Brain Monoamine Oxidase A Binding in Major Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence
Abstract
CONTEXT: Highly significant elevations in regional brain monoamine oxidase A (MAO-A) binding were recently reported during major depressive episodes (MDEs) of major depressive disorder (MDD). The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown. OBJECTIVES: To determine whether brain MAO-A binding changes after SSRI treatment, whether brain MAO-A binding normalizes in subjects with MDD in recovery, and whether there is a relationship between prefrontal and anterior cingulate cortex MAO-A binding in recovery and subsequent recurrence of MDE. DESIGN: Case-control study. SETTING: Tertiary care psychiatric hospital. PARTICIPANTS: Twenty-eight healthy subjects, 16 subjects with an MDE secondary to MDD, and 18 subjects with MDD in recovery underwent carbon 11-labeled harmine positron emission tomography scans. Subjects with MDE were scanned before and after 6 weeks of SSRI treatment. All were otherwise healthy, nonsmoking, and medication free. Subjects with MDD in recovery were followed up for 6 months after MAO-A binding measurement. MAIN OUTCOME MEASURE: Monoamine oxidase A V(T), an index of MAO-A density, was measured in the prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, dorsal putamen, ventral striatum, thalamus, anterior temporal cortex, midbrain, and hippocampus. RESULTS: Monoamine oxidase A V(T) was significantly elevated in each brain region both during MDE and after SSRI treatment as compared with healthy controls. During recovery, MAO-A V(T) was significantly elevated in each brain region; however, those who went on to recurrence had significantly higher MAO-A V(T) in the prefrontal and anterior cingulate cortex than those who did not. CONCLUSIONS: Elevated MAO-A binding after SSRI treatment indicates persistence of a monoamine-lowering process not present in health. This provides a strong conceptual rationale for continuing SSRI treatment during early remission. Greater MAO-A binding in the prefrontal and anterior cingulate cortex in subjects with MDD in recovery and its association with subsequent recurrence argue that deficient monoamine neuromodulation may persist into recovery and contribute to recurrence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In major depressive disorder, higher oxidative stress, lower antioxidants, and oxidant-antioxidant imbalance are well documented in the hippocampus and medial prefrontal cortex, along with markers of DNA/RNA damage.
“increased oxidative stress, lower antioxidant levels, and imbalanced oxidant:antioxidant levels have been well documented within the hippocampus (103,104) and mPFC (104–106), resulting in associated markers of DNA/RNA damage in these regions.”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [104]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works
An overlap invariant entropy measure of 3D medical image alignment
Studholme, C., Hill, D., & Hawkes, D. J. (1999) · Pattern Recognition · doi:10.1016/s0031-3203(98)00091-0 · Cited by 2,167 · see citing works
Global burden of depressive disorders in the year 2000
Üstün, T. B., Ayuso-Mateos, J. L., Chatterji, S., Mathers, C., & Murray, C. J. L. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.5.386 · Cited by 1,735 · see citing works
The neural basis of loss aversion in decision-making under risk
Tom, S. M., Fox, C. R., Trepel, C., & Poldrack, R. A. (2007) · Science · doi:10.1126/science.1134239 · Cited by 1,733 · see citing works
The therapeutic potential of monoamine oxidase inhibitors
Youdim, M. B. H., Edmondson, D. E., & Tipton, K. F. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1883 · Cited by 1,374 · see citing works
Three-Year Outcomes for Maintenance Therapies in Recurrent Depression
Frank, E. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810240013002 · Cited by 1,294 · see citing works
MONOAMINE OXIDASE: From Genes to Behavior
Shih, J. C., Chen, K., & Ridd, M. J. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.197 · Cited by 1,211 · see citing works
Distributed Neural Representation of Expected Value
Knutson, B., Taylor, J., Kaufman, M., Peterson, R., & Glover, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0642-05.2005 · Cited by 955 · see citing works
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
Geddes, J. R., Carney, S. M., Davies, C., Furukawa, T. A., Kupfer, D. J., Frank, E., & Goodwin, G. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12599-8 · Cited by 945 · see citing works
