Cited by 148Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans

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Soetanto, Ainie, Wilson, Robert S., Talbot, Konrad, Un, Ashley, Schneider, Julie A., Sobiesk, Mark, Kelly, Jeremiah, Leurgans, Sue, Bennett, David A., Arnold, Steven E.·2010·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2010.48PMC PMC2926797

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Abstract

CONTEXT: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines. OBJECTIVES: To examine whether analogous distress-related neuroanatomic changes occur in humans and whether such changes might also be related to cognitive dysfunction observed in older people who report greater psychological distress. DESIGN: Postmortem study of brain tissues from participants of the Religious Orders Study, an ongoing population-based clinicopathological study of aging and cognition. SETTING: The Rush University Religious Orders Study and the University of Pennsylvania Cellular and Molecular Neuropathology Program. PARTICIPANTS: Seventy-two deceased participants of the Religious Orders Study. MAIN OUTCOME MEASURES: Densities of microtubule-associated protein 2-immunolabeled dendrites and synaptopodin-immunolabeled dendritic spines in the CA3 subfield of the hippocampus, quantified using semiautomated image acquisition and analysis. RESULTS: Higher levels of trait anxiety and longitudinal depression scores were associated with decreased densities of dendrites and spines in CA3. Dendrite and spine densities did not correlate with an index of global cognition or with densities of common age-related pathological changes. CONCLUSIONS: Regressive neuronal changes occur in humans who experience greater psychological distress. These changes are analogous to neuronal changes in animal models of chronic stress.

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Authors: Soetanto, A., Wilson, R. S., Talbot, K., Un, A., Schneider, J. A., Sobiesk, M., Kelly, J., Leurgans, S., Bennett, D. A., & Arnold, S. E.
Affiliations: University of Pennsylvania (US)
Rush University Medical Center (US)
ORCID: Soetanto, Ainie
Talbot, Konrad
Schneider, Julie A.
Leurgans, Sue
Bennett, David A.
Arnold, Steven E.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2010-05-01
Volume: 67
Issue: 5
Pages: 448
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2010.48
PMC: PMC2926797
OpenAlex: W2123329302
Cited by: 148
References: 83
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 30 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 15
FWCI: 4.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p50mh064045-10)
National Institute on Aging (P30-AG 10161, P30AG10124, R01 AG15819, P30AG010124, R01AG015819, P30AG010161, R01AG024871)
National Institute of Mental Health (P50 MH-064045, R29MH055199, R01MH057401)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: anxiety, depression, hippocampal CA3, dendritic spines, MAP2, synaptopodin, psychological distress, chronic stress, aging, cognitive impairment, postmortem brain, Religious Orders Study
MeSH terms: Aged, Aged, 80 and over, Anxiety Disorders, Catholicism, Cognition Disorders, Dendrites, Depressive Disorder, Female, Humans, Longitudinal Studies, Male, Microtubule-Associated Proteins, Religion and Psychology, Dendritic Spines, CA3 Region, Hippocampal

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Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans

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