

Ross, D. W., Ayscue, L. H., Watson, J. S., & BENTLEY, S. A. (1988) · American Journal of Clinical Pathology · doi:10.1093/ajcp/90.3.262 · Cited by 72 · see citing works

Pharmacokinetics of dopamine in infants and children

Eldadah, M. K., Schwartz, P. H., HARRISON, R., & Newth, C. J. L. (1991) · Critical Care Medicine · doi:10.1097/00003246-199108000-00006 · Cited by 42 · see citing works

Regional striatal DOPA transport and decarboxylase activity in Parkinson's disease.

Kuwabara, H., Cumming, P. D., Yasuhara, Y., Léger, G. C., Guttman, M., Dikšić, M., Evans, A. C., & GJEDDE, A. H. (1995) · PubMed · Cited by 40 · see citing works

Monitoring of Respiration and Circulation

Blom, J. A. (2003) · CRC Press eBooks · doi:10.1201/9780203503287 · Cited by 35 · see citing works

Endocytosis and exocytosis of protein in capillary endothelium

Williams, S. K., Greener, D. A., & Solenski, N. J. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041200208 · Cited by 26 · see citing works

Brain-Specific Delivery of Dopamine Mediated by N,N-Dimethyl Amino Group for the Treatment of Parkinson’s Disease

Li, Y., Zhou, Y., Qi, B., Gong, T., Sun, X., Fu, Y. S., & Zhang, Z. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500352p · Cited by 24 · see citing works

Dose-dependent neuroprotective effect of caffeine on a rotenone-induced rat model of parkinsonism: A histological study

Soliman, A. M., Fathalla, A., & Moustafa, A. A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.057 · Cited by 22 · see citing works

Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential

Zhdanov, A. V., Aviello, G., Knaus, U. G., & Papkovsky, D. B. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.10.023 · Cited by 19 · see citing works

Current treatments in Parkinson's including the proposal of an innovative dopamine microimplant

Velázquez-Paniagua, M., Vázquez-Álvarez, A. M., Valverde-Aguilar, G., & Aragón, P. V. (2015) · Revista Médica Del Hospital General De México · doi:10.1016/j.hgmx.2015.10.006 · Cited by 7 · see citing works

Practical guidelines for examination of adults with asymptomatic hypertransaminasaemia

Bruguera, M. (2017) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2016.03.011 · Cited by 4 · see citing works

DISTRIBUTION OF SIX TF C (TRANSFERRIN) SUBTYPES IN CORD BLOODS AND BLOOD DONORS

Nicholls, C., & Mulley, J. (1982) · Immunology and Cell Biology · doi:10.1038/icb.1982.48 · Cited by 3 · see citing works

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138 · see citing works

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 627 · see citing works

Unlocking the promise of mRNA therapeutics

Rohner, E., Yang, R., Foo, K. S., Goedel, A., & Chien, K. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01491-z · Cited by 612 · see citing works

Biodistribution of extracellular vesicles following administration into animals: A systematic review

Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 498 · see citing works

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Zhao, L., Gu, C., Gan, Y. H., Shao, L., Chen, H., & Zhu, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.005 · Cited by 443 · see citing works

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Zeng, H., Guo, S., Ren, X., Wu, Z., Liu, S., & Yao, X. (2023) · Cells · doi:10.3390/cells12101416 · Cited by 452 · see citing works

Cell-cell communication: New insights and clinical implications

Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433 · see citing works

Dosing extracellular vesicles

Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113961 · Cited by 431 · see citing works

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

Guo, S., Perets, N., Betzer, O., Ben-Shaul, S., Sheinin, A., Michaelevski, I., Popovtzer, R., Offen, D., & Levenberg, S. (2019) · ACS Nano · doi:10.1021/acsnano.9b01892 · Cited by 424 · see citing works

Exosome detection via the ultrafast-isolation system: EXODUS

Chen, Y., Zhu, Q., Cheng, L., Wang, Y., Li, M., Yang, Q., Hu, L., Lou, D., Li, J., Dong, X., et al. (2021) · Nature Methods · doi:10.1038/s41592-020-01034-x · Cited by 423 · see citing works

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 416 · see citing works

A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes

Gurunathan, S., Kang, M.-H., & Kim, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291956 · Cited by 388 · see citing works