Pharmacological profile of antidepressants and related compounds at human monoamine transporters
Tatsumi, M., Groshan, K., Blakely, R. D., & Richelson, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01393-9 · Cited by 939 · see citing works
Multimodal Image Coregistration and Partitioning—A Unified Framework
Ashburner, J., & Friston, K. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0290 · Cited by 932 · see citing works
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works
Exact and approximate rebinning algorithms for 3-D PET data
Defrise, M., Kinahan, P. E., Townsend, D. W., Michel, C. J., Sibomana, M., & Newport, D. F. (1997) · IEEE Transactions on Medical Imaging · doi:10.1109/42.563660 · Cited by 757 · see citing works
Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites
Owens, M. J., Morgan, W. N., Plott, S. J., & Nemeroff, C. B. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37161-7 · Cited by 676 · see citing works
Neural mechanisms mediating optimism bias
Sharot, T., Riccardi, A. M., Raio, C. M., & Phelps, E. A. (2007) · Nature · doi:10.1038/nature06280 · Cited by 659 · see citing works
Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585 · see citing works
Self-citationMawlawi, O., Martinez, D., Slifstein, M., Broft, A., Chatterjee, R., Hwang, D.-R., Huang, Y., Simpson, N., Ngo, K., Van Heertum, R., et al. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00002 · Cited by 525 · see citing works
Meyer, J. H., Wilson, A. A., Sagrati, S., Hussey, D., Carella, A., Potter, W. Z., Ginovart, N., Spencer, E. P., Cheok, A., & Houle, S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.826 · Cited by 517 · see citing works
Self-citationIncorporating Prior Knowledge into Image Registration
Ashburner, J., Neelin, P., Collins, D. L., Evans, A. C., & Friston, K. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0299 · Cited by 455 · see citing works
Cognitive Therapy and Pharmacotherapy for Depression
Simons, A. D. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800010045006 · Cited by 440 · see citing works
Relapse of depression after rapid depletion of tryptophan
Smith, K., Fairburn, C. G., & Cowen, P. J. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07044-4 · Cited by 428 · see citing works
Brain monoamine oxidase A inhibition in cigarette smokers
Fowler, J. S., Volkow, N. D., Wang, G., Pappas, N. R., Logan, J., Shea, C. E., Alexoff, D. L., MacGregor, R. R., Schlyer, D. J., Zezulkova, I., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14065 · Cited by 423 · see citing works
Stockmeier, C. A. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00050-5 · Cited by 357 · see citing works
Meyer, J. H., Wilson, A. A., Ginovart, N., Goulding, V. S., Hussey, D. F., Hood, K., & Houle, S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1843 · Cited by 339 · see citing works
Self-citationLiotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1830 · Cited by 331 · see citing works
Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
Freis, E. D. (1954) · New England Journal of Medicine · doi:10.1056/nejm195412162512504 · Cited by 322 · see citing works
Mitochondrial involvement in psychiatric disorders
Shao, L., Martin, M. V., Watson, S. J., Schatzberg, A. F., Akil, H., Myers, R., Jones, E. G., Bunney, W. E., & Vawter, M. P. (2008) · Annals of Medicine · doi:10.1080/07853890801923753 · Cited by 303 · see citing works
Neumeister, A., Nugent, A. C., Waldeck, T., Geraci, M., Schwarz, M., Bonne, O., Bain, E. E., Luckenbaugh, D. A., Herscovitch, P., Charney, D. S., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.765 · Cited by 273 · see citing works
Lower dopamine transporter binding potential in striatum during depression
Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269 · see citing works
Self-citationMeyer, J. H., Houle, S., Sagrati, S., Carella, A., Hussey, D. F., Ginovart, N., Goulding, V. S., Kennedy, J. L., & Wilson, A. A. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.12.1271 · Cited by 265 · see citing works
Self-citationDysfunctional Attitudes and 5-HT<sub>2</sub> Receptors During Depression and Self-Harm
Meyer, J. H., McMain, S., Kennedy, S. H., Korman, L., Brown, G. M., DaSilva, J. N., Wilson, A. A., Blak, T., Eynan-Harvey, R., Goulding, V. S., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.90 · Cited by 264 · see citing works
Self-citationBel, N., & Artigas, F. (1993) · Synapse · doi:10.1002/syn.890150310 · Cited by 237 · see citing works
