Long-term Effects of Modest Weight Loss in Type II Diabetic Patients
Abstract
Since most obese patients with type II diabetes are unable to achieve ideal body weight, this study examined whether more modest weight losses would provide a long-term benefit. Type II diabetic patients (N = 114) were treated in a behavioral weight control program and followed up for one year. Weight loss was significantly correlated with improvements in glycosylated hemoglobin values at posttreatment (r = .55) and one year (r = .51). Patients who lost more than 6.9 kg or had more than 5% reduction in body weight had significant improvements in glycosylated hemoglobin values at one year, while patients losing less weight had nonsignificant changes and those gaining weight had significant worsening. Thus, modest weight loss can have a long-term impact on glycemic control. However, the improvement in glycemic control for a given weight loss was greater initially than at one year, suggesting that energy restriction, in addition to weight loss, may contribute to initial improvement. Neither percent overweight nor diabetes treatment affected weight loss.
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Small long-term reductions in body weight (fat) improve glucose tolerance and the other metabolic CHD risk factors evaluated in the present study.
“Small long-term reductions in body weight (fat) improve glucose tolerance and the other metabolic CHD risk factors evaluated in the present study (2,3,12-14).”
From Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease (2008) · cites this paper as [2]
Even moderate (e.g., 10%) weight loss improves all cardiometabolic risk factors simultaneously in obese patients.
“Diet-induced fat loss is recommended for obese patients who have these cardiometabolic risk factors, because even moderate (e.g., 10%) weight loss improves all risk factors simultaneously (1-3).”
From Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease (2008) · cites this paper as [2]
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- Authors
- Wing, R. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Wing, Rena R.
- ORCID
- Wing, Rena R.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1987-10-01
- Volume
- 147
- Issue
- 10
- Pages
- 1749
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2003301702
- Cited by
- 484
- References
- 0
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 17 · 2015: 6 · 2014: 10 · 2013: 17 · 2012: 20
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am029757-05)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, weight loss, obesity, glycemic control, HbA1c, behavioral weight control, caloric restriction, long-term outcomes, weight regain
- MeSH terms
- Adult, Aged, Analysis of Variance, Behavior Therapy, Body Weight, Diabetes Mellitus, Type 2, Diet, Reducing, Female, Follow-Up Studies, Humans, Insulin, Cholesterol, HDL, Male, Middle Aged, Triglycerides
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