Psychiatric Diagnoses and Risk of Suicide in Veterans
Abstract
CONTEXT: Although numerous studies have documented the clear link between psychiatric conditions and suicide, few have allowed for the comparison between the strength of association between different psychiatric diagnoses and suicide. OBJECTIVE: To examine the strength of association between different types of psychiatric diagnoses and the risk of suicide in patients receiving health care services from the Department of Veterans Affairs in fiscal year (FY) 1999. DESIGN: This project examined National Death Index data and Veterans Health Administration patient treatment records. SETTING: Department of Veterans Affairs, Veterans Health Administration. PARTICIPANTS: All veterans who used Veterans Health Administration services during FY 1999 (N = 3 291 891) who were alive at the start of FY 2000. MAIN OUTCOME MEASURES: Psychiatric diagnoses were obtained from patient treatment records in FY 1998 and 1999 and used to predict subsequent death by suicide during the following 7 years in sex-stratified survival analyses controlling for age. RESULTS: In the 7 years after FY 1999, 7684 veterans died by suicide. In diagnosis-specific analyses, patients with bipolar disorder had the greatest estimated risk of suicide among men (hazard ratio, 2.98; 95% confidence interval, 2.73-3.25), and patients with substance use disorders had the greatest risk among women (6.62; 4.72-9.29). CONCLUSIONS: Although all the examined psychiatric diagnoses were associated with elevated risk of suicide in veterans, results indicate that men with bipolar disorder and women with substance use disorders are at particularly elevated risk for suicide.
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Consistent with other research, the study shows that people who die by suicide are more likely than the general population to have a mental health or substance use diagnosis.
“Consistent with other research, this study demonstrates that those who die by suicide are more likely than the general population to have a mental health or substance use diagnosis.36”
From Variation in patterns of health care before suicide: a population case-control study. (2019) · cites this paper as [36]
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Britton, P. C., Bohnert, K. M., Ilgen, M. A., Kane, C., Stephens, B., & Pigeon, W. R. (2017) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-017-1377-x · Cited by 41 · see citing works
“Among psychiatric disorders, mood disorders, such as depression and bipolar disorder, and other anxiety disorders were also associated with increased suicide risk, replicating VHA general population findings [22].”
BackgroundSelf-citationCorson, K., Denneson, L. M., Bair, M., Helmer, D., Goulet, J., & Dobscha, S. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.043 · Cited by 41 · see citing works
“Our non-findings for PTSD, SUD, anxiety disorders and TBI lie in contrast to several prior reports (Guerra and Calhoun, 2011; Ilgen et al., 2010; Kessler et al., 1999; Kline et al., 2011; Lemaire and Graham, 2011; Pietrzak et al., 2010).”
BackgroundResultMilitary Personnel Who Seek Health and Mental Health Services Outside the Military.
Waitzkin, H., Cruz, M., Shuey, B., Smithers, D., Muncy, L., & Noble, M. (2018) · Military Medicine · doi:10.1093/milmed/usx051 · Cited by 39 · see citing works
Magruder, K., Yeager, D., & Brawman-Mintzer, O. (2012) · American Journal of Public Health · doi:10.2105/ajph.2011.300451 · Cited by 39 · see citing works
Service use in the month and year prior to suicide among adults enrolled in Ohio Medicaid
Fontanella, C. A., Warner, L. A., Hiance-Steelesmith, D. L., Sweeney, H. A., Bridge, J. A., McKeon, R., & Campo, J. V. (2017) · Psychiatric Services · doi:10.1176/appi.ps.201600206 · Cited by 36 · see citing works
Suicide in bipolar disorder: characteristics and subgroups
Schaffer, A., Sinyor, M., Reis, C., Goldstein, B. I., & Levitt, A. (2014) · Bipolar Disorders · doi:10.1111/bdi.12219 · Cited by 36 · see citing works
Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts
Wilcox, H., Fullerton, J., Glowinski, A., Benke, K., Kamali, M., Hulvershorn, L., Stapp, E., Edenberg, H., Roberts, G., Ghaziuddin, N., et al. (2017) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1016/j.jaac.2017.09.428 · Cited by 35 · see citing works
Rozek, D. C., Baker, S. N., Rugo, K. F., Steigerwald, V. L., Sippel, L. M., Holliday, R., Roberge, E. M., Held, P., Mota, N., & Smith, N. B. (2021) · Journal of Traumatic Stress · doi:10.31234/osf.io/2bcdw · Cited by 34 · see citing works
Wastler, H., Lucksted, A., Phalen, P., & Drapalski, A. L. (2019) · Psychiatric rehabilitation journal · doi:10.1037/prj0000386 · Cited by 34 · see citing works
“Given the high rates of suicide among veterans with serious mental illness (e.g. Ilgen et al., 2010; Jahn et al., 2018), even this modest effect has important implications for suicide risk assessment, prevention, and intervention efforts.”