Meyer, J. H., Kapur, S., Eisfeld, B., Brown, G. M., Houle, S., DaSilva, J., Wilson, A. A., Rafi-Tari, S., Mayberg, H. S., & Kennedy, S. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.78 · Cited by 231 · see citing works
Self-citationElevated Brain Serotonin Turnover in Patients With Depression
Barton, D. A., Esler, M., Dawood, T., Lambert, É., Haikerwal, D., Brenchley, C., Socratous, F., Hastings, J. A., Guo, L. J., Wiesner, G., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.11 · Cited by 220 · see citing works
Evaluation of simulation-based scatter correction for 3-D PET cardiac imaging
Watson, C. C., Newport, D. F., Casey, M., deKemp, R. A., Beanlands, R. S., & Schmand, M. J. (1997) · IEEE Transactions on Nuclear Science · doi:10.1109/23.554831 · Cited by 218 · see citing works
Bhagwagar, Z., Hinz, R., Taylor, M. J., Fancy, S., Cowen, P. J., & Grasby, P. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1580 · Cited by 214 · see citing works
Hasler, G., Fromm, S., Carlson, P. J., Luckenbaugh, D. A., Waldeck, T., Geraci, M., Roiser, J. P., Neumeister, A., Meyers, N., Charney, D. S., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.521 · Cited by 209 · see citing works
Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex
Biver, F., Wikler, D., Lotstra, F., Damhaut, P., Goldman, S., & Mendlewicz, J. (1997) · The British Journal of Psychiatry · doi:10.1192/bjp.171.5.444 · Cited by 197 · see citing works
An automated method for the extraction of regional data from PET images
Rusjan, P., Mamo, D. C., Ginovart, N., Hussey, D., Vitcu, I., Yasuno, F., Suhara, T., Houle, S., & Kapur, S. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.011 · Cited by 177 · see citing works
Self-citationBrain Serotonin2 Receptors in Major Depression
Yatham, L. N., Liddle, P. F., Shiah, I., Scarrow, G., Lam, R. W. M., Adam, M. J., Zis, A. P., & Ruth, T. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.9.850 · Cited by 170 · see citing works
Mintun, M. A., Sheline, Y. I., Moerlein, S. M., Vlassenko, A. G., Huang, Y. H., & Snyder, A. Z. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.015 · Cited by 160 · see citing works
Meyer, J. H., McNeely, H. E., Sagrati, S., Boovariwala, A., Martin, K., Verhoeff, N. P. L. G., Wilson, A. A., & Houle, S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1594 · Cited by 160 · see citing works
Self-citationA Psychometric Evaluation of the DSM-IV Personality Disorder Criteria
Blais, M. A., & Norman, D. K. (1997) · Journal of Personality Disorders · doi:10.1521/pedi.1997.11.2.168 · Cited by 137 · see citing works
Krüger, S., Alda, M., Young, L. T., Goldapple, K., Parikh, S., & Mayberg, H. S. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.257 · Cited by 126 · see citing works
Reproducibility of BOLD-based functional MRI obtained at 4 T
Tegeler, C., Strother, S. C., Anderson, J. R., & Kim, S. (1999) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1999)7:4 · Cited by 121 · see citing works
Brain Biogenic Amine Depletion and Mood
Mendels, J. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760100019004 · Cited by 119 · see citing works
Transient Depressive Relapse Induced by Catecholamine Depletion
Berman, R., Narasimhan, M., Miller, H., Anand, A., Cappiello, A., Oren, D. A., Heninger, G. R., & Charney, D. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.395 · Cited by 118 · see citing works
Pinsonneault, J. K., Papp, A. C., & Sadée, W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl192 · Cited by 114 · see citing works
Tryptophan depletion and depressive vulnerability
Moreno, F., Gelenberg, A. J., Heninger, G. R., Potter, R. L., McKnight, K., Allen, J. J. B., Phillips, A. P., & Delgado, P. L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00095-5 · Cited by 111 · see citing works
Biochemistry and pharmacology of moclobemide, a prototype RIMA
Haefely, W. E., Burkard, W. P., Cesura, A. M., Kettler, R., Lorez, H. P., Martin, J. R., Richards, J. G., Scherschlicht, R., & Prada, M. D. (1992) · Psychopharmacology · doi:10.1007/bf02246225 · Cited by 110 · see citing works
Psychomotor slowing as a predictor of fluoxetine nonresponse in depressed outpatients
Taylor, B. P., Bruder, G. E., Stewart, J. W., McGrath, P. J., Halperin, J., Ehrlichman, H., & Quitkin, F. M. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.73 · Cited by 109 · see citing works
Evaluating antidepressant therapies: remission as the optimal outcome.