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2019) · Nanoscale · doi:10.1039/c9nr01255a · Cited by 324 · see citing works

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization

Li, H., Feng, Y., Zheng, X. C., Jia, M., Mei, Z., Wang, Y., Zhang, Z., Zhou, M., & Li, C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.019 · Cited by 265 · see citing works

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 262 · see citing works

Immune Exosomes Loading Self-Assembled Nanomicelles Traverse the Blood–Brain Barrier for Chemo-immunotherapy against Glioblastoma

Cui, J., Wang, X., Li, J., Zhu, A., Du, Y., Zeng, W., Guo, Y., Di, L., & Wang, R. (2023) · ACS Nano · doi:10.1021/acsnano.2c10219 · Cited by 254 · see citing works

Designer Exosomes: A New Platform for Biotechnology Therapeutics

Jafari, D., Shajari, S., Jafari, R., Mardi, N., Gomari, H., Ganji, F., Moghadam, M. F., & Samadikuchaksaraei, A. (2020) · BioDrugs · doi:10.1007/s40259-020-00434-x · Cited by 251 · see citing works

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

Qi, Y., Guo, L., Jiang, Y., Shi, Y., Sui, H., & Zhao, L. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1762262 · Cited by 239 · see citing works

Exosomes based strategies for brain drug delivery

Rehman, F. U., Liu, Y., Zheng, M., & Shi, B. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121949 · Cited by 232 · see citing works

Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies

Xu, M., Feng, T., Liu, B., Qiu, F., Xu, Y., Zhao, Y., & Zheng, Y. (2021) · Theranostics · doi:10.7150/thno.62330 · Cited by 229 · see citing works

Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis.

Wei, Z.-X., Xie, G.-J., Mao, X., Zou, X.-P., Liao, Y.-J., Liu, Q.-S., Wang, H., & Cheng, Y. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0622-2 · Cited by 227 · see citing works

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219 · see citing works

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

de Castilla, P. E. M., Tong, L., Huang, C., Sofias, A. M., Pastorin, G., Chen, X. S., Storm, G., Schiffelers, R. M., & Wang, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.011 · Cited by 214 · see citing works

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 214 · see citing works

Exosome-based nanocarriers as bio-inspired and versatile vehicles for drug delivery: recent advances and challenges

Zhang, M., Zang, X., Wang, M., Li, Z., Qiao, M., Hu, H., & Chen, D. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00170k · Cited by 210 · see citing works

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

Guo, M., Yin, Z., Chen, F., & Lei, P. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00670-x · Cited by 203 · see citing works

Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

Yan, F., Zhong, Z., Wang, Y., Feng, Y., Mei, Z., Li, H., Chen, X., Cai, L., & Li, C. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00675-6 · Cited by 197 · see citing works

Exosomes as drug delivery systems: A brief overview and progress update

Patil, S. M., Sawant, S. S., & Kunda, N. K. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.07.026 · Cited by 194 · see citing works

Exosome: a significant nano-scale drug delivery carrier

Peng, H., Ji, W., Zhao, R., Yang, J., Lü, Z., Li, Y., & Zhang, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01499k · Cited by 189 · see citing works

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

Mitusova, K. A., Peltek, O. O., Karpov, T. E., Muslimov, A. R., Zyuzin, M. V., & Timin, A. S. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01610-7 · Cited by 186 · see citing works

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

Sen, S., Xavier, J., Kumar, N., Ahmad, M. Z., & Ranjan, O. P. (2023) · 3 Biotech · doi:10.1007/s13205-023-03521-2 · Cited by 194 · see citing works

How to decrease pharmaceuticals in the environment? A review

Caban, M., & Stepnowski, P. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01194-y · Cited by 183 · see citing works

Recent Advancements in the Loading and Modification of Therapeutic Exosomes

Xu, M., Yang, Q., Sun, X., & Wang, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.586130 · Cited by 177 · see citing works

Insights into Exosome Transport through the Blood–Brain Barrier and the Potential Therapeutical Applications in Brain Diseases

Abdelsalam, M., Ahmed, M., Osaid, Z., Hamoudi, R., & Harati, R. (2023) · Pharmaceuticals · doi:10.3390/ph16040571 · Cited by 156 · see citing works

Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

Heidarzadeh, M., Özdemir, Y., Kaya, M., Abriz, A. E., Zarebkohan, A., Rahbarghazi‬, R., & Sokullu, E. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00650-0 · Cited by 175 · see citing works

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

Rajput, A., Varshney, A., Bajaj, R., & Pokharkar, V. (2022) · Molecules · doi:10.3390/molecules27217289 · Cited by 165 · see citing works

Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162 · see citing works

ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease

Ma, X., Huang, M., Zheng, M., Dai, C., Song, Q., Zhang, Q., Li, Q., Gu, X. Q., Chen, H., Jiang, G., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.019 · Cited by 162 · see citing works

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 160 · see citing works

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles

Picca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040805 · Cited by 159 · see citing works

Exosomes from different cells: Characteristics, modifications, and therapeutic applications

Li, M., Li, S., Du, C., Zhang, Y., Li, Y., Chu, L., Han, X., Galons, H., Zhang, Y., Sun, H., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112784 · Cited by 159 · see citing works

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Kučuk, N., Primožič, M., Knez, Ž., & Leitgeb, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179543 · Cited by 157 · see citing works

Exosome as drug delivery system: Current advancements

Sharma, V., & Mukhopadhyay, C. D. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100032 · Cited by 156 · see citing works

Nanostructured particles assembled from natural building blocks for advanced therapies

Ju, Y., Liao, H., Richardson, J. J., Guo, J., & Caruso, F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00343g · Cited by 157 · see citing works

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152 · see citing works

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 154 · see citing works

Genome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia

Du, Y., Yu, Y., Hu, Y., Li, X., Wei, Z., Pan, R., Li, X.-S., Zheng, G.-E., Qin, X., Liu, Q., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby191 · Cited by 152 · see citing works

Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis

He, R., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111314 · Cited by 148 · see citing works

Separation, characterization, and standardization of extracellular vesicles for drug delivery applications

Buschmann, D., Mussack, V., & Byrd, J. B. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.027 · Cited by 151 · see citing works

The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases

Huo, L., Du, X., Li, X., Liu, S., & Xu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.738442 · Cited by 145 · see citing works

Exosomes in Parkinson disease

Pinnell, J. R., Cui, M., & Tieu, K. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15288 · Cited by 144 · see citing works

Harnessing Exosomes for the Development of Brain Drug Delivery Systems

Zheng, M., Huang, M., Ma, X., Chen, H., & Gao, X. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00085 · Cited by 136 · see citing works

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

Klyachko, N. L., Arzt, C. J., Li, S. M., Gololobova, O. A., & Batrakova, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121171 · Cited by 132 · see citing works

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

Burnouf, T., Agrahari, V., & Agrahari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s225453 · Cited by 113 · see citing works

Recent progresses in exosome-based systems for targeted drug delivery to the brain

Bashyal, S., Chhitij, T., & Lee, S. K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.011 · Cited by 129 · see citing works

Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis

Yu, H., Sun, T., An, J., Wen, L., Liu, F., Bu, Z., Cui, Y., & Feng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00086 · Cited by 127 · see citing works

Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies

Mehdizadeh, S., Mamaghani, M., Hassanikia, S., Pilehvar‐Soltanahmadi, Y., & Ertaş, Y. N. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03352-8 · Cited by 124 · see citing works

Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Li, M., Fang, F., Sun, M., Zhang, Y., Hu, M., & Zhang, J. (2022) · Theranostics · doi:10.7150/thno.72812 · Cited by 122 · see citing works

Extracellular vesicles in tumor immunity: mechanisms and novel insights

Kuang, L., Wu, L., & Li, Y. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02233-w · Cited by 131 · see citing works

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

Gangadaran, P., & Ahn, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050442 · Cited by 118 · see citing works

Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy

Zhan, Q., Yi, K., Cui, X., Li, X., Yang, S., Wang, Q., Fang, C., Tan, Y., Li, L., Xu, C., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac071 · Cited by 116 · see citing works

MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

Esteves, M., de Abreu, R. C., Fernandes, H., Serra-Almeida, C., Martins, P. A. T., Barão, M., Cristóvão, A. C., Saraiva, C., Ferreira, R., Ferreira, L., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.06.003 · Cited by 115 · see citing works

Engineering Exosomes for Therapeutic Applications: Decoding Biogenesis, Content Modification, and Cargo Loading Strategies

