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Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
Open accessAbstract
CONTEXT: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines. OBJECTIVES: To examine whether analogous distress-related neuroanatomic changes occur in humans and whether such changes might also be related to cognitive dysfunction observed in older people who report greater psychological distress. DESIGN: Postmortem study of brain tissues from participants of the Religious Orders Study, an ongoing population-based clinicopathological study of aging and cognition. SETTING: The Rush University Religious Orders Study and the University of Pennsylvania Cellular and Molecular Neuropathology Program. PARTICIPANTS: Seventy-two deceased participants of the Religious Orders Study. MAIN OUTCOME MEASURES: Densities of microtubule-associated protein 2-immunolabeled dendrites and synaptopodin-immunolabeled dendritic spines in the CA3 subfield of the hippocampus, quantified using semiautomated image acquisition and analysis. RESULTS: Higher levels of trait anxiety and longitudinal depression scores were associated with decreased densities of dendrites and spines in CA3. Dendrite and spine densities did not correlate with an index of global cognition or with densities of common age-related pathological changes. CONCLUSIONS: Regressive neuronal changes occur in humans who experience greater psychological distress. These changes are analogous to neuronal changes in animal models of chronic stress.
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“We found that synaptopodin, an actin-associated protein enriched in postsynaptic densities is a robust marker of dendritic spines (Soetanto, et al., 2010).”
From Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer’s disease (2013) · cites this paper as Soetanto, et al., 2010
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Metadata
- Authors
- Soetanto, A., Wilson, R. S., Talbot, K., Un, A., Schneider, J. A., Sobiesk, M., Kelly, J., Leurgans, S., Bennett, D. A., & Arnold, S. E.
- Affiliations
- University of Pennsylvania (US)
- Rush University Medical Center (US)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-05-01
- Volume
- 67
- Issue
- 5
- Pages
- 448
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC2926797
- OpenAlex
- W2123329302
- Cited by
- 148
- References
- 83
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 30 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50mh064045-10)
- National Institute on Aging (P30-AG 10161, P30AG10124, R01 AG15819, P30AG010124, R01AG015819, P30AG010161, R01AG024871)
- National Institute of Mental Health (P50 MH-064045, R29MH055199, R01MH057401)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- anxiety, depression, hippocampal CA3, dendritic spines, MAP2, synaptopodin, psychological distress, chronic stress, aging, cognitive impairment, postmortem brain, Religious Orders Study
- MeSH terms
- Aged, Aged, 80 and over, Anxiety Disorders, Catholicism, Cognition Disorders, Dendrites, Depressive Disorder, Female, Humans, Longitudinal Studies, Male, Microtubule-Associated Proteins, Religion and Psychology, Dendritic Spines, CA3 Region, Hippocampal
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