Thase, M. E. (2003) · PubMed · Cited by 107 · see citing works
Constrained Fourier space method for compensation of missing data in emission computed tomography
Karp, J. S., Muehllehner, G., & Lewitt, R. M. (1988) · IEEE Transactions on Medical Imaging · doi:10.1109/42.3925 · Cited by 107 · see citing works
Ginovart, N., Meyer, J. H., Boovariwala, A., Hussey, D. F., Rabiner, E. A., Houle, S., & Wilson, A. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600197 · Cited by 102 · see citing works
Self-citationMoreno, F., Heninger, G. R., McGahuey, C. A., & Delgado, P. L. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00893-3 · Cited by 82 · see citing works
11C-harmine as a tracer for monoamine oxidase a (MAO-A): In vitro and in vivo studies
Bergström, M., Westerberg, G., & Långström, B. (1997) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(97)00013-9 · Cited by 75 · see citing works
In vivo regulation of the serotonin-2 receptor in rat brain
Stockmeier, C. A., & Kellar, K. J. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90003-2 · Cited by 73 · see citing works
Characterization of Two [3H]Ketanserin Recognition Sites in Rat Striatum
Roth, B. L., McLean, S., Zhu, X., & Chuang, D. M. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb02444.x · Cited by 66 · see citing works
Leyton, M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00262-x · Cited by 60 · see citing works
Bergström, M., Westerberg, G., Kihlberg, T., & Långström, B. (1997) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(97)80003-0 · Cited by 57 · see citing works
Relapse of depression after rapid depletion of tryptophan
Leyton, M., Young, S. N., & Benkelfat, C. (1997) · The Lancet · doi:10.1016/s0140-6736(05)61726-6 · Cited by 48 · see citing works
Todd, K. G., McManus, D. J., & Baker, G. B. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02089946 · Cited by 43 · see citing works
Applying Neuroimaging Ligands to Study Major Depressive Disorder
Meyer, J. H. (2008) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2008.02.007 · Cited by 41 · see citing works
Self-citationTweedie, D., & Burke, M. D. (1987) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06611-5 · Cited by 32 · see citing works
A behavioural and neurochemical analysis of chronic and selective monoamine oxidase inhibition
O'Regan, D., Kwok, R. P. S., Yu, P. H., Bailey, B. A., Greenshaw, A. J., & Boulton, A. A. (1987) · Psychopharmacology · doi:10.1007/bf00215477 · Cited by 27 · see citing works
Evaluation of single photon transmission for the HRRT
Knoess, C., Rist, J., Michel, C. J., Burbar, Z., Eriksson, L., Panin, V., Byars, L. G., Lenox, M., Wienhard, K., Heiss, W., et al. (2003) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nssmic.2003.1352258 · Cited by 20 · see citing works
Immune Disturbances in Treatment-Resistant Depression: Modulation by Antidepressive Treatments
Maes, M. H. J., Vandoolaeghe, E., Hunsel, F. V., Bril, T., Demedts, P., Wauters, A., & Neels, H. M. (1997) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199703/04)12:2 · Cited by 19 · see citing works
Depression associated with reserpine therapy.
Rh, B. (1956) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603 · see citing works
Belleau, E. L., Treadway, M. T., & Pizzagalli, D. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.031 · Cited by 550 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
A Treatment-Resistant Default Mode Subnetwork in Major Depression
Li, B., Liu, L., Friston, K. J., Shen, H., Wang, L., Zeng, L.-L., & Hu, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.007 · Cited by 333 · see citing works
Synaptic plasticity in depression: molecular, cellular and functional correlates.
Marsden, W. N. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 321 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Setiawan, E., Attwells, S., Wilson, A. A., Mizrahi, R., Rusjan, P., Miler, L., Xu, C., Sharma, S. K., Kish, S. J., Houle, S., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30048-8 · Cited by 245 · see citing works
Self-citationTranylcypromine in mind (Part I): Review of pharmacology
Ulrich, S., Ricken, R., & Adli, M. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.05.007 · Cited by 239 · see citing works
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 247 · see citing works
Distribution of Monoamine Oxidase Proteins in Human Brain: Implications for Brain Imaging Studies
Tong, J., Meyer, J. H., Furukawa, Y., Boileau, I., Chang, L., Wilson, A. A., & Houle, S. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.19 · Cited by 214 · see citing works
Self-citationBrain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders
Tong, J., Rathitharan, G., Meyer, J. H., Furukawa, Y., Ang, L.-C., Boileau, I., Guttman, M., Hornykiewicz, O., & Kish, S. J. (2017) · Brain · doi:10.1093/brain/awx172 · Cited by 204 · see citing works