BackgroundBritton, P. C., Stephens, B., Wu, J., Kane, C. P., Gallegos, A. M., Ashrafioun, L., Tu, X., & Conner, K. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.029 · Cited by 33 · see citing works
Conner, K., & Bagge, C. (2019) · Alcohol research : current reviews · doi:10.35946/arcr.v40.1.02 · Cited by 32 · see citing works
Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder.
Harvey, P. D., Posner, K., Rajeevan, N., Yershova, K., Aslan, M., & Concato, J. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.04.014 · Cited by 32 · see citing works
Klimkiewicz, A., Ilgen, M., Bohnert, A., Jakubczyk, A., Wojnar, M., & Brower, K. (2012) · Alcohol and Alcoholism · doi:10.1093/alcalc/ags069 · Cited by 32 · see citing works
“Alcohol use disorders are consistent predictors of suicidal thoughts and behavior (Henriksson et al., 1993, 1995; Inskip et al., 1998; Sher, 2006; Ilgen et al., 2010) and these disorders are more common among”
BackgroundSelf-citationIovine-Wong, P. E., Nichols-Hadeed, C., Stone, J. T., Gamble, S., Cross, W. F., Cerulli, C., & Levandowski, B. (2019) · Military Medicine · doi:10.1093/milmed/usy355 · Cited by 31 · see citing works
Bullman, T., Schneiderman, A. I., & Gradus, J. (2018) · Suicide and Life-Threatening Behaviour · doi:10.1111/sltb.12482 · Cited by 31 · see citing works
Gradus, J., Leatherman, S., Curreri, A. J., Myers, L., Ferguson, R. E., & Miller, M. C. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.11.012 · Cited by 31 · see citing works
Lin, L., Fortney, J., Bohnert, A., Coughlin, L., Zhang, L., & Piette, J. (2021) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2021.108492 · Cited by 30 · see citing works
Self-citationSleep Disturbances and Suicidality in Posttraumatic Stress Disorder: An Overview of the Literature
Weber, F., Norra, C., & Wetter, T. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00167 · Cited by 30 · see citing works
Cooper, S. A., Szymanski, B. R., Bohnert, K. M., Sripada, R. K., & McCarthy, J. F. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.15707 · Cited by 29 · see citing works
Self-citationThe Unique Health Needs of Post-9/11 U.S. Veterans
Waszak, D. L., & Holmes, A. (2017) · Workplace Health & Safety · doi:10.1177/2165079916682524 · Cited by 29 · see citing works
Motivational interviewing to address suicidal ideation: A randomized controlled trial in veterans
Britton, P. C., Conner, K. R., Chapman, B. P., & Maisto, S. A. (2020) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12581 · Cited by 28 · see citing works
Kilbourne, A., Evans, E., & Atkins, D. (2021) · FASEB bioAdvances · doi:10.1096/fba.2020-00124 · Cited by 28 · see citing works
McClure, J. R., Criqui, M., Macera, C., Ji, M., Nievergelt, C., & Zisook, S. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.09.010 · Cited by 28 · see citing works
“We chose a Veterans Administration psychiatric emergency clinic (VA PEC) for our study setting because VA PEC visitors represent a heterogeneous population that includes veterans at high risk of SI and SA such as recent returnees from Iraq and Afghanistan [8], and veterans with acute and chronic psychiatric or substan…”
MethodValenstein, M., Kim, H., Ganoczy, D., Eisenberg, D., Pfeiffer, P. N., Downing, K., Hoggatt, K., Ilgen, M., Austin, K. L., Zivin, K., et al. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182539f11 · Cited by 28 · see citing works
