Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

Neaton, James D.

doi:10.1001/archinte.1992.00400130082009

Cited by 784Cardiovascular Health and Risk FactorsHealth Promotion and Cardiovascular PreventionLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

Neaton, James D.·1992·Archives of Internal Medicine

DOI 10.1001/archinte.1992.00400130082009

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Abstract

To assess the combined influence of blood pressure (BP), serum cholesterol level, and cigarette smoking on death from coronary heart disease (CHD) and to describe how these associations vary with age, data on those factors and on mortality for 316 099 men screened for the Multiple Risk Factor Intervention Trial (MRFIT) were examined. Vital sta tus of participants has been determined after an average follow-up of 12 years; 6327 deaths from CHD have been identified. Strong graded relationships between serum cho lesterol levels above 4.65 mmol/L (180 mg/dL), systolic BP above 110 mm Hg, and diastolic BP above 70 mm Hg and mortality due to CHD were evident. Smokers with serum cholesterol and systolic BP levels in the highest quintiles had CHD death rates that were approximately 20 times greater than nonsmoking men with systolic BP and cholesterol lev els in the lowest quintile. Systolic and diastolic BP, serum cholesterol level, and cigarettes per day were significant predictors of death due to CHD in all age groups. Systolic BP was a stronger predictor than diastolic BP. These results, together with the findings of clinical trials, offer strong support for intensified preventive efforts in all age groups. (Arch Intern Med. 1992;152:56-64)

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Metabolic syndrome is a common additional cardiovascular risk factor in 40% of hypertensive patients.
“metabolic syndrome (40%)”
From 2020 International Society of Hypertension Global Hypertension Practice Guidelines (2020) · cites this paper as [30]
Overweight-obesity is a common additional cardiovascular risk factor in 40% of hypertensive patients.
“overweight-obesity (40%)”
From 2020 International Society of Hypertension Global Hypertension Practice Guidelines (2020) · cites this paper as [30]
Hyperuricemia is a common additional cardiovascular risk factor in 25% of hypertensive patients.
“hyperuricemia (25%)”
From 2020 International Society of Hypertension Global Hypertension Practice Guidelines (2020) · cites this paper as [30]
Lipid disorders (elevated LDL-C and triglycerides) are a common additional cardiovascular risk factor in 30% of hypertensive patients.
“lipid disorders (elevated low-density lipoprotein-cholesterol [LDL-C] and triglycerides [30%])”
From 2020 International Society of Hypertension Global Hypertension Practice Guidelines (2020) · cites this paper as [30]
Diabetes is a common additional cardiovascular risk factor in 15%-20% of hypertensive patients.
“diabetes (15%-20%)”
From 2020 International Society of Hypertension Global Hypertension Practice Guidelines (2020) · cites this paper as [30]

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Authors: Neaton, J. D.
Corresponding author: Neaton, James D.
ORCID: Neaton, James D.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1992-01-01
Volume: 152
Issue: 1
Pages: 56
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1992.00400130082009
OpenAlex: W1995779077
Cited by: 784
References: 37
Citations by year: 2026: 3 · 2025: 8 · 2024: 3 · 2023: 13 · 2022: 11 · 2021: 7 · 2020: 17 · 2019: 7 · 2018: 13 · 2017: 15 · 2016: 23 · 2015: 16 · 2014: 30 · 2013: 19 · 2012: 23
FWCI: 16.15
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (1-RO1-HL-28715)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: coronary heart disease mortality, serum cholesterol, blood pressure, cigarette smoking, age differences, systolic blood pressure, cardiovascular risk factors, Multiple Risk Factor Intervention Trial, white men

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Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

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