Self-citationElevated brain monoamine oxidase A binding in the early postpartum period
Sacher, J., Wilson, A. A., Houle, S., Rusjan, P., Hassan, S., Bloomfield, P. M., Stewart, D. E., & Meyer, J. H. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.32 · Cited by 202 · see citing works
Self-citationDavis, M. T., Holmes, S. E., Pietrzak, R. H., & Esterlis, I. (2017) · Chronic Stress · doi:10.1177/2470547017710916 · Cited by 176 · see citing works
Neuroreceptor imaging in depression
Savitz, J. B., & Drevets, W. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.001 · Cited by 165 · see citing works
The Development, Past Achievements, and Future Directions of Brain PET
Jones, T., & Rabiner, E. (2012) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2012.20 · Cited by 128 · see citing works
Shumay, E., Logan, J., Volkow, N. D., & Fowler, J. S. (2012) · Epigenetics · doi:10.4161/epi.21976 · Cited by 120 · see citing works
Depression: Biological markers and treatment
Erjavec, G. N., Šagud, M., Perković, M. N., Štrac, D. Š., Konjevod, M., Tudor, L., Uzun, S., & Pivac, N. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110139 · Cited by 120 · see citing works
Flanagan, S., Bartizal, K. F., Minassian, S. L., Fang, E., & Prokocimer, P. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00431-13 · Cited by 108 · see citing works
Grunewald, M. E., Johnson, S., Lu, D., Wang, Z., Lomberk, G. A., Albert, P. R., Stockmeier, C. A., Meyer, J. H., Urrutia, R. A., Miczek, K. A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.373936 · Cited by 102 · see citing works
Self-citationBrand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95 · see citing works
Sacher, J., Rekkas, P. V., Wilson, A. A., Houle, S., Romano, L., Hamidi, J., Rusjan, P., Fan, I., Stewart, D. E., & Meyer, J. H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.190 · Cited by 94 · see citing works
Self-citationLum, C. T., & Stahl, S. M. (2012) · CNS Spectrums · doi:10.1017/s1092852912000594 · Cited by 91 · see citing works
Erritzøe, D., Godlewska, B. R., Rizzo, G., Searle, G. E., Agnorelli, C., Lewis, Y. L., Ashok, A. H., Colasanti, A., Boura, I., Farrell, C. M., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.012 · Cited by 90 · see citing works
Monoamine oxidases in major depressive disorder and alcoholism.
Duncan, J. W., Johnson, S., & Ou, X.-M. (2012) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2012.v6.3.112 · Cited by 84 · see citing works
The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder
Johnson, S., Stockmeier, C. A., Meyer, J. H., Austin, M. C., Albert, P. R., Wang, J., May, W. L., Rajkowska, G., Overholser, J. C., Jurjus, G., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.105 · Cited by 85 · see citing works
Self-citationRekkas, P. V., Wilson, A. A., Lee, V. W. H., Yogalingam, P., Sacher, J., Rusjan, P., Houle, S., Stewart, D. E., Kolla, N. J., Kish, S. J., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.250 · Cited by 80 · see citing works
Self-citationBiomarker Approaches in Major Depressive Disorder Evaluated in the Context of Current Hypotheses
Jentsch, M., van Buel, E. M., Bosker, F. J., Gladkevich, A. V., Klein, H. C., Voshaar, R. C. O., Ruhé, H. G., Eisel, U. L., & Schoevers, R. A. (2015) · Biomarkers in Medicine · doi:10.2217/bmm.14.114 · Cited by 79 · see citing works
Chiuccariello, L., Houle, S., Miler, L., Cooke, R. G., Rusjan, P., Rajkowska, G., Levitan, R. D., Kish, S. J., Kolla, N. J., Ou, X., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.297 · Cited by 75 · see citing works
Self-citationSuchting, R., Tirumalaraju, V., Gareeb, R., Bockmann, T., de Dios, C., Aickareth, J., Pinjari, O., Soares, J. C., Cowen, P. J., & Selvaraj, S. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.021 · Cited by 73 · see citing works
Bacher, I. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.82 · Cited by 71 · see citing works
Zebrafish models of major depressive disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S. H. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23639 · Cited by 72 · see citing works
Drugs related to monoamine oxidase activity
Fišar, Z. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.012 · Cited by 72 · see citing works
Meyer, J. H. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.285 · Cited by 64 · see citing works
Self-citationTranslational PET imaging research
Hargreaves, R. J., & Rabiner, E. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.08.017 · Cited by 61 · see citing works
Pino, J. M. V., da Luz, M. H. M., Antunes, H. K. M., Giampá, S. Q. D. C., Martins, V. R., & Lee, K. S. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00145 · Cited by 60 · see citing works
Rincón‐Cortés, M., & Grace, A. A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100839 · Cited by 60 · see citing works
