Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D 2 Receptor Parameter Measurements in Ventral Striatum

Mawlawi, Osama; Martinez, Diana; Slifstein, Mark; Broft, Allegra; Chatterjee, Rano; Hwang, Dah-Ren; Huang, Yiyun; Simpson, Norman; Ngo, Kim; Van Heertum, Ronald; Laruelle, Marc

doi:10.1097/00004647-200109000-00002

Cited by 525Neurotransmitter Receptor Influence on BehaviorMedical Imaging Techniques and ApplicationsSchizophrenia research and treatment

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D 2 Receptor Parameter Measurements in Ventral Striatum

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Mawlawi, Osama, Martinez, Diana, Slifstein, Mark, Broft, Allegra, Chatterjee, Rano, Hwang, Dah-Ren, Huang, Yiyun, Simpson, Norman +3 more·2001·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1097/00004647-200109000-00002

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Abstract

Dopamine transmission in the ventral striatum (VST), a structure which includes the nucleus accumbens, ventral caudate, and ventral putamen, plays a critical role in the pathophysiology of psychotic states and in the reinforcing effects of virtually all drugs of abuse. The aim of this study was to assess the accuracy and precision of measurements of D(2) receptor availability in the VST obtained with positron emission tomography on the high-resolution ECAT EXACT HR+ scanner (Siemens Medical Systems, Knoxville, TN, U.S.A.). A method was developed for identification of the boundaries of the VST on coregistered high-resolution magnetic resonance imaging scans. Specific-to-nonspecific partition coefficient (V(3)") and binding potential (BP) of [(11)C]raclopride were measured twice in 10 subjects, using the bolus plus constant infusion method. [(11)C]Raclopride V(3)" in the VST (1.86 +/- 0.29) was significantly lower than in the dorsal caudate (DCA, 2.33 +/- 0.28) and dorsal putamen (DPU, 2.99 +/- 0.26), an observation consistent with postmortem studies. The reproducibility of V(3)" and BP were appropriate and similar in VST (V(3)" test-retest variability of 8.2% +/- 6.2%, intraclass correlation coefficient = 0.83), DCA (7.7% +/- 5.1%, 0.77), DPU (6.0% +/- 4.1%, 0.71), and striatum as a whole (6.3% +/- 4.1%, 0.78). Partial volume effects analysis revealed that activities in the VST were significantly contaminated by counts spilling over from the adjacent DCA and DPU: 70% +/- 5% of the specific binding measured in the VST originated from D(2) receptors located in the VST, whereas 12% +/- 3% and 18% +/- 3% were contributed by D(2) receptors in the DCA and DPU, respectively. Thus, accuracy of D(2) receptor measurement is improved by correction for partial voluming effects. The demonstration of an appropriate accuracy and precision of D(2) receptor measurement with [(11)C]raclopride in the VST is the first critical step toward the use of this ligand in the study of synaptic dopamine transmission at D(2) receptors in the VST using endogenous competition techniques.

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The peak of the interaction effect was located in the caudate head, as part of the ventral striatum, but not in the nucleus accumbens proper.
“Note, though, that the peak of this interaction effect was located in the caudate head, as part of the ventral striatum (Mawlawi et al., 2001), but not in the nucleus accumbens proper (see Fig. 2).”
From Differentiating neural reward responsiveness in autism versus ADHD (2014) · cites this paper as Mawlawi et al., 2001

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Authors: Mawlawi, O., Martinez, D., Slifstein, M., Broft, A., Chatterjee, R., Hwang, D.-R., Huang, Y., Simpson, N., Ngo, K., Van Heertum, R., & Laruelle, M.
Affiliations: Columbia University Irving Medical Center (US)
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, U.S.A.
New York State Psychiatric Institute (US)
Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY, U.S.A.
ORCID: Mawlawi, Osama
Slifstein, Mark
Huang, Yiyun
Simpson, Norman
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2001-09
Volume: 21
Issue: 9
Pages: 1034-1057
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1097/00004647-200109000-00002
OpenAlex: W1992381398
Cited by: 525
References: 63
Citations by year: 2026: 5 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 16 · 2020: 22 · 2019: 24 · 2018: 34 · 2017: 29 · 2016: 23 · 2015: 30 · 2014: 34 · 2013: 32 · 2012: 28
FWCI: 3.82
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da010219-06)
National Institute of Mental Health (MH-54192, K02 MH01603-0, R01-MH54192, MH01603, K02 MH01603, NIMH K02, K02MH001603, R01MH054192)
National Institute on Drug Abuse (R01 DA 10219-01)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: mesolimbic dopamine system, ventral striatum, [11C]raclopride, binding potential, partial volume correction, test-retest reproducibility, dorsal caudate
MeSH terms: Adult, Carbon Radioisotopes, Cerebellum, Dopamine, Female, Haloperidol, Humans, Male, Middle Aged, Nucleus Accumbens, Tomography, Emission-Computed, Reproducibility of Results, Artifacts, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride

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Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D 2 Receptor Parameter Measurements in Ventral Striatum

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