Bahadorani, M., Nasiri, M., Dellinger, K., Aravamudhan, S., & Zadegan, R. M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464249 · Cited by 125 · see citing works

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

Agrahari, V., Burnouf, P., Burnouf, T. P. R., & Agrahari, V. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.008 · Cited by 114 · see citing works

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

Ortega, A., Martínez-Arroyo, O., Forner, M. J., & Cortés, R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010003 · Cited by 111 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Extracellular Vesicles in neural cell interaction and CNS homeostasis

Schnatz, A., Müller, C., Brahmer, A., & Krämer‐Albers, E. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00035 · Cited by 110 · see citing works

Anti-Parkinsonian Therapy: Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials

Cheng, G., Liu, Y., Ma, R., Cheng, G., Guan, Y., Chen, X., Wu, Z., & Chen, T. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00847-z · Cited by 110 · see citing works

Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases

Zou, Z., Han, L., Xu, G., Hu, Y., Zhang, W., & Tian, K. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s417422 · Cited by 114 · see citing works

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 104 · see citing works

Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine

Fan, Z., Jiang, C., Wang, Y., Wang, K., Marsh, J., Zhang, D., Chen, X., & Nie, L. (2022) · Nanoscale Horizons · doi:10.1039/d2nh00070a · Cited by 103 · see citing works

Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy

Khatami, S. H., Karami, N., Taheri‐Anganeh, M., Taghvimi, S., Tondro, G., Khorsand, M., Fard, E. S., Sedighimehr, N., Kazemi, M., Jaberi, K. R., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03365-0 · Cited by 102 · see citing works

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol, E. A., Lei, Z., Roefs, M. T., Bakker, M. H., Goumans, M., Doevendans, P. A., Dankers, P. Y. W., Vader, P., & Sluijter, J. P. G. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900847 · Cited by 100 · see citing works

Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., L’Episcopo, F., Tirolo, C., Raciti, G., Pappalardo, F., Giachino, C., Caniglia, S., Serapide, M. F., et al. (2020) · Biomolecules · doi:10.3390/biom10091327 · Cited by 100 · see citing works

Exosomes as therapeutic and drug delivery vehicle for neurodegenerative diseases

Nouri, Z., Barfar, A., Perseh, S., Motasadizadeh, H., Maghsoudian, S., Fatahi, Y., Nouri, K., Yektakasmaei, M. P., Dinarvand, R., & Atyabi, F. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02681-4 · Cited by 97 · see citing works

Ultrasound Facilitates Naturally Equipped Exosomes Derived from Macrophages and Blood Serum for Orthotopic Glioma Treatment

Bai, L., Liu, Y., Guo, K., Zhang, K., Liu, Q., Wang, P., & Wang, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b00893 · Cited by 96 · see citing works

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

Yan, L., Lu, Y., & Li, X. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1641508 · Cited by 96 · see citing works

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

Gaurav, I., Thakur, A., Iyaswamy, A., Wang, X., Chen, X., & Yang, Z. (2021) · Molecules · doi:10.3390/molecules26061544 · Cited by 95 · see citing works

Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design

Song, H., Chen, X., Hao, Y., Wang, J., Xie, Q., & Wang, X. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01638-9 · Cited by 96 · see citing works

Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

Xia, X., Wang, Y., & Zheng, J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00330-0 · Cited by 93 · see citing works

The application of exosomes and Exosome-nanoparticle in treating brain disorders

Salarpour, S., Barani, M., Pardakhty, A., Khatami, M., & Chauhan, N. P. S. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.118549 · Cited by 92 · see citing works

Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine

Lin, Q., Qu, M., Zhou, B., Patra, H. K., Sun, Z., Luo, Q., Yang, W., Wu, Y., Zhang, Y., Li, L., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.08.037 · Cited by 88 · see citing works

Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy

Yang, L., Han, D., Zhan, Q., Li, X., Shan, P., Hu, Y., Ding, H., Wang, Y., Zhang, L., Zhang, Y., et al. (2019) · Theranostics · doi:10.7150/thno.37220 · Cited by 89 · see citing works

Potential Role of Exosomes in Cancer Metastasis

Tian, W., Liu, S., & Li, B. (2019) · BioMed Research International · doi:10.1155/2019/4649705 · Cited by 87 · see citing works

Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

Chiangjong, W., Netsirisawan, P., Hongeng, S., & Chutipongtanate, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761362 · Cited by 85 · see citing works

Biomimetic drug-delivery systems for the management of brain diseases

Chen, Y., Wei, C., Lyu, Y., Chen, H., Jiang, G., & Gao, X. (2019) · Biomaterials Science · doi:10.1039/c9bm01395d · Cited by 86 · see citing works

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease

Upadhya, R., & Shetty, A. K. (2021) · Aging and Disease · doi:10.14336/ad.2021.0516 · Cited by 86 · see citing works

Lipid-Based Nanovesicular Drug Delivery Systems

Limongi, T., Susa, F., Marini, M., Allione, M., Torre, B., Pisano, R., & Fabrizio, E. M. D. (2021) · Nanomaterials · doi:10.3390/nano11123391 · Cited by 87 · see citing works

Molecular Biomarkers and Their Implications for the Early Diagnosis of Selected Neurodegenerative Diseases

Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094610 · Cited by 84 · see citing works

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

Shetgaonkar, G. G., Marques, S. M., DCruz, C. E. M., Vibhavari, R. J. A., Kumar, L., & Shirodkar, R. K. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01026-0 · Cited by 83 · see citing works

Overcoming the blood-brain barrier: Exosomes as theranostic nanocarriers for precision neuroimaging

Li, C., Qin, S., Wen, Y., Zhao, W. G., Huang, Y., & Liu, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.002 · Cited by 85 · see citing works

Exosomes Interactions with the Blood–Brain Barrier: Implications for Cerebral Disorders and Therapeutics

Osaid, Z., Haider, M. A., Hamoudi, R., & Harati, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115635 · Cited by 87 · see citing works

Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases

Yuan, Y., Wang, J., Zhang, Y., Li, L., Reza, A. M. M. T., & Gurunathan, S. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407029 · Cited by 81 · see citing works

The exosome: a review of current therapeutic roles and capabilities in human reproduction

Dimik, M., Abeysinghe, P., Logan, J., & Mitchell, M. D. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01225-3 · Cited by 80 · see citing works

Extracellular Vesicles as Drug Transporters

Nowak, M., Górczyńska, J., Kołodzińska, K., Rubin, J., & Choromańska, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210267 · Cited by 79 · see citing works

Extracellular vesicles for the treatment of central nervous system diseases

Gratpain, V., Mwema, A., Labrak, Y., Muccioli, G. G., Pesch, V. V., & Rieux, A. D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.006 · Cited by 78 · see citing works

Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

Najm, A., Niculescu, A.-G., Grumezescu, A. M., & Beuran, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084300 · Cited by 78 · see citing works

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

Picca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102373 · Cited by 78 · see citing works

Native and Bioengineered Exosomes for Ischemic Stroke Therapy

Khan, H. L., Pan, J., Li, Y.-F., Zhang, Z., & Yang, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619565 · Cited by 79 · see citing works

Applications of Exosomes in Targeted Drug Delivery for the Treatment of Parkinson’s Disease: A Review of Recent Advances and Clinical Challenges

Kumar, B., Pandey, M., Fayaz, F., Izneid, T. A., Pottoo, F. H., Manchanda, S., Sharma, A., & Sahoo, P. K. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666201019112557 · Cited by 12 · see citing works

Potential Therapeutic Applications and Developments of Exosomes in Parkinson’s Disease

Luo, S., Du, L., & Cui, Y. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00195 · Cited by 34 · see citing works

Exosomes: Cellular capsules for drug delivery in Parkinson’s disease

Samal, J., Demir, S., & Pandit, A. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-50922-0.00006-7 · Cited by 3 · see citing works

Plant-derived exosomes as cell homogeneous nanoplatforms for brain biomacromolecules delivery ameliorate mitochondrial dysfunction against Parkinson’s disease

Xu, Y., Yan, G., Zhao, J., Ren, Y., Xiao, Q., Tan, M., & Peng, L. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102438 · Cited by 80 · see citing works

Research progress on exosome-mediated vascular endothelial growth factor–nerve growth factor cotransplantation in the treatment of Parkinson’s disease

Yan, W., Meng, X., & Li, X. (2025) · Journal of Aging and Rehabilitation · doi:10.1097/jagr.0000000000000024