Cited by 184Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

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Reduced Structural Connectivity of a Major Frontolimbic Pathway in Generalized Anxiety Disorder

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Tromp, Do P. M., Grupe, Daniel W., Oathes, Desmond J., McFarlin, Daniel R., Hernandez, Patric J., Kral, Tammi R. A., Lee, Jee Eun, Adams, Marie, Alexander, Andrew L., Nitschke, Jack B.·2012·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2011.2178PMC PMC3566704

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Abstract

CONTEXT: Emotion regulation deficits figure prominently in generalized anxiety disorder (GAD) and in other anxiety and mood disorders. Research examining emotion regulation and top-down modulation has implicated reduced coupling of the amygdala with prefrontal cortex and anterior cingulate cortex, suggesting altered frontolimbic white matter connectivity in GAD. OBJECTIVES: To investigate structural connectivity between ventral prefrontal cortex or anterior cingulate cortex areas and the amygdala in GAD and to assess associations with functional connectivity between those areas. DESIGN: Participants underwent diffusion-tensor imaging and functional magnetic resonance imaging. SETTING: University magnetic resonance imaging facility. PARTICIPANTS: Forty-nine patients with GAD and 39 healthy volunteer control subjects, including a matched subset of 21 patients having GAD without comorbid Axis I diagnoses and 21 healthy volunteers matched for age, sex, and education. MAIN OUTCOME MEASURES: The mean fractional anisotropy values in the left and right uncinate fasciculus, as measured by tract-based analysis for diffusion-tensor imaging data. RESULTS: Lower mean fractional anisotropy values in the bilateral uncinate fasciculus indicated reduced frontolimbic structural connectivity in patients with GAD. This reduction in uncinate fasciculus integrity was most pronounced for patients without comorbidity and was not observed in other white matter tracts. Across all participants, higher fractional anisotropy values were associated with more negative functional coupling between the pregenual anterior cingulate cortex and the amygdala during the anticipation of aversion. CONCLUSIONS: Reduced structural connectivity of a major frontolimbic pathway suggests a neural basis for emotion regulation deficits in GAD. The functional significance of these structural differences is underscored by decreased functional connectivity between the anterior cingulate cortex and the amygdala in individuals with reduced structural integrity of the uncinate fasciculus.

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Authors: Tromp, D. P. M., Grupe, D. W., Oathes, D. J., McFarlin, D. R., Hernandez, P. J., Kral, T. R. A., Lee, J. E., Adams, M., Alexander, A. L., & Nitschke, J. B.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Nitschke, Jack B.
ORCID: Tromp, Do P. M.
Grupe, Daniel W.
Oathes, Desmond J.
Kral, Tammi R. A.
Lee, Jee Eun
Alexander, Andrew L.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2012-09-01
Volume: 69
Issue: 9
Pages: 925
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2011.2178
PMC: PMC3566704
OpenAlex: W1992691945
Cited by: 184
References: 87
Citations by year: 2026: 11 · 2025: 10 · 2024: 11 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 7 · 2019: 15 · 2018: 12 · 2017: 22 · 2016: 21 · 2015: 16 · 2014: 11 · 2013: 15 · 2012: 1
FWCI: 18.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5k02mh082130-05)
National Institute of Mental Health (K02‑MH082130, R01MH074847, K08MH063984, P50MH084051, T32MH018931)
National Institute of General Medical Sciences (R25GM083252, T32GM007507)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003352)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: generalized anxiety disorder, uncinate fasciculus, structural connectivity, fractional anisotropy, amygdala, anterior cingulate cortex, prefrontal cortex, emotion regulation, functional connectivity, white matter integrity, comorbidities
MeSH terms: Adolescent, Adult, Amygdala, Anxiety Disorders, Arousal, Brain Mapping, Dominance, Cerebral, Emotions, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Male, Neural Pathways, Reference Values, Temporal Lobe, Comorbidity, Imaging, Three-Dimensional, Diffusion Magnetic Resonance Imaging, Young Adult

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Reduced Structural Connectivity of a Major Frontolimbic Pathway in Generalized Anxiety Disorder

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