New insights on the antidepressant discontinuation syndrome
Harvey, B. H., & Slabbert, F. N. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2429 · Cited by 61 · see citing works
Korb, A. S., Hunter, A. M., Cook, I. A., & Leuchter, A. F. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.12.007 · Cited by 59 · see citing works
Sacher, J., Houle, S., Parkes, J., Rusjan, P., Sagrati, S., Wilson, A. A., & Meyer, J. H. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100117 · Cited by 58 · see citing works
Self-citationThe molecular mechanism, targets, and novel molecules in the treatment of Alzheimer’s disease
Verma, A., Waiker, D. K., Bhardwaj, B., Saraf, P., & Shrivastava, S. K. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105562 · Cited by 58 · see citing works
A neuroscientific update on monoamine oxidase and its inhibitors
Schwartz, T. L. (2013) · CNS Spectrums · doi:10.1017/s1092852913000734 · Cited by 58 · see citing works
Therapeutic Drug Monitoring for Antidepressant Drug Treatment
Haji, E. O., Hiemke, C., & Pfuhlmann, B. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523699 · Cited by 57 · see citing works
Lin, Y., Lin, S.-H., Chen, W.-C., Ho, C., Lai, Y.-S., Panyod, S., & Sheen, L. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.04.032 · Cited by 57 · see citing works
Regulatory Pathways of Monoamine Oxidase A during Social Stress
Higuchi, Y., Soga, T., & Parhar, I. S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00604 · Cited by 57 · see citing works
Increased Seasonal Variation in Serotonin Transporter Binding in Seasonal Affective Disorder
Tyrer, A. E., Levitan, R. D., Houle, S., Wilson, A. A., Nóbrega, J. N., & Meyer, J. H. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.54 · Cited by 56 · see citing works
Self-citationRelationship of monoamine oxidase A binding to adaptive and maladaptive personality traits
Soliman, A., Bagby, R. M., Wilson, A. A., Miler, L., Clark, M., Rusjan, P., Sacher, J., Houle, S., & Meyer, J. H. (2010) · Psychological Medicine · doi:10.1017/s0033291710001601 · Cited by 52 · see citing works
Self-citationMonoamine Oxidase Inhibitors and Neuroprotection
Al-Nuaimi, S. K., MacKenzie, E. M., & Baker, G. B. (2012) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31825b9eb5 · Cited by 51 · see citing works
Kolla, N. J., Chiuccariello, L., Wilson, A. A., Houle, S., Links, P. S., Bagby, R. M., McMain, S., Kellow, C., Patel, J., Rekkas, P. V., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.024 · Cited by 47 · see citing works
Self-citationLow glucocorticoids in stress-related disorders: the role of inflammation
Sarapultsev, A., Sarapultsev, P., Dremencov, E., Komelkova, M. V., Tseilikman, O. B., & Цейликман, В. Э. (2020) · Stress · doi:10.1080/10253890.2020.1766020 · Cited by 47 · see citing works
Eap, C. B., Gründer, G., Baumann, P., Ansermot, N., Conca, A., Corruble, E., Crettol, S., Dahl, M., de León, J., Greiner, C., et al. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1878427 · Cited by 49 · see citing works
Self-citationHarris, S., Johnson, S., Duncan, J. W., Udemgba, C., Meyer, J. H., Albert, P. R., Lomberk, G. A., Urrutia, R. A., Ou, X., Stockmeier, C. A., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.321 · Cited by 43 · see citing works
Self-citationSerotonin transporter binding is reduced in seasonal affective disorder following light therapy
Tyrer, A. E., Levitan, R. D., Houle, S., Wilson, A. A., Nóbrega, J. N., Rusjan, P., & Meyer, J. H. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12632 · Cited by 44 · see citing works
Self-citationZhang, Y., Wang, Q., Liu, R., Zhou, H., Crommen, J., Moaddel, R., Jiang, Z., & Zhang, T. (2019) · Journal of Chromatography A · doi:10.1016/j.chroma.2019.01.062 · Cited by 43 · see citing works
Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides
Kim, J.-H., Kim, G.-H., & Hwang, K.-H. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.214 · Cited by 41 · see citing works
Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex
Harrison, S. J., Tyrer, A. E., Levitan, R. D., Xu, X., Houle, S., Wilson, A. A., Nóbrega, J. N., Rusjan, P., & Meyer, J. H. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12424 · Cited by 41 · see citing works
Self-citationDevelopment of new radiopharmaceuticals for imaging monoamine oxidase B.
Vasdev, N., Sadovski, O., Moran, M. D., Parkes, J., Meyer, J., Houle, S., & Wilson, A. (2011) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2011.03.003 · Cited by 38 · see citing works
Self-citationBanerjee, C., Tripathy, D., Kumar, D., & Chakraborty, J. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105831 · Cited by 40 · see citing works
Zsido, R. G., Villringer, A., & Sacher, J. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1397607 · Cited by 39 · see citing works
Self-citationPET radiopharmaceuticals for probing enzymes in the brain.
