Cited by 1,155Sleep and related disordersSleep and Work-Related FatigueCardiovascular Health and Risk Factors

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A Prospective Study of Sleep Duration and Coronary Heart Disease in Women

Ayas, Najib T., White, David P., Manson, JoAnn E., Stampfer, Meir J., Speizer, Frank E., Malhotra, Atul, Hu, Frank B.·2003·Archives of Internal Medicine

DOI 10.1001/archinte.163.2.205

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Abstract

Background Long-term sleep deprivation is common in today's society. Recent experiments have demonstrated that short-term sleep deprivation in healthy subjects results in adverse physiologic changes, including a decreased glucose tolerance and an increased blood pressure. However, the long-term health consequences of long-term sleep deprivation are unclear. The objective of this study was to determine whether decreased sleep duration (from self-reports) is associated with an increased risk of coronary events. Methods We studied a cohort of 71 617 US female health professionals (aged 45-65 years), without reported coronary heart disease (CHD) at baseline, who were enrolled in the Nurses' Health Study. Subjects were mailed a questionnaire in 1986 asking about daily sleep duration. Subjects were followed up until June 30, 1996, for the occurrence of CHD-related events. We assessed the relationship between self-reported sleep duration and incident CHD. Results A total of 934 coronary events were documented (271 fatal and 663 nonfatal) during the 10 years of follow up. Age-adjusted relative risks (95% confidence intervals) of CHD (with 8 hours of daily sleep being considered the reference group) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.82 (1.34-2.41), 1.30 (1.08-1.57), and 1.06 (0.89-1.26), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.57 (1.18-2.11). After adjusting for various potential confounders, including snoring, body mass index, and smoking, the relative risks of CHD (95% confidence intervals) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.45 (1.10-1.92), 1.18 (0.98-1.42), and 1.09 (0.91-1.30), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.38 (1.03-1.86). Conclusion Short and long self-reported sleep durations are independently associated with a modestly increased risk of coronary events.

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Untitled work
(2006) · Cited by 58

Authors: Ayas, N. T., White, D. P., Manson, J. E., Stampfer, M. J., Speizer, F. E., Malhotra, A., & Hu, F. B.
Affiliations: Vancouver General Hospital (CA)
Corresponding author: Ayas, Najib T.
ORCID: Ayas, Najib T.
Manson, JoAnn E.
Stampfer, Meir J.
Malhotra, Atul
Hu, Frank B.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2003-01-27
Volume: 163
Issue: 2
Pages: 205
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.163.2.205
OpenAlex: W1996391039
Cited by: 1,155
References: 14
Citations by year: 2026: 15 · 2025: 42 · 2024: 23 · 2023: 25 · 2022: 50 · 2021: 57 · 2020: 40 · 2019: 51 · 2018: 48 · 2017: 59 · 2016: 50 · 2015: 88 · 2014: 62 · 2013: 82 · 2012: 69
FWCI: 40.88
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL24074, HL34594, R01HL048531)
National Cancer Institute (CA-87969)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: sleep duration, coronary artery disease, women, short sleep duration, excessive sleep, coronary events, Nurses' Health Study, self-reported sleep

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A Prospective Study of Sleep Duration and Coronary Heart Disease in Women

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