Real-time fMRI neurofeedback with War Veterans with chronic PTSD: a feasibility study

Gerin, Mattia I.; Fichtenholtz, Harlan; Roy, Alicia; Walsh, Christopher J.; Krystal, John H.; Southwick, Steven; Hampson, Michelle

doi:10.3389/fpsyt.2016.00111

Cited by 84Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchTranscranial Magnetic Stimulation Studies

Real-time fMRI neurofeedback with War Veterans with chronic PTSD: a feasibility study

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Gerin, Mattia I., Fichtenholtz, Harlan, Roy, Alicia, Walsh, Christopher J., Krystal, John H., Southwick, Steven, Hampson, Michelle·2016·Frontiers in Psychiatry

DOI 10.3389/fpsyt.2016.00111PMC PMC4914513

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Abstract

Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in this feasibility study. All three participants tolerated well the NF training. Moreover, two participants, despite the chronicity of their symptoms, showed clinically meaningful improvements, while one participant showed a smaller symptom reduction. Examination of changes in resting-state functional connectivity patterns revealed a normalization of brain connectivity consistent with clinical improvement. These preliminary results support feasibility of this novel intervention for PTSD and indicate that larger, well-controlled studies of efficacy are warranted.

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Two other studies reported clinically meaningful reduction in PTSD symptoms after amygdala down-regulation training in PTSD (Gerin et al., 2016, Zotev et al., 2018).
“Two other studies reported clinically meaningful reduction in PTSD symptoms after amygdala down-regulation training in PTSD (Gerin et al., 2016, Zotev et al., 2018).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Gerin et al., 2016

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Self-citation

Authors: Gerin, M. I., Fichtenholtz, H., Roy, A., Walsh, C. J., Krystal, J. H., Southwick, S., & Hampson, M.
Affiliations: Anna Freud Centre (GB)
Yale University (US)
Corresponding author: Hampson, Michelle
ORCID: Gerin, Mattia I.
Fichtenholtz, Harlan
Walsh, Christopher J.
Krystal, John H.
Southwick, Steven
Hampson, Michelle
Venue: Frontiers in Psychiatry
Publisher: Frontiers Media SA
Published: 2016-06-21
Volume: 7
Pages: 111-111
ISSN: 1664-0640 (ISSN-L)
DOI: 10.3389/fpsyt.2016.00111
PMC: PMC4914513
OpenAlex: W2473398431
Cited by: 84
References: 82
Citations by year: 2026: 4 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 3
FWCI: 12.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Psychiatry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: U.S. Department of Veterans Affairs
Yale University
National Center for PTSD, U.S. Department of Veterans Affairs
National Institute of Mental Health (R01MH095789, R01MH100068)
Yale Center for Clinical Investigation, Yale School of Medicine
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: real-time fMRI neurofeedback, post-traumatic stress disorder, chronic PTSD, war veterans, combat veterans, amygdala activity, resting-state functional connectivity, treatment feasibility, symptom relief

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Real-time fMRI neurofeedback with War Veterans with chronic PTSD: a feasibility study

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