Holland, J. P., Cumming, P. D., & Vasdev, N. (2013) · Europe PMC (PubMed Central) · Cited by 39 · see citing works
Chiuccariello, L., Cooke, R. G., Miler, L., Levitan, R. D., Baker, G. B., Kish, S. J., Kolla, N. J., Rusjan, P., Houle, S., Wilson, A. A., et al. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv078 · Cited by 36 · see citing works
Self-citationDowlati, Y., Ravindran, A. V., Segal, Z. V., Stewart, D. E., Steiner, M. S., & Meyer, J. H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611965114 · Cited by 36 · see citing works
Self-citationConvergent Effects of Acute Stress and Glucocorticoid Exposure upon MAO-A in Humans
Soliman, A., Udemgba, C., Fan, I., Xu, X. Y., Miler, L., Rusjan, P., Houle, S., Wilson, A. A., Pruessner, J. C., Ou, X., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2091-12.2012 · Cited by 36 · see citing works
Self-citationSacher, J., Rabiner, E. A., Clark, M., Rusjan, P., Soliman, A., Boskovic, R., Kish, S. J., Wilson, A. A., Houle, S., & Meyer, J. H. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.184 · Cited by 33 · see citing works
Self-citationBrain monoamine oxidase A in seasonal affective disorder and treatment with bright light therapy
Spies, M., James, G. M., Vraka, C., Philippe, C., Hienert, M., Gryglewski, G., Komorowski, A., Kautzky, A., Silberbauer, L., Pichler, V., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0227-2 · Cited by 33 · see citing works
Kim, J. H., Son, Y. K., Kim, G. H., & Hwang, K. H. (2013) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.100 · Cited by 32 · see citing works
Higuchi, Y., Soga, T., & Parhar, I. S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01549 · Cited by 31 · see citing works
Luykx, J. J., Bakker, S. C., van Geloven, N., Eijkemans, M. J. C., Horvath, S., Lentjes, E. G. W. M., Boks, M. P., Strengman, E., DeYoung, J. A., Buizer‐Voskamp, J. E., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.84 · Cited by 31 · see citing works
Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment
Ebrahimi-Ghiri, M., Nasehi, M., & Zarrindast, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.034 · Cited by 31 · see citing works
Neuroprogression and Immune Activation in Major Depressive Disorder
Meyer, J. H. (2017) · Modern trends in psychiatry · doi:10.1159/000470804 · Cited by 30 · see citing works
Self-citationLi, R., Sahu, S. S., & Schachner, M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.05.013 · Cited by 30 · see citing works
Baldinger, P., Gryglewski, G., Philippe, C., James, G. M., Vraka, C., Silberbauer, L., Balber, T., Vanicek, T., Pichler, V., Unterholzner, J., et al. (2019) · Brain stimulation · doi:10.1016/j.brs.2018.12.976 · Cited by 30 · see citing works
Liu, W., Rabinovich, A., Nash, Y., Frenkel, D., Wang, Y., Youdim, M. B. H., & Weinreb, O. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.028 · Cited by 30 · see citing works
Olayinka, J. N., Akawa, O. B., Ogbu, E. K., Eduviere, A. T., Ozolua, R. I., & Soliman, M. E. S. (2023) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2023.100161 · Cited by 28 · see citing works
Greater Monoamine Oxidase A Binding in Alcohol Dependence
Matthews, B. A., Kish, S. J., Xu, X. Y., Boileau, I., Rusjan, P., Wilson, A. A., DiGiacomo, D., Houle, S., & Meyer, J. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.010 · Cited by 27 · see citing works
Self-citationBludau, S., Mühleisen, T. W., Eickhoff, S. B., Hawrylycz, M., Cichon, S., & Amunts, K. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1620-6 · Cited by 27 · see citing works
Kolla, N. J., Dunlop, K., Downar, J. H., Links, P. S., Bagby, R. M., Wilson, A. A., Houle, S., Rasquinha, F., Simpson, A. I. F., & Meyer, J. H. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.030 · Cited by 27 · see citing works
Self-citationCannabinoids and monoamine neurotransmission with focus on monoamine oxidase
Fišar, Z. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.010 · Cited by 27 · see citing works
Wong, P., Sze, Y., Gray, L. J. M., Chang, C. C. R., Cai, S., & Zhang, X. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00094 · Cited by 27 · see citing works
Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity
Smith, D. F., & Jakobsen, S. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00008 · Cited by 25 · see citing works
Barriers to achieving treatment goals: A focus on sleep disturbance and sexual dysfunction
Morehouse, R. L., MacQUEEN, G. M., & Kennedy, S. H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.047 · Cited by 24 · see citing works
Potential Roles of microRNAs in the Regulation of Monoamine Oxidase A in the Brain
Higuchi, Y., Soga, T., & Parhar, I. S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00339 · Cited by 22 · see citing works
Sivamaruthi, B. S., Madhumita, R., Balamurugan, K., & Rajan, K. E. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00188 · Cited by 22 · see citing works
Serotonin Receptor Imaging: Clinically Useful?
Parsey, R. V. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068908 · Cited by 22 · see citing works
Molecular imaging as a guide for the treatment of central nervous system disorders
Kim, E., Howes, O., & Kapur, S. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.3/ekim · Cited by 23 · see citing works
Ajiboye, T. O. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.189 · Cited by 22 · see citing works
Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update
Choudhary, D., Kaur, R., Singh, T. G., & Kumar, B. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266280249240126052505 · Cited by 19 · see citing works
Molecular Imaging for Depressive Disorders
Lee, T. S., Quek, S., & Krishnan, K. R. R. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3965 · Cited by 19 · see citing works
Chen, Y., Xie, S.-Y., Chen, C., & Lu, D. (2021) · Molecular Brain · doi:10.1186/s13041-021-00860-0 · Cited by 19 · see citing works
No effect of oral l-tryptophan or alpha-lactalbumin on total tryptophan levels in breast milk
Dowlati, Y., Ravindran, A. V., Maheux, M., Steiner, M. S., Stewart, D. E., & Meyer, J. H. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.005 · Cited by 18 · see citing works
Self-citationZanderigo, F., D’Agostino, A. E., Joshi, N., Schain, M., Kumar, D. J. S., Parsey, R. V., DeLorenzo, C., & Mann, J. J. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1165-3 · Cited by 17 · see citing works
Philippe, C., Zeilinger, M., Mitterhauser, M., Dumanic, M., Lanzenberger, R. R., Hacker, M., & Wadsak, W. (2015) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2015.01.002 · Cited by 17 · see citing works
Zhang⋆, Y., Luo, Y., Zhang, D., Pang, B., Wen, J., & Zhou, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.625108 · Cited by 16 · see citing works
Resting-state mapping of neural signatures of vulnerability to depression relapse
Liu, C., Tang, L., Gao, Y., Zhang, G., Li, B., Li, M., Woelfer, M., Martin, W., & Wang, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.03.022 · Cited by 17 · see citing works
Sex and the serotonergic underpinnings of depression and migraine
Spies, M., Handschuh, P. A., Lanzenberger, R. R., & Kranz, G. S. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00009-6 · Cited by 16 · see citing works
Machado‐Vieira, R. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1062 · Cited by 16 · see citing works
Xiao, Y., Wang, D., Tan, Z., Hong, L., Wang, Y., Pan, C., Lan, Z., Kuai, C., & Xue, S. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.059 · Cited by 14 · see citing works
Clinical, Research and Treatment Approaches to Affective Disorders
Juruena, M. F. (2012) · InTech eBooks · doi:10.5772/1482 · Cited by 7 · see citing works
Scarpato, B. S., Swardfager, W., Eid, M., Ploubidis, G. B., & Cogo‐Moreira, H. (2020) · Psychological Medicine · doi:10.1017/s0033291719003805 · Cited by 13 · see citing works
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
Bockstaele, E. J. V. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7940-6 · Cited by 13 · see citing works
- Authors
- Meyer, J. H., Wilson, A. A., Sagrati, S., Miler, L., Rusjan, P., Bloomfield, P. M., Clark, M., Sacher, J., Voineskos, A. N., & Houle, S.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Meyer, Jeffrey H.
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2009-12-01
- Volume
- 66
- Issue
- 12
- Pages
- 1304
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2152918255
- Cited by
- 182
- References
- 69
- Citations by year
- 2026: 4 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 21 · 2014: 12 · 2013: 17 · 2012: 24
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- GlaxoSmithKline
- H. Lundbeck A/S
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, monoamine oxidase A, selective serotonin reuptake inhibitors, depression remission, depression recurrence, prefrontal cortex, anterior cingulate cortex, monoamine depletion
- MeSH terms
- Adult, Brain, Brain Mapping, Carbon Radioisotopes, Major Depressive Disorder, Female, Gyrus Cinguli, Harmine, Humans, Male, Monoamine Oxidase, Recurrence, Severity of Illness Index, Tissue Distribution, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review