“(J Clin Psychopharmacol 2012;32: 346Y353) P atients with depressive disorders are at high risk for suicide.(1,2) Although antidepressant medications are effective in reducing depressive symptoms among adults, concerns have reemerged that antidepressant medications may increase rather than decrease suicide risks, parti…”
BackgroundSelf-citationEvaluation of Suicide Mortality Among Sexual Minority US Veterans From 2000 to 2017
Lynch, K. E., Gatsby, E., Viernes, B., Schliep, K., Whitcomb, B., Alba, P. R., Duvall, S., & Blosnich, J. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.31357 · Cited by 26 · see citing works
Team-Based Telecare for Bipolar Disorder
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“53 Not only was CVT-based consultation not associated with lapses in patient safety, the care model increased vigilance, activating the individual’s home medical center staff on multiple occasions to respond to suicidal ideation; this enhanced response may have contributed to the lack of reduction…”
Integration of peer support and computer-based CBT for veterans with depression
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Self-citationTreatment-resistant depression and risk of suicide.
Pfeiffer, P. N., Kim, H., Ganoczy, D., Zivin, K., & Valenstein, M. (2013) · Suicide and Life-Threatening Behaviour · doi:10.1111/sltb.12022 · Cited by 26 · see citing works
“approximately 2% to 5% of those with affective disorders who will die by suicide (Bostwick & Pankratz, 2000; Ilgen et al., 2010).”
BackgroundResultInfluentialSelf-citationMood-, Anxiety-, and Substance Use Disorders and Suicide Risk in a Military Population Cohort
Conner, K., McCarthy, M. D., Bajorska, A., Caine, E., Tu, X., & Knox, K. (2012) · Suicide and Life-Threatening Behaviour · doi:10.1111/j.1943-278x.2012.00125.x · Cited by 26 · see citing works
“Accordingly, major western reports on suicide have noted the importance of preventing, detecting, and treating mental disorders as part of a comprehensive strategy for suicide prevention (U.S. Public Health Service, 1999; Institute of Medicine, 2002; U.S. Department of Defense, 2010).”
BackgroundInfluentialMccarthy, J., Szymanski, B. R., Karlin, B., & Katz, I. (2013) · American Journal of Public Health · doi:10.2105/ajph.2013.301292 · Cited by 25 · see citing works
Self-citationGulf War and Health: Treatment for Chronic Multisymptom Illness.
War, G. (2017) · Military Medicine · doi:10.7205/milmed-d-16-00325 · Cited by 25
- Authors
- Ilgen, M. A., Bohnert, A. S. B., Ignacio, R. V., McCarthy, J. F., Valenstein, M. M., Kim, H. M., & Blow, F. C.
- Affiliations
- University of Michigan (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-11-01
- Volume
- 67
- Issue
- 11
- Pages
- 1152
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2060307158
- Cited by
- 311
- References
- 40
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 30 · 2020: 25 · 2019: 23 · 2018: 26 · 2017: 18 · 2016: 19 · 2015: 19 · 2014: 18 · 2013: 25 · 2012: 29
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- suicide risk, psychiatric diagnosis, veterans, bipolar disorder, substance use disorders, sex differences, suicide mortality, Department of Veterans Affairs, National Death Index
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Mental Disorders, Cause of Death, Centers for Disease Control and Prevention, U.S., Delivery of Health Care, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Suicide, United States, United States Department of Veterans Affairs, Veterans, Age Distribution, Substance-Related Disorders
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