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Dietary Fiber and Risk of Coronary Heart Disease: A Pooled Analysis of Cohort Studies
Open accessAbstract
BACKGROUND: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease. METHODS: We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease. RESULTS: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women. CONCLUSION: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.
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“Insoluble fiber has been associated with decreased CVD risk 36 -38 and slower progression of CVD in high-risk individuals.39”
From Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee (2006) · cites this paper as [38]
In the citing paper
“Insoluble fiber has been associated with decreased CVD risk 36 -38 and slower progression of CVD in high-risk individuals.39”
From Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee (2006) · cites this paper as [36]
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Metadata
- Authors
- Pereira, M. A., O'Reilly, E., Augustsson, K., Fraser, G. E., Goldbourt, U., Heitmann, B. L., Hallmans, G., Knekt, P., Liu, S., Pietinen, P., Spiegelman, D., Stevens, J., Virtamo, J., Willett, W. C., & Ascherio, A.
- Affiliations
- University of Minnesota (US)
- Loma Linda University (US)
- Sheba Medical Center (IL)
- University of Copenhagen (DK)
- Finnish Institute for Health and Welfare (FI)
- Harvard University (US)
- Corresponding author
- Pereira, Mark A.
- ORCID
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2004-02-23
- Volume
- 164
- Issue
- 4
- Pages
- 370
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2126541538
- Cited by
- 630
- References
- 41
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 4 · 2023: 22 · 2022: 13 · 2021: 17 · 2020: 21 · 2019: 20 · 2018: 26 · 2017: 20 · 2016: 27 · 2015: 40 · 2014: 48 · 2013: 44 · 2012: 55
- FWCI
- 35.47
- Type
- journal article
- Language
- en
- Open access
- green
- nrs.harvard.edu
- Licence
- cc-by
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL58904, R01HL058904)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- dietary fiber, coronary artery disease, cereal fiber, fruit fiber, plant fibers, coronary heart disease mortality, sex differences, pooled analysis of cohort studies, measurement error correction
- MeSH terms
- Edible Grain, Coronary Artery Disease, Dietary Fiber, Female, Fruit, Humans, Male, Nutritional Physiological Phenomena, Cohort Studies, Risk